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    • 71. 发明公开
    • 피부표면의 멜라닌 분포를 가시적으로 표현할 수 있는각질세포의 멜라닌을 정량하는 방법
    • 色氨酸的定量分析方法可以直观地表达在肌肤表面的梅毒素分布
    • KR1020070098073A
    • 2007-10-05
    • KR1020060029257
    • 2006-03-31
    • (주)아모레퍼시픽
    • 김은주남개원이해광김승훈문성준
    • G01N33/48G01N33/483
    • A quantitatively analyzing method of melanin in a corneocyte for visually expressing distribution of melanin in the skin surface is provided to express melanin amount visually and quantitatively by quantification of melanin spot area per corneocyte, so that a user confirm the efficacy of skin whitening cosmetics easily. A quantitatively analyzing method of melanin in a corneocyte for visually expressing distribution of melanin in the skin surface comprises the steps of: (a) collecting a horny layer from the skin surface; (b) dyeing melanin in the collected horny layer; and (c) observing the dyed horny layer sample with a microscope, picturing the image of dyed horny layer sample, and quantifying the melanin spot area per corneocyte, wherein the melanin amount is classified into 5 grades; and a first grade corresponds to 0-5% melanin distribution per corneocyte, a second grade corresponds to 5-10% melanin distribution per corneocyte, a third grade corresponds to 10-20% melanin distribution per corneocyte, a fourth grade corresponds to 20-40% melanin distribution per corneocyte, and a fifth grade corresponds to more than 40% melanin distribution per corneocyte.
    • 提供角质细胞中黑色素在视觉上表达黑色素在皮肤表面的分布的定量分析方法,以通过定量每个角质细胞的黑色素斑点面积来定量表达黑色素量,从而使用者容易地确认皮肤美白化妆品的功效。 用于视觉表达皮肤表面黑色素分布的角质细胞中黑色素的定量分析方法包括以下步骤:(a)从皮肤表面收集角质层; (b)在收集的角质层中染黑色素; 和(c)用显微镜观察染色的角质层样品,绘制染色角质层样品的图像,并定量每个角质细胞的黑色素斑点面积,其中黑色素量分为5个等级; 一级对应于每个角质细胞的0-5%黑色素分布,二级对应于每个角质细胞的5-10%黑色素分布,三级对应于每个角质细胞的10-20%黑色素分布,四级对应于20- 每个角质细胞的黑色素分布为40%,五年级对应于每个角质细胞超过40%的黑色素分布。
    • 72. 发明授权
    • 히드록시벤조산 아미드 화합물과 그 제조방법 및 이를함유하는 미백화장료 조성물
    • 히드록시벤조산아미드화합물과그제조방법및이를함유하는미백화장료조성물
    • KR100643514B1
    • 2006-11-23
    • KR1020050041060
    • 2005-05-17
    • (주)아모레퍼시픽
    • 백흥수이찬우노호식안수미김연준주희경이해광김덕희장이섭
    • C07C233/64A61K8/368
    • Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.
    • 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示,其中R 1和R 2是H或OH。 该方法包括以下步骤:将羟基苯甲酸溶解在溶剂中,逐滴加入催化剂和碱,并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱,氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解(参见反应方案1),其中R 3和R 4是H或乙酰氧基。
    • 79. 发明公开
    • 피부 특성 시각화 방법
    • 如何可视化皮肤特征
    • KR1020170062676A
    • 2017-06-08
    • KR1020150168162
    • 2015-11-30
    • (주)아모레퍼시픽
    • 김민아김은주김현정이해광
    • A61B5/00
    • A61B5/00G06F19/00
    • 본발명은피부특성시각화방법에관한것으로, 보다상세하게는 (a) 분석영역의피부특성에관한수치데이터를측정하고시각화프로그램에베이스이미지를입력하는단계; (b) 상기시각화프로그램에나타난베이스이미지상에수치데이터입력영역을설정하는단계; (c) 상기시각화프로그램에수치데이터를입력하고, 색채팔레트영역을설정하는단계; 및 (d) 상기시각화프로그램으로부터구축된시각화이미지를획득하는단계;를포함한다. 본발명의피부특성시각화방법에따르면, 복수개의수치데이터를하나의시각화이미지로통합구축할수 있고, 이를통해분석영역의피부특성분포및 변화를보다효과적으로확인할수 있다.
    • 本发明涉及一种方法,包括在皮肤特征的可视化的方法,并且更具体地涉及测量皮肤的(a)的分析区域,并进入基座图像是可视化程序的特性的数值数据; (b)在可视化程序中显示的基本图像上设置数字数据输入区域; (c)向可视化程序输入数字数据并设置调色板区域; (d)获得由可视化程序构建的可视化图像。 根据本发明的特征性的皮肤可视化方法,可以是多个数值的数据作为建筑物集成可视化的,人们可以通过更有效地验证在分析区域这皮肤属性分布和变化。
    • 80. 发明公开
    • 화장료의 지속성 평가 방법
    • 如何评估化妆品的一致性
    • KR1020170038222A
    • 2017-04-07
    • KR1020150137277
    • 2015-09-30
    • (주)아모레퍼시픽
    • 김혜림정유철이해광
    • G01N21/84G06T7/00
    • 복수의피험자들각각으로부터화장료가도포된피부의제1 이미지를획득하는단계, 상기제1 이미지들로부터피부의색상에대응되는제1 색상값들을측정하는단계, 미리결정된양의땀을분비한상기복수의피험자들각각으로부터상기화장료가도포된피부의제2 이미지를획득하는단계, 상기제2 이미지들로부터피부의색상에대응되는제2 색상값들을측정하는단계및 상기제1 색상값들및 상기제2 색상값들간의차이를분석하는단계를포함하는, 화장료의지속성평가방법.
    • 从第一图像测量对应于皮肤颜色的第一颜色值;从多个对象测量与预定量的汗水相对应的第一颜色量;从多个对象中的每一个获得施加有化妆品的皮肤的第一图像; 该方法包括以下步骤:从皮肤的每个受试者获得应用了化妆品的皮肤的第二图像;根据第二图像测量与皮肤的颜色相对应的第二颜色值; 并分析两个颜色值之间的差异。