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71. 发明授权

US5904651A Systems and methods for visualizing tissue during diagnostic or therapeutic procedures 失效
标题翻译：在诊断或治疗过程中可视化组织的系统和方法
公开(公告)号：US5904651A
公开(公告)日：1999-05-18
申请号：US739504
申请日：1996-10-28
申请人： David K. Swanson , David McGee , Dorin Panescu , James G. Whayne , Harm TenHoff
发明人： David K. Swanson , David McGee , Dorin Panescu , James G. Whayne , Harm TenHoff
IPC分类号： A61B1/313 , A61B5/00 , A61B5/05 , A61B8/12 , A61B8/14 , A61N1/05
CPC分类号： A61B8/12 , A61B5/0084 , A61B5/6852 , A61B8/445 , A61B8/54 , A61B8/543 , A61B5/0066 , A61B5/7285 , A61B6/541
摘要： A catheter tube carries an imaging element for visualizing tissue. The catheter tube also carries a support structure, which extends beyond the imaging element for contacting surrounding tissue away from the imaging element. The support element stabilizes the imaging element, while the imaging element visualizes tissue in the interior body region. The support structure also carries a diagnostic or therapeutic component to contact surrounding tissue.
摘要翻译：导管管携带用于使组织可视化的成像元件。导管还具有延伸超过成像元件的支撑结构，用于使周围组织远离成像元件。支撑元件稳定成像元件，而成像元件可视化内部身体区域中的组织。支撑结构还携带用于接触周围组织的诊断或治疗部件。

72. 发明授权

US5891136A Expandable-collapsible mesh electrode structures 失效
标题翻译：可膨胀 - 可折叠网状电极结构
公开(公告)号：US5891136A
公开(公告)日：1999-04-06
申请号：US630721
申请日：1996-04-08
申请人： David McGee , Patrick M. Owens , James G. Whayne , Russell B. Thompson , Thomas F. Kordis , David K. Swanson , Dorin Panescu
发明人： David McGee , Patrick M. Owens , James G. Whayne , Russell B. Thompson , Thomas F. Kordis , David K. Swanson , Dorin Panescu
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61N1/05 , A61B17/39
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00839
摘要： Collapsible electrode assemblies and associated methods employ an array of filaments assembled to form a mesh structure. The mesh structure is adapted to selectively assume an expanded geometry having a first maximum diameter and a collapsed geometry having a second maximum diameter less than the first maximum diameter. Preferably, at least one of the filaments includes an electrically conductive material adapted for coupling to a source of ablation energy for transmitting ablation energy.
摘要翻译：可折叠电极组件和相关联的方法采用组装成形成网格结构的细丝阵列。网格结构适于选择性地假设具有第一最大直径和具有小于第一最大直径的第二最大直径的折叠几何形状的扩展几何形状。优选地，所述长丝中的至少一个包括适于耦合到用于传导消融能量的消融能量源的导电材料。

73. 发明授权

US5879348A Electrode structures formed from flexible, porous, or woven materials 失效
标题翻译：由柔性，多孔或编织材料形成的电极结构
公开(公告)号：US5879348A
公开(公告)日：1999-03-09
申请号：US631577
申请日：1996-04-12
申请人： Patrick M. Owens , James G. Whayne , David K. Swanson , Dorin Panescu
发明人： Patrick M. Owens , James G. Whayne , David K. Swanson , Dorin Panescu
IPC分类号： A61B18/14 , A61N1/06 , A61B17/39
CPC分类号： A61N1/06 , A61B18/1492 , A61B2018/00065 , A61B2018/00113 , A61B2018/00214 , A61B2018/00267 , A61B2018/00839 , A61B2018/1253 , A61B2018/1472 , A61B2218/002
摘要： Electrode structures are formed from flexible, porous, or woven materials. One such structure is made by forming first and second body sections, each including a peripheral edge. The first and second body sections are joined together about their peripheral edges with a seam, thereby forming a composite structure. Another one of such structures is made by forming a body having a three dimensional shape and opposite open ends, and at least partially closing at least one of the opposite ends by forming a seam. Another one of such structures is formed from a sheet of material having peripheral edges. The sheet is placed on the distal end of a fixture, while the peripheral edges of the sheet are gathered about the proximal end of a fixture, thereby imparting to the sheet a desired shape. At least one pleat is formed to secure the gathered peripheral edges together. The seams or pleats are formed by thermal bonding, or ultrasonic welding, or laser welding, or adhesive bonding, or sewing.
摘要翻译：电极结构由柔性，多孔或编织材料形成。一个这样的结构通过形成第一和第二主体部分而形成，每个主体部分包括周边边缘。第一和第二主体部分通过接缝围绕其周边边缘连接在一起，从而形成复合结构。通过形成具有三维形状和相对的开口端的主体，并且通过形成接缝至少部分地闭合相对端中的至少一个来制造另一个这样的结构。这种结构中的另一个由具有外围边缘的材料片形成。片材被放置在固定装置的远端，而片材的周边边缘围绕固定装置的近端聚集，从而赋予片材所需的形状。形成至少一个褶皱以将聚集的周边边缘固定在一起。接缝或褶皱是通过热粘合或超声波焊接，或激光焊接，粘合或粘合形成的。

