专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US06509459B1 Base protecting groups and rapid process for oligonucleotide synthesis 失效
标题翻译：碱基保护基和寡核苷酸合成的快速过程
公开(公告)号：US06509459B1
公开(公告)日：2003-01-21
申请号：US08846303
申请日：1997-04-30
申请人： Sudhir Agrawal , Radhakrishnan P. Iyer , Ivan Habus , Dong Yu
发明人： Sudhir Agrawal , Radhakrishnan P. Iyer , Ivan Habus , Dong Yu
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07H19/10 , C07H19/16 , C07H19/20 , Y02P20/55
摘要： The invention provides new processes for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more rapid and/or more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups, as well as nucleoside synthons having such base protecting groups. The invention also provides oligonucleotides containing any of a variety of base labile functionalities and methods for using such oligonucleotides.
摘要翻译：本发明提供了合成寡核苷酸的新方法，其允许寡核苷酸在比现有方法更快和/或更温和的条件下脱保护。本发明还提供了在寡核苷酸合成条件下稳定但可被除去的核苷碱基保护基在比现有保护基更温和的条件下，以及具有这种碱保护基的核苷合成子。本发明还提供了含有各种碱不稳定功能的寡核苷酸的寡核苷酸和使用这些寡核苷酸的方法。

72. 发明授权

US6140482A Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same 失效
标题翻译：初级氨基磷酸核苷间核苷键和含有其的寡核苷酸
公开(公告)号：US6140482A
公开(公告)日：2000-10-31
申请号：US519318
申请日：1995-08-25
申请人： Radhakrishnan P. Iyer , Theresa Devlin , Ivan Habus , Dong Yu , Sudhir Agrawal
发明人： Radhakrishnan P. Iyer , Theresa Devlin , Ivan Habus , Dong Yu , Sudhir Agrawal
IPC分类号： C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
CPC分类号： C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要： The invention provides new primary phosphoramidate internucleoside linkages that are less sterically constrained than existing phosphoramidate linkages, as well as oligonucleotides containing such linkages and processes for making and methods for using such oligonucleotides.
摘要翻译：本发明提供了比现有氨基磷酸酯键更少的空间限制的新的初级氨基磷酸酯核苷间键，以及含有这种连接的寡核苷酸和制备方法以及使用这种寡核苷酸的方法。

73. 发明授权

US5631361A Method of synthesizing radioisotopically labeled oligonucleotides by direct solid-phase 5' phosphitylation 失效
标题翻译：通过直接固相5'磷酸化合成放射性同位素标记的寡核苷酸的方法
公开(公告)号：US5631361A
公开(公告)日：1997-05-20
申请号：US447092
申请日：1995-05-22
申请人： Weitian Tan , Radhakrishnan P. Iyer , Zhiwei Jiang , Dong Yu , Sudhir Agrawal
发明人： Weitian Tan , Radhakrishnan P. Iyer , Zhiwei Jiang , Dong Yu , Sudhir Agrawal
IPC分类号： C07H21/00 , C07H1/02
CPC分类号： C07H21/00
摘要： The present invention comprises a novel method of incorporating radiolabels and other type of labels at one or more predetermined sites within an oligonucleotide. In particular, the method comprises contacting a nascent, support-bound oligonucleotide having an unprotected 5' hydroxyl group with a suitable activating agent, followed by contacting the resulting activated nascent oligonucleotide with a labeled, Y-protected mononucleotide having an unprotected 3'-hydroxyl, thereby condensing the labeled mononucleotide and nascent oligonucleotide. Normal automated synthesis can then be continued to yield the oligonucleotide of desired length having the label in the desired location. This method advantageously yields oligonucleotides with high specific activity. The oligonucleotides thereby produced are useful for determining the pharmacokinetics and biodistribution of their non-radiolabeled counterparts, both in vitro and in vivo.
摘要翻译：本发明包括在寡核苷酸内的一个或多个预定位点掺入放射性标记和其他类型的标记的新方法。特别地，该方法包括将具有未保护的5'羟基的新生支持结合的寡核苷酸与合适的活化剂接触，然后将所得活化的新生寡核苷酸与具有未保护的3'-羟基的标记的受Y保护的单核苷酸接触从而使标记的单核苷酸和新生寡核苷酸缩合。然后可以继续进行正常的自动合成，得到所需长度的寡核苷酸，其具有所需位置的标记。该方法有利地产生具有高比活性的寡核苷酸。由此产生的寡核苷酸可用于在体外和体内测定其非放射性标记的对应物的药代动力学和生物分布。

