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71. 发明专利

NO782332A 未知
公开(公告)号：NO782332A
公开(公告)日：1979-01-23
申请号：NO782332
申请日：1978-07-04
申请人： BAYER AG
发明人： STEINERT GERD , HORSTMANN HARALD , SITT RUEDIGER , KRAUSE HANS PETER , PULS WALTER
IPC分类号： A61K31/075 , A61K31/77 , C08G65/00 , C08G65/02 , C08G65/26 , C08G65/28 , C08G
CPC分类号： C08G65/2609 , A61K31/77

72. 发明专利

RO63749A 未知
公开(公告)号：RO63749A
公开(公告)日：1979-01-15
申请号：RO7842074
申请日：1974-04-15
申请人： BAYER AG
发明人： MOELLER EIKE , MENG KARL , WEHINGER EGBERT , HORSTMANN HARALD
IPC分类号： A61K31/415 , C07D231/18 , A61P7/02 , A61P7/10 , A61P9/12 , C07D231/20 , C07D231/24 , C07D231/52 , C07D401/06 , C07D231/12
摘要： 1429141 Pyrazolin-5-ones BAYER AG 16 April 1974 [17 April 1973 19 Dec 1973] 16507/74 Heading C2C The invention comprises compounds of formula (including tautomers thereof, especially when R is amino), wherein R is H, amino, alkyl, alkenyl, CF 3 or Ph; R 1 is H, alkyl, alkenyl or an optionally substituted aryl or aralkyl radical; R 2 is an alkyl group; and R 3 is a pyridyl radical or an aryl radical carrying 1 or 2 identical or different substituents, which are selected from halogen, CF 3 , alkyl, alkenyl, and alkoxy radicals, or carrying one mono- or di-alkylamino, CF 3 O, nitro, nitrile, carbamoyl, alkyl- or dialkylcarbamoyl, sulphamyl, or alkyl- or dialkylsulphamyl radical, or a group -B, -CO.B or -SO 2 .B (in which B is a saturated ring containing a nitrogen atom in the 1-position) or a -SO n alkyl group (in which n=0, 1 or 2), optionally together with 1 or 2 substituents selected from alkyl, alkenyl, alkoxy, halogen and CF 3 , or carrying none or 1 only of these substituents and a fused branched or unbranched, saturated or unsaturated 5-, 6- or 7- membered ring optionally containing 1 or 2 oxygen or sulphur atoms. In examples, these compounds are prepared by (a) reacting R 2 R 3 CHNHNH 2 with an appropriate ring-forming co-reactant, (2) replacing a compound in which R is halogen, by amino, (3) hydrolysing a compound in which R is (e.g.) NHCO 2 Et, or (4) introducing the R 2 R 3 CH group by N 1 -substitution. Therapeutic compositions having diuretic, saluretic, antihypertensive and antithrombotic activity comprise compounds of the above formula, and may be administered orally, parenterally, rectally, topically, or by spray.

73. 发明专利

CH603593A5 未知
公开(公告)号：CH603593A5
公开(公告)日：1978-08-31
申请号：CH524374
申请日：1974-04-16
申请人： BAYER AG
发明人： MOELLER EIKE , MENG KARL , WEHINGER EGBERT , HORSTMANN HARALD
IPC分类号： A61K31/415 , A61P7/02 , A61P7/10 , A61P9/12 , C07D231/20 , C07D231/24 , C07D231/52
摘要： 1-Substituted pyrazole-5-ones of the formula AND PHARMACEUTICALLY ACCEPTABLE, NONTOXIC SALTS THEREOF, WHEREIN R is hydrogen or amino; R1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky; X is A. ETHYLENE, ETHYLENE WHEREIN 1 HYDROGEN ATOM ON ONE OF THE CARBON ATOMS IS SUBSTITUTED BY ALKYL OF 1 TO 4 CARBON ATOMS, ETHYLENE WHEREIN 1 HYDROGEN ATOM ON EACH OF THE TWO CARBON ATOMS IS SUBSTITUTED BY ALKYL OF 1 TO 4 CARBON ATOMS OR SAID ETHYLENE WHICH IS LINKED TO R2 via an oxygen or sulphur atom; B. PROPENYL, PROPENYL WHEREIN 1 HYDROGEN ATOM ON ONE, TWO OR THREE OF THE CARBON ATOMS IS SUBSTITUTED BY ALKYL OF 1 TO 4 CARBON ATOMS, SAID PROPENYL BEING LINKED TO THE N1 atom of the pyrazol ring via its methylene moiety; or C. METHYLENE; PROVIDED THAT WHEN X is methylene, R1 is not hydrogen if R is amino; R2 is aryl unsubstituted or substituted by:

