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71. 发明申请

US20180303824A1 Compositions for deterring abuse of pharmaceutical products and alcohol 审中-公开
公开(公告)号：US20180303824A1
公开(公告)日：2018-10-25
申请号：US15770193
申请日：2016-10-21
申请人： NOVA SOUTHEASTERN UNIVERSITY
发明人： Hossein Omidian , Srinath Muppalaneni , Yogesh N. Joshi , David J. Mastropietro
IPC分类号： A61K31/485 , A61K31/135 , A61K9/20
CPC分类号： A61K31/485 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K31/135
摘要： The invention enables the formation of prescription drugs less likely to be abused. Different approaches are employed that can potentially deter abuse by reducing the efficacy of main processes utilized by abusers to speed drug absorption and enhance its effect. Pharmaceutical compositions of the invention incorporate one or more of the following elements: super water-absorbency, alcohol absorption, organic binding agents, inorganic binding agents, adsorption, and tough platforms. These compositions function by preventing the isolation and concentration of drug constituents for misuse and/or preventing excessive intake. Thus, the invention encompasses various compositions and methods for reducing abuse of pharmaceutical products and alcohol.

72. 发明授权

US10070158B2 Data adaptive compression and data encryption using kronecker products 有权
公开(公告)号：US10070158B2
公开(公告)日：2018-09-04
申请号：US15505665
申请日：2015-08-21
申请人： NOVA SOUTHEASTERN UNIVERSITY
发明人： Abdelkrim Bourouihiya
IPC分类号： H04N7/167 , H04N21/2347 , H04N19/46 , G06F17/16 , H04L9/30
摘要： Digital files are compressed using a process including Schmidt decompositions of matrices using an algorithm, termed ‘BSD’ herein, which is based on an algebraic method generalizing QR decomposition. Software analyzes an input file and initially identifies a matrix M, with entries within a predefined set of integers, within the file. Next, essential entries are defined, extracted from M, that contain sufficient information to recover M using BSD. The compressed file includes the essential entries and their positions within M. To achieve an encryption process, software encrypts the pattern matrix that includes the positions of the essential entries of M. To achieve a lossy compression, software identifies essential entries that contain sufficient information to recover an approximation to M for which the quality is determined by an error threshold. For a more efficient lossy compression, software uses singular value decomposition, BSD, and other signal processing of M.

73. 发明申请

US20180147145A1 EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE 审中-公开
公开(公告)号：US20180147145A1
公开(公告)日：2018-05-31
申请号：US15882399
申请日：2018-01-29
申请人： Nova Southeastern University
发明人： Mutasem Rawas-Qalaji , Ousama Rachid , Keith Simons , Estelle Simons
IPC分类号： A61K9/14 , A61K47/36 , A61K9/00 , A61K31/137 , A61K47/02
CPC分类号： A61K9/14 , A61K9/006 , A61K9/2054 , A61K9/5115 , A61K9/5161 , A61K31/137 , A61K31/194 , A61K47/02 , A61K47/36
摘要： The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

74. 发明授权

US09877921B2 Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine 有权
公开(公告)号：US09877921B2
公开(公告)日：2018-01-30
申请号：US15266843
申请日：2016-09-15
申请人： NOVA SOUTHEASTERN UNIVERSITY
发明人： Mutasem Rawas-Qalaji , Ousama Rachid , Keith Simons , Estelle Simons
IPC分类号： A61K9/16 , A61K9/14 , A61K9/00 , A61K31/137 , A61K47/36 , A61K47/02
CPC分类号： A61K31/137 , A61K9/006 , A61K9/2054 , A61K9/5161
摘要： The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

75. 发明申请

US20170071881A1 EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE 审中-公开
标题翻译： EPINEPHRINE NANOPARTICLES，其制备方法及其用于治疗对EPINEPHRINE的病症的治疗方法
公开(公告)号：US20170071881A1
公开(公告)日：2017-03-16
申请号：US15358743
申请日：2016-11-22
申请人： NOVA SOUTHEASTERN UNIVERSITY
发明人： Mutasem RAWAS-QALAJI , Ousama RACHID , Keith John SIMONS , Estelle SIMONS , Enrique NIEVES
IPC分类号： A61K31/137 , A61K9/19 , A61K9/00
摘要： The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.
摘要翻译：本发明提供了包含肾上腺素纳米颗粒的组合物和用于治疗使用该组合物治疗对肾上腺素（例如心脏事件或过敏反应，特别是过敏反应）的病症的方法。肾上腺素纳米颗粒可以掺入到口腔崩解和快速崩解片剂药物制剂中，并且可以显着增加肾上腺素的舌下生物利用度，从而降低所需的肾上腺素剂量。另外，本发明提供了用于制备用于所述组合物的稳定的肾上腺素纳米颗粒的方法。

76. 发明申请

US20160275236A1 Analyzing Immune Signaling Networks for Identification of Therapeutic Targets in Complex Chronic Medical Disorders, Identification of a Natural Killer Cell Population as a Potential Therapeutic Target for Gulf War Illness And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, And Modulation of Natural Killer Cell Function by Stimulation with Interleukin 15 审中-公开
标题翻译：分析免疫信号网络在复杂慢性医学疾病中的治疗靶点鉴定，鉴定天然杀伤细胞群体作为海湾战争疾病和肌痛脑脊髓炎/慢性疲劳综合征的潜在治疗靶点，并用白细胞介素刺激自然杀伤细胞功能的调节 15
公开(公告)号：US20160275236A1
公开(公告)日：2016-09-22
申请号：US15028757
申请日：2014-10-14
申请人： NOVA SOUTHEASTERN UNIVERSITY
发明人： Mary Ann FLETCHER , Gordan BRODERICK , Nancy KLIMAS , Zachary BARNES
IPC分类号： G06F19/12 , A61K38/20
CPC分类号： G16B5/00 , A61K38/2086 , G16B40/00
摘要： A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).
摘要翻译：描述了分析用于鉴定复杂，慢性医学病症中的潜在治疗靶标的免疫信号网络的一般方法。本公开提供了CD3 / CD56 +自然杀伤（NK）细胞群作为临床重叠疾病海湾病（GWI）和Myalg脑脊髓炎/慢性疲劳综合征（ME / CFS）的潜在治疗靶点。本公开还提供了通过用白细胞介素-15（IL-15）刺激NK细胞来改善或恢复天然杀伤（NK）细胞功能的方法。

