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    • 72. 发明申请
    • NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA
    • 新生儿多发性肿瘤抗利什曼抗体肿瘤免疫反应在多发性甲状旁腺病患者亚组中的研究
    • WO2008057795A9
    • 2008-12-31
    • PCT/US2007082605
    • 2007-10-26
    • UNIV TEMPLEYANG XIAO-FENG
    • YANG XIAO-FENG
    • C12Q1/68
    • C07K16/30
    • The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3'untranslated region (3'UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and/or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy.
    • 本发明提供了新的抗原,MPD5,PV13和PV65,其属于无常规基因组结构的隐性抗原组,并且由位于肌营养素mRNA的3'非翻译区(3'UTR)中的隐蔽性开放阅读框编码。 抗原在PV患者亚群以及慢性粒细胞白血病和前列腺癌患者中引发IgG抗体应答。 MPD5,PV13和PV65的翻译由开放阅读框上游的新型内部核糖体进入位点(IRES)介导。 在患有骨髓增生性疾病的患者中引发针对MPD5,PV13和/或PV65抗原的抗肿瘤免疫应答是一种新颖的免疫疗法。
    • 74. 发明申请
    • NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA
    • 新型肿瘤抗原在多发性硬化症患者中的抗肿瘤免疫反应
    • WO2008057795A3
    • 2008-10-30
    • PCT/US2007082605
    • 2007-10-26
    • UNIV TEMPLEYANG XIAO-FENG
    • YANG XIAO-FENG
    • C12Q1/68
    • C07K16/30
    • The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3'untranslated region (3'UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and/or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy.
    • 本发明提供新型抗原,MPD5,PV13和PV65,属于没有常规基因组结构的隐性抗原组,由位于肌营养蛋白mRNA的3'非翻译区(3'UTR)的隐性开放阅读框编码。 抗原在PV患者的一个子集中以及患有慢性骨髓性白血病和前列腺癌的患者中引起IgG抗体应答。 MPD5,PV13和PV65的翻译由开放阅读框架上游的新型内部核糖体进入位点(IRES)介导。 在骨髓增生性疾病患者中引起针对MPD5,PV13和/或PV65抗原的抗肿瘤免疫应答是一种新型免疫治疗。
    • 77. 发明申请
    • METHOD AND DEVICE FOR DATA CAPTURE FOR PUSH OVER CELLULAR
    • 用于推送细胞的数据采集的方法和装置
    • WO2008077269A1
    • 2008-07-03
    • PCT/CN2006/003540
    • 2006-12-22
    • MOTOROLA, INC.DAI, Zhuo-MingZHU, Xiao-Feng
    • DAI, Zhuo-MingZHU, Xiao-Feng
    • H04Q7/28
    • H04M1/656G11B27/105H04L51/04H04L51/38H04L65/4061H04M1/72519H04W4/10H04W76/45
    • A system (100) and method (300) for data record and playback for push-over-cellular (PoC) is provided. The method can include receiving (302) a push-to-talk (PTT) key-up from a first mobile device during a group dispatch call, identifying (304) the first mobile device from the PTT key-up to produce a first contact identifier (361), recording (306) data during the PTT key-up until a PTT key-down is received to produce a PTT recorded segment (311), marking (308) the PTT recorded segment with the contact identifier, and storing (310) the first PTT recorded segment to memory. The method steps can be repeated for creating a marked PTT conversation (360). The marked PTT conversation can be played back (230) by contact identifier, or played back (240) by call session. During playback, a contact identifier for each PTT recorded segment can be visually or audibly presented.
    • 提供了一种用于推送蜂窝(PoC)的数据记录和重放的系统(100)和方法(300)。 该方法可以包括在群组调度呼叫期间从第一移动设备接收(302)即按即说(PTT)密钥,从PTT密钥识别(304)第一移动设备以产生第一联系人 标识符(361),在PTT加密期间记录(306)数据,直到接收到PTT关闭以产生PTT记录段(311),标记(308)具有联系人标识符的PTT记录段, 310)第一个PTT记录段到存储器。 可以重复方法步骤以创建标记的PTT对话(360)。 标记的PTT对话可以通过联系人标识来播放(230),或者通过呼叫会话播放(240)。 在播放期间,每个PTT记录片段的联系人标识符可以在视觉或听觉上呈现。
    • 78. 发明申请
    • METHOD AND APPARATUS FOR DATA INTEGRATION AND MANAGEMENT
    • 数据整合与管理的方法与装置
    • WO2007002686A3
    • 2007-10-04
    • PCT/US2006025017
    • 2006-06-26
    • SIPERIAN INCWONG STANLEYHOSKIN STEVEQIAN XIAO FENG
    • WONG STANLEYHOSKIN STEVEQIAN XIAO FENG
    • G06F17/00G06F17/30
    • G06F17/30557G06Q30/02Y10S707/99939Y10S707/99942Y10S707/99943Y10S707/99944Y10S707/99945
    • A system for maintaining master reference data for entities is discloased (100). The system includes multiple reference data sets at multiple different data storages. A reference data set for a particular entity uniquely identifies the particular entity. The system also includes a first master reference data set at first data storage (160) that is at least as reliable as a second reference data set at a second data storage (120). In some embodiments, the first data storage can be updated through real-time process or an offline process (e.g., a batch process). The first master reference data set includes at least one data record, and content metadata regarding the data record. In some embodiments, content metadata comprises lineage data that includes each preceding value that was contained in the data record. In some of these embodiments, lineage includes other factors that affected the present and previous values contained in the data record
    • 用于维护实体的主参考数据的系统被剥离(100)。 该系统在多个不同的数据存储器中包括多个参考数据集。 用于特定实体的参考数据集唯一地标识特定实体。 该系统还包括在第一数据存储(160)处的第一主参考数据集,其至少与在第二数据存储(120)处的第二参考数据集一样可靠。 在一些实施例中,可以通过实时过程或离线过程(例如,批处理)来更新第一数据存储。 第一主参考数据集包括至少一个数据记录和关于数据记录的内容元数据。 在一些实施例中,内容元数据包括包含数据记录中包含的每个先前值的谱系数据。 在这些实施例中的一些实施例中,谱系包括影响数据记录中包含的当前值和先前值的其他因素