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71. 发明申请

WO2021173977A1 ACTIVATION OF LYTIC GENES IN CANCER CELLS 审中-公开
公开(公告)号：WO2021173977A1
公开(公告)日：2021-09-02
申请号：PCT/US2021/019880
申请日：2021-02-26
申请人： THE JACKSON LABORATORY , THE CHINESE UNIVERSITY OF HONG KONG
发明人： CHENG, Albert , LO, Kwok Wai , HAU, Pok Man Tom , WU, Man
IPC分类号： C07K19/00 , C12N5/10 , C12N9/22 , C12N15/09 , C12N15/11 , C12N15/113 , C07K14/005 , C12N15/1133 , C12N2310/20 , C12N2710/16222 , C12N2830/003 , C12N7/00
摘要： The present disclosure provides methods of inducing EBV early lytic cycle genes with high specificity. These methods slow or stop cancer cell growth in vitro and in vivo.

72. 发明申请

WO2021072049A1 HIGH FREQUENCY TARGETED ANIMAL TRANSGENESIS 审中-公开
公开(公告)号：WO2021072049A1
公开(公告)日：2021-04-15
申请号：PCT/US2020/054745
申请日：2020-10-08
申请人： THE JACKSON LABORATORY
发明人： WILES, Michael, V. , LOW, Benjamin, E.
IPC分类号： A01K67/027
摘要： The present disclosure provides methods and compositions for high frequency mouse transgenesis using, for example, a Bxbl landing pad.

73. 发明申请

WO2021016131A1 CONVOLUTIONAL NEURAL NETWORKS FOR CLASSIFICATION OF CANCER HISTOLOGICAL IMAGES 审中-公开
公开(公告)号：WO2021016131A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/042675
申请日：2020-07-17
申请人： THE JACKSON LABORATORY , CHUANG, Jeffrey Hsu-Min , NOORBAKHSH, Javad , FOROUGHI POUR, Ali , ZARRINGHALAM, Kourosh , FARAHMAND, Saman , SOLTANIEH-HA, Mohammad
发明人： CHUANG, Jeffrey Hsu-Min , NOORBAKHSH, Javad , FOROUGHI POUR, Ali , ZARRINGHALAM, Kourosh , FARAHMAND, Saman , SOLTANIEH-HA, Mohammad
IPC分类号： G06N3/08
摘要： Techniques for classifying, using a deep learning model, histopathological whole slide images (WSIs) as comprising images of cancerous or non-cancerous tissue and/or as comprising images of cancerous tissue having a genetic mutation or not having a genetic mutation are described herein. The techniques include at least one processor configured to instantiate a container-based processing architecture to train and/or use the deep learning model to process and classify at least one WSI. In some embodiments, a treatment may be selected and administered based on a classification result obtained from the deep learning model.

74. 发明申请

WO2019032622A1 LONG-TERM AND CONTINUOUS ANIMAL BEHAVIORAL MONITORING 审中-公开
公开(公告)号：WO2019032622A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045676
申请日：2018-08-07
申请人： THE JACKSON LABORATORY
发明人： KUMAR, Vivek , GEUTHER, Brian, Q. , PETERSON, Jim , CHURCHILL, Gary
IPC分类号： A01K1/03 , A01K11/00 , A01K29/00 , G06K9/46 , G06K9/66
摘要： Systems and methods for continuous monitoring of the behavior of animals, such as small rodents, are provided. Monitoring can include video, audio, and other sensor modalities. In one embodiment, the system can include cameras, arena design, environmental sensors, and ultrasonic sensors. The system uniquely provides a continuous long-term monitoring system suitable for mouse behavioral study. Further provided is a neural network based tracker configured for use with video data acquired by the monitoring system. 3 different neural network architectures have been tested to determine their performance on genetically diverse mice under varying environmental conditions. It has been observed that that an encoder- decoder segmentation neural network achieves high accuracy and speed with minimal training data. This general purpose neural network tracker can be easily extended to other experimental paradigms and even to other animals through transfer learning, thus forming a robust, generalizable solution for bio-behavioral research.

75. 发明申请

WO2018232396A1 SINGLE NUCLEUS AND SINGLE MOLECULE CHROMATIN INTERACTION ASSAYS 审中-公开
公开(公告)号：WO2018232396A1
公开(公告)日：2018-12-20
申请号：PCT/US2018/038071
申请日：2018-06-18
申请人： THE JACKSON LABORATORY
发明人： RUAN, Yijun , ZHENG, Meizhen , PIECUCH, EMaly
IPC分类号： C12Q1/6804
摘要： The present invention provides a method for next generation chromatin interaction assays based on the single molecule protein-detection and DNA-sequencing platform at the single molecule and single nucleus single molecule levels. The present invention has the advantages of single molecule resolution in single nuclei and the elimination of proximity ligation and PCR amplification steps. The present invention provides revolutionary biological insights in the organization of the 3D genome and its modulation.

