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71. 发明公开

EP3266872A4 NOVEL ANTI-PAD4 ANTIBODY 有权
公开(公告)号：EP3266872A4
公开(公告)日：2018-01-17
申请号：EP16761721
申请日：2016-03-07
申请人： PUBLIC UNIV CORPORATION YOKOHAMA CITY UNIV , PUBLIC UNIV CORPORATION NAGOYA CITY UNIV , PHARMA FOODS INT CO LTD
发明人： SATO MAMORU , YAMADA MICHIYUKI , KANAZAWA SATOSHI , TOYOURA MASAYOSHI , SHOYA YUJI , SAITO KENJI , YAMAZAKI CHIHIRO
IPC分类号： C07K16/40 , A61K39/00 , A61K39/395 , A61P19/02 , C12N9/99 , C12N15/09 , C12P21/08
CPC分类号： A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N9/99 , C12N15/09 , A61K2300/00
摘要： Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0 × 10 -9 or less. Optionally, the anti-PAD4 antibody and a TNF± inhibitor are used in combination.

72. 发明公开

EP2871630A4 WAKEFULNESS-MAINTENANCE APPARATUS 审中-公开
标题翻译： VORRICHTUNG ZURWACHHEITSÜBERWACHUNG
公开(公告)号：EP2871630A4
公开(公告)日：2015-06-17
申请号：EP13817264
申请日：2013-07-08
申请人： TS TECH CO LTD , PUBLIC UNIV CORP NAGOYA CITY UNIV
发明人： SUGIYAMA SHINJI , NAKANO TOYOKAZU , YOKOYAMA KIYOKO , TAKAHASHI ISSEY
IPC分类号： G08G1/16 , A61B5/00 , A61B5/0245 , A61B5/0456 , A61B5/18 , A61M21/00 , B60K28/00 , B60N2/00 , B60N2/90
CPC分类号： B60N2/002 , A61B5/0051 , A61B5/0245 , A61B5/0456 , A61B5/18 , A61B5/6891 , A61B5/6893 , A61B5/742 , A61M21/00 , A61M2021/0022 , A61M2021/005 , A61M2021/0061 , A61M2021/0083 , A61M2230/06 , A61M2230/10 , A61M2230/205 , A61M2230/63 , B60K28/00 , B60N2/44 , B60N2002/4485
摘要： Provided is a wakefulness-maintenance apparatus capable of applying a stimulus, which is not perceived to be unpleasant to most seated persons, to a seated person, and effectively maintaining the wakefulness of the seated person. After a control device provided to the wakefulness-maintenance apparatus stimulates the seated person using a first stimulus at a timing close to a human heartbeat, if an index showing the wakefulness of the seated person departs within a predetermined time from a standard indicating that the wakefulness has been maintained, the control device drives a stimulus device to stimulate the seated person using a second stimulus having a timing that differs from the first stimulus.
摘要翻译：提供了一种唤醒维护装置，其能够对被安置的人施加不被大多数坐着的人感觉到不愉快的刺激，并且有效地保持就座者的觉醒。在提供给觉醒维护装置的控制装置在靠近人心跳的时刻，使用第一刺激刺激就座的人，如果表示所述就座者的觉醒的指标在预定时间内从表示觉醒的标准已经维持，控制装置驱动刺激装置以使用具有不同于第一刺激的定时的第二刺激来刺激就座的人。

73. 发明公开

EP2589664A4 MATERIAL FOR SCREENING FOR COMPOUND CAPABLE OF ACTING ON ION CHANNEL, AND USE THEREOF 有权
标题翻译：材料筛选CONNECTION影响AT A离子通道及其用途
公开(公告)号：EP2589664A4
公开(公告)日：2014-03-05
申请号：EP11800922
申请日：2011-06-29
申请人： PUBLIC UNIV CORP NAGOYA CITY UNIV , CHANNELOSEARCH TECHNOLOGY
发明人： IMAIZUMI YUJI , FUJII MASATO , OHYA SUSUMU , YAMAMURA HISAO
IPC分类号： C12Q1/02 , C12M1/34 , C12N15/09 , G01N33/68
CPC分类号： C12Q1/025 , C07K14/705 , G01N33/6872 , G01N2500/10 , G01N2510/00

