专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

WO1996017924A2 NOVEL HEDGEHOG-DERIVED POLYPEPTIDES 审中-公开
标题翻译：新型的HEDGEHOG衍生多肽
公开(公告)号：WO1996017924A2
公开(公告)日：1996-06-13
申请号：PCT/US1995015463
申请日：1995-12-04
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF WASHINGTON
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF WASHINGTON , BEACHY, Philip, A. , MOON, Randall, T. , PORTER, Jeffrey, A.
IPC分类号： C12N00/00
CPC分类号： G01N33/5058 , A01K67/0339 , A01K2217/05 , A01K2227/40 , A01K2227/50 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/92 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G CF site recognized by the autoproteolytic domain in the native protein. Also provided are methods of use of the N and C fragments.
摘要翻译：本发明涉及一种所谓的“刺猬”的片段称为“N”和“C”两个新的多肽或分别N-末端片段和C-末端这些多肽切割后在特定的所获得在自然蛋白水平上其自溶蛋白结构域识别的G CF位点。本发明还涉及使用N和C片段的方法。

72. 发明申请

WO1996017261A1 METHOD OF MINIMIZING DEAD-PERIODS IN ORDER TO OBTAIN HARDWARE OPTIMIZED GRADIENT WAVEFORMS 审中-公开
标题翻译：最终将死亡期限最小化的方法用于获取硬件优化梯度波形
公开(公告)号：WO1996017261A1
公开(公告)日：1996-06-06
申请号：PCT/US1995011167
申请日：1995-09-01
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , ATALAR, Ergin , McVEIGH, Elliot, Ross
IPC分类号： G01V03/00
CPC分类号： G01R33/4833 , G01R33/561
摘要： A method of minimizing dead-periods in magnetic resonance imaging pulse sequences employs a specimen disposed within magnetic field (6), a source of RF signals (2), a receiver (8) for receiving signals from the specimen responsive to RF pulses and emitting respective output signals. A computer (12) is provided for receiving the output signals from the receiver and establishing image information which may be displayed (16). For the dead-period, the minimum and maximum phase encoding step, the scan plane gradient pulse for the slice, phase encoding and readout directions are determined and the moments contained within the dead-period waveform is determined. The values are transformed into gradient amplifier coordinates and the minimum dead-period based on the dead-period waveform is determined. The dead-period is employed in establishing a hardware optimized waveform which may be trapezoidal. The trapezoidal waveform is preferably established by for each phase encoding step determining the starting and ending gradient levels and the moments contained within the dead-period waveform using the calculated minimum dead-period.
摘要翻译：一种使磁共振成像脉冲序列中的死区最小化的方法使用设置在磁场（6）内的样本，RF信号源（2），用于从RF脉冲接收来自样本的信号的接收器（8）各自的输出信号。提供一种计算机（12），用于接收来自接收机的输出信号并建立可显示的图像信息（16）。在死区期间，确定最小和最大相位编码步骤，用于切片，相位编码和读出方向的扫描平面梯度脉冲，并且确定包含在死区波形内的力矩。将值转换为梯度放大器坐标，并确定基于死区波形的最小死区。死区是用来建立可能是梯形的硬件优化波形。优选地，对于每个相位编码步骤，使用所计算的最小死区确定起始和结束梯度水平以及包含在死区波形内的力矩来建立梯形波形。

73. 发明申请

WO1995003789A1 CONTROLLED RELEASE OF PHARMACEUTICALLY ACTIVE SUBSTANCES FROM COACERVATE MICROCAPSULES 审中-公开
标题翻译：控制释放来自相关微生物的药物活性物质
公开(公告)号：WO1995003789A1
公开(公告)日：1995-02-09
申请号：PCT/US1994006828
申请日：1994-06-16
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , LEONG, Kam, W. , AZHARI, Rosa, V.
IPC分类号： A61K09/16
CPC分类号： A61K9/1652 , A61K9/1658 , Y10T428/2984
摘要： A controlled-release pharmaceutical composition comprising a pharmaceutically active substance, encapsulated in the form of microspheres by a coating of a crosslinked coacervate of gelatin and chondroitin sulfate, as well as processes for the preparation thereof.
摘要翻译：包含通过明胶和硫酸软骨素的交联凝聚层的涂层以微球形式包封的药物活性物质的控释药物组合物，以及其制备方法。

74. 发明申请

WO2004009029A2 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING INFECTION 审中-公开
标题翻译：用于治疗和预防感染的组合物和方法
公开(公告)号：WO2004009029A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022877
申请日：2003-07-22
申请人： LA JOLLA BIOSCIENCES , THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , SCHEELE, George, A. , HILDRETH, James, E.
发明人： SCHEELE, George, A. , HILDRETH, James, E.
IPC分类号： A61K
CPC分类号： A61K31/724 , A61K39/00
摘要： This invention relates to cholesterol-sequestering agents and methods of using cholesterol-sequestering agents to treat or prevent infection. The compositions of the invention can be used in vitro or in vivo to decrease the load of a microorganism in a biological sample. Methods of generating an immune response against a microorganism are also included.
摘要翻译：本发明涉及胆固醇螯合剂和使用胆固醇螯合剂治疗或预防感染的方法。本发明的组合物可以在体外或体内使用以降低生物样品中微生物的负荷。还包括产生针对微生物的免疫应答的方法。

75. 发明申请

WO2003084390A3 DEVICE, SYSTEMS AND METHODS FOR HEATING OF A VESSEL IN COMBINATION WITH MR/NMR IMAGING 审中-公开
公开(公告)号：WO2003084390A3
公开(公告)日：2003-10-16
申请号：PCT/US2003/009784
申请日：2003-04-01
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： YANG, Xiaoming , ATALAR, Ergin , YEUNG, Christopher
IPC分类号： A61F7/00
摘要： Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging (500) of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device (100) proximal a target site of an internal vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.

