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71. 发明申请

WO1985003357A1 IMPROVEMENTS RELATING TO GROWTH FACTORS 审中-公开
标题翻译：与增长因素相关的改进
公开(公告)号：WO1985003357A1
公开(公告)日：1985-08-01
申请号：PCT/GB1985000045
申请日：1985-01-30
申请人： ICRF PATENTS LTD. , YEDA RESEARCH & DEVELOPMENT CO. LTD. , GENENTECH INC. , WATERFIELD, Michael, D. , SCHLESSINGER, J. , ULLRICH, Axel
发明人： ICRF PATENTS LTD. , YEDA RESEARCH & DEVELOPMENT CO. LTD. , GENENTECH INC.
IPC分类号： G01N33/574
CPC分类号： G01N33/74 , A61K38/00 , A61K47/6849 , A61K49/00 , C07K14/71 , C07K16/2863 , C07K2317/34 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/5748 , H01L21/0276 , Y10S436/813 , Y10S436/815 , Y10S436/817
摘要： Neoplastic and other diseases can be diagnosed by assaying a human test sample e.g. body fluid, tissue or cultured tumour explant cells, for structurally altered or abnormally expressed growth factor receptors or for the nRNA transcripts of genes which encode them. For example, the assay can be for truncated EGF receptor having at least a portion of its mature amino terminus deleted. Antibodies, capable of binding a predetermined amino acid sequence within the EGF receptor, are also useful in diagnosis and therapy as are conjugates of an immunogenic polymer bound to a polypeptide fragment of EGF receptor. DNA and RNA encoding EGF receptor or fragments thereof are also decribed.
摘要翻译：可以通过测定人类测试样品来诊断肿瘤和其它疾病，例如，体液，组织或培养的肿瘤外植体细胞，用于结构改变或异常表达的生长因子受体或编码它们的基因的nRNA转录物。例如，该测定可以是具有其成熟氨基末端的至少一部分缺失的截短的EGF受体。能够结合EGF受体内的预定氨基酸序列的抗体也可用于诊断和治疗，与免疫原性聚合物与EGF受体的多肽片段结合的缀合物也是有用的。编码EGF受体或其片段的DNA和RNA也被描述。

72. 发明申请

WO2020249723A1 CYSTEINE-FREE INTEINS 审中-公开
公开(公告)号：WO2020249723A1
公开(公告)日：2020-12-17
申请号：PCT/EP2020/066291
申请日：2020-06-12
申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER , YEDA RESEARCH & DEVELOPMENT CO. LTD
发明人： MOOTZ, Henning D. , BHAGAWATI, Maniraj , TERHORST, Tobias , PIETROKOVSKI, Shmuel
IPC分类号： C07K14/005
摘要： The present invention relates to an isolated polypeptide or to a composition of isolated polypeptides comprising (a) at least one first intein amino acid sequence (a1) and at least one first extein amino acid sequence (a2); wherein the at least one first intein amino acid sequence is an N-terminal sequence of a split intein or fragment thereof; wherein the at least one first extein sequence is fused to the N-terminus of the at least one first intein sequence and has a length of at least 1; and (b) at least one second intein amino acid sequence (b1) and at least one second extein sequence (b2); wherein the at least one second intein sequence is a C-terminal sequence of a split intein or fragment thereof; wherein the at least one second extein sequence is fused to the C-terminus of the at least one second intein sequence and has a length of at least 1; wherein the catalytic motifs of the at least one first intein amino acid sequence and/or of the at least one second intein amino acid sequence are free of cysteine residues; wherein the first and second intein amino acid sequence specifically interact with each other. Additionally, the invention relates to at least one isolated nucleic acid molecule comprising at least one nucleotide sequence encoding an isolated polypeptide according to the invention or a homolog, variant or complement thereof. Finally, the invention pertains to a method for modifying amino acid sequences or to a use of said isolated polypeptide(s) or said at least one isolated nucleic acid molecule.

73. 发明申请

WO2005060350A2 DIASTEREOMERIC PEPTIDES USEFUL AS INHIBITORS OF MEMBRANE PROTEIN ASSEMBLY 审中-公开
标题翻译：可用作膜蛋白组装抑制剂的地那吡那多肽
公开(公告)号：WO2005060350A2
公开(公告)日：2005-07-07
申请号：PCT/IL2004/001157
申请日：2004-12-22
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD. , SHAI, Yechiel
发明人： SHAI, Yechiel
IPC分类号： A61K38/00 , C07K14/16 , C07K14/195
CPC分类号： C07K14/195 , A61K38/00 , C07K14/005 , C12N2740/16122
摘要： The present invention relates to membrane binding diastereomeric peptides comprising amino acid sequences corresponding to a fragment of a transmembrane proteins, wherein at least two amino acid residues of the diastereomeric peptides being in a D-isomer configuration. The diastereomeric peptides are useful in inhibiting fusion membrane protein events, including specifically viral replication and transmission.
摘要翻译：本发明涉及包含对应于跨膜蛋白片段的氨基酸序列的膜结合非对映异构肽，其中非对映异构肽的至少两个氨基酸残基为D-异构体构型。非对映异构肽可用于抑制融合膜蛋白质事件，包括特异性病毒复制和传播。

