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71. 发明公开

EP1320356A2 PREPARATION OF VITAMIN EMULSIONS AND CONCENTRATES THEREOF 有权
标题翻译：维生素乳液和浓缩其制造
公开(公告)号：EP1320356A2
公开(公告)日：2003-06-25
申请号：EP01967545.3
申请日：2001-09-20
申请人： Nycomed Pharma AS
发明人： SCHLYTER, Jimmy Hirschsprung , PIENE, Jan Yngvar
IPC分类号： A61K9/107 , A61K9/00 , A23L1/302 , A23L1/22 , A61K31/5513 , A61P3/02 , A61K31/55 , A61K31/10 , A61K31/58
CPC分类号： A61K9/0095 , A23L27/80 , A23L33/15 , A23V2002/00 , A61K9/107 , A61K47/14 , A23V2250/642 , A23V2250/054 , A23V2250/5024 , A23V2250/505 , A23V2250/1944 , A23V2250/70 , A23V2250/1842 , A23V2250/61 , A23V2250/606 , A23V2250/156 , A23V2250/712 , A23V2250/702 , A23V2250/71 , A23V2250/714 , A23V2250/704 , A23V2250/708 , A23V2250/211 , A23V2250/1614 , A23V2250/1592 , A23V2250/1642 , A23V2250/16 , A23V2250/1598 , A23V2250/507 , A23V2250/506 , A23V2250/032
摘要： The invention provides a process for the preparation of a liquid emulsion composition having a continuous aqueous phase containing a gelling agent and a thickener and optionally a physiologically tolerable amount of at least one water soluble vitamin and/or non-vitamin drug, and a discontinuous oil phase, optionally comprising at least one lipophilic vitamin and/or non-vitamin lipophilic drug and optionally an edible triglyceride, said emulsion composition further containing at least one emulsifying agent, said process comprising: forming an aqueous composition comprising an aqueous solution of a gelling agent and a thickener and optionally at least one water soluble vitamin and/or non-vitamin drug; forming a water-immiscible liquid composition comprising at least one emulsifying agent and optionally at least one lipophilic vitamin and/or non-vitamin drug; mixing said water-immiscible composition with at least part of said aqueous composition whereby to form an oil-in-vater emulsion; and if required mixing further components with said emulsion whereby to form said liquid emulsion composition.

72. 发明公开

EP2436378A1 Film-coated and/or granulated calcium-containing compounds and use thereof in pharmaceutical compositions 有权转让
标题翻译：薄膜包衣和/或制粒的含钙化合物和它们的药物组合物中
公开(公告)号：EP2436378A1
公开(公告)日：2012-04-04
申请号：EP11191733.2
申请日：2006-12-07
申请人： Nycomed Pharma AS
发明人： Piene, Jan Yngvar
IPC分类号： A61K9/16 , A61K9/20 , A61K47/26 , A61K33/06 , A23L1/09 , A23L1/304 , A23L1/303
CPC分类号： A61K33/10 , A23L29/37 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K9/0056 , A61K9/0095 , A61K9/1623 , A61K9/1635 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K33/06 , Y10T428/31844 , Y10T428/31971 , A23V2250/1578 , A23V2200/224 , A23V2250/6422 , A23V2250/264 , A23V2200/254 , A23V2250/64 , A23V2250/24
摘要： A method for the preparation of an at least partly film-coated calcium-containing compound, wherein the calcium-containing compound is in the form of particles and/or crystals, the method comprising applying a coating composition comprising
i) one or more water-soluble substances selected from the group consisting of polyols and carbohydrates and
ii) one or more polymeric substances selected from the group consisting of povidones and copovidone
to the calcium-containing compound,
and the water-soluble substance and the polymeric substance is dispersed or dissolved in a solvent.

73. 发明公开

EP1547626A3 Carrier with solid fibrinogen and solid thrombin 审中-公开
标题翻译：运营商与固体纤维蛋白原和凝血酶
公开(公告)号：EP1547626A3
公开(公告)日：2009-07-29
申请号：EP05075501.6
申请日：2002-01-25
申请人： Nycomed Pharma AS
发明人： Stimmeder, Dagmar
IPC分类号： A61L24/10 , A61L15/32 , A61L24/08
CPC分类号： A61L15/32 , A61F13/36 , A61F2013/00472 , A61L15/225 , A61L15/325 , A61L15/425 , A61L24/08 , A61L24/106 , A61L31/041 , A61L31/044 , A61L31/046 , A61L2400/04 , C08H1/06 , C08L89/06 , C08L89/00
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin.
The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, ε-aminocaproic acid or α2-antiplasmin,

