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71. 发明授权

US09889169B2 Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor 有权
公开(公告)号：US09889169B2
公开(公告)日：2018-02-13
申请号：US14960608
申请日：2015-12-07
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM , RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
发明人： Antonio Marchini , Junwei Li , Lea Schroeder , Jean Rommelaere , Karsten Geletneky
IPC分类号： A61K35/768 , A61K31/495 , A61K45/06 , A61K31/5377 , A61K31/63 , A61K31/635
CPC分类号： A61K35/768 , A61K31/495 , A61K31/5377 , A61K31/63 , A61K31/635 , A61K45/06 , C12N2750/14332 , A61K2300/00
摘要： Described is a pharmaceutical composition comprising (a) a parvovirus and (b) an Bcl-2 inhibitor and the use of said composition for treatment of cancer, e.g., a solid tumor. Preferred inhibitors are the BH3 mimetics ABT-737 and ABT-199.

72. 发明申请

US20170167980A1 METHODS AND MEANS FOR MULTISPECTRAL IMAGING 审中-公开
公开(公告)号：US20170167980A1
公开(公告)日：2017-06-15
申请号：US15316455
申请日：2015-06-03
申请人： Universität Heidelberg
发明人： Nikolas DIMITRIADIS , Nikolaos DELIOLANIS
IPC分类号： G01N21/64 , G01N21/91 , G01J3/44 , A61B1/06 , A61B5/1455 , A61B5/00 , A61B1/04 , G01N21/80 , G01J3/10
CPC分类号： G01N21/6456 , A61B1/043 , A61B1/0638 , A61B3/14 , A61B5/0071 , A61B5/14551 , G01J3/10 , G01J3/32 , G01J3/4406 , G01J2003/102 , G01J2003/106 , G01N21/6428 , G01N21/80 , G01N21/91 , G01N2021/6417 , G01N2021/6439
摘要： Multispectral imaging of samples, in particular of biological tissues. A method for acquisition of fluorescence and reflectance images of an object including alternatingly illuminating the object with at least a first light having several spectral regions of high intensity, wherein the first light has at least one region of low intensity that is of longer wavelength to a region of high intensity, and at least a second light having at least one spectral region of high intensity, recording a first image of the object during illumination of the object with the first light and a second image of the object during illumination of the object with the second light using a common sensor array, wherein the light recorded by the sensor array is attenuated in at least one of the spectral regions in which the first light has high intensities.

73. 发明授权

US09566319B2 p16INK4a derived peptides for prophylaxis and therapy of HPV-associated tumors and other p16INK4a expressing tumors 有权
标题翻译： p16INK4a衍生肽用于预防和治疗HPV相关肿瘤和其他p16INK4a表达肿瘤
公开(公告)号：US09566319B2
公开(公告)日：2017-02-14
申请号：US14800586
申请日：2015-07-15
申请人： Ruprecht-Karls-Universität Heidelberg
发明人： Matthias Kloor , Miriam Reuschenbach , Magnus Von Knebel-Doeberitz
IPC分类号： C07K14/00 , A61K39/00 , C12N15/86
CPC分类号： A61K39/0011 , A61K2039/53 , C12N15/86
摘要： Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing IFN-γ secretion of T cells or inducing proliferation of T cells and the use of said fragments for immunizing an individual against HPV-associated or other p16INK4a expressing carcinomas, preferably advanced carcinomas.
摘要翻译：描述了能够增加T细胞的IFN-γ分泌或诱导T细胞增殖的细胞周期蛋白依赖性激酶抑制剂p16的特定片段，以及使用所述片段免疫个体以免疫HPV相关或其它p16INK4a表达癌，优选为高级癌。

74. 发明申请

US20160206699A1 USE OF INTERLEUKIN 10 MRNA TRANSFECTED MACROPHAGES IN ANTI-INFLAMMATORY THERAPIES 审中-公开
公开(公告)号：US20160206699A1
公开(公告)日：2016-07-21
申请号：US15071163
申请日：2016-03-15
申请人： Ruprecht-Karls-Universität Heidelberg , Universität Ulm
发明人： Ziya KAYA , Hugo KATUS , Oliver ZIMMERMANN , Wolfgang ROTTBAUER , Jan TORZEWSKI
IPC分类号： A61K38/20 , C12N5/0786 , A61K45/06
CPC分类号： C07K14/5428 , A61K35/15 , A61K38/2066 , A61K45/06 , C12N5/0645 , C12N2510/00
摘要： The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.