74. 发明申请

WO2005048914A3 DNA VACCINES ENCODING HSP60 PEPTIDE FRAGMENTS FOR TREATING AUTOIMMUNE DISEASES 审中-公开
公开(公告)号：WO2005048914A3
公开(公告)日：2005-06-02
申请号：PCT/IL2004/001080
申请日：2004-11-24
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD. , COHEN, Irun, R. , QUINTANA, Francisco
发明人： COHEN, Irun, R. , QUINTANA, Francisco
IPC分类号： C12N15/00
摘要： The present invention is related to recombinant constructs encoding active fragments of HSP60 which are effective in treating T cell-mediated inflammatory autoimmune diseases by DNA vaccines. The HSP60 fragments of the present invention are identified by their ability to react with T cells isolated from an animal vaccinated with DNA constructs encoding HSP70 to induce Th2/3 T-cell responses.

75. 发明申请

WO2004004453A2 A SLOW-RELEASE AGROCHEMICALS DISPENSER AND METHOD OF USE 审中-公开
标题翻译：一种缓释型农药分配器及其使用方法
公开(公告)号：WO2004004453A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/020966
申请日：2003-07-03
申请人： CENTRO INTERNACIONAL DE MEJORAMIENTO DE MAIZ Y TRIGO , YEDA RESEARCH & DEVELOPMENT CO. LTD. , SYMPORE GMBH , BURNET, Michael, William , KANAMPIU, Fred , GRESSEL, Jonathan
发明人： BURNET, Michael, William , KANAMPIU, Fred , GRESSEL, Jonathan
IPC分类号： A01N
CPC分类号： A01N43/50 , A01N25/10 , A01N25/26 , A01N43/54 , A01N2300/00
摘要： Acetolactate synthase inhibitors, such as imazapyr and pyrithiobac and mixtures thereof, prepared as slow-release formulations are useful for the preparation of seed dressing, seed priming, seed or particle-substrate coating herbicidal compositions for control of parasitic weeds such as Orobanche spp., Striga spp. and Alectra spp. The use of agrochemicals can be rendered more efficient when coated or bound as a slow release formulation. Particles used as the substrateto be coated may be plant seeds or particles made of a strong or weak ionic resin or a biodegradable carbohydrate natural polymer, a modified polymer, or artificially lignified cellulose. The herbicidal formulation may be covalently linked or adsorbed to the surface of the particle. The same slow release formulations are invaluable for preventing rapid herbicide leaching in agricultural as well as non-agricultural weed control situations.
摘要翻译：制备成缓释制剂的乙酰乳酸合酶抑制剂，例如灭草烟和吡硫菌素及其混合物可用于制备拌种，种子底漆，种子或颗粒 - 底物包衣除草组合物，用于防治寄生性杂草如Orobanche spp。，Striga spp。和Alectra 。当涂覆或结合为缓释制剂时，农用化学品的使用可以变得更有效。用作待包衣基质的颗粒可以是植物种子或由强或弱离子树脂或可生物降解的碳水化合物天然聚合物，改性聚合物或人造木质纤维素制成的颗粒。除草制剂可以共价连接或吸附到颗粒表面。相同的缓释制剂对于防止农业中的快速除草剂浸出以及非农业杂草控制情况是无价的。

76. 发明申请

WO2003072598A2 HSP70-DERIVED PEPTIDES AN USES THEREOF IN THE DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译： HSP70衍生肽及其在自身免疫性疾病诊断和治疗中的应用
公开(公告)号：WO2003072598A2
公开(公告)日：2003-09-04
申请号：PCT/IL2003/000143
申请日：2003-02-24
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , YEDA RESEARCH & DEVELOPMENT CO. LTD. , ABULAFIA-LAPID, Rivka , ATLAN, Henri , COHEN, Irun R.
发明人： ABULAFIA-LAPID, Rivka , ATLAN, Henri , COHEN, Irun R.
IPC分类号： C07K7/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4713 , C07K16/18
摘要： The invention relates to specific peptides derived from hsp70, and to pharmaceutical compositions comprising the same. The peptides and compositions of the invention are particularly suitable for the prevention or treatment of an autoimmune disease such as Type 1 Diabetes, Systemic Lupus Erithematosus, Multiple Sclerosis or Rheumatoid Arthritis. The invention further relates to a method for diagnosing the occurrence or incipience of an autoimmune disease in a patient by use of the peptides of the invention, by testing a blood or urine sample of a patient for the presence of antibodies or T-cells which are immunologically reactive to human hsp70.The invention also relates to a kit for the diagnosis of an autoimmune disease by testing for the presence of anti-hsp70 antibodies by aid of the peptides of the invention.
摘要翻译：本发明涉及源自hsp70的特定肽，并涉及包含其的药物组合物。本发明的肽和组合物特别适用于预防或治疗自身免疫性疾病，例如1型糖尿病，系统性红斑狼疮，多发性硬化症或类风湿性关节炎。本发明进一步涉及通过使用本发明的肽来诊断患者自身免疫性疾病的发生或发展的方法，所述方法通过测试患者的血液或尿液样品存在抗体或T-细胞本发明还涉及通过借助于本发明的肽测试抗-hsp70抗体的存在来诊断自身免疫性疾病的试剂盒。

