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71. 发明申请

WO1996032730A1 SYNTHESIS OF Bi1.8Pb0.4Sr2Ca2Cu3Ox SUPERCONDUCTORS 审中-公开
标题翻译： Bi1.8Pb0.4Sr2Ca2Cu3Ox超导体的合成
公开(公告)号：WO1996032730A1
公开(公告)日：1996-10-17
申请号：PCT/US1996004939
申请日：1996-04-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SMITH, Michael, G. , WILLIS, Jeffrey, O. , PETERSON, Dean, E.
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： H01B12/00
CPC分类号： H01L39/248 , C04B35/4525 , C04B35/626 , Y10S505/782
摘要： Two-powder processes for the synthesis of superconducting (Bi,Pb) - 2223/Ag-clad wires by the oxide-powder-in-the-tube are provided. The first precursor powder, of nominal stoichiometry CaCuOx, is a solution-synthesized mixture of Ca0.45Cu0.55O2 and CaO. Using these oxide precursor mixtures, superconducting tapes with well-aligned grains and reproducible critical current densities Jc in the range of 20,000 to 26,000 A/cm at 5 K in self-field after annealing less than 200 hours were obtained.
摘要翻译：提供了通过氧化物粉末管合成超导（Bi，Pb）-2223 / Ag包层线的双粉末工艺。名义化学计量CaCuOx的第一种前体粉末是Ca0.45Cu0.55O2和CaO的溶液合成混合物。使用这些氧化物前体混合物，获得具有良好排列的晶粒的超导带，并且在退火后小于200小时的自激场中在5K下在20,000KPa至26,000A / cm 2的范围内的可再现的临界电流密度Jc。

72. 发明申请

WO1996032139A1 METHOD FOR IN VIVO REGULATION OF CARDIAC MUSCLE CONTRACTILITY 审中-公开
标题翻译：心脏肌肉收缩压力调节方法
公开(公告)号：WO1996032139A1
公开(公告)日：1996-10-17
申请号：PCT/US1996005052
申请日：1996-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DILLMANN, Wolfgang, H. , GIORDANO, Frank , MESTRIL, Rubin
IPC分类号： A61K48/00
CPC分类号： C12N9/14 , A61K38/00 , A61K48/00 , C12N2799/022
摘要： A method for regulating in vivo calcium transport in cardiac muscle of animals suffering from congestive heart failure is disclosed. According to the method, calcium ATPase activity (which decreases as congestive heart failure develops) and cardiac muscle contractility augmented by delivering a gene which operatively encodes the enzyme into the heart. Delivery systems (including recombinant expression vectors) are provided, as are methods for monitoring the expression and effect of the gene product on cardiac performance.
摘要翻译：公开了一种用于调节患有充血性心力衰竭的动物心肌肌体内钙转运的方法。根据该方法，通过将可操作地编码酶的基因递送到心脏中，钙ATP酶活性（其随着充血性心力衰竭发展而减少）和心肌收缩力增加。提供递送系统（包括重组表达载体），以及用于监测基因产物对心脏性能的表达和作用的方法。

73. 发明申请

WO1996031596A1 BH55 HYALURONIDASE 审中-公开
公开(公告)号：WO1996031596A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004448
申请日：1996-03-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SANSUM MEDICAL RESEARCH FOUNDATION , CALIFORNIA PACIFIC MEDICAL CENTER, RESEARCH INSTITUTE
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SANSUM MEDICAL RESEARCH FOUNDATION , CALIFORNIA PACIFIC MEDICAL CENTER, RESEARCH INSTITUTE , STERN, Robert , FROST, Gregory, I. , HALL, Jackson , SHUSTER, Svetlana , FORMBY, Bent , COLBERN, Gail, T.
IPC分类号： C12N09/26
CPC分类号： C12N9/2408 , A61K38/00 , Y10S514/912
摘要： The invention features a purified hyaluronidase BH55 polypeptide isolated from a mammalian species, preferably bovine or human. The invention also features DNA encoding BH55, vectors and transformed host cells containing DNA encoding BH55, methods of making BH55 hyaluronidase polypeptides, and antibodies that specifically bind BH55.
摘要翻译：本发明的特征在于从哺乳动物物种，优选牛或人分离的纯化的透明质酸酶BH55多肽。本发明还具有编码BH55的DNA，载体和含有编码BH55的DNA的转化宿主细胞，制备BH55透明质酸酶多肽的方法，以及特异性结合BH55的抗体。

