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71. 发明专利

DE69931038D1 未知
公开(公告)号：DE69931038D1
公开(公告)日：2006-06-01
申请号：DE69931038
申请日：1999-02-26
申请人： SEIKAGAKU KOGYO CO LTD
发明人： USUKI SEIGOU , KARIYA YUTAKA
IPC分类号： C08B37/00 , A61K31/726 , C08B37/10
摘要： The invention provides novel glycosaminoglycan derivatives having a repeating unit structure of two saccharides of hexosamine and hexuronic acid as a backbone structure, in which the bonds between 2- and 3-positions carbon atoms of hexuronic acid as its constituting monosaccharide are partially cleaved and a part or all of the 2-position hydroxyl groups of uncleaved hexuronic acid are not substituted with a sulfate group, which has low anticoagulation activity and excellent neurite outgrowth promotion accelerating activity and sialidase inhibition activity; a process for producing the glycosaminoglycan derivatives, comprising a cleavage treatment of the bond between the 2- and 3-position carbon atoms of hexuronic acid having no sulfate group at the 2-position of glycosaminoglycan, and a selective desulfation treatment of the 2-position sulfate group of hexuronic acid; and a pharmaceutical composition comprising the glycosaminoglycan derivative as an active ingredient.

72. 发明专利

DE69929669D1 未知
公开(公告)号：DE69929669D1
公开(公告)日：2006-04-13
申请号：DE69929669
申请日：1999-11-12
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HOSODA AKIHIKO , KOBAYASHI NOBUO , TANABE NAOKO , KOJI TSUNEO , SHIBATA MASAHIRO , SEKINE AKIHIRO , DOZEN MASAHARU
IPC分类号： C07C211/00 , C07D295/20 , A61K31/325 , A61K31/36 , A61K31/495 , A61K31/535 , A61P19/00 , A61P19/02 , C07C271/24 , C07C275/26 , C07C311/20 , C07C311/29 , C07C311/46 , C07C317/44 , C07C323/60 , C07D213/71 , C07D213/75 , C07D223/12 , C07D231/40 , C07D243/08 , C07D277/48 , C07D277/68 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/14 , C07D307/20 , C07D307/33 , C07D307/52 , C07D309/20 , C07D317/28 , C07D317/46 , C07D317/58 , C07D317/66 , C07D317/68 , C07D317/72 , C07D319/06
摘要： Alcohol derivatives represented by the general formula (IV); wherein: R 1 represents a substituted C 1 -C 12 alkyl group; a substituted C 2 -C 6 alkenyl group; a substituted amino group; a substituted C 1 -C 6 alkoxy group; a substituted C 1 -C 6 alkylthio group; a substituted carbamoyl group; a substituted sulfonamide group; or a substituted amide group; the ring A represents a saturated cyclic alkyl group with 5 to 7 carbon atoms; R 2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R 3 represents a hydrogen atom, a group represented by the general formula R 4 O- ; or a group represented by the general formula R 5 (R 6 )N-wherein R 4 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R 5 and R 6 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group, The cyclic carboxylic acid derivatives of formula (IV) are useful for the synthesis of cyclic amide derivatives useful as cathepsin K inhibitors.

73. 发明专利

DE69829605T2 未知
公开(公告)号：DE69829605T2
公开(公告)日：2006-02-09
申请号：DE69829605
申请日：1998-04-30
申请人： SEIKAGAKU KOGYO CO LTD
发明人： ISHIKAWA SHIN-ICHI , HIGUCHI MINE
IPC分类号： A61K9/00 , A61K38/51 , A61K47/10 , A61K47/26 , A61K47/34 , A61P3/00
摘要： This invention provides pharmaceutical compositions containing chondroitinase wherein a decrease in enzyme activity is very little even after long-term storage, and the pharmaceutical compositions are characterized in that they contain chondroitinase and a pharmaceutical carrier, and that an amount of reducing impurities per 1 g of said pharmaceutical carrier is 0.4 mL or less as a titer by a titration method with 0.01 N of ammonium ceric nitrate.