74. 发明授权

US5614622A 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses 失效
标题翻译： 5-戊烯酰基部分作为核苷 - 氨基保护基，4-戊烯酰基保护的核苷酸合成子和相关的寡核苷酸合成
公开(公告)号：US5614622A
公开(公告)日：1997-03-25
申请号：US518921
申请日：1995-08-24
申请人： Radhakrishnan P. Iyer , Theresa Devlin , Ivan Habus , Dong Yu , Sudhir Agrawal
发明人： Radhakrishnan P. Iyer , Theresa Devlin , Ivan Habus , Dong Yu , Sudhir Agrawal
IPC分类号： C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H19/06
CPC分类号： C07H19/16 , C07H19/10 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more mild conditions than existing methods. The invention further provides a nucleoside base protective group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protective groups, as well as nucleoside synthons having such base protective groups.
摘要翻译：本发明提供了合成寡核苷酸的新方法，其允许寡核苷酸在比现有方法更温和的条件下脱保护。本发明还提供了在寡核苷酸合成条件下稳定但可在比现有保护基更温和的条件下除去的核苷碱基保护基以及具有这种碱性保护基的核苷合成子。

75. 发明授权

US4908222A Microwave brewing apparatus and method 失效
标题翻译：微波酿造设备及方法
公开(公告)号：US4908222A
公开(公告)日：1990-03-13
申请号：US322980
申请日：1989-03-14
申请人： Dong Yu
发明人： Dong Yu
IPC分类号： A23F5/26 , A47J31/54 , A47J36/02 , B65D81/34
CPC分类号： A23F5/26 , A47J31/547 , A47J36/027 , B65D2581/3409 , Y10S99/14
摘要： A beverage brewing apparatus and method using microwave energy is disclosed. The apparatus comprises a pressurizable water reservoir and a filter chamber disposed below the reservoir. The reservoir is provided with pressure overflow means which, in operation, prevents water in the reservoir from overflowing into the filter chamber until vapor pressure is built up in the reservoir due to the influx of microwave energy so as to force the heated water to overflow into the filter chamber to mix with an infusible material, e.g. ground coffee to make a beverage.
摘要翻译：公开了一种使用微波能量的饮料冲泡设备和方法。该装置包括可加压的储水器和设置在贮存器下方的过滤室。储存器设置有压力溢流装置，其在操作中防止储存器中的水溢出到过滤室中，直到由于微波能量的涌入而在储存器中形成蒸气压力，以便迫使加热的水溢出过滤室与不熔材料混合，例如研磨咖啡来制作饮料。

76. 发明授权

US09165243B2 Tensor deep stacked neural network 有权
标题翻译：张量深层神经网络
公开(公告)号：US09165243B2
公开(公告)日：2015-10-20
申请号：US13397580
申请日：2012-02-15
申请人： Dong Yu , Li Deng , Brian Hutchinson
发明人： Dong Yu , Li Deng , Brian Hutchinson
IPC分类号： G06N3/04 , G06N3/08
CPC分类号： G06N3/04 , G06N3/08
摘要： A tensor deep stacked neural (T-DSN) network for obtaining predictions for discriminative modeling problems. The T-DSN network and method use bilinear modeling with a tensor representation to map a hidden layer to the predication layer. The T-DSN network is constructed by stacking blocks of a single hidden layer tensor neural network (SHLTNN) on top of each other. The single hidden layer for each block then is separated or divided into a plurality of two or more sections. In some embodiments, the hidden layer is separated into a first hidden layer section and a second hidden layer section. These multiple sections of the hidden layer are combined using a product operator to obtain an implicit hidden layer having a single section. In some embodiments the product operator is a Khatri-Rao product. A prediction is made using the implicit hidden layer and weights, and the output prediction layer is consequently obtained.
摘要翻译：张量深层次神经（T-DSN）网络，用于获得鉴别建模问题的预测。 T-DSN网络和方法使用具有张量表示的双线性建模来将隐藏层映射到预测层。 T-DSN网络由单个隐层张量神经网络（SHLTNN）的堆叠堆叠构成。然后，每个块的单个隐藏层被分离或分成多个两个或更多个部分。在一些实施例中，隐藏层被分成第一隐藏层部分和第二隐藏层部分。使用产品运算符组合隐藏层的这些多个部分以获得具有单个部分的隐式隐藏层。在一些实施例中，产品操作者是Khatri-Rao产品。使用隐式隐层和权重进行预测，从而获得输出预测层。

