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71. 发明专利

DE602004006379T2 未知
公开(公告)号：DE602004006379T2
公开(公告)日：2008-01-10
申请号：DE602004006379
申请日：2004-01-27
申请人： CYCLACEL LTD
发明人： MCINNES CAMPBELL , MEADES CHRISTOPHER , MEZNA MOKDAD , FISCHER PETER
IPC分类号： A61K31/428 , A61P35/00 , C07D277/68
摘要： The present invention relates to the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently H, NO 2 , CF 3 , SCF 3 , CN, halo, OH, OR 6 , NH 2 , NHR 6 , NR 6 R 7 , N + R 6 R 7 R 8 , COOH, COOR 6 , CONH 2 , CONHR 6 , CONR 6 R 7 , COH, COR 6 , SR 6 , SOR 6 , SO 2 R 6 , SO 2 OH, SO 2 OR 6 , SO 2 NH 2 , SO 2 NHR 6 , SO 2 NR 6 R 7 , alkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl, with the proviso that at least one of R 1 , R 2 , R 3 , and R 4 is other than H; or R 1 and R 2 , R 2 and R 3 , or R 3 and R 4 , may together form part of a fused or unfused saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; R 5 is OH, OR 9 , CN, CONH 2 , CONHNH 2 , CONHOH, CONHR 9 , CONR 9 R 10 , NH 2 , NHR 9 , or NR 9 R 10 ; each R 6 , R 7 and R 8 is independently hydrocarbyl, or two of R 6 , R 7 and R 8 together form part of a saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; each R 9 and R 10 is independently hydrocarbyl, or R 9 and R 10 together form part of a saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; in the preparation of a medicament for treating a proliferative disorder.

72. 发明专利

AT373653T 未知
公开(公告)号：AT373653T
公开(公告)日：2007-10-15
申请号：AT03811029
申请日：2003-11-14
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , O'BOYLE JANICE , MCINNES CAMPBELL , FISCHER PETER
IPC分类号： C07D417/04 , A61K31/506 , A61K31/513 , A61P35/00

73. 发明专利

DE60304871D1 未知
公开(公告)号：DE60304871D1
公开(公告)日：2006-06-01
申请号：DE60304871
申请日：2003-08-13
申请人： CYCLACEL LTD
发明人： FISCHER PETER , JARMAN MICHAEL , MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL
IPC分类号： C07D473/16 , A61K31/52 , A61P3/10 , A61P9/00 , A61P17/06 , A61P17/14 , A61P25/28 , A61P31/12 , A61P35/00 , A61P35/02
摘要： The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

74. 发明专利

BR0313477A 未知
公开(公告)号：BR0313477A
公开(公告)日：2005-06-21
申请号：BR0313477
申请日：2003-08-13
申请人： CYCLACEL LTD
发明人： FISCHER PETER , JARMAN MICHAEL , MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL
IPC分类号： A61K31/52 , A61P3/10 , A61P9/00 , A61P17/06 , A61P17/14 , A61P25/28 , A61P31/12 , A61P35/00 , C07D473/16 , C07D473/00
摘要： The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

75. 发明专利

CA2530455A1 THIAZOLO-, OXAZALO AND IMIDAZOLO-QUINAZOLINE COMPOUNDS CAPABLE OF INHIBITING PROT EIN KINASES 未知
公开(公告)号：CA2530455A1
公开(公告)日：2005-01-20
申请号：CA2530455
申请日：2004-07-07
申请人： CYCLACEL LTD
发明人： MCINTYRE NEIL , WESTWOOD NICHOLAS , MCINNES CAMPBELL , THOMAS MARK , FISCHER PETER , WANG SHUDONG
IPC分类号： C07D513/04 , A61K31/519 , A61P25/00 , C07D413/04
摘要： compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein: X is S, 0, or NH; "a" is a single bond; or "a" is a double bond and one of R3 and R4 and one of R5 and R6 are absent; R1 is H; or is selected fr om an alkyl group, a cycloalkyl group, a heteroaryl group, an aralkyl group, CO - alkyl, S02-alkyl, C02R13 and an aryl group, each of which optionally contain s one or more heteroatoms, and is optionally substituted with one or more grou ps selected from R8 and R9; R2 is H, R8 , or an alkyl group optionally substituted with one or more R8 groups; R3 , R4, R5, and R6 are each independently selected from H, R8 , an alkyl group and an alkenyl group, wherein said alkyl and alkenyl groups are optionally substituted with one or more R8 groups; or R3 and R4, and/or R5 and R6 together represent =0; R7 is H, R8, NH(CH2)nR9, CO(CH2)nR9, NHCO(CH2)nR9, O(CH2)nR9, or an alkyl or phenyl group, each of which is optionally substituted with one or more groups selected from R8 and R9; R8is OR10, NR10R11, halogen, CF3, N02, COR10, CN, COOR10, CONR10R11, S02R10 or S02NR10R11; R9 is a saturated or unsaturated 5- or 6-membered cyclic group optionally containing one or more heteroatoms selected from N, 0 and S, and optionally substituted with one or more R8 groups; R10, R11, R12 and R13 are eachindependently H or a hydrocarbyl group ; and n is 0, 1, 2 or 3. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (1), and the therapeutic use thereof in the treatment of proliferative disorders, viral disorders, CNS disorders, diabetes, stroke and cardiovascular disorders.

76. 发明专利

AU2003267547A1 NEW PURINE DERIVATIVES 未知
公开(公告)号：AU2003267547A1
公开(公告)日：2004-03-03
申请号：AU2003267547
申请日：2003-08-13
申请人： CYCLACEL LTD
发明人： MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL , FISCHER PETER , JARMAN MICHAEL
IPC分类号： A61K31/52 , A61P3/10 , A61P9/00 , A61P17/06 , A61P17/14 , A61P25/28 , A61P31/12 , A61P35/00 , C07D473/16 , C07D473/00
摘要： The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

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