专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US5156850A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：用于药物递送时间变化的剂型
公开(公告)号：US5156850A
公开(公告)日：1992-10-20
申请号：US576042
申请日：1990-08-31
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

72. 发明授权

US5091190A Delivery system for administration blood-glucose lowering drug 失效
标题翻译：用于降血糖药物的给药系统
公开(公告)号：US5091190A
公开(公告)日：1992-02-25
申请号：US652717
申请日：1991-02-08
申请人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S. Wong
发明人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S. Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K31/64
CPC分类号： A61K9/0004 , A61K31/64 , A61K9/2027 , A61K9/2031 , A61K9/2054 , Y10S514/866
摘要： A dosage form is disclosed comprising the antidiabetic drug glipizide for administering to a patient in need of glipizide therapy.
摘要翻译：公开了一种剂型，其包含用于给予需要格列吡嗪治疗的患者的抗糖尿病药物格列吡嗪。

73. 发明授权

US5045082A Long-term delivery device including loading dose 失效
标题翻译：长期输送装置，包括负荷剂量
公开(公告)号：US5045082A
公开(公告)日：1991-09-03
申请号：US463109
申请日：1990-01-10
申请人： Atul D. Ayer , James B. Eckenhoff , Jeremy C. Wright , Anthony L. Kuczynski
发明人： Atul D. Ayer , James B. Eckenhoff , Jeremy C. Wright , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The invention provides a long-term dispensing device comprising a first agent delivery means for short-term and continuous delivery of agent, retained together with a second agent delivery means capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (1) a short term delivery means for rapid and continuous delivery of agent to the environment of use; and (2) a long-term delivery means comprising a semipermeable wall which surrounds and defines an internal lumen; a means in the lumen for expanding and occupying an increased volume of the lumen; a beneficial agent in the lumen that provides a dispensable formulation to the environment of use; and a means in the device for delivery of the beneficial agent to the environment of use over time.
摘要翻译：本发明提供了一种长期分配装置，其包括用于短期和连续输送药剂的第一药剂递送装置，与能够长期和连续递送药剂的第二药剂递送装置保持在一起。第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。随后快速递送有益药剂，其次是持续和长期的药剂输送。在优选实施例中，该装置包括（1）用于将药剂快速且连续地递送到使用环境的短期递送装置; 和（2）包括围绕并限定内腔的半透壁的长期递送装置; 用于扩张和占据体积增加的管腔中的一种装置; 内腔中的有益剂，为使用环境提供可分配的配方; 以及用于将有益剂递送到使用环境的装置中的装置。

74. 发明授权

US5035897A Dosage form for delivering soluble or insoluble drugs 失效
标题翻译：用于递送可溶性或不溶性药物的剂型
公开(公告)号：US5035897A
公开(公告)日：1991-07-30
申请号：US403523
申请日：1989-09-05
申请人： Atul D. Ayer , Anthony L. Kuczynski , Patrick S. Wong
发明人： Atul D. Ayer , Anthony L. Kuczynski , Patrick S. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising granule means for delivering soluble to insoluble drug to a warm-blooded animal.
摘要翻译：公开了一种剂型，其包含用于将可溶性不溶性药物递送至温血动物的颗粒装置。

75. 发明授权

US4915954A Dosage form for delivering a drug at two different rates 失效
标题翻译：以不同的速率递送药物的剂型
公开(公告)号：US4915954A
公开(公告)日：1990-04-10
申请号：US313006
申请日：1989-02-21
申请人： Atul D. Ayer , Maureen L. Jordan , Paul R. Magruder , David E. Edgren
发明人： Atul D. Ayer , Maureen L. Jordan , Paul R. Magruder , David E. Edgren
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
摘要翻译：公开了一种剂型，其包括围绕隔室的壁，壁上具有出口装置。隔室包括第一或快速释放层和经由出口装置在两个不同时间段内输送的第二或短释放层。

76. 发明授权

US4842867A Pulsed drug delivery of doxylamine 失效
标题翻译：脉冲药物递送多西拉敏
公开(公告)号：US4842867A
公开(公告)日：1989-06-27
申请号：US861188
申请日：1986-05-09
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
IPC分类号： A61K31/445 , A61K9/00 , A61K9/22 , A61K9/58
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