77. 发明授权

US08793130B2 Confidence measure generation for speech related searching 有权
标题翻译：语音相关搜索的置信度生成
公开(公告)号：US08793130B2
公开(公告)日：2014-07-29
申请号：US13428917
申请日：2012-03-23
申请人： Ye-Yi Wang , Yun-Cheng Ju , Dong Yu
发明人： Ye-Yi Wang , Yun-Cheng Ju , Dong Yu
IPC分类号： G10L15/00
CPC分类号： G10L15/1822
摘要： A method of generating a confidence measure generator is provided for use in a voice search system, the voice search system including voice search components comprising a speech recognition system, a dialog manager and a search system. The method includes selecting voice search features, from a plurality of the voice search components, to be considered by the confidence measure generator in generating a voice search confidence measure. The method includes training a model, using a computer processor, to generate the voice search confidence measure based on selected voice search features.
摘要翻译：提供了一种产生置信度量产生器的方法，用于语音搜索系统中，该语音搜索系统包括包括语音识别系统，对话管理器和搜索系统的语音搜索组件。该方法包括从多个语音搜索组件中选择语音搜索特征，以由置信度量产生器在生成语音搜索置信度量时考虑。该方法包括使用计算机处理器来训练模型，以基于所选择的语音搜索特征生成语音搜索置信度度量。

78. 发明授权

US08716253B2 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes 有权
标题翻译：通过位置化学变化调节免疫刺激性寡核苷酸类似物的免疫刺激活性
公开(公告)号：US08716253B2
公开(公告)日：2014-05-06
申请号：US10694075
申请日：2003-10-27
申请人： Ekambar R. Kandimalla , Qiuyan Zhao , Dong Yu , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Qiuyan Zhao , Dong Yu , Sudhir Agrawal
IPC分类号： C07H21/04 , C07H21/02 , A01N43/04 , A61K39/00 , A61K39/38
CPC分类号： C12N15/117 , A61K31/7088 , A61K31/7115 , A61K2039/55561 , C07H21/00 , C12N2310/18 , C12N2310/3125 , C12N2310/317 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/334 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
摘要翻译：本发明涉及在免疫治疗应用中寡核苷酸或寡核苷酸类似物作为免疫刺激剂的治疗用途。本发明提供了增强由免疫刺激性寡核苷酸化合物引起的免疫应答的方法。

79. 发明授权

US08426375B2 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response 有权
公开(公告)号：US08426375B2
公开(公告)日：2013-04-23
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K48/00 , C12N15/11
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

80. 发明授权

US08361986B2 Synthetic agonists of TLR9 有权
标题翻译： TLR9的合成激动剂
公开(公告)号：US08361986B2
公开(公告)日：2013-01-29
申请号：US13156140
申请日：2011-06-08
申请人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A01N43/04 , A61K39/00 , A61K45/00 , C07H21/02
CPC分类号： A61K31/711 , A61K39/39
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.
摘要翻译：本发明涉及可用于调节Toll样受体（TLR）介导的免疫应答的合成化学组合物。特别地，本发明涉及产生独特细胞因子和趋化因子分布的Toll样受体9（TLR9）的激动剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式