76. 发明申请

WO2018106594A2 FAT DROPLETS IN RETINA AND OPTIC NERVE AS A DIAGNOSTIC MARKER FOR NEURODEGENERATION AND GLAUCOMA IN HUMANS 审中-公开
公开(公告)号：WO2018106594A2
公开(公告)日：2018-06-14
申请号：PCT/US2017/064504
申请日：2017-12-04
申请人： THE JACKSON LABORATORY
发明人： JOHN, Simon, W., M. , WILLIAMS, Peter, Alexander
IPC分类号： A61B3/12

77. 发明申请

WO2018081561A1 GENETICALLY MODIFIED MOUSE MODEL FOR HUMAN HEPATOCYTE XENOTRANSPLANTATION 审中-公开
标题翻译：遗传修饰的小鼠肝细胞异种移植模型
公开(公告)号：WO2018081561A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/058758
申请日：2017-10-27
申请人： THE JACKSON LABORATORY
发明人： SHULTZ, Leonard, D.
IPC分类号： C07K14/81 , C12N5/071 , C12N15/113 , C12N15/86
摘要： One or more embodiments of the present invention include an immunodeficient mouse genetically modified to include a gene encoding a PiZ variant (Glu342Lys) of human α-1 antitrypsin (AAT), wherein the mouse expresses the PiZ variant of human α-1 antitrypsin (Z-AAT), and has a reduced number of mouse hepatocytes compared to an immunodeficient mouse of the same type which does not express Z-AAT. The immunodeficient mouse genetically modified to include a gene encoding a PiZ variant of human AAT can be a genetically modified NSG, NRG or NOG mouse. The immunodeficient mouse may further include xenogeneic hepatocytes, such as human hepatocytes. Putative treatments of human liver disease can be assessed in mice provided according to aspects of the present disclosure.
摘要翻译：本发明的一个或多个实施方案包括经遗传修饰以包含编码人α-1抗胰蛋白酶（AAT）的PiZ变体（Glu342Lys）的基因的免疫缺陷小鼠，其中所述小鼠表达PiZ变体的人α-1抗胰蛋白酶（Z-AAT），并且与不表达Z-AAT的相同类型的免疫缺陷小鼠相比，小鼠肝细胞的数量减少。遗传修饰以包括编码人AAT的PiZ变体的基因的免疫缺陷小鼠可以是遗传修饰的NSG，NRG或NOG小鼠。免疫缺陷小鼠还可以包含异种肝细胞，如人肝细胞。可以根据本公开内容的方面提供的小鼠中评估人肝脏疾病的推定治疗。

78. 发明申请

WO2018053037A1 TARGETED ENHANCED DNA DEMETHYLATION 审中-公开
标题翻译：靶向强化DNA二甲基化
公开(公告)号：WO2018053037A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051411
申请日：2017-09-13
申请人： THE JACKSON LABORATORY
发明人： CHENG, Albert , TAGHBALOUT, Aziz , JILLETTE, Nathaniel
IPC分类号： A61K38/00 , A61K38/46 , C07K14/315 , C12N5/00 , C12N9/22 , C12N15/09
摘要： Provided herein are, inter alia , compositions and methods for the delivery of enhanced demethylation activity to target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
摘要翻译：本文提供了用于将增强的去甲基化活性递送至哺乳动物细胞中的靶DNA序列的组合物和方法。该组合物和方法可用于靶向基因的活性调节，或创建基因调控网络。

79. 发明申请

WO2018031920A1 METHODS AND COMPOSITIONS RELATING TO IMPROVED HUMAN RED BLOOD CELL SURVIVAL IN GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMALS 审中-公开
标题翻译：有关在遗传修饰的免疫非人动物中改善的人红细胞存活的方法和组合物
公开(公告)号：WO2018031920A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/046566
申请日：2017-08-11
申请人： THE JACKSON LABORATORY
发明人： SHULTZ, Leonard D. , WILES, Michael V.
IPC分类号： A01K67/02 , A01K67/027 , A61K49/00 , C12N15/63
摘要： A genetically modified immunodeficient non-human animal whose genome includes a genetic modification that renders the non-human animal deficient in macrophages and/or macrophage anti-human red blood cell activity so as to prolong the survival of human red blood cells when administered into said non-human animal is provided according to aspects of the present invention. Methods of assaying effects of putative therapeutic agents in such a genetically modified immunodeficient non-human animal are provided by the present invention.
摘要翻译：遗传修饰的非免疫缺陷的非人动物，其基因组包括使非人动物缺乏巨噬细胞和/或巨噬细胞抗人红细胞活性的遗传修饰，从而延长根据本发明的方面提供了当施用到所述非人动物中时人红细胞。本发明提供了测定推定的治疗剂在这种遗传修饰的免疫缺陷非人动物中的作用的方法。

80. 发明申请

WO2017070647A1 NICOTINAMIDE FOR USE IN THE TREATMENT AND PREVENTION OF OCULAR NEURODEGENERATIVE DISORDER (E.G. GLAUCOMA) 审中-公开
标题翻译： NICOTINAMIDE用于治疗和预防眼部神经退行性疾病（E.G. GLAUCOMA）
公开(公告)号：WO2017070647A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058388
申请日：2016-10-24
申请人： THE JACKSON LABORATORY
发明人： JOHN, Simon, W.M. , WILLIAMS, Peter, Alexander
IPC分类号： A61K31/455 , A61K31/465 , A61K31/19 , A61K48/00 , C12N15/86 , A61P27/02 , A61P27/06 , A61K45/06
CPC分类号： A61K31/455 , A61K31/19 , A61K31/4745 , A61K31/706 , A61K38/00 , A61K48/005 , C12N2750/14143 , C12Y207/07001 , A61K2300/00
摘要： The invention relates to the use of a pharmaceutical composition containing nicotinamide (NAM) and/or pyruvate as a neuroprotective medicament or gene therapy in the treatment of neurodegenerative disorders, in particular axon degeneration of neuronal tissue in ocular-related neurodegeneration diseases including glaucoma.
摘要翻译：本发明涉及含有烟酰胺（NAM）和/或丙酮酸盐的药物组合物作为神经保护药物或基因治疗用于治疗神经变性疾病，特别是神经元组织在眼内的轴突变性的用途相关的神经退行性疾病，包括青光眼。

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