74. 发明专利

DE69534619D1 未知
公开(公告)号：DE69534619D1
公开(公告)日：2005-12-22
申请号：DE69534619
申请日：1995-02-17
申请人： SEIKAGAKU KOGYO CO LTD
发明人： MIYAUTI SATOSI , HORIE KATUYUKI
IPC分类号： G01N33/564 , G01N33/68
摘要： A method for assay of normal aggrecan wherein normal aggrecan capable of binding hyaluronan is separated from proteoglycan incapable of binding hyaluronan so that only normal aggrecan can be detected, and a measurement kit used for the assay. Normal aggrecan thus separated is detected with a means for detection of proteoglycan. The specimen is preferably synovial fluid from the joint to be examined. A method for evaluation of information on a joint wherein information on the amount of normal aggrecan and the amount of total proteoglycan in the specimen is detected with said method and said measurement kit for assay of normal aggrecan, such information is compared with the previously obtained information on the amount of said substances in synovial fluid from a normal joint, and the information is evaluated to be the one derived from a normal joint or a pathological joint based on the absence or presence of significant difference. Presence of significant difference is considered to indicate a disease selected among a group of diseases consisting of osteoarthritis, rheumatoid arthritis, traumatic arthritis, and gout. This invention is usable for biochemical diagnosis of joint diseases in the field of orthopedics. Determination of the concentration of normal aggrecan and the percentage of normal aggrecan in total proteoglycan is useful for differentiation between a normal joint and a pathological joint, for understanding of the pathological conditions, such as the type of the joint disease and estimation of the prognosis, and also for evaluation of the effect of therapies.

75. 发明专利

DE69825653T2 未知
公开(公告)号：DE69825653T2
公开(公告)日：2005-08-25
申请号：DE69825653
申请日：1998-04-03
申请人： SEIKAGAKU KOGYO CO LTD
发明人： MIYAURA SHUICHI , TAKESHITA SAWAKO , ISHIMARU TAKESHI
IPC分类号： G01N33/53 , G01N33/68 , G01N33/543 , G01N33/544

76. 发明专利

CA2538090A1 POLYSACCHARIDE PSEUDO-SPONGE 未知
公开(公告)号：CA2538090A1
公开(公告)日：2005-03-24
申请号：CA2538090
申请日：2004-09-10
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SATO TOMOYA
IPC分类号： C08B37/08 , A61K9/16 , A61K47/36 , A61L31/00 , C08B11/12 , C08B37/00 , C08B37/04
摘要： A novel photocrosslinked polysaccharide which has low swelling properties an d high in vivo decomposability while retaining some degree of strength. It is a polysaccharide pseudo-sponge which is obtained by the crosslinking reaction of a photoreactive polysaccharide produced by introducing a photoreactive group into a polysaccharide and which has the low swelling properties and low dyeability with blue dextran shown under the following (I) and (II). (I) Whe n a test piece (thickness, 1 mm; length, 10 mm; width, 10 mm) having a solvent content of 96 wt.% is prepared, immersed in water for injection at room temperature for 1 hour, and then examined, the test piece has a degree of swelling as represented by the following equation of 125% or lower. [Numeric al formula 1] degree of swelling = {(S2-S1)/S1} .times. 100 (S1 represents the area before immersion and S2 represents the area after immersion, each area being calculated from the length and width dimensions of the test piece.) (I I) When a test piece (thickness, 1 mm; length, 20 mm; width, 10 mm) having a solvent content of 96 wt.% is prepared, immersed in a 0.5 g/mL aqueous solution of blue dextran having a weight-average molecular weight of 2,000,000, rinsed with water, and then hydrolyzed to prepare an aqueous solution having a concentration of 0.67 wt.% in terms of polysaccharide concentration, this aqueous solution has an absorbance of 0.15 or lower as measured at a wavelength of 620 nm.

