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71. 发明专利

ES2683046T3 Derivados de benzofuran-2-sulfonamida como moduladores del receptor de quimiocinas 未知
公开(公告)号：ES2683046T3
公开(公告)日：2018-09-24
申请号：ES13711995
申请日：2013-03-01
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD L , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA , GARST MICHAEL E
IPC分类号： A61K31/443 , C07D405/12 , A61P29/00 , C07D405/14
摘要： Un compuesto que tiene la siguiente fórmula, sus hidratos, solvatos, formas cristalinas, tautómeros o una sal farmacéuticamente aceptable de los mismos: **(Ver fórmula)**

72. 发明专利

ES2655090T3 Derivados de 1,2-bis-sulfonamida como moduladores de receptores de quimiocinas 未知
公开(公告)号：ES2655090T3
公开(公告)日：2018-02-16
申请号：ES15164047
申请日：2011-12-12
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA , GARST MICHAEL E
IPC分类号： C07D231/18 , C07C311/21 , C07C311/44 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： Un compuesto que tiene Fórmula I, sus enantiómeros, diastereoisómeros, hidratos, solvatos, formas cristalinas e isómeros individuales, tautómeros o una sal farmacéuticamente aceptable del mismo,**Fórmula** en donde R1 es H; R2 es H; R3 es C-R7; R4 es C-R8; R5 es 2-tienilo, fenilo, fenil-4-acetamida, 4-cloro-3-trifluorometilfenilo, -1-metil-1H-imidazol, 3-piridina, 2 aminofenilo, 1,3-dimetil-1H-pirazol, 1-metil-1H-pirazol, 1-metil-1H-imidazol, 4-(1H-pirazol-1-il)fenilo, 1,3-tiazol-4-il)fenilo, 4-(1,3- oxazol-5-il)fenilo, 2-(metilamino)benzoato, 1-metil-1H-indol, 2-oxoindolina, 1-metil-2,3-dioxoindolina, 1-metil-2- oxoindolina, 2-furano, 4-bifenilo, 3,5-difluorofenilo, 3,5-diclorofenilo, -3,5-dimetilisoxazol, 4-cloro-2,5-difluorofenilo, 4- (2-metilfenoxi)fenilo, 5-isoxazol-3-iltiofeno, 2,6-diclorofenilo, 4-(metilsulfonil)fenilo, 3,4-difluorofenilo, 4-cloro-3- metilfenilo, 2-oxo-2,3-dihidro-1,3-benzoxazol, ácido 4-benzoico, ácido 2-metoxibenzoico, 3-cianofenilo, 4-tercbutilfenilo, 1,3-benzotiazol, 1H-1,2,4-triazol, 2-cloro-1,3-benzotiazol, 2,4-dimetoxifenilo, 2,5-dicloro-3-tienilo, 3- metoxifenilo, 3-(metilsulfonil)fenilo, 3-cloro-2-metilfenilo, ácido 4fenilpropanoico, ácido 2-etoxibenzoico, 2- metilfenil}acetamida, 3,5-bis(trifluorometil)fenilo, 1H-pirazol, 4-(trifluorometoxi)fenilo, 4-(benciloxi)fenilo, ácido 2-cloro- 4-fluorobenzoico, tiofeno-2-carboxilato, ácido 4-fluorobenzoico, 2-cloro-quinolina, 2,3-dihidro-1H-indeno, 1-naftilo, 1,3-benzodioxol, 3,5-dicloro-2-hidroxifenilo, 2-benzofurano, quinolina, 4-metilbenzoato, 2,4-dimetil-1,3-tiazol, 4-metil- 1,3-tiazol-2-il}acetamida, 5-cloro-8-quinolina, 2,4,5-trifluorofenilo, 3,4-dimetoxifenilo, 3,5-dimetil-1H-pirazol, 1- (fenilsulfonil)-1H-pirrol, N-acetilindolina, 