77. 发明授权

US4816263A Dosage form for treating cardiovascular diseases comprising isradipine 失效
标题翻译：用于治疗心血管疾病的剂型，包括伊拉地平
公开(公告)号：US4816263A
公开(公告)日：1989-03-28
申请号：US104006
申请日：1987-10-02
申请人： Atul D. Ayer , David R. Swanson , Anthony L. Kuczynski
发明人： Atul D. Ayer , David R. Swanson , Anthony L. Kuczynski
IPC分类号： A61K31/455 , A61K9/00 , A61K9/52 , A61K31/44 , A61K47/32 , A61K47/38 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D417/04 , A61M7/00 , A61M31/00
CPC分类号： A61K9/0004 , A61K31/44
摘要： An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
摘要翻译：公开了一种渗透装置，其包含第一组合物，第二组合物在第一组合物中具有有益药物阿拉度铂。

78. 发明授权

US4624847A Drug delivery device for programmed delivery of beneficial drug 失效
标题翻译：药物输送装置，用于程序性递送有益药物
公开(公告)号：US4624847A
公开(公告)日：1986-11-25
申请号：US725839
申请日：1985-04-22
申请人： Atul D. Ayer , Brian Barclay
发明人： Atul D. Ayer , Brian Barclay
IPC分类号： A61K9/00 , A61K9/52 , A61M31/00 , A61M7/00
CPC分类号： A61K9/0004
摘要： An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment with an osmotic passageway in the semipermeable wall connecting the outside of the device with the compartment. The compartment houses a medicine releasable carrier by a means for increasing in size for delivering the beneficial medicine from the device over time.
摘要翻译：公开了用于将药物递送到生物生物学环境的渗透分配装置。该装置包括围绕隔室的半透壁，该隔室具有连接设备外部与隔室的半透壁中的渗透通道。隔间通过一种增加尺寸的装置来容纳药物可释放的载体，以随着时间从装置输送有益药物。

79. 发明授权

US4200098A Osmotic system with distribution zone for dispensing beneficial agent 失效
标题翻译：渗透系统具有分配区域用于分配有益剂
公开(公告)号：US4200098A
公开(公告)日：1980-04-29
申请号：US953906
申请日：1978-10-23
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61J3/07 , A61K9/00 , A61K9/22 , B01J4/04 , A61M7/00
CPC分类号： A61K9/0004 , Y10T428/31536
摘要： An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.
摘要翻译：公开了用于分配有益试剂的渗透系统。该系统包括（1）半透性材料的第一壁，该第一壁围绕包含药物制剂的隔室，并且具有通过所述壁的通道，用于从所述隔间释放剂，（2）位于远离所述第一壁的第二壁，所述第二壁第二壁是围绕第一壁延伸的微孔或水凝胶材料，以及（3）介于第一和第二壁之间的分配区，并且初始地容纳可溶于进入系统的外部流体的化合物。在操作中，通过流体通过第二壁将流体从系统中分配到进入区域中的流体进一步从第一壁吸入到隔室中，该隔室形成通过通道被释放到该区域中的溶液，然后通过第二个墙壁到系统的外部。

80. 发明授权

US4160020A Therapeutic device for osmotically dosing at controlled rate 失效
标题翻译：用于以受控速率渗透给药的治疗装置
公开(公告)号：US4160020A
公开(公告)日：1979-07-03
申请号：US864954
申请日：1977-12-27
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61M37/00 , A61K9/00 , A61M29/04 , A61M31/00 , A61K9/24 , A61K9/44
CPC分类号： A61K9/0036 , A61K9/0004
摘要： An osmotic device is disclosed for delivering an active agent. The device comprises a wall surrounding a compartment with a passageway through the wall for releasing the agent. The wall comprises a material permeable to an external fluid and substantially impermeable to agent and at least one additional material independently selected from materials that impart stability to the wall, enhance the permeability of the wall to fluids, or aid in forming the wall. The compartment contains an agent that exhibits an osmotic pressure gradient across the wall against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbided through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, thereby producing a solution containing agent that is released through the passageway at a controlled rate over time.
摘要翻译：公开了用于递送活性剂的渗透装置。该装置包括围绕隔室的壁，通过该壁的通道用于释放该试剂。该壁包括可渗透外部流体的材料，并且基本上不可渗透到试剂和至少一种附加材料，其独立地选自赋予壁稳定性的材料，增强壁对流体的渗透性或有助于形成壁。隔间含有一种在外壁上显示渗透压梯度以抵抗外部流体的试剂，或者该试剂与渗透压梯度相对于流体的渗透性有效化合物混合。通过流体通过壁被渗透到隔室中的剂量通过壁的渗透性和穿过壁的渗透压梯度控制的速率从装置释放，从而产生溶液包含试剂，其通过通道在受控的随着时间的推移。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式