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71. 发明授权

US09737353B2 System for controlling tissue ablation using temperature sensors 有权
公开(公告)号：US09737353B2
公开(公告)日：2017-08-22
申请号：US12969684
申请日：2010-12-16
申请人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
发明人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
IPC分类号： A61B18/00 , A61B18/18 , A61B18/12 , A61B18/20 , A61B5/01 , A61B5/055 , A61B18/14 , A61B18/24 , A61B17/00 , A61N7/02 , A61B90/00
CPC分类号： A61B18/1206 , A61B5/01 , A61B5/055 , A61B18/1233 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B2017/00243 , A61B2018/00023 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2090/374 , A61B2090/378 , A61N7/022
摘要： Body tissue ablation is carried out by inserting a probe into a body of a living subject, urging the probe into contact with a tissue in the body, generating energy at a power output level, and transmitting the generated energy into the tissue via the probe. While transmitting the generated energy the ablation is further carried out by determining a measured temperature of the tissue and a measured power level of the transmitted energy, and controlling the power output level responsively to a function of the measured temperature and the measured power level. Related apparatus for carrying out the ablation is also described.

72. 发明授权

US09713435B2 Cardiac mapping using non-gated MRI 有权
公开(公告)号：US09713435B2
公开(公告)日：2017-07-25
申请号：US13191867
申请日：2011-07-27
申请人： Assaf Govari , Andres Claudio Altmann
发明人： Assaf Govari , Andres Claudio Altmann
IPC分类号： A61B5/055 , A61B5/042
CPC分类号： A61B5/055 , A61B5/0422
摘要： A method includes accepting a plurality of Magnetic Resonance Imaging (MRI) data points of a cardiac chamber, acquired over multiple phases of at least one cardiac cycle. A simulated surface of the cardiac chamber is constructed by processing the MRI data points. Measurements of a parameter, acquired at respective points on a surface of the cardiac chamber, are accepted from an intra-cardiac probe. The measurements are overlaid on the simulated surface constructed from the MRI data points, so as to produce a map of the parameter on the surface.

73. 发明授权

US09173638B2 Cardiac mechanical assessment using ultrasound 有权
标题翻译：使用超声心脏机械评估
公开(公告)号：US09173638B2
公开(公告)日：2015-11-03
申请号：US12126032
申请日：2008-05-23
申请人： Assaf Govari , Andres Claudio Altmann , Alexander Levin
发明人： Assaf Govari , Andres Claudio Altmann , Alexander Levin
IPC分类号： A61B8/14 , A61B8/00 , A61B8/08 , A61B8/12 , A61B19/00 , G01S7/52 , G06T7/00 , G06T7/20 , A61B5/06 , A61B6/00 , G01S15/89
CPC分类号： A61B8/4488 , A61B5/06 , A61B5/061 , A61B6/503 , A61B8/08 , A61B8/0883 , A61B8/12 , A61B8/4254 , A61B8/463 , A61B8/483 , A61B8/485 , A61B8/543 , A61B34/20 , A61B2034/2051 , A61B2090/364 , A61B2090/367 , A61B2090/378 , G01S7/52038 , G01S7/52071 , G01S15/8918 , G01S15/8979 , G06T7/0016 , G06T7/12 , G06T7/246 , G06T2207/10076 , G06T2207/30048
摘要： A method for diagnosis includes capturing a sequence of two-dimensional ultrasound images of a moving organ within a body of a patient. At least one contour of the organ is identified in a succession of the images in the sequence and is processed to generate an output indicative of motion of the organ over time.
摘要翻译：一种用于诊断的方法包括捕获患者体内的运动器官的二维超声图像的序列。在序列中的一系列图像中识别器官的至少一个轮廓，并且被处理以产生指示器官随时间的运动的输出。

74. 发明授权

US09089254B2 Synchronization of medical devices via digital interface 有权
标题翻译：医疗器械通过数字接口同步化
公开(公告)号：US09089254B2
公开(公告)日：2015-07-28
申请号：US12200431
申请日：2008-08-28
申请人： Assaf Govari , Andres Claudio Altmann
发明人： Assaf Govari , Andres Claudio Altmann
IPC分类号： H04J3/06 , A61B5/00 , A61B5/06 , G06F19/00
CPC分类号： A61B5/0002 , A61B5/06 , G06F19/00 , G16H40/40
摘要： A method for device control includes bringing a plurality of medical devices into contact with a body of a patient. The medical devices are coupled to communicate with a console via a digital interface. A message is transmitted over the digital interface from the console, to be received simultaneously by the plurality of the medical devices. The medical devices are synchronized with one another responsively to receiving the message.
摘要翻译：一种用于装置控制的方法包括使多个医疗装置与患者的身体接触。医疗设备被耦合以经由数字接口与控制台通信。通过数字接口从控制台发送消息，由多个医疗设备同时接收。响应于接收消息，医疗设备彼此同步。