77. 发明申请

US20160045457A1 EPINEPHRINE FINE PARTICLES AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE 审中-公开
标题翻译： EPINEPHRINE精细颗粒及其用于治疗对EPINEPHRINE有反应的病症的方法
公开(公告)号：US20160045457A1
公开(公告)日：2016-02-18
申请号：US14778887
申请日：2014-03-24
申请人： Ousama RACHID , Keith SIMONS , Estelle SIMONS , NOVA SOUTHEASTERN UNIVERSITY
发明人： Mutasem RAWAS-QALAJI , Ousama RACHID , Keith SIMONS , Estelle SIMONS
IPC分类号： A61K31/137 , A61K9/00
CPC分类号： A61K31/137 , A61K9/0056 , A61K9/006 , A61K9/14 , A61K31/00 , A61K47/12 , A61K47/26
摘要： The invention provides compositions including epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.
摘要翻译：本发明提供了包括肾上腺素细颗粒，包括肾上腺素纳米颗粒或纳米晶体和肾上腺素微粒或微晶的组合物，以及用于治疗使用该组合物治疗对肾上腺素（例如心脏事件或过敏反应特别是过敏反应）的病症的方法。肾上腺素细颗粒可以掺入口腔崩解和快速崩解片剂药物制剂中，并可显着增加肾上腺素的舌下生物利用度，从而降低所需的肾上腺素剂量。

78. 发明申请

US20140314890A1 COMBINATION ANTI-CANCER THERAPY 审中-公开
标题翻译：组合抗癌治疗
公开(公告)号：US20140314890A1
公开(公告)日：2014-10-23
申请号：US14354939
申请日：2012-10-30
申请人： THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES , NOVA SOUTHEASTERN UNIVERSITY
发明人： Miroslav Gantar , Appu Rathinavelu , Sivanesan Dhandayuthapani
IPC分类号： A61K35/74 , A61K45/06 , A61K38/16
CPC分类号： A61K35/748 , A61K31/175 , A61K31/337 , A61K31/407 , A61K31/4745 , A61K31/475 , A61K31/555 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/164 , A61K45/06 , A61K2300/00
摘要： Discloses herein is a combination therapy for treating cancer by administration of a phycocyanin and a chemotherapeutic.
摘要翻译：本文公开了通过施用藻蓝蛋白和化学治疗来治疗癌症的组合疗法。

79. 发明申请

US20140059675A1 BIOMETRIC AUTHENTICATION 审中-公开
标题翻译：生物鉴定
公开(公告)号：US20140059675A1
公开(公告)日：2014-02-27
申请号：US13975534
申请日：2013-08-26
申请人： RAYTHEON COMPANY , NOVA SOUTHEASTERN UNIVERSITY
发明人： Robert B. BATIE, JR. , Yair LEVY
IPC分类号： G06F21/32
CPC分类号： G06F21/32
摘要： A method of authenticating a user includes using at least one computer and connected scanner to obtain biometric measurements of a plurality of biometric parameters of the user. The parameters are stored as templates for comparison, as well as a sequence in which the plurality of biometric parameters are to be scanned in order to perform a valid authentication. Authentication is determined by comparing each biometric parameter submitted with the stored biometric templates, to determine if each biometric parameter matches a stored template. In addition, the sequence with which each matched template was presented is identified, and this sequence is compared with the stored sequence. If a predetermined number of biometric parameters match, and a predetermined number of elements in a sequence match, the user is authenticated.
摘要翻译：认证用户的方法包括使用至少一台计算机和连接的扫描仪来获得用户的多个生物特征参数的生物测量。将参数存储为用于比较的模板，以及为了执行有效认证而要扫描多个生物特征参数的序列。通过比较提交的存储的生物特征模板的每个生物特征参数来确定认证，以确定每个生物特征参数是否与存储的模板匹配。此外，识别出与每个匹配模板呈现的序列，并将该序列与存储的序列进行比较。如果预定数量的生物特征参数匹配，并且序列中的预定数量的元素匹配，则认证用户。

80. 发明申请

WO2021097317A1 METHODS AND COMPOSITIONS FOR TREATMENT OF SOLID TUMORS USING F16 ISOINDOLE SMALL MOLECULES 审中-公开
公开(公告)号：WO2021097317A1
公开(公告)日：2021-05-20
申请号：PCT/US2020/060549
申请日：2020-11-13
申请人： NOVA SOUTHEASTERN UNIVERSITY
发明人： RATHINAVELU, Appu , VENKATESAN, Thiagarajan , DAS, Jayanta K. , ALGAHTANI, Mohammad Mansour S.
IPC分类号： A01N47/34 , A01N47/36 , C07D249/08
摘要： The invention provides methods for using F16 isoindole small molecules for treatment of solid tumors, particularly brain cancers, such as glioblastoma multiforme (GBM). F16 isoindole is an inhibitor of angiogenesis and is capable of antagonizing tumor vasculature. The invention also provides pharmaceutical compositions including F16 isoindole small molecules.

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