77. 发明申请

WO2021144792A1 STRESS MANAGEMENT IN HUMAN SUBJECTS IN NEED THEREOF 审中-公开
公开(公告)号：WO2021144792A1
公开(公告)日：2021-07-22
申请号：PCT/IL2021/050038
申请日：2021-01-13
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD.
发明人： SOBEL, Noam , MISHOR, Eva , ENDEVELT-SHAPIRA, Yaara , KARAGACH, Shiri , MAMA, Yaniv , SHARON, Yigal
IPC分类号： A61K31/11 , A61K9/00 , A61P25/22
摘要： The present invention discloses uses of hexadecanal in managing stress.

78. 发明申请

WO2015086825A1 ATYPICAL INTEINS 审中-公开
标题翻译：特殊功能
公开(公告)号：WO2015086825A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/077578
申请日：2014-12-12
申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER , YEDA RESEARCH & DEVELOPMENT CO. LTD.
发明人： MOOTZ, Henning Dieter , THIEL, Ilka , VOLKMANN, Gerrit , PIETROKOVSKI, Shmuel , BACHMANN, Anne-Lena
IPC分类号： C12N9/22 , C12N15/10
CPC分类号： C12N15/62 , C07K7/06 , C07K14/00 , C07K14/005 , C07K14/245 , C07K2319/21 , C07K2319/92 , C12N9/22 , C12N15/102 , C12N2795/10122
摘要： The present invention relates to an isolated polypeptide comprising at least one intein or at least one intein fragment of said intein, wherein said intein is a naturally split intein with a N-terminal intein fragment split after 14-60 amino acids from the intein's N-terminal end and methods of using the same.
摘要翻译：本发明涉及包含所述内含肽的至少一个内含肽或至少一个内含肽片段的分离的多肽，其中所述内含肽是天然裂解的内含肽，其与在内含肽的N-末端的14-60个氨基酸之间分裂的N末端内蛋白片段，终端及其使用方法。

79. 发明申请

WO2007078821A3 METHOD AND APPARATUS FOR ACQUIRING HIGH RESOLUTION SPECTRAL DATA OR HIGH DEFINITION IMAGES IN INHOMOGENEOUS ENVIRONMENTS 审中-公开
公开(公告)号：WO2007078821A3
公开(公告)日：2007-07-12
申请号：PCT/US2006/047689
申请日：2006-12-14
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD. , FLEIT, Lois , FRYDMAN, Lucio , SHAPIRA, Boaz , TAL, Assaf
发明人： FRYDMAN, Lucio , SHAPIRA, Boaz , TAL, Assaf
IPC分类号： G01V3/00
摘要： A method and apparatus for treating a sample for acquiring high-definition magnetic resonance images, (MRI images) or high resolution nuclear magnetic resonance (NMR) spectra even in the presence of magnetic field distortions within one or multiple scans The spatial nature and temporal dependence of the field inhomogeneities are determined a pnori using any of several literature procedures A static or oscillating magnetic field gradient is applie d on the sample so as to endow spins at different positions within the sample with different resonance frequencies A phase- and amplitude-modulated radiofrequency (RF) pulse is applied in unison with the magnetic field gradient so as to endow spins a t different positions within the sample with a homogeneous excitation/inversion profile

80. 发明申请

WO2006077601A3 HIV-1 gp41 FUSION PEPTIDES FOR IMMUNOMODULATION 审中-公开
公开(公告)号：WO2006077601A3
公开(公告)日：2006-07-27
申请号：PCT/IL2006/000096
申请日：2006-01-24
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD. , SHAI, Yechiel , COHEN, Irun, R. , QUINTANA, Francisco, J. , GERBER, Doron
发明人： SHAI, Yechiel , COHEN, Irun, R. , QUINTANA, Francisco, J. , GERBER, Doron
IPC分类号： A61K38/00
摘要： The present invention provides pharmaceutical compositions and methods for prevention or treatment of autoimmune diseases and other T cell mediated inflammatory diseases and conditions, which comprise as an active ingredient an effective quantity of a peptide derived from HIV gp41 fusion peptide domain or fragments, analogs, homologs and derivatives thereof. The invention further provides novel peptides derived from HIV gp41 fusion peptide domain, useful in the treatment of T cell mediated pathologies.

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