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71. 发明授权

US07625579B2 Antimicrobial coatings 失效
标题翻译：抗微生物涂料
公开(公告)号：US07625579B2
公开(公告)日：2009-12-01
申请号：US10257245
申请日：2001-04-10
申请人： Roger Read , Naresh Kumar , Mark Wilcox , Hua Zhu , Hnas Griesser , Ben Muir , Helmut Thissen , Tim Hughes
发明人： Roger Read , Naresh Kumar , Mark Wilcox , Hua Zhu , Hnas Griesser , Ben Muir , Helmut Thissen , Tim Hughes
IPC分类号： A61F2/00 , A01N43/08
CPC分类号： D06M16/00 , A01N25/34 , A01N43/36 , A61K31/341 , A61L27/28 , A61L27/54 , A61L2300/404 , D06M13/228 , D06M13/364 , Y10T442/2525 , A01N2300/00
摘要： The present invention provides a substrate having a plurality of immobilised furanone moieties associated with at least part of a surface of the substrate. The invention also relates to articles consisting of or comprising such a substrate.
摘要翻译：本发明提供了一种具有多个固定的呋喃酮部分的基底，该部分与基底的至少部分表面缔合。本发明还涉及由这种基材组成或包含这种基材的制品。

72. 发明授权

US07488748B2 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效
标题翻译： 3,6-二取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US07488748B2
公开(公告)日：2009-02-10
申请号：US10543585
申请日：2003-01-23
申请人： Anita Mehta , Arundutt V. Silamkoti , Naresh Kumar , Jang Bahadur Gupta
发明人： Anita Mehta , Arundutt V. Silamkoti , Naresh Kumar , Jang Bahadur Gupta
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D401/04 , C07D209/52 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04
摘要： This invention generally relates to derivatives of 3,6 disubstituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及3,6-二取代的氮杂双环己烷的衍生物。本发明的化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

73. 发明授权

US07446123B2 Azabicyclo derivatives as muscarinic receptor antagonists 失效
标题翻译：偶氮二环衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US07446123B2
公开(公告)日：2008-11-04
申请号：US10552455
申请日：2004-01-07
申请人： Mohammad Salman , Anita Mehta , Pakala Kumara Savithru Sarma , Naresh Kumar , Sankaranarayanan Dharmarajan , Kirandeep Kaur , Anita Chugh
发明人： Mohammad Salman , Anita Mehta , Pakala Kumara Savithru Sarma , Naresh Kumar , Sankaranarayanan Dharmarajan , Kirandeep Kaur , Anita Chugh
IPC分类号： A61K31/40 , A61K31/4035 , C07D209/52
CPC分类号： C07D209/52 , C07D403/06
摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

74. 发明申请

US20080255188A1 Muscarinic Receptor Antagonists 审中-公开
标题翻译：毒蕈碱受体拮抗剂
公开(公告)号：US20080255188A1
公开(公告)日：2008-10-16
申请号：US11995433
申请日：2006-07-11
申请人： Naresh Kumar , Mohammad Salman , Kirandeep Kaur , Anita Chugh , Sandeep Sinha
发明人： Naresh Kumar , Mohammad Salman , Kirandeep Kaur , Anita Chugh , Sandeep Sinha
IPC分类号： A61K31/472 , C07D217/26
CPC分类号： C07D471/08
摘要： This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

75. 发明申请

US20070292477A1 Association of Antimicrobial Compounds with Surfaces and Polymers 审中-公开
标题翻译：抗菌化合物与表面和聚合物的关联
公开(公告)号：US20070292477A1
公开(公告)日：2007-12-20
申请号：US10581710
申请日：2004-12-06
申请人： Naresh Kumar
发明人： Naresh Kumar
IPC分类号： A61K31/765 , A61K31/787 , A61K9/00 , A61L15/20 , A61M25/00 , A61P31/00 , C07D207/24 , C07D307/26
CPC分类号： C07D307/58 , A61K31/341 , A61K31/4015 , A61K47/59 , A61K47/60 , C07B2200/11 , C07D207/44 , C07F7/1804 , C08G77/38 , C08G77/388 , G02B1/043
摘要： The invention describes antimicrobial silicone oligomers or polymers comprising a silicone oligomer or polymer associated with at least one compound of formula (I). Also described are methods of associating compounds of formula (I) to surfaces and products thereof.
摘要翻译：本发明描述了抗微生物聚硅氧烷低聚物或包含与至少一种式（I）化合物缔合的聚硅氧烷低聚物或聚合物的聚合物。还描述了将式（I）化合物与其表面及其产物缔合的方法。