74. 发明授权

US5871483A Folding electrode structures 失效
标题翻译：折叠电极结构
公开(公告)号：US5871483A
公开(公告)日：1999-02-16
申请号：US629171
申请日：1996-04-08
申请人： Jerome Jackson , Dorin Panescu , David K. Swanson , Russell B. Thompson , James G. Whayne
发明人： Jerome Jackson , Dorin Panescu , David K. Swanson , Russell B. Thompson , James G. Whayne
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61N1/05 , A61B17/39
CPC分类号： A61B18/1492 , A61N1/056 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00839
摘要： Improved folding electrode assemblies and associated methods employ a structure comprising a wall peripherally enclosing an interior. The structure is adapted to selectively assume a geometry that changes between an expanded geometry having a first maximum diameter and a collapsed geometry having a second maximum diameter less than the first maximum diameter. At least one folding region in the wall is adapted to fold upon itself along a predefined fold line as the structure geometry changes. The folding region is formed when a portion of the wall is coated with an electrically conductive material for the purpose of transmitting electrical ablating energy, while another portion of the wall is left free of the electrically conductive material. Alternatively, the folding region is formed by forming an array of apertures in the wall.
摘要翻译：改进的折叠电极组件和相关联的方法采用包括外围围绕内部的壁的结构。该结构适于选择性地假设在具有第一最大直径的膨胀几何形状和具有小于第一最大直径的第二最大直径的折叠几何形状之间变化的几何形状。当结构几何形状改变时，壁中的至少一个折叠区域适于沿着预定折叠线自身折叠。当壁的一部分涂覆有用于传递电消融能量的导电材料时，同时壁的另一部分没有导电材料形成折叠区域。或者，通过在壁中形成孔阵列来形成折叠区域。

75. 发明授权

US5853411A Enhanced electrical connections for electrode structures 失效
标题翻译：电极结构的增强电连接
公开(公告)号：US5853411A
公开(公告)日：1998-12-29
申请号：US629363
申请日：1996-04-08
申请人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
发明人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61N1/05 , A61B17/39 , A61B5/042
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022
摘要： Enhanced electrical connections for electrodes are provided. In one implementation, an electrode body comprises a first electrically nonconductive layer and a second electrically nonconductive layer overlying at least a portion of the first layer. An intermediate region is formed between the first and second layers. An electrically conductive pathway extends within the intermediate region. An formed opening extends to the intermediate region, exposing a part of the electrically conductive pathway. An electrically conductive material is deposited on the second layer so that a part of the electrically conductive material passes through the opening to establish electrical contact between the electrically conductive material and the electrically conductive pathway.
摘要翻译：提供了电极的增强电连接。在一个实施方案中，电极体包括覆盖在第一层的至少一部分上的第一非导电层和第二非导电层。在第一和第二层之间形成中间区域。导电通路在中间区域内延伸。形成的开口延伸到中间区域，暴露导电路径的一部分。导电材料沉积在第二层上，使得导电材料的一部分通过开口以在导电材料和导电通路之间建立电接触。