75. 发明申请

US20150344935A1 ANALYSIS OF DIRECT FACTOR Xa INHIBITORS 有权
标题翻译：直接因子Xa抑制剂的分析
公开(公告)号：US20150344935A1
公开(公告)日：2015-12-03
申请号：US14823450
申请日：2015-08-11
申请人： RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
发明人： Job Harenberg , Roland Krämer
IPC分类号： C12Q1/56
CPC分类号： G01N33/86 , C12Q1/56 , G01N33/58 , G01N2333/811 , G01N2333/96444 , G01N2458/30
摘要： The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
摘要翻译：本发明涉及一种用于检测除了柠檬酸盐血浆以外的样品中的至少一种直接因子Xa抑制剂的方法，其包括以下步骤：将含有因子Xa抑制剂的样品与含有因子Xa的组合物混合在允许因子Xa 从显色底物释放可检测物质。

76. 发明申请

US20150301203A1 NEUTRON DETECTOR UNIT AND NEUTRON DETECTOR ARRANGEMENT 有权
标题翻译：中子检测器单元和中性探测器安装
公开(公告)号：US20150301203A1
公开(公告)日：2015-10-22
申请号：US14392032
申请日：2013-09-13
申请人： FORSCHUNGSZENTRUM JÜLICH GMBH , CDT CASCADE DETECTOR TECHNOLOGIES GMBH , RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
发明人： Peter Lennert , Martin Klein , Christian J. Schmidt , Werner Schweika
IPC分类号： G01T3/00 , H01J47/12 , G01T3/08
CPC分类号： G01T3/008 , G01T3/08 , H01J47/1266 , H01J47/1294
摘要： The invention relates to a neutron detector unit for neutrons, in particular thermal and cold neutrons, comprising a detector housing (7, 17, 27), cathode elements and a plurality of anode elements (5, 15, 25), wherein in order to form a volume detector unit the anode elements (5, 15, 25) and the cathode elements enable a three-dimensional spatial resolution for conversion events, characterised by a converter gas in the detector housing (7, 17, 27). According to the invention, in a neutron detector arrangement which includes at least one neutron detector unit the neutron detector unit (3, 13, 23) or at least one of the neutron detector units (3, 13, 23) is oriented in such a way that at least some of the anode elements (5, 15, 25) of the at least one neutron detector unit (3, 13, 23) extend at least predominantly in a longitudinal orientation parallel or almost parallel to the direction of travel of the neutrons (4) to be detected.
摘要翻译：本发明涉及一种用于中子，特别是热和冷中子的中子检测器单元，其包括检测器壳体（7,17,27），阴极元件和多个阳极元件（5,15,25），其中为了形成体积检测器单元，阳极元件（5,15,25）和阴极元件能够实现用于转换事件的三维空间分辨率，其特征在于检测器壳体（7,17,27）中的转换器气体。根据本发明，在包括至少一个中子检测器单元的中子探测器装置中，中子探测器单元（3,13,23）或至少一个中子探测器单元（3,13,23）被定向在所述至少一个中子探测器单元（3,13,23）的阳极元件（5,15,25）中的至少一些至少主要在与所述至少一个中子探测器单元（3,13,23）的行进方向平行或几乎平行的纵向方向上延伸中子（4）被检测。

77. 发明授权

US11618773B2 NFAT binding polynucleotides 有权
公开(公告)号：US11618773B2
公开(公告)日：2023-04-04
申请号：US16962427
申请日：2019-01-14
申请人： Universität Heidelberg
发明人： Markus Hecker , Andreas Wagner , Andreas Jungmann , Oliver Müller , Anca Remes , Hugo Katus
IPC分类号： C07K14/47 , A61K31/713 , C07H21/00 , C12N15/113 , A61K38/00
摘要： The present invention relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence separated by a spacer sequence, to said polynucleotide for use in treating and/or preventing disease, and to viral particles, compositions, and uses related thereto. The present invention further relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence for use in treating and/or preventing an NFAT-mediated disease.