76. 发明申请

US20070106078A1 Process for the preparation of fexofenadine 审中-公开
标题翻译：非索非那定制备方法
公开(公告)号：US20070106078A1
公开(公告)日：2007-05-10
申请号：US10543517
申请日：2004-01-30
申请人： Mukesh Sharma , Chandra Khanduri , Naresh Kumar , Yatendra Kumar
发明人： Mukesh Sharma , Chandra Khanduri , Naresh Kumar , Yatendra Kumar
IPC分类号： C07D211/34
CPC分类号： C07D211/22
摘要： The invention relates to highly pure fexofenadine and a process for preparing highly pure fexofenadine. The invention also relates to pharmaceutical compositions that include the highly pure fexofenadine and use of said compositions for treating a patient for allergic reactions.
摘要翻译：本发明涉及高纯度非索非那定和制备高纯度非索非那定的方法。本发明还涉及包含高纯度非索非那定的药物组合物和所述组合物用于治疗患者过敏反应的用途。

77. 发明申请

US20070021487A1 Azabicyclo derivatives as muscarinic receptor antagonists 审中-公开
标题翻译：偶氮二环衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20070021487A1
公开(公告)日：2007-01-25
申请号：US10552503
申请日：2004-01-06
申请人： Mohammad Salman , Naresh Kumar , Pakala Sarma , Sankaranarayanan Dharmarajan , Anita Chugh
发明人： Mohammad Salman , Naresh Kumar , Pakala Sarma , Sankaranarayanan Dharmarajan , Anita Chugh
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： C07D209/52 , C07D403/06
摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0]hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。具体地，本发明涉及氮杂二环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷，以及含有这些化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。

78. 发明申请

US20060111425A1 Azabicyclo derivatives as muscarinic receptor antagonists 失效
公开(公告)号：US20060111425A1
公开(公告)日：2006-05-25
申请号：US10520572
申请日：2003-04-11
申请人： Mohammad Salman , Anita Mehta , Pakala Kumara Sarma , Shankar Shetty , Sankaranarayanan Dharmarajan , Naresh Kumar , Arundutt Silamkoti , Anita Chugh
发明人： Mohammad Salman , Anita Mehta , Pakala Kumara Sarma , Shankar Shetty , Sankaranarayanan Dharmarajan , Naresh Kumar , Arundutt Silamkoti , Anita Chugh
IPC分类号： A61K31/403 , C07D403/02 , C07D209/02
CPC分类号： C07D401/12 , C07D209/52 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

79. 发明授权

US06932300B2 Device for closing parachute packs 失效
标题翻译：关闭降落伞包装置
公开(公告)号：US06932300B2
公开(公告)日：2005-08-23
申请号：US10481868
申请日：2002-06-21
申请人： Naresh Kumar
发明人： Naresh Kumar
IPC分类号： B64D17/46
CPC分类号： B64D17/46
摘要： The invention provides a device for closing parachute packs, each of which has a plurality of flaps and a closing cord (36), the device (10) being characterised by a base (12) for bearing on a flap in one direction during the packing operation, and by a mechanism (18, 22) adapted to draw a pull cord (34) connectable to the closing cord (36) in substantially an opposite direction to allow the flaps to be secured relative to the closing cord (36) by a pin.
摘要翻译：本发明提供了一种用于关闭降落伞包装件的装置，每个装置具有多个翼片和闭合绳索（36），该装置（10）的特征在于在包装期间沿一个方向承载在翼片上的底座（12）操作，以及适于沿大致相反的方向拉出可连接到关闭绳索（36）的拉绳（34）的机构（18,22），以允许翼片相对于关闭绳索（36）被固定销。

80. 发明授权

US06835848B1 One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments 有权
标题翻译：一锅合成3-环丙基氨基-2Ä2,4-二溴-3-（二氟甲氧基）苯甲酰基-2-丙烯酸烷基酯作为抗菌喹诺酮药物的有用中间体
公开(公告)号：US06835848B1
公开(公告)日：2004-12-28
申请号：US10221113
申请日：2003-01-06
申请人： Prosenjit Bose , Naresh Kumar , Taro Kiyoto
发明人： Prosenjit Bose , Naresh Kumar , Taro Kiyoto
IPC分类号： C07C22900
CPC分类号： C07C227/16 , C07C229/34 , C07C2601/02
摘要： The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates for the production of highly active antibacterial quinolone medicaments.
摘要翻译：本发明涉及用于制备3-环丙基氨基-2- [2,4-二溴-3-（二氟甲氧基）苯甲酰基] -2-丙烯酸烷基酯的新的和工业上有利的一锅法，其中R代表甲基或乙基，它们是生产高活性抗菌喹诺酮药物的有价值的中间体。

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