76. 发明授权

US5846239A Tissue heating and ablation systems and methods using segmented porous electrode structures 失效
标题翻译：组织加热和消融系统和使用分段多孔电极结构的方法
公开(公告)号：US5846239A
公开(公告)日：1998-12-08
申请号：US634338
申请日：1996-04-12
申请人： David K. Swanson , Dorin Panescu , James G. Whayne , Patrick M. Owens , Russell B. Thompson
发明人： David K. Swanson , Dorin Panescu , James G. Whayne , Patrick M. Owens , Russell B. Thompson
IPC分类号： A61N1/05 , A61B17/39
CPC分类号： A61N1/05 , A61B18/1492 , A61B2018/00238 , A61B2018/00357 , A61B2018/00791 , A61B2018/00839
摘要： A porous electrode assembly for tissue heating and ablation systems and methods includes a wall having an exterior peripherally surrounding an interior area. The assembly includes a lumen to convey a medium containing ions into the interior area. An element couples the medium within the interior area to a source of electrical energy. According to the invention, the wall includes at least two spaced apart zones. Each zone comprises a porous material sized to pass ions contained in the medium, to thereby enable ionic transport of electrical energy from the source through the medium and porous material to the exterior of the wall. In a preferred embodiment, the at least two zones are spaced apart by a third zone comprising a material that blocks passage of ions contained in the medium.
摘要翻译：用于组织加热和消融系统和方法的多孔电极组件包括具有周围围绕内部区域的外部的壁。组件包括用于将含有离子的介质输送到内部区域中的内腔。元件将内部区域内的介质耦合到电能源。根据本发明，壁包括至少两个间隔开的区域。每个区域包括多孔材料，其尺寸适于通过包含在介质中的离子，从而使得电能从源通过介质和多孔材料离子输送到壁的外部。在一个优选实施例中，所述至少两个区域间隔开第三区域，所述第三区域包括阻挡介质中包含的离子通过的材料。

77. 发明授权

US5722416A Systems and methods for analyzing biopotential morphologies in heart tissue to locate potential ablation sites 失效
标题翻译：用于分析心脏组织中的生物电位形态以定位潜在消融部位的系统和方法
公开(公告)号：US5722416A
公开(公告)日：1998-03-03
申请号：US393126
申请日：1995-02-17
申请人： David K. Swanson , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Dorin Panescu , James G. Whayne
IPC分类号： A61B1/005 , A61B5/042 , A61B5/0452 , A61N1/05 , A61N1/40 , G06F17/00 , A61B5/0402
CPC分类号： A61N1/403 , A61B5/0422 , A61B5/04525 , A61B5/6855 , A61B5/6858 , A61N1/056 , A61B1/0051
摘要： Systems and methods analyze biopotential morphologies in body tissue. The systems and methods use a template of a biopotential event of known cause in body tissue. The template comprises a plot of variations in biopotentials over time and not a spacial distribution of endocardial surface activation. The systems and methods compare this template to a sample of a biopotential event externally triggered in body tissue. The sample comprises a plot of variations in biopotentials over time and not a spacial distribution of endocardial surface activation. The systems and methods generate an output based upon the comparison. The systems and methods can be used to compare an event-specific template of a cardiac event of known diagnosis to a sample of a paced cardiac event. The comparison yields a matching factor indicating how alike the input sample is to the input template. The systems and methods compare the matching factor to a predetermined value to determine the location of sites that are potentially appropriate for ablation. A matching factor that indicates close similarity between the sample and the template suggests that the pacing site lies close to a region potentially appropriate for ablation to treat the arrhythmia.
摘要翻译：系统和方法分析身体组织中的生物电位形态。系统和方法使用身体组织中已知原因的生物潜在事件的模板。该模板包括随时间的生物电势的变化图，而不是心内膜表面活化的空间分布。系统和方法将该模板与身体组织中外部触发的生物潜在事件的样本进行比较。样品包括生物电势随时间变化的图，而不是心内膜表面活化的空间分布。系统和方法基于比较产生输出。系统和方法可用于将已知诊断的心脏事件的事件特定模板与起搏心脏事件的样本进行比较。比较产生一个匹配因子，表明输入样本与输入模板的相似度。系统和方法将匹配因子与预定值进行比较，以确定潜在适合于消融的部位的位置。表明样品和模板之间密切相似的匹配因子表明，起搏部位靠近可能适合消融治疗心律失常的区域。