76. 发明申请

WO2003076593A3 GENOMIC SCREEN FOR EPIGENETICALLY SILENCED GENES ASSOCIATED WITH CANCER 审中-公开
公开(公告)号：WO2003076593A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/007244
申请日：2003-03-07
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , BAYLIN, Stephen, B. , HERMAN, James, G. , SUZUKI, Hiromu , SIDRANSKY, David
发明人： BAYLIN, Stephen, B. , HERMAN, James, G. , SUZUKI, Hiromu , SIDRANSKY, David
IPC分类号： C12Q1/68
摘要： A method of identifying epigenetically silenced genes, e.g., methylation silenced genes,in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided.

77. 发明申请

WO2003058283A1 MRI TUNABLE ANTENNA AND SYSTEM 审中-公开
标题翻译： MRI可控天线和系统
公开(公告)号：WO2003058283A1
公开(公告)日：2003-07-17
申请号：PCT/US2002/041901
申请日：2002-12-31
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , BOTTOMLEY, Paul, A.
发明人： BOTTOMLEY, Paul, A.
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/3415
摘要： A strip array antenna including a number of conductors (14) that are connected to ground or virtual ground though at least one reactive component (150). The apparent electrical length of conductors (140) is tuned so that it equals an integer multiple of a quarter wavelength at the operating frequency.
摘要翻译：一种带状阵列天线，包括通过至少一个无功部件（150）连接到接地或虚拟接地的多个导体（14）。调整导体（140）的视在电气长度，使其等于工作频率下四分之一波长的整数倍。

78. 发明申请

WO2002083705A1 SOCS-1 GENE METHYLATION IN CANCER 审中-公开
标题翻译：癌症SOCS-1基因甲基化
公开(公告)号：WO2002083705A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011790
申请日：2002-04-15
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , NATIONAL CANCER INSTITUTE , HERMAN, James, G. , YOSHIKAWA, Hirohide , HARRIS, Curtis, C.
发明人： HERMAN, James, G. , YOSHIKAWA, Hirohide , HARRIS, Curtis, C.
IPC分类号： C07H21/04
CPC分类号： C12Q1/6886 , A61K31/706 , A61K38/00 , A61K48/00 , C07K14/4703 , C12Q1/683 , C12Q1/6858 , C12Q2600/154 , C12Q2600/158 , C12Q2521/331 , C12Q2531/113 , C12Q2523/125
摘要： Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods.
摘要翻译：提供了用于鉴定表现出与细胞因子信号传导抑制剂（SOCS）/细胞因子诱导型SH2蛋白（CIS）家族成员（SOCS / CIS）基因如SOCS-1基因的甲基化沉默转录相关的不受调节生长的细胞的方法。此外，提供了治疗癌症患者的方法，其中患者中的癌细胞表现出SOCS / CIS基因如SOCS-1基因的甲基化沉默转录，以及用于实施这些方法的试剂。

79. 发明申请

WO2002004113A3 METHODS OF PATTERNING PROTEIN AND CELL ADHESIVITY 审中-公开
公开(公告)号：WO2002004113A3
公开(公告)日：2002-01-17
申请号：PCT/US2001/041344
申请日：2001-07-11
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： CHEN, Christopher, S. , TIEN, Joe, Y. , TAN, John , BHATIA, Sangeeta, N. , JASTROMB, William, E.
IPC分类号： G01N33/543
摘要： The invention relates to a method of adhering a biomolecule to a substrate, comprising treating the substrate with a surfactant compound and a biomolecule. More particularly, the invention relates to a method of adhering a biomolecule to a substrate wherein the surfactant compound is not covalently linked to the substrate. The invention also relates to a device for adhering a biomolecule in a predetermined position comprising: a substrate having thereon a plurality of cytophilic regions that can adhere a biomolecule on the substrate by cytophobic regions to which the biomolecules do not adhere contiguous with the cytophilic regions, wherein the cytophobic regions comprise one or more surfactant compounds.

80. 发明申请

WO1996035708A1 FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR-1 (FHF-1) AND METHODS OF USE 审中-公开
标题翻译：纤维生长因子同源因子-1（FHF-1）及其使用方法
公开(公告)号：WO1996035708A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006664
申请日：1996-05-10
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , NATHANS, Jeremy , SMALLWOOD, Philip, M. , MACKE, Jennifer, P.
IPC分类号： C07K01/00
CPC分类号： C07K16/22 , A61K38/00 , C07K14/50 , C12Q1/6886 , C12Q2600/158
摘要： A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
摘要翻译：公开了一种新型蛋白质，成纤维细胞生长因子同源因子-1（FHF-1），编码FHF-1的多核苷酸序列和推定的氨基酸序列。还公开了使用FHF-1多肽和特异性结合FHF-1的多核苷酸序列和抗体的诊断和治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式