74. 发明专利

NO138530B 未知
公开(公告)号：NO138530B
公开(公告)日：1978-05-12
申请号：NO741365
申请日：1974-04-16
申请人： BAYER AG
发明人： MOELLER EIKE , MENG KARL , WEHINGER EGBERT , HORSTMANN HARALD
IPC分类号： A61K31/415 , A61P7/02 , A61P7/10 , C07D231/18 , A61P9/12 , C07D231/20 , C07D231/24 , C07D231/52 , C07D401/06
摘要： 1429141 Pyrazolin-5-ones BAYER AG 16 April 1974 [17 April 1973 19 Dec 1973] 16507/74 Heading C2C The invention comprises compounds of formula (including tautomers thereof, especially when R is amino), wherein R is H, amino, alkyl, alkenyl, CF 3 or Ph; R 1 is H, alkyl, alkenyl or an optionally substituted aryl or aralkyl radical; R 2 is an alkyl group; and R 3 is a pyridyl radical or an aryl radical carrying 1 or 2 identical or different substituents, which are selected from halogen, CF 3 , alkyl, alkenyl, and alkoxy radicals, or carrying one mono- or di-alkylamino, CF 3 O, nitro, nitrile, carbamoyl, alkyl- or dialkylcarbamoyl, sulphamyl, or alkyl- or dialkylsulphamyl radical, or a group -B, -CO.B or -SO 2 .B (in which B is a saturated ring containing a nitrogen atom in the 1-position) or a -SO n alkyl group (in which n=0, 1 or 2), optionally together with 1 or 2 substituents selected from alkyl, alkenyl, alkoxy, halogen and CF 3 , or carrying none or 1 only of these substituents and a fused branched or unbranched, saturated or unsaturated 5-, 6- or 7- membered ring optionally containing 1 or 2 oxygen or sulphur atoms. In examples, these compounds are prepared by (a) reacting R 2 R 3 CHNHNH 2 with an appropriate ring-forming co-reactant, (2) replacing a compound in which R is halogen, by amino, (3) hydrolysing a compound in which R is (e.g.) NHCO 2 Et, or (4) introducing the R 2 R 3 CH group by N 1 -substitution. Therapeutic compositions having diuretic, saluretic, antihypertensive and antithrombotic activity comprise compounds of the above formula, and may be administered orally, parenterally, rectally, topically, or by spray.

75. 发明专利

AU7670474A PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIRUSE AS MEDICAMENTS 未知
公开(公告)号：AU7670474A
公开(公告)日：1976-07-01
申请号：AU7670474
申请日：1974-12-20
申请人： BAYER AG
发明人： MOLLER EIKE , MENG KARL , WEHINGER EGBERT , HORSTMANN HARALD
IPC分类号： A61K31/415 , A61K31/42 , A61K31/495 , A61P3/00 , A61P7/02 , A61P7/10 , A61P9/12 , C07D231/20 , C07D231/22 , C07D231/24 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K27/00 , C07D49/18

76. 发明专利

FI751654A 未知
公开(公告)号：FI751654A
公开(公告)日：1975-12-07
申请号：FI751654
申请日：1975-06-04
申请人： BAYER AG
发明人： MOELLER EIKE , MENG ILSE HEIDE , HORSTMANN HARALD , SEUTER FRIEDEL , WEHINGER EGBERT
IPC分类号： A61K31/415 , A61P7/02 , C07D231/20 , C07D
摘要： 1454733 1 - (2 - Beta - naphthoxyethyl)- 3 - methylpyrazolin - 5 - one BAYER AG 6 May 1975 [6 June 1974 11 July 1974] 18970/75 Heading C2C The invention comprises the title compound and its salts. In examples, it is prepared by reacting (1) 2-beta-naphthoxyethylhydrazine with an alkyl or benzyl acetoacetate or tetrolate, or (2) a 2-beta-naphthoxyethyl halide with 3-methylpyrazolin-5-one or its sodium derivative. Therapeutic compositions having antithrombotic and thrombolytic activity comprise the above compound or its salts, and may be administered orally, parenterally or rectally.

