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71. 发明申请

US20060188895A1 Rapid prognostic assay for malignancies treated with epidermal growth factor receptor 审中-公开
标题翻译：用表皮生长因子受体治疗的恶性肿瘤的快速预后测定
公开(公告)号：US20060188895A1
公开(公告)日：2006-08-24
申请号：US11217657
申请日：2005-08-31
申请人： Piotr Kulesza , Antonio Jimeno , Manuel Hidalgo , Douglas Clark , Erik Kincaid
发明人： Piotr Kulesza , Antonio Jimeno , Manuel Hidalgo , Douglas Clark , Erik Kincaid
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： A molecular assay for determining the sensitivity or resistance of malignancies to chemotherapy prior to initiation of chemotherapy and which also allows for monitoring the therapeutic effects of the chemotherapy during treatment. The molecular assay measures tumor response to therapy with EGFR modulators and utilizes tumor mRNA as a starting material and a quantitative measurement of c-fos expression as an analytical endpoint.
摘要翻译：用于在化疗开始之前确定恶性肿瘤对化学疗法的敏感性或耐药性的分子测定法，并且还允许监测治疗期间化疗的治疗效果。分子测定法测量肿瘤对EGFR调节剂治疗的反应，并利用肿瘤mRNA作为起始物质，并作为分析终点的c-fos表达定量测定。

72. 发明申请

US20060172916A1 Use of a polymer dispersant as a fluidising agent for hydraulic binder compositions and preparation thereof 审中-公开
标题翻译：使用聚合物分散剂作为水硬性粘合剂组合物的流化剂及其制备方法
公开(公告)号：US20060172916A1
公开(公告)日：2006-08-03
申请号：US10547626
申请日：2004-02-25
申请人： Manuel Hidalgo , Djamel Bensarsa , Martial Pabon , Fabio Giberti , Jean-Marc Corpart
发明人： Manuel Hidalgo , Djamel Bensarsa , Martial Pabon , Fabio Giberti , Jean-Marc Corpart
IPC分类号： C11D3/37
CPC分类号： C08F220/04 , B01F17/0028 , B01F17/005 , B01F17/0057 , C04B24/163 , C04B24/20 , C04B24/2641 , C04B24/2647 , C04B24/2676 , C04B24/2688 , C04B28/02 , C04B2103/408 , C04B2103/10 , C04B2103/20 , C04B2103/50 , C04B2103/54
摘要： Polymer dispersant of polycarboxylate type comprising at least one copolymer obtained from a monomer composition comprising, in moles: A) 40 to 95% of at least one unsaturated carboxylic monomer, B) 5 to 60% of at least one acrylic ester or methacrylic ester monomer comprising a polyether chain, C) 0 to 20% of at least one third monomer selected from: acrylic ester or methacrylic ester or acrylamide or acrylamide derivative or vinylaromatic monomer or its sulphonated derivative, the copolymer having a controlled molecular mass distribution and being able to be obtained by a process comprising the stages of: i) polymerization in aqueous solution at a temperature ranging from 70 to 95° C. with an initiation and transfer system comprising: D) an oxidizing agent, E) a reducing agent selected from metabisulphite salts, and preferably from sodium metabisulphite or potassium metabisulphite, the monomers/reducing agent molar ratio not exceeding 50, ii) semi-continuous addition of the oxidizing agent and of the mixture of monomers over a time ranging from 1 to 4 hours, iii) introduction of the reducing agent, either as vessel heel, before the beginning of the addition of the oxidizing agent and of the monomers, or semi-continuously, mixed with the monomers, or semi-continuously, as a separate feed from the latter and from the oxidizing agent. The invention also relates to a specific preparation process and to uses as plasticizer in inorganic hydraulic binder compositions or as dispersing agent in pigment pastes or aqueous polymer dispersions.
摘要翻译：包含至少一种由单体组合物得到的共聚物的聚羧酸酯类聚合物分散剂，其包含摩尔数：A）40至95％的至少一种不饱和羧酸单体，B）5至60％的至少一种丙烯酸酯或甲基丙烯酸酯单体包括聚醚链，C）0至20％的至少一种选自丙烯酸酯或甲基丙烯酸酯或丙烯酰胺或丙烯酰胺衍生物或乙烯基芳族单体或其磺化衍生物的第三单体，所述共聚物具有受控的分子量分布，并且能够通过包括以下步骤的方法获得：i）在70至95℃的温度范围内在水溶液中聚合，引发和转移体系包括：D）氧化剂，E）选自偏亚硫酸氢盐，优选偏亚硫酸氢钠或偏亚硫酸氢钾，单体/还原剂摩尔比不超过50，ii）半连续添加氧化物 g试剂和单体混合物在1至4小时的时间内，iii）在开始加入氧化剂和单体之前引入还原剂，作为容器脚跟，或半连续与单体混合，或半连续地作为与后者和氧化剂的单独进料混合。本发明还涉及具体的制备方法，并且用作无机水硬性粘合剂组合物中的增塑剂或作为分散剂在颜料糊或水性聚合物分散体中使用。