1,3,4-oxadiazol-2-il-fenilo, 3-(1-metil-1H-pirazol-3-il)fenilo, 2- tienilsulfonil)amino]fenil-4-metilo, 2-oxo-2H-cromeno, 6-fenil-3-piridina, 2-cloro-4-(trifluorometil)fenilo, 6-fenoxipiridina, 5-feniltiofeno, 2,5-dimetil-3-tienilo, 2-clorofenil-4-acetamida, (5-cloro-2,4-difluorofenilo, 4-(1-metil-1H-pirazol-3- il)fenilo, 5-metil-1-benzotiofeno, 2,5-dimetilfurano, 4-(pirrolidin-1-ilsulfonil)fenilo, metil-2-metil-3-furoato, 3-oxo-3,4- dihidro-2H-1,4-benzoxazina, ácido 2,4-dicloro-benzoico, 5-{[(dimetilamino)carbonil]amino}-2-etoxifenilo, 2- metoxifenil}acetamida, 2- imidazo[2,1-b][1,3]tiazol, 6-morfolin-4-ilpiridina, 3-[(6-metilpirazin-2-il)oxi]fenilo, 5-piridin-2- iltiofeno, 3-pirimidin-2-ilfenilo, 4-dihidro-2H-pirido[3,2-b][1,4]oxazina, 6-(dimetilamino)-2-naftilo, 2-(metilsulfonil)fenilo, 3-metil-8-quinolina, 5-isoxazol-5-iltiofeno, 5-(dimetilamino)-1-naftilo, 2-cloro-tienilo, metilo, etilo, bencilo, iso-butilo, 2,2-dimetilcromano, 2-oxo-2,3,4,5-tetrahidro-1H-1-benzacepina, 4-metil-3,4-dihidro-2H-1,4-benzoxazina, 4-acetil-3,4- dihidro-2H-1,4-benzoxazina, 4-(benciloxi)fenilo, 2,4-dimetil-1,3-tiazol, 3,5-dimetilisoxazol, 5-cloro-3-metil-1-benzotien- 2-ilo, ácido 2-cloro-4-fluorobenzoico, 4-metil-1,3-tiazol-2-il}acetamida, 1H-1,2,4-triazol, ácido fenilpropanoico, 5- clorotiofeno-2-carboxilato, 3-fenilacetamida, 2-oxoindolina, 2-oxo-2,3-dihidro-1,3-benzoxazol, 5-isoxazol-3-il-2-tienilo, 2-cloroquinolina, 1-(fenilsulfonil)-1H-pirrol, 2,5-dicloro-3-tienilo, 5-{[(dimetilamino)carbonil]amino}-2-etoxifenilo, 6- morfolin-4-ilpiridina, 4-metoxitiofeno, 3-furilo, 1-metil-1H-pirazol, 6-cloroimidazo[2,1-b][1,3]tiazol, 3-(5-metil-1,2,4-oxadiazol-3-il)fenilo, 3-pirimidin-2-ilfenilo, 1-acetil-indolina, isonicotinato, 3-(5-metil-1,3,4-oxadiazol-2- il)fenilo, 4-(3,5-dimetil-1H-pirazol-1-il)fenilo, 3,5-dimetil-1-fenil-1H-pirazol, 4-metil-3,4-dihidro-2H-1,4-benzoxazina, 3,4-dihidro-2H-1,5-benzodioxepina, 2,2-dimetilcromano, 4-metil-2-fenil-1,3-tiazol, 5-piridin-2-il-2-tienilo, 4-metil-3,4- dihidro-2H-pirido[3,2-b][1,4]oxazina, 3-oxo-3,4-dihidro-2H-1,4-benzoxazina, 5,6-dicloro-3-piridina, 2,3-dioxo-1,2,3,4- tetrahidroquinoxalina o 4-acetil-3,4-dihidro-2H-1,4-benzoxazina; R6 es 2-benzofurano, 2-tienilo, 5-cloro-2-tienilo, 4,5-dicloro-2-tienilo, 4-cloro-3-metilfenilo, o 4-cloro-3- trifluorometilfenilo; R15 es C-R16; R17 es N o C-R18; R7 es H, metilo o cloro; R8 es H o cloro; R16 es H, y R18 es H con la condición; a). R6 no es el mismo que R5; b). cuando R5 es un heterociclo sustituido entonces no es**Fórmula** c). cuando R6 es 2-tienilo entonces R7, R8, R16 y R18 no son todos hidrógenos al mismo tiempo; d). el compuesto no es de las siguientes estructuras:**Fórmula**