74. 发明申请

WO1996031115A1 NUCLEIC ACIDS ENCODING ASCORBATE FREE RADICAL REDUCTASE AND THEIR USES 审中-公开
标题翻译：核酸编码抗坏血酸的自由基减少及其用途
公开(公告)号：WO1996031115A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004500
申请日：1996-04-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BENNETT, Alan, B.
IPC分类号： A01H05/00
CPC分类号： C12N9/0036 , C12N15/8241 , C12N15/8271
摘要： The present invention provides isolated nucleic acid constructs comprising tomato AFR reductase polynucleotide sequences. The polynucleotides encode AFR reductase polypeptides having ability to catalyze the reduction of AFR, which provide enhanced resistance to oxidative stress. The invention further provides transgenic plants comprising the recombinant expression cassettes, as well as methods of enhancing resistance to oxidative stress in a plant.
摘要翻译：本发明提供了包含番茄AFR还原酶多核苷酸序列的分离的核酸构建体。多核苷酸编码具有催化AFR降低的能力的AFR还原酶多肽，其提供增强的抗氧化应激性。本发明还提供了包含重组表达盒的转基因植物，以及增强植物中氧化应激抗性的方法。

75. 发明申请

WO1996030771A2 NARROW FIELD ELECTROMAGNETIC SENSOR SYSTEM AND METHOD 审中-公开
标题翻译：窄场电磁传感器系统及方法
公开(公告)号：WO1996030771A2
公开(公告)日：1996-10-03
申请号：PCT/US1996003583
申请日：1996-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , McEWAN, Thomas, E.
IPC分类号： G01R00/00
CPC分类号： G01F23/284 , G01S1/045 , G01S5/14 , G01S7/285 , G01S11/02 , G01S13/003 , G01S13/0209 , G01S13/0218 , G01S13/04 , G01S13/103 , G01S13/106 , G01S13/18 , G01S13/885 , G01S2013/9314 , G01S2013/9321 , G01V3/12 , G08B13/2497 , G08G1/04 , H04B1/7163
摘要： A narrow field electromagnetic sensor system and method of sensing a characterisitc of an object provide the capability to realize a characteristic of an object such as density, thickness, or presence, for any desired coordinate position on the object. One application is imaging. The sensor can also be used as an obstruction detector or an electronic trip wire with a narrow field without the disadvantages of impaired performance when exposed to dirt, snow, rain, or sunlight. The sensor employs a transmitter for transmitting a sequence of electromagnetic signals in response to a transmit timing signal, a receiver for sampling only the initial direct RF path of the electromagnetic signal while excluding all other electromagnetic signals in response to a receive timing signal, and a signal processor for processing the sampled direct RF path electromagnetic signal and providing an indication of the characteristic of an object. Usually, the electromagnetic signal is a short RF burst and the obstruction must provide a substantially complete eclipse of the direct RF path. By employing time-of-flight techniques, a timing circuit controls the receiver to sample only the initial direct RF path of the electromagnetic signal while not sampling indirect path electromagnetic signals. The sensor system also incorporates circuitry for ultra-wideband spread spectrum operation that reduces interference to and from other RF services while allowing co-location of multiple electronic sensors without the need for frequency assignments.
摘要翻译：用于感测物体特征的窄场电磁传感器系统和方法提供了对物体的任何所需坐标位置实现诸如密度，厚度或存在的物体的特性的能力。一个应用是成像。传感器也可以用作狭窄的障碍物检测器或电子跳闸线，而不会受到暴露于污物，雪，雨或阳光下的性能受损的缺点。该传感器采用发送器，用于响应于发送定时信号发送一系列电磁信号;接收器，用于仅对电磁信号的初始直接RF路径进行采样，同时响应于接收定时信号排除所有其它电磁信号;以及信号处理器，用于处理采样的直接RF路径电磁信号并提供对象特征的指示。通常，电磁信号是短的RF突发，并且障碍物必须提供直接RF路径的基本上完全的日食。通过采用飞行时间技术，定时电路控制接收机仅对电磁信号的初始直接RF路径进行采样，而不对间接路径电磁信号进行采样。传感器系统还集成了用于超宽带扩频操作的电路，可减少与其他RF服务的干扰，同时允许多个电子传感器的共同定位，而无需频率分配。