77. 发明专利

AU5705173A 3-AMINO-PYRAZOLONES-%5<. 3-AMINO-PYRAZOLONES-%5<. 未知
公开(公告)号：AU5705173A
公开(公告)日：1974-12-19
申请号：AU5705173
申请日：1973-06-18
申请人： BAYER AG
发明人： HORSTMANN HARALD , MENG KARL , WEHINGER EGBERT
IPC分类号： C07D231/44 , C07D231/52 , C07D49/16 , A61K27/00
摘要： 1391051 Aminopyrazolones BAYER AG 22 June 1973 [23 June 1972] 29785/73 Heading C2C The invention comprises compounds of the tautomeric formulae and their salts, wherein R is (a) a phenyl radical carrying one or two identical or different substituents selected from alkyl, phenyl, trifluoromethyl, trifluoromethoxy, nitro, nitrile, carbamoyl, sulphamoyl, alkylamino, fluorine, bromine and iodine radicals but cannot be a phenyl radical carrying trifluoromethyl only as one substituent, or (b) a phenyl radical carrying an annellated, branched or unbranched, saturated or unsaturated, five to seven-membered isocyclic or heterocyclic ring (the heterocyclic ring containing one or more oxygen and/or sulphur atoms); or (c) a phenyl radical carrying as substituent an SO n -alkyl group (n = 0, 1 or 2), an alkoxy group, or an -O-(CH 2 ) n -N(alkyl) 2 group (n = 2 or 3); or (d) a phenyl radical carrying two identical substituents selected from alkoxy and trifluoromethyl groups; or (e) a phenyl radical carrying two different substituents selected from alkyl, phenyl, halogen, alkoxy, trifluoromethyl, trifluoromethoxy, alkylamino, nitrile, carbamoyl, sulphamoyl, -SO n alkyl (n = 0, 1 or 2) and nitro radicals; or (f) a trichlorophenyl radical; or (g) a naphthyl radical carrying one or two identical or different substituents selected from halogen atoms and alkyl groups; or (h) an unsubstituted #-naphthyl, anthryl or phenanthryl radical. These compounds are prepared by reacting RCH 2 NHNH 2 with CNCH 2 COX or where X is OH, alkoxy, aralkoxy, NH 2 or alkylamino, and Y is alkoxy, aryloxy, aralkoxy, alkylmercapto, aralkylmercapto or NH 2 . Therapeutic compositions having diuretic, saluretic and antihypertensive activity comprise compounds of the above formulae, and may be administered orally, parenterally, rectally, topically or by means of a spray.

78. 发明专利

AU3387671A THIAZOLONE-%2< DERIVATIVES 未知
公开(公告)号：AU3387671A
公开(公告)日：1973-03-29
申请号：AU3387671
申请日：1971-09-24
申请人： BAYER AG
发明人： LINKE SIEGFRIED , SITT RUDIGER , HORSTMANN HARALD , MENG KARL
IPC分类号： C07D277/34 , A61K27/00 , C07D91/32

79. 发明专利

CA876743A BIGUANIDE-NAPHTHALENE-1,5-DISULPHONATES AND BLOOD SUGAR-DEPRESSING COMPOSITIONS THEREOF 未知
公开(公告)号：CA876743A
公开(公告)日：1971-07-27
申请号：CA876743D
申请人： BAYER AG
发明人： KABBE HANS-JOACHIM , PULS WALTER , HORSTMANN HARALD , PLUMPE HANS

80. 发明专利

CA849539A DISULFONAMIDES SUBSTITUTED WITH A PYRROLIDINE OR PIPERIDINE RING 未知
公开(公告)号：CA849539A
公开(公告)日：1970-08-18
申请号：CA849539D
申请人： BAYER AG
发明人： MENG KARL , HORSTMANN HARALD , WOLLWEBER HARTMUND

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