73. 发明专利

AU2011344146B2 Sulfur derivatives as chemokine receptor modulators 未知
公开(公告)号：AU2011344146B2
公开(公告)日：2017-03-16
申请号：AU2011344146
申请日：2011-12-09
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD L , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA , GARST MICHAEL E
IPC分类号： C07C311/21 , A61K31/18 , A61K31/343 , A61P17/00 , A61P27/02 , A61P29/00 , A61P31/00 , C07C311/00 , C07D213/34 , C07D213/62 , C07D233/64 , C07D307/18 , C07D307/82 , C07D333/34 , C07D407/12 , C07D417/12
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

74. 发明专利

BRPI0817397A2 Compostos indol contendo grupos arila ou heteroarila com atividade biológica do receptor de esfingosina-1-fosfato (sip) 未知
公开(公告)号：BRPI0817397A2
公开(公告)日：2015-04-07
申请号：BRPI0817397
申请日：2008-09-18
申请人： ALLERGAN INC
发明人： BEARD RICHARD L , YUAN HAIQING , DONELLO JOHN E
IPC分类号： C07D209/42 , A61K31/404 , C07D401/06 , C07D401/12 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/14 , C07D513/04

75. 发明专利

AU2012352572A1 Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators 未知
公开(公告)号：AU2012352572A1
公开(公告)日：2014-07-31
申请号：AU2012352572
申请日：2012-12-11
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD L , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA
IPC分类号： C07D275/04 , A61K31/425 , A61P27/02 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel benzisothiazol-3(1 H)-one-5-sulfonyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

76. 发明专利

HK1189891A1 作為趨化因子受體調節劑的硫衍生物未知
公开(公告)号：HK1189891A1
公开(公告)日：2014-06-20
申请号：HK14103078
申请日：2014-03-31
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD L , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA , GARST MICHAEL E
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101 , C07C20060101

77. 发明专利

HK1189890A1 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 12-- 未知
公开(公告)号：HK1189890A1
公开(公告)日：2014-06-20
申请号：HK14103077
申请日：2014-03-31
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD L , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA , GARST MICHAEL E
IPC分类号： C07D20060101 , A61K20060101 , C07C20060101
摘要： The present invention relates to novel bis-sulfonamide derivatives of Formula I, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

78. 发明专利

AU2008304657B2 Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity 未知
公开(公告)号：AU2008304657B2
公开(公告)日：2013-09-05
申请号：AU2008304657
申请日：2008-09-18
申请人： ALLERGAN INC
发明人： DONELLO JOHN E , YUAN HAIQING , BEARD RICHARD L
IPC分类号： C07D209/42 , A61K31/404 , C07D401/06 , C07D401/12 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as sphingosine-1 -phosphate agonists or antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of sphingosine-1 -phosphate receptors.

79. 发明专利

CA2642668C INDOLE-3-CARBOXYLIC ACID AMIDE AND ESTER COMPOUNDS BEARING PHENYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (SIP) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY 未知
公开(公告)号：CA2642668C
公开(公告)日：2013-01-08
申请号：CA2642668
申请日：2007-02-14
申请人： ALLERGAN INC
发明人： BEARD RICHARD L , DONELLO JOHN E , YUAN HAIQING , LIU XIAOXIA , DUONG TIEN , COLON DIANA F , HU YIHUI
IPC分类号： C07D209/42 , A61K31/404 , A61P27/00 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06
摘要： The invention provides compounds, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, A, X, Z, R1, o, R3, R2 and p are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing. Compounds may be represented by the structure: (see above formula)

80. 发明专利

CA2822040A1 PHOSPHOROUS DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 未知
公开(公告)号：CA2822040A1
公开(公告)日：2012-06-21
申请号：CA2822040
申请日：2011-12-09
申请人： ALLERGAN INC
发明人： YUAN HAIQING , BEARD RICHARD L , LIU XIAOXIA , DONELLO JOHN E , VISWANATH VEENA , GARST MICHAEL E
IPC分类号： C07F9/32 , A61K31/662 , C07F9/36
摘要： The present invention relates to novel phosphorous derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

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