74. 发明公开

EP3061396A4 ALERTNESS DEVICE, SEAT, AND METHOD FOR DETERMINING ALERTNESS 有权
标题翻译： WACHSAMKEITSVORRICHTUNG，SITZ UND VERFAHREN ZUR BESTIMMUNG VON WACHSAMKEIT
公开(公告)号：EP3061396A4
公开(公告)日：2016-11-09
申请号：EP14855514
申请日：2014-10-20
申请人： TS TECH CO LTD , PUBLIC UNIV CORP NAGOYA CITY UNIV
发明人： SUGIYAMA SHINJI , ITO TAKAYOSHI , YOKOYAMA KIYOKO , TAKAHASHI ISSEY
IPC分类号： A61B5/18 , A61B5/00 , A61B5/024 , A61B5/0245 , A61B5/0452 , A61B5/0456 , A61B5/16
CPC分类号： A61B5/18 , A61B5/02405 , A61B5/0245 , A61B5/02455 , A61B5/0456 , A61B5/168 , A61B5/6893 , A61B5/7264 , A61B2503/22 , B60W40/08
摘要： Provided are an alertness device configured such that a load is low in the processing for alertness determination and that the accuracy in alertness determination is high, a seat including the alertness device, and an alertness determination method. The alertness device includes a heart rate sensor configured to obtain an electrocardiographic signal of a person, a calculation unit configured to calculate the electrocardiographic signal obtained from the heart rate sensor, a waveform generation unit configured to generate an RRI waveform from an electrocardiographic waveform of the electrocardiographic signal, and a determination unit configured to determine the alertness of the person based on the electrocardiographic signal. The calculation unit replicates the same number of RRI waveforms as that of anchors, each anchor being a point where a certain RRI is shorter than the next preceding RRI. Then, the calculation unit moves the time axes of the replicated RRI waveforms such that the anchors of the replicated RRI waveforms are in phase with each other, and calculates a PRSA signal defined as an RRI average for each time axis. The determination unit determines the alertness of the person based on the RRIs and the PRSA signals.
摘要翻译：提供了一种警报装置，其被配置为使得在用于警觉性确定的处理中的负载低，并且警觉性确定的准确度高，包括警觉性装置的座椅和警觉性确定方法。所述警觉性装置包括被配置为获得人的心电图信号的心率传感器，被配置为计算从所述心率传感器获得的所述心电图信号的计算单元，被配置为从所述心律图像的心电图波形生成RRI波形的波形生成单元心电图信号，以及确定单元，被配置为基于心电图信号确定人的警觉性。计算单元复制与锚点相同数量的RRI波形，每个锚点是某个RRI短于下一个RRI的点。然后，计算单元移动复制的RRI波形的时间轴，使得复制的RRI波形的锚点彼此同相，并计算定义为每个时间轴的RRI平均值的PRSA信号。确定单元基于RRI和PRSA信号确定人的警觉性。

75. 发明专利

CA2980507A1 USE OF 4-(4-FLUORO-2-METHOXYPHENYL)-N-{3-[(S-METHYLSULFONIMIDOYL)METHYL]PHENYL}-1,3,5-TRIAZIN-2-AMINE FOR TREATING LYMPHOMAS 未知
公开(公告)号：CA2980507A1
公开(公告)日：2016-09-29
申请号：CA2980507
申请日：2016-03-21
申请人： PUBLIC UNIV CORP NAGOYA CITY UNIV , BAYER PHARMA AG
发明人： SCHOLZ ARNE , ISHIDA TAKASHI
IPC分类号： A61K31/53 , A61K45/06 , A61P35/00
摘要： The present invention relates to 4-(4-Fluoro-2-methoxyphenyl)-N- {3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine (compound A), more particularly (+)-4-(4-Fluoro-2-methoxyphenyl)-N- {3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine (compound A'), for use in treating lymphoma, preferably diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymBurkitt's lymphoma, adult T-cell lymphoma (ATL) and Hodgkin's lymphoma, more preferably DLBCL and ATL.

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