73. 发明申请

US20060128892A1 Ductile and transparent thermoplastic compositions comprising an amorphous matrix and a block copolymer 审中-公开
标题翻译：包含无定形基质和嵌段共聚物的延性和透明热塑性组合物
公开(公告)号：US20060128892A1
公开(公告)日：2006-06-15
申请号：US10532385
申请日：2003-10-15
申请人： Manuel Hidalgo , Silvija Abele , Francois Court , Ludwik Leibler , Djamel Bensarsa
发明人： Manuel Hidalgo , Silvija Abele , Francois Court , Ludwik Leibler , Djamel Bensarsa
IPC分类号： C08L53/00 , B32B27/20
CPC分类号： C08L33/12 , Y10T428/249921 , C08L2666/02
摘要： The invention concerns transparent materials having good impact resistance, a high modulus and good heat resistance. The inventive materials comprise an amorphous matrix, preferably based on styrene/methyl methacrylate statistical copolymer whether impact-reinforced of not with a standard additive, and a block copolymer having at least an elastomeric block and at least a block partly or entirely compatible with the amorphous matrix.
摘要翻译：本发明涉及具有良好抗冲击性，高模量和良好耐热性的透明材料。本发明的材料包括无定形基质，优选基于苯乙烯/甲基丙烯酸甲酯统计共聚物，不论是否用标准添加剂进行冲击强化，以及至少具有弹性体嵌段和至少部分或完全与非晶形态相容的嵌段的嵌段共聚物矩阵。

74. 发明申请

US20060111479A1 Water-soluble or water-dispersible acrylic dispersants obtained by controlled radical polymerization 失效
标题翻译：通过控制自由基聚合获得的水溶性或水分散性丙烯酸分散剂
公开(公告)号：US20060111479A1
公开(公告)日：2006-05-25
申请号：US11270751
申请日：2005-11-09
申请人： Manuel Hidalgo , Stephanie Magnet , Olivier Guerret
发明人： Manuel Hidalgo , Stephanie Magnet , Olivier Guerret
IPC分类号： C04B24/26
CPC分类号： C08F220/32 , C04B24/2647 , C04B24/2694 , C04B2103/0045 , C04B2103/408 , C08F2/16 , C08F2/38 , C08F220/06
摘要： The present invention relates to a process for the preparation in aqueous solution of water-soluble acrylic polymers or for the preparation in aqueous dispersion of water-dispersible acrylic co-polymers, polymerised from, being 100 mol %: a) 5 to 70 mol % of one or more monomer(s) (A) which are (alkoxy)polyalkylene glycol (meth)acrylates and/or ((alkoxy)polyalkylene glycol)(meth)acrylamides; b) 5 to 95 mol % of one or more unsaturated carboxylic monomer(s) (B); and c) 0 to 85 mol % of one or more hydrophobic monomer(s) (C) which are water insoluble, in the absence of a chain-transfer agent, and in the presence of a sufficient amount of a water-soluble alkoxyamine, until a conversion of at least 90% by weight of the monomers (A), (B) and (C) is obtained. The polymer has a polydispersity index {overscore (Mw)}/{overscore (Mn)} advantageously 50%) is converted by the alkoxyamine and the polymerization is completed by a conventional radical initiator. The polymer obtained has a polydispersity index {overscore (Mw)}/{overscore (Mn)}
摘要翻译：本发明涉及一种在水溶性丙烯酸类聚合物的水溶液中制备或在水分散性丙烯酸共聚物的水分散体中制备方法，聚合度为100摩尔％：a）5-70摩尔％（甲氧基）聚亚烷基二醇（甲基）丙烯酸酯和/或（（烷氧基）聚亚烷基二醇）（甲基）丙烯酰胺的一种或多种单体（A） b）5〜95摩尔％的一种或多种不饱和羧酸单体（B）; 和c）在不存在链转移剂的情况下，在足够量的水溶性烷氧基胺存在下，0至85mol％的一种或多种水不溶性疏水单体（C）直到得到至少90重量％的单体（A），（B）和（C）的转化率。聚合物具有多分散性指数（超核（Mw / {超芯（Mn有利地<2）和（超核（Mn在10,000至50,000之间）。或者，仅一些单体（> 50％）由烷氧基胺转化，所获得的聚合物具有多分散性指数（超核（Mw / {超晶核（Mn <6，有利地<5，优选<4），并且（超晶核（Mw在10,000至500000 有利地在3万到15万之间。

75. 发明申请

US20050004018A1 Use of antitumoral compound in cancer therapy 审中-公开
标题翻译：抗肿瘤化合物在癌症治疗中的应用
公开(公告)号：US20050004018A1
公开(公告)日：2005-01-06
申请号：US10492320
申请日：2002-10-21
申请人： Jose Jimeno , Ana Casado , Luis Lazaro , Eric Rowensky , Manuel Hidalgo
发明人： Jose Jimeno , Ana Casado , Luis Lazaro , Eric Rowensky , Manuel Hidalgo
IPC分类号： A61J1/14 , A61G12/00 , A61K31/198 , A61K31/4995 , A61K31/704 , A61K33/24 , A61K38/00 , A61K45/00 , A61K45/06 , A61P35/00 , A61P43/00 , C07D515/22 , A61K38/17
CPC分类号： A61K31/704 , A61K31/198 , A61K31/4995 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Improved dosing schedules for ecteinascidin 743 are given for treatment of cancer.
摘要翻译：给予ecteinascidin 743的改善的给药方案用于治疗癌症。

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