76. 发明申请

WO1996030540A2 SUBSTRATES FOR BETA-LACTAMASE AND USES THEREOF 审中-公开
标题翻译： BETA-LACTAMASE的基质及其用途
公开(公告)号：WO1996030540A2
公开(公告)日：1996-10-03
申请号：PCT/US1996004059
申请日：1996-03-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TSIEN, Roger, Y. , ZLOKARNIK, Gregor
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12Q00/00
CPC分类号： C07D501/36 , C07D501/00 , C07D505/00 , C07D519/00 , C12N9/86 , C12N15/85 , C12N2800/90 , C12N2830/002 , C12P17/184 , C12P17/188 , C12P35/00 , C12Q1/18 , C12Q1/34 , C12Q1/6897 , C12Q2334/00 , G01N2333/986 , G01N2415/00 , Y10S435/805
摘要： Substrates for beta -lactamase of general formula (I) in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R' is selected from the group consisting of H, lower (i.e., alkyl of 1 to about 5 carbon atoms) and (CH2)nOH, in which n is 0 or an integer from 1 to 5; R" is selected from the group consisting of H, physiologically acceptable metal and ammonium cations, -CHR OCO(CH2)nCH3, -CHR OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, delta-butyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, acyloxyalkyl, dialkylaminocarbonyloxymethyl and aliphatic, in which R is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z' and Z" are linkers for the fluorescent donor and quencher moieties. Methods of assaying beta -lactamase activity and monitoring expression in systems using beta -lactamase as a reporter gene also are disclosed.
摘要翻译：通式（I）的β-内酰胺酶的底物，其中X和Y中的一个是荧光供体部分，另一个是猝灭剂（其可以或不再发射）; R'选自H，低级（即1至约5个碳原子的烷基）和（CH 2）nOH，其中n为0或1至5的整数; R“选自H，生理学上可接受的金属和铵阳离子，-CHR 2 OCO（CH 2）n CH 3，-CHR 2 OCOC（CH 3）3，酰硫基甲基，酰氧基-α-苄基，丁基内酰胺，甲氧基羰基氧基甲基，苯基，甲基亚磺酰基甲基，β-吗啉代乙基，二烷基氨基乙基，酰氧基烷基，二烷基氨基羰基氧基甲基和脂族，其中R 2选自H和低级烷基; A选自S，O， SO，SO 2和CH 2; Z'和Z“是荧光供体和猝灭剂部分的连接体。公开了使用β-内酰胺酶作为报告基因的系统中测定β-内酰胺酶活性和监测表达的方法。

77. 发明申请

WO1996029394A1 METHOD FOR TREATING TUMORS 审中-公开
标题翻译：治疗肿瘤的方法
公开(公告)号：WO1996029394A1
公开(公告)日：1996-09-26
申请号：PCT/US1996003621
申请日：1996-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GRANGER, Gale, A.
IPC分类号： C12N05/00
CPC分类号： A61K35/16 , A61K31/407 , A61K35/17 , A61K39/0011 , A61K2035/124 , C12N5/0636 , A61K2300/00
摘要： A method is provided for treatment of a mammalian patient having a tumor by administering to the patient allogenic donor lymphocytes that have been co-cultured in the presence of the patient-derived lymphocytes under conditions sufficient to alloactivate the donor lymphocytes. It is preferred that the donor lymphocytes be introduced intralesionally. This method is preferred for treatment of glioblastoma in humans.
摘要翻译：提供了一种方法，用于通过在足以使供体淋巴细胞激活的条件下向患者施用已经在患者来源的淋巴细胞存在下共培养的同种异体供体淋巴细胞来治疗具有肿瘤的哺乳动物患者。供体淋巴细胞优选以病灶内引入。该方法优选用于治疗人类胶质母细胞瘤。

78. 发明申请

WO1996029086A1 COMPOSITIONS AND METHODS FOR REDUCING ADHESIVENESS OF DEFECTIVE RED BLOOD CELLS 审中-公开
标题翻译：用于降低缺血性红血细胞粘连的组合物和方法
公开(公告)号：WO1996029086A1
公开(公告)日：1996-09-26
申请号：PCT/US1996003180
申请日：1996-03-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SHERMAN, Irwin, William , CRANDALL, Ian, Edward , SHOHET, Stephen, Byron , THEVENIN, Bernard, Jean-Marie
IPC分类号： A61K38/00
CPC分类号： C07K16/205 , A61K38/00 , C07K14/705 , Y02A50/411
摘要： Peptide sequences and analogs thereof based on amino acid motifs in band 3 which are effective in reducing the adhesiveness of pathologically adhesive red blood cells. One class of peptide sequences are characterized by the sequence motif Z xKxxx+, wherein Z is selected from the group consisting of tyrosine, phenylalanine and alanine; x is an unobstructive residue and + is a positively charged residue (e.g., K or P-H). These peptides are used to reduce adhesiveness in the treatment of sickle cell disease, thalassemia and diabetes. A second class of peptide sequences are characterized by the sequence motif Z Z Z x-xxx-, wherein Z represents a hydrophobic residue, x is an unobstructive residue and - is a negatively charged residue. These peptides can be used to reduce adhesiveness in the treatment of malaria, sickle cell disease, thalassemia and diabetes.
摘要翻译：基于带3中的氨基酸基序的肽序列及其类似物，其有效降低病理粘附性红细胞的粘附性。一类肽序列的特征在于序列基序Z 1 x K x x x +，其中Z 1选自酪氨酸，苯丙氨酸和丙氨酸; x是不阻挡残基，+是带正电荷的残基（例如K或P-H）。这些肽用于降低治疗镰状细胞病，地中海贫血和糖尿病的粘附性。第二类肽序列的特征在于序列基序Z 2 Z 2 Z x-xxx-，其中Z 2表示疏水残基，x是不阻碍残基， - 是带负电荷的残留。这些肽可用于降低治疗疟疾，镰状细胞病，地中海贫血和糖尿病的粘附性。