77. 发明专利

CA2526022A1 SULFATE GROUP TRANSFERASE INHIBITOR 未知
公开(公告)号：CA2526022A1
公开(公告)日：2004-11-25
申请号：CA2526022
申请日：2004-05-19
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HABUCHI HIROKO , KIMATA KOJI
IPC分类号： A61K31/7028 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07H15/04 , C12N9/99
摘要： A hexuronic acid derivative characterized by being represented by the following formula (1) or a salt thereof is used as an active ingredient of heparin/heparan sulfate sulfate group transferase inhibitor. (1) wherein eac h of R1, R2 and R3 independently is SO3- or H provided that at least one there of is SO3- and that these may be substituted or unsubstituted; X is OR4, SR4, N(R4)2 or C(R4)3 in which each of R4~s independently is H, alkyl, alkenyl, alkynyl, acyl, aryl or aralkyl; one of R5 and R6 is COOH while the other is H; and the wavy line is .alpha.-glycoside bond or .beta.-glycoside bond.

78. 发明专利

AU2004224510A1 Remedy for nerve damage 未知
公开(公告)号：AU2004224510A1
公开(公告)日：2004-10-07
申请号：AU2004224510
申请日：2004-03-25
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KATO TADAHIKO , ASARI AKIRA
IPC分类号： A61K31/70 , A61K31/726 , A61K31/728 , A61P25/00 , C07H5/06 , C07H7/033 , C08B37/08

79. 发明专利

DE69531958T2 未知
公开(公告)号：DE69531958T2
公开(公告)日：2004-07-29
申请号：DE69531958
申请日：1995-08-31
申请人： SEIKAGAKU KOGYO CO LTD
发明人： TAMURA HIROSHI , TANAKA SHIGENORI
IPC分类号： C07K14/435 , C07K16/18 , G01N33/579
摘要： A (1->3)- beta -D-glucan-binding protein that can be obtained by subjecting limulus hemocyte extract to affinity chromatography and gel filtration and has a molecular weight of about 580 kDa (according to gel filtration under nonreductive conditions) or about 170 kDa (according to SDS-PAGE under reductive conditions) or a variant thereof; and antibody that recognizes selectively the protein and the variant; a method of detecting (1->3)- beta -D-glucan contained in a specimen by using the protein and the antibody; and a method of removing (1->3)-D-glucan contained in a sample by using a carrier containing the protein bound thereto. The protein and the antibody can thus be used for detecting an endotoxin, (1->3)- beta -D-glucan, contained in a specimen or sample and removing (1->3)- beta -D-glucan therefrom.

80. 发明专利

AT270677T 未知
公开(公告)号：AT270677T
公开(公告)日：2004-07-15
申请号：AT99933225
申请日：1999-08-02
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KARIYA YUTAKA , TAKANO RYO , KAMEI KAEKO , HARA SABURO , ONAYA JUNICHI , HORI YUSUKE
IPC分类号： C08B37/00 , C08B37/10 , A61K31/727
摘要： There is provided a glycosaminoglycan having a backbone structure comprising a repetitive disaccharide bearing a uronic acid residue and a glucosamine residue, and having sulfate groups, wherein substantially no sulfate group bound to the hydroxyl group at the 6-position of the glucosamine residue in the backbone structure is detected as determined by a chemical disaccharide analysis method in which the glycosaminoglycan is decomposed with nitrous acid, reacted with para-nitrophenylhydrazine and analyzed by high performance liquid chromatography, and the molar % of a uronic acid residue having a sulfate group at the 2-position is not less than 45% relative to total uronic acid residues, which is calculated from a disaccharide composition obtained by an enzymatic disaccharide analysis method in which the glycosaminoglycan is digested with glycosaminoglycan-degrading enzymes and analyzed by high performance liquid chromatography. The glycosaminoglycan can be used as an active ingredient of phamaceuticals.

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