74. 发明公开

EP1861073A2 PROCESS FOR THE PRODUCTION OF CALCIUM COMPOSITIONS IN A CONTINUOUS FLUID BED 有权转让
标题翻译：用于生产连续流动床的钙化合物
公开(公告)号：EP1861073A2
公开(公告)日：2007-12-05
申请号：EP06710498.4
申请日：2006-03-06
申请人： Nycomed Pharma AS , Nycomed Danmark ApS
发明人： PIENE, Jan, Yngvar , LUNDE, Kjell, Tomas
IPC分类号： A61K9/16 , A61K9/20 , A61K47/26 , A61K33/10 , A61K31/593
CPC分类号： A61K33/10 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K31/593
摘要： The present invention discloses a process for producing a particulate material comprising a calcium-containing compound, the process comprises granulating and/or coating a powder mixture, which comprises the calcium-containing compound together with one or more pharmaceutically acceptable excipients in a continuous fluid bed apparatus.

75. 发明公开

EP1755578A2 CHEWABLE, SUCKABLE AND SWALLOWABLE TABLET CONTAINING A CALCIUM-CONTAINING COMPOUND AS AN ACTIVE SUBSTANCE 有权转让
标题翻译： KAUBARE，LUTSCHBARE UND VERSCHLUCKBARE TABLETTE MIT EINER CALCIUMHALTIGEN VERBINDUNG ALS WIRKSTOFF
公开(公告)号：EP1755578A2
公开(公告)日：2007-02-28
申请号：EP05744221.2
申请日：2005-05-24
申请人： Nycomed Pharma AS
发明人： OLSEN, Peder, Mohr , CHRISTENSEN, Karin, Löwenstein , SØRENSEN, Dina, Wulff
IPC分类号： A61K31/19 , A61K31/593 , A61K9/00 , A61J3/06 , A61J7/00
CPC分类号： A61K9/2866 , A61K9/0056 , A61K9/0095
摘要： The present invention relates to a nutriceutical and/or pharmaceutical composition for oral use containing a calcium-containing compound. The composition is in the form of tablets that are designed so that they have an acceptable taste and mouthfeel, whereby the tablets are chewable or suckable, and at the same time the tablets fulfil the requirements with respect to technical properties in order to ensure that the tablets can be dispensed by means of a dose-dispensing machine. In a preferred embodiment, the tablet comprises calcium carbonate and sorbitol with a mean particle size of 38 or 110 microns. In another embodiment, the tablets comprise calcium carbonate and Vitamin D as active ingredients.
摘要翻译：本发明涉及含有钙的化合物的口服营养药物和/或药物组合物。组合物是片剂的形式，其设计使得它们具有可接受的味道和口感，由此片剂是可咀嚼或可吸收的，并且同时片剂满足技术性能的要求，以确保片剂可以通过剂量分配机器分配。在优选的实施方案中，片剂包含平均粒度为38或110微米的碳酸钙和山梨糖醇。在另一个实施方案中，片剂包含碳酸钙和维生素D作为活性成分。

76. 发明公开

EP1743629A1 Process for preparing oral calcium compositions 审中-公开
标题翻译： Verhfahren zur Herstellung von oralen Calcium Zusammensetzungen
公开(公告)号：EP1743629A1
公开(公告)日：2007-01-17
申请号：EP06021395.6
申请日：1999-11-05
申请人： Nycomed Pharma AS
发明人： Piene, Jan Yngvar , Schmidt, Dina Dogger
IPC分类号： A61K9/16
CPC分类号： A61K9/0007 , A61K9/0056 , A61K9/0095 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2077 , Y10S514/819
摘要： The invention provides a process for the preparation of an orally administrable calcium composition, said process comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range 3 to 40µm, having a crystalline structure and having a surface area of 0.1 to 1.2 m 2 /g; (ii) mixing said calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and drying the resulting mixture to produce a first granulate; (iii) optionally mixing said first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing said first or second granulate to form tablets.
摘要翻译：本发明提供了一种制备可口服给药的钙组合物的方法，所述方法包括以下步骤：（i）获得平均粒度在3至40μm范围内的生理学上可耐受的颗粒状钙化合物，具有结晶结构并具有表面积为0.1〜1.2m 2 / g; （ii）将所述钙化合物与水溶性稀释剂和水溶性粘合剂的水溶液混合在流化床造粒装置中并干燥所得混合物以产生第一颗粒; （iii）任选地将所述第一颗粒与一种或多种其它组分混合以产生第二颗粒; 和（iv）任选地压缩所述第一或第二颗粒以形成片剂。