78. 发明授权

US5595183A Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes 失效
标题翻译：使用多个电极结构和粗纱电极检查心脏组织的系统和方法
公开(公告)号：US5595183A
公开(公告)日：1997-01-21
申请号：US390383
申请日：1995-02-17
申请人： David K. Swanson , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Dorin Panescu , James G. Whayne
IPC分类号： A61B5/0408 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B18/14 , A61N1/05 , A61N1/362
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/6858 , A61N1/056 , A61B18/1492 , A61B2090/065 , A61B2562/0209 , A61B2562/043
摘要： Systems and methods use an array of multiple electrodes supported for operative association with a region of heart tissue, in tandem with a roving second electrode supported for movement relative to the multiple electrode means for operative association with selected, different regions of endocardial tissue within the heart. An analog or digital processing element conditions one of the multiple electrodes and the roving electrode to emit a pacing signal while the other one of the multiple electrodes and the roving electrode records paced electrograms occurring as a result of the pacing signal. A processing element and method input a template of a cardiac event of known diagnosis sensed using the array of multiple electrodes. The processing element and method inputs a sample of a cardiac event acquired by pacing from at least one roving electrode and sensed with the array of multiple electrodes. The processing element and method electronically compare the input sample to the input template and generates an output based upon the comparison. The output can aid the physician in locating potentially appropriate sites for ablation.
摘要翻译：系统和方法使用多个电极的阵列，其被支撑用于与心脏组织的区域操作性关联，与被支撑用于相对于多个电极装置移动的粗纱第二电极串联，以与心脏内心脏组织的选定的不同区域有效结合。模拟或数字处理元件调节多个电极和粗纱电极之一以发出起搏信号，而多个电极和粗纱电极中的另一个记录起搏电迹作为起搏信号的结果。处理元件和方法输入使用多个电极阵列感测的已知诊断的心脏事件的模板。处理元件和方法输入通过起搏从至少一个粗纱电极获取的心脏事件的样本，并用多个电极的阵列感测。处理元件和方法将输入样本与输入模板进行电子比较，并根据比较生成输出。输出可以帮助医生定位潜在的适当的消融部位。

79. 发明授权

US06192266B1 Systems and methods for controlling the use of diagnostic or therapeutic instruments in interior body regions using real and idealized images 失效
标题翻译：使用真实和理想化图像来控制在室内区域中使用诊断或治疗仪器的系统和方法
公开(公告)号：US06192266B1
公开(公告)日：2001-02-20
申请号：US09048643
申请日：1998-03-26
申请人： Daniel A. Dupree , Tuan Nguyen , Dorin Panescu , James G. Whayne
发明人： Daniel A. Dupree , Tuan Nguyen , Dorin Panescu , James G. Whayne
IPC分类号： A61B500
CPC分类号： A61B5/0422 , A61B5/0464 , A61B5/06 , A61B5/068 , A61B5/6858 , A61B5/7435 , A61B5/7475 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , G06F19/00 , G16H40/63
摘要： An interface for association with an electrode structure deployed in contact with heart tissue generates a real image of the electrode structure acquired by an imaging device. The interface also generates an idealized image of the electrode structure based at least in part upon the real image. The interface displays either the real image, or the idealized image, or both on a display screen.
摘要翻译：与与心脏组织接触部署的电极结构相关联的界面产生由成像装置获取的电极结构的实际图像。界面还至少部分地基于真实图像生成电极结构的理想化图像。界面在显示屏幕上显示实际图像或理想图像，或两者。

80. 发明授权

US5647870A Multiple electrode support structures 失效
标题翻译：多电极支撑结构
公开(公告)号：US5647870A
公开(公告)日：1997-07-15
申请号：US587251
申请日：1996-01-16
申请人： Thomas F. Kordis , Dorin Panescu , James G. Whayne
发明人： Thomas F. Kordis , Dorin Panescu , James G. Whayne
IPC分类号： A61B5/0408 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B18/12 , A61B18/14 , A61B5/04
CPC分类号： A61B5/6858 , A61B5/0422 , A61B18/1492 , A61B2018/00267 , A61B2018/1407 , A61B2018/1435 , A61B2562/0209 , A61B2562/043
摘要： An electrode support structure has spline elements radiating from a center hub in a circumferentially spaced relationship. The spline elements include terminal ends spaced from the hub which are joined to a base member to form a three dimensional structure for supporting electrodes. The center hub lies essentially within the envelope of the spline elements to present a surface free of projections that can poke into and cause tissue trauma during use.
摘要翻译：电极支撑结构具有花键元件，其沿圆周间隔开地从中心毂辐射。花键元件包括与轮毂间隔开的端部，其连接到基座构件以形成用于支撑电极的三维结构。中心毂基本上位于花键元件的外壳内，以呈现出没有突起的表面，其可以在使用过程中进入并引起组织损伤。

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