75. 发明授权

US09005217B2 Robotic drive for catheter 有权
标题翻译：导管机器人驱动
公开(公告)号：US09005217B2
公开(公告)日：2015-04-14
申请号：US12539707
申请日：2009-08-12
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath , Christopher Thomas Beeckler
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath , Christopher Thomas Beeckler
IPC分类号： A61B1/00 , A61B19/00 , A61B17/00 , A61M25/01
CPC分类号： A61B19/2203 , A61B34/30 , A61B2017/003 , A61B2034/301 , A61M25/0105 , A61M25/0113
摘要： Apparatus for controlling a steerable invasive probe having a handle. The apparatus includes a platform and a jig, which is mounted on the platform and is configured to receive the handle. The jig includes at least a first gear that is positioned and shaped to rotate the handle about an axis of the probe and a second gear that is positioned and shaped to operate a control on the handle for deflecting a tip of the probe. A drive module includes one or more motors. A transmission is coupled to the drive module and to the jig so as to controllably rotate at least the first and second gears and to translate the platform along a direction parallel to the axis in order to advance and retract the probe.
摘要翻译：用于控制具有手柄的可操纵入侵探针的装置。该装置包括平台和夹具，该平台和夹具安装在平台上并构造成接收手柄。所述夹具包括至少第一齿轮，所述第一齿轮被定位和成形以围绕所述探针的轴线旋转所述手柄;以及第二齿轮，所述第二齿轮被定位和成形以操作所述手柄上的控制以偏转所述探针的尖端。驱动模块包括一个或多个电动机。传动装置联接到驱动模块和夹具，以便可控制地旋转至少第一和第二齿轮并使平台沿平行于轴线的方向平移，以便推进和缩回探针。

76. 发明授权

US08926604B2 Estimation and mapping of ablation volume 有权
标题翻译：消融量的估计和绘图
公开(公告)号：US08926604B2
公开(公告)日：2015-01-06
申请号：US12646197
申请日：2009-12-23
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
IPC分类号： A61B18/14 , A61B18/00 , A61M25/01 , A61B19/00 , A61B18/18 , A61M25/00
CPC分类号： A61B18/1492 , A61B18/1815 , A61B34/20 , A61B2018/00351 , A61B2018/00577 , A61B2018/00702 , A61B2018/00714 , A61B2018/00761 , A61B2018/00791 , A61B2034/104 , A61B2034/2051 , A61B2090/064 , A61B2090/065 , A61M25/0158 , A61M2025/0002 , A61M2025/0166
摘要： Tissue ablation systems and methods are provided, wherein a cardiac catheter incorporates a pressure detector for sensing a mechanical force against the distal tip when engaging an ablation site. Responsively to the pressure detector, a controller computes an ablation volume according to relationships between the contact pressure against the site, the power output of an ablator, and the energy application time. A monitor displays a map of the heart which includes a visual indication of the computed ablation volume. The monitor may dynamically display the progress of the ablation by varying the visual indication.
摘要翻译：提供组织消融系统和方法，其中心脏导管结合有压力检测器，用于在接合消融部位时感测抵抗远侧末端的机械力。响应于压力检测器，控制器根据与现场的接触压力，消融器的功率输出和能量施加时间之间的关系来计算消融体积。监视器显示包括计算的消融体积的视觉指示的心脏图。监视器可以通过改变视觉指示来动态显示消融的进展。

77. 发明授权

US08798952B2 Weight-based calibration system for a pressure sensitive catheter 有权
标题翻译：用于压敏导管的基于重量的校准系统
公开(公告)号：US08798952B2
公开(公告)日：2014-08-05
申请号：US12797693
申请日：2010-06-10
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
IPC分类号： A61B5/103 , A61M25/00 , G01L1/04
CPC分类号： A61B5/1495 , A61B5/6885 , A61B2560/0223 , A61B2560/0228
摘要： A calibration apparatus includes a fixture, which is coupled to hold a distal end of a medical probe. A plurality of weights, which have respective masses and respective bottom surfaces that are oriented at respective angles with respect to the distal end of the probe, are coupled to rest on a distal tip of the probe so as to apply to the distal tip respective force vectors that cause a deformation of the distal tip relative to the distal end. A calibration processor is configured to receive from the probe measurements indicative of the deformation of the distal tip in response to the force vectors, and to compute, based on the measurements, the masses and the angles, calibration coefficients for assessing the force vectors as a function of the measurements.
摘要翻译：校准装置包括固定装置，其被联接以保持医疗探针的远端。具有相对于相对于探针的远端以相应角度定向的相应质量和相应底表面的多个重物联接以保持在探针的远侧末端上，以便向远侧末端施加相应的力导致远侧末端相对于远端变形的载体。校准处理器被配置为从所述探针接收响应于所述力向量的指示所述远侧末端的变形的测量，并且基于所述测量来计算所述质量和角度，用于将所述力矢量评估为测量功能。