77. 发明授权

EP1343542B1 CARRIER WITH SOLID FIBRINOGEN AND SOLID THROMBIN 有权
标题翻译：对于固定纤维蛋白原和凝血酶CARRIER
公开(公告)号：EP1343542B1
公开(公告)日：2005-03-23
申请号：EP02724554.7
申请日：2002-01-25
申请人： Nycomed Pharma AS
发明人： STIMMEDER, Dagmar
IPC分类号： A61L24/10
CPC分类号： A61L15/32 , A61F13/36 , A61F2013/00472 , A61L15/225 , A61L15/325 , A61L15/425 , A61L24/08 , A61L24/106 , A61L31/041 , A61L31/044 , A61L31/046 , A61L2400/04 , C08H1/06 , C08L89/06 , C08L89/00

78. 发明公开

EP1343542A2 CARRIER WITH SOLID FIBRINOGEN AND SOLID THROMBIN 有权
标题翻译： TRÄGERMIT FESTEM FIBRINOGEN UND THROMBIN
公开(公告)号：EP1343542A2
公开(公告)日：2003-09-17
申请号：EP02724554.7
申请日：2002-01-25
申请人： Nycomed Pharma AS
发明人： STIMMEDER, Dagmar
IPC分类号： A61L24/10
CPC分类号： A61L15/32 , A61F13/36 , A61F2013/00472 , A61L15/225 , A61L15/325 , A61L15/425 , A61L24/08 , A61L24/106 , A61L31/041 , A61L31/044 , A61L31/046 , A61L2400/04 , C08H1/06 , C08L89/06 , C08L89/00
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm3, chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified form a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, ε-aminocaproic acid or α2-antiplasmin.
摘要翻译：本发明涉及用于组织胶粘，组织密封和止血的固体组合物，其基本上由a）具有以下物理性质中的至少一种的载体：弹性模量在5-100N / cm的范围内，密度 1-10毫克/立方厘米，室直径大于0.75毫米，小于4毫米，和/或室直径平均值低于3mm，均匀分布和固定在载体上，b）固体纤维蛋白原，和c）固体凝血酶。载体是可生物降解的聚合物，例如多透明质酸，多羟基酸，乳酸，葡萄糖酸，羟基丁酸，纤维素，明胶或胶原，例如胶原海绵，例如胶原蛋白。基本上由I型胶原纤维组成的胶原海绵。纤维蛋白原和凝血酶优选为人，从天然来源或转基因或重组人纤维蛋白原和/或凝血酶纯化。在优选的实施方案中，组合物不包含任何抗纤维蛋白溶解剂，例如抑肽酶，μ-氨基己酸或±2-抗血浆素，

79. 发明公开

EP0701446A4 HEMOREGULATORY PEPTIDES 失效
标题翻译：海洛因依赖肽
公开(公告)号：EP0701446A4
公开(公告)日：1997-04-23
申请号：EP94919232
申请日：1994-05-24
申请人： SMITHKLINE BEECHAM CORP , NYCOMED PHARMA AS
发明人： BHATNAGAR PRADIP KUMAR , HEERDING DIRK , FISCHER PETER MARTIN
IPC分类号： A61K38/00 , A61P7/00 , A61P31/04 , A61P31/12 , A61P33/02 , C07K5/02 , C07K5/078 , C07K5/097 , C07C5/02
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06139

80. 发明公开

EP0703787A1 CELL GROWTH REGULATORS 失效
标题翻译：细胞生长调节剂
公开(公告)号：EP0703787A1
公开(公告)日：1996-04-03
申请号：EP94916343.0
申请日：1994-06-01
申请人： NYCOMED PHARMA AS
发明人： BOYUM, Arne
IPC分类号： A61K31 , A61K38 , A61P7 , A61P35 , A61P43 , C12N9
CPC分类号： C12N9/78 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K45/06 , C12Y305/04005 , A61K2300/00
摘要： The invention relates to cytidine deaminase and its enhancers for use in inhibiting cell proliferation, especially haemopoiesis and to the use of cytidine deaminase inhibitors to stimulate cell proliferation, especially in leukopenic conditions and to mobilize stem cells to the blood.
摘要翻译：本发明涉及用于抑制细胞增殖，特别是造血作用的胞苷脱氨酶及其增强剂，以及使用胞苷脱氨酶抑制剂刺激细胞增殖，特别是在白细胞减少症状中以及将干细胞动员至血液中。

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