78. 发明授权

US11555063B2 Norovirus antibodies 有权
公开(公告)号：US11555063B2
公开(公告)日：2023-01-17
申请号：US16649345
申请日：2018-09-19
申请人： Universität Heidelberg , Deutsches Krebsforschungszentrum
发明人： Grant Hansman , Anna Koromyslova
IPC分类号： C07K16/10
摘要： The present invention relates to a binding polypeptide specifically binding to an epitope comprised in an amino acid sequence corresponding to amino acids 250 to 300 of the norovirus genotype II.10 capsid polypeptide, and to a polynucleotide encoding the same. The present invention further relates to a composition comprising the binding polypeptide according to the present invention and a carrier, and to the binding polypeptide or the composition comprising the same use in diagnosis and/or for use in medicine. Further more, the present invention relates to kits, devices, vaccines, methods, and uses related to the binding polypeptide of the present invention.

79. 发明申请

US20220370681A1 OSTEOTROPIC BONE REPLACEMENT 有权
公开(公告)号：US20220370681A1
公开(公告)日：2022-11-24
申请号：US17619952
申请日：2020-08-14
申请人： Andreas Haas , Universität Heidelberg
发明人： Andreas Haas , Christian Kasperk , Michael Burchard
IPC分类号： A61L27/12 , C04B35/447
摘要： The invention relates to a method for producing an osteotropic bone replacement material from a starting material which substantially has portlandite, calcium oxide, aragonite; calcite and/or apatite. The starting material is introduced into an autoclave with a strontium, fluorine and/or gallium source, wherein when using a starting material which substantially has portlandite, calcium oxide, aragonite; calcite a phosphate source is introduced. In addition, H2O is added into the autoclave as part of a solvent and the pH value in the autoclave is set to a range above 7. Afterwards, the closed and filled autoclave is heated for at least 1 hour and then cooled. The osteotropic bone replacement material thus developed is subsequently cleaned from residues of the phosphorus, strontium, fluorine and/or gallium source. Furthermore, the invention relates to an osteotropic bone replacement material which substantially consists of apatite and in which strontium ions are incorporated into the crystal lattice.

80. 发明申请

US20220354727A1 APPARATUS CAPABLE OF ACTUATING A DISTAL JOINT AND TRANSFERRING THE CONSTRAINING REACTIONS IN AN UNDERACTUATED SHOULDER EXOSKELETON 有权
公开(公告)号：US20220354727A1
公开(公告)日：2022-11-10
申请号：US17622400
申请日：2020-06-25
申请人： Scuola Superiore di Studi Universitari e di Perfezionamanto Sant'Anna , Universität Heidelberg
发明人： Lorenzo MASIA , Antonio FRISOLI , Luca TISENI , Domenico CHIARADIA , Michele XILOYANNIS , Massimiliano SOLAZZI
IPC分类号： A61H1/02
摘要： An underactuated mechanism has a first rotoidal joint connected to a human torso and rotating about a first joint rotation axis, a hyper-redundant connection mechanism connected to the first rotoidal joint, and a second rotoidal joint rotating about a second joint rotation axis, coplanar with the first joint rotation axis. The second rotoidal joint is remotely actuated by a driven pulley and Bowden cables or by a direct drive actuation system with co-located motor, and is fixed to the hyper-redundant connection mechanism on one side and to a human arm on the other side. The hyper-redundant connection mechanism has at least three members. Two members of the at least three members are rigidly fixed to one of the rotoidal joints, respectively. All members are connected together by rotation joints with axes parallel to one another and arranged to connect one member to a successive member to form a rotation constraint.

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