78. 发明授权

US08374819B2 Actuator-based calibration system for a pressure-sensitive catheter 有权
标题翻译：用于压敏导管的基于执行器的校准系统
公开(公告)号：US08374819B2
公开(公告)日：2013-02-12
申请号：US12646050
申请日：2009-12-23
申请人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
发明人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
IPC分类号： G01L1/04
CPC分类号： A61B5/1495 , A61B5/6885 , A61B2560/0223
摘要： A calibration apparatus includes a fixture coupled to hold a distal end of a medical probe. An actuator is configured to press against the distal tip of the probe and apply to the distal tip multiple force vectors having respective magnitudes and angles with respect to the distal end, so as to cause a deformation of the distal tip relative to the distal end. A sensing device is configured to measure the magnitudes of the force vectors applied by the actuator. A calibration processor is configured to receive from the probe first measurements indicative of the deformation of the distal tip in response to the force vectors, to receive from the sensing device second measurements indicative of the magnitudes of the force vectors, and to compute, based on the angles and the first and second measurements, calibration coefficients for assessing the force vectors as a function of the first measurements.
摘要翻译：校准装置包括联接以保持医疗探针的远端的固定装置。致动器被构造成压靠探针的远侧末端并且向远侧末端施加具有相对于远端具有相应大小和角度的多个力矢量，以便引起远侧末端相对于远端的变形。感测装置被配置为测量由致动器施加的力矢量的大小。校准处理器被配置为从探针接收第一测量值，其指示响应于力矢量的远侧尖端的变形，从感测装置接收指示力矢量的幅度的第二测量值，并且基于角度和第一和第二测量值，用于评估作为第一测量的函数的力矢量的校准系数。

79. 发明授权

US08357152B2 Catheter with pressure sensing 有权
标题翻译：导管与压力感应
公开(公告)号：US08357152B2
公开(公告)日：2013-01-22
申请号：US11868733
申请日：2007-10-08
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath , Yitzhack Schwartz
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath , Yitzhack Schwartz
IPC分类号： A61B18/14 , A61B5/05
CPC分类号： A61B18/18 , A61B5/06 , A61B5/065 , A61B5/6843 , A61B18/1492 , A61B2018/00351 , A61B2018/00702 , A61B2034/2051 , A61B2090/064 , A61B2090/065 , A61B2090/067 , A61B2090/3958 , A61N1/056 , A61N1/08
摘要： A medical probe includes a flexible insertion tube, having a distal end for insertion into a body cavity of a patient, and a distal tip, which is disposed at the distal end of the insertion tube and is configured to be brought into contact with tissue in the body cavity. A resilient member couples the distal tip to the distal end of the insertion tube and is configured to deform in response to pressure exerted on the distal tip when the distal tip engages the tissue. A position sensor within the probe senses a position of the distal tip relative to the distal end of the insertion tube, which changes in response to deformation of the resilient member.
摘要翻译：医疗探针包括柔性插入管，其具有用于插入患者体腔的远端和远端，所述远端位于插入管的远端，并被构造成与组织接触体腔。弹性构件将远端尖端连接到插入管的远端，并且构造成当远侧末端接合组织时响应于施加在远侧末端上的压力而变形。探针内的位置传感器感测远侧末梢相对于插入管的远端的位置，其随着弹性构件的变形而变化。

80. 发明申请

US20120157890A1 SYSTEM FOR CONTROLLING TISSUE ABLATION USING TEMPERATURE SENSORS 有权
标题翻译：使用温度传感器控制组织消融的系统
公开(公告)号：US20120157890A1
公开(公告)日：2012-06-21
申请号：US12969684
申请日：2010-12-16
申请人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
发明人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
IPC分类号： A61B18/12 , A61B17/00 , A61B18/20 , A61B18/18 , A61N7/02
CPC分类号： A61B18/1206 , A61B5/01 , A61B5/055 , A61B18/1233 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B2017/00243 , A61B2018/00023 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2090/374 , A61B2090/378 , A61N7/022
摘要： Body tissue ablation is carried out by inserting a probe into a body of a living subject, urging the probe into contact with a tissue in the body, generating energy at a power output level, and transmitting the generated energy into the tissue via the probe. While transmitting the generated energy the ablation is further carried out by determining a measured temperature of the tissue and a measured power level of the transmitted energy, and controlling the power output level responsively to a function of the measured temperature and the measured power level. Related apparatus for carrying out the ablation is also described.
摘要翻译：身体组织消融通过将探针插入活体的体内，使探针与身体中的组织接触，在功率输出水平产生能量，并通过探针将生成的能量传递到组织中来进行。在发送所产生的能量的同时，通过确定组织的测量温度和所测量的发射能量的功率水平来进一步执行烧蚀，并且响应于所测量的温度和所测量的功率水平的函数来控制功率输出水平。还描述了用于进行消融的相关装置。

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