79. 发明申请

WO1996026439A1 HELICOBACTER PYLORI BACTERIAL DERIVED FACTOR 审中-公开
标题翻译： HELICOBACTER PYLORI BACTERIAL DERIVED因子
公开(公告)号：WO1996026439A1
公开(公告)日：1996-08-29
申请号：PCT/US1996002668
申请日：1996-02-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ANTON, Peter, A. , REEVE, Joseph, R., Jr. , WALSH, John, H. , FAULL, Kym, F.
IPC分类号： G01N33/53
CPC分类号： G01N33/56922 , C12P7/44 , C12Q1/04 , G01N33/5308 , G01N33/94 , G01N2333/205
摘要： Chemotactin,, diethyl phthalate, is shown to be a chemoattractant secreted by H. pylori. Chemotactin attracts phagocytic cells with a resulting inflammatory episode. Chemotactin and its metabolites may be used for diagnosis and monitoring courses of infection by H. pylori or other chemotactin secreting organisms. In addition, chemotactin may be used in research for studying the inflammatory process, for identifying new drugs for modulating chemoattraction and activation of phagocytic cells, and for inducing an inflammatory response as a therapeutic intervention.
摘要翻译： Chemotactin ,,邻苯二甲酸二乙酯显示为幽门螺杆菌分泌的化学引诱物。化学趋化因子吸引吞噬细胞与炎症发作。 Chemotactin及其代谢物可用于诊断和监测幽门螺杆菌或其他分泌生物体的趋化因子的感染过程。此外，chemotactin可用于研究炎症过程的研究，用于鉴定用于调节吞噬细胞的化学吸引和活化的新药物，以及作为治疗性介入诱导炎性反应。

80. 发明申请

WO1996024145A2 MICROMACHINED MAGNETIC ACTUATOR AND METHOD OF MAKING THE SAME 审中-公开
标题翻译： MICROMACHINED MAGNETIC ACTUATOR及其制造方法
公开(公告)号：WO1996024145A2
公开(公告)日：1996-08-08
申请号：PCT/US1996000848
申请日：1996-01-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CALIFORNIA INSTITUTE OF TECHNOLOGY , HO, Chih-Ming , MIU, Denny, K. , LEU, Jeremy, Tzong-Shyng , MILLER, Raanan , DESAI, Amish , LIU, Chang , TSAO, Tom , TAI, Yu-Chong
IPC分类号： H01F00/00
CPC分类号： H02K99/00
摘要： A surface micromachined micromagnetic actuator is provided with a flap capable of achieving large deflections above 100 microns using magnetic force as the actuating force. The flap is coupled by one or more beams to a substrate and is cantilevered over the substrate. A Permalloy layer or a magnetic coil is disposed on the flap such that when the flap is placed in a magnetic field, it can be caused to selectively interact and rotate out of the plane of the magnetic actuator. The cantilevered flap is released from the underlying substrate by etching out an underlying sacrificial layer disposed between the flap and the substrate. The etched out and now cantilevered flap is magnetically actuated to maintain it out of contact with the substrate while the just etched device is dried in order to obtain high release yields.
摘要翻译：表面微加工微磁致动器设置有能够使用磁力作为致动力来实现高于100微米的大偏转的挡板。翼片通过一个或多个梁耦合到基底并且在基底上悬臂。坡度合金层或磁性线圈设置在翼片上，使得当翼片被放置在磁场中时，可以使其选择性地相互作用并旋转出磁致动器的平面。通过蚀刻设置在翼片和基底之间的下面的牺牲层，将悬臂翼片从下面的基底释放。蚀刻出来的和现在的悬臂翼片被磁力驱动，以保持其与基底不接触，同时刚刚蚀刻的装置被干燥以获得高的释放产率。

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