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71. 发明公开

EP2556797A1 PUNCTURE ASPIRATION METHOD AND PUNCTURE ASPIRATION DEVICE 有权转让
标题翻译：普恩库拉布邦乌干达·旺多姆
公开(公告)号：EP2556797A1
公开(公告)日：2013-02-13
申请号：EP11766009.2
申请日：2011-04-08
申请人： Kurume University , OLYMPUS MEDICAL SYSTEMS CORP.
发明人： OKABE Yoshinobu , KAJI Ryohei , ISHIDA Yusuke , YASUMOTO Makiko , YAMAGUCHI Tomohiko , TAHIRA Tomoki , MAMIYA Tomohiko , SHIBAKI Kenji
IPC分类号： A61B10/02 , A61B1/00
CPC分类号： A61B10/0275 , A61B1/00094 , A61B1/018 , A61B10/0266 , A61B10/0283 , A61B17/3421 , A61B17/3478 , A61B2010/045 , A61B2017/306 , A61B2017/320064
摘要： A puncture needle (2) has an outer tube (11) that has an opening edge of a front end formed in the shape of a blade, and a stopper member (12) that has a front end disposed within the outer tube (11) at a position separated from the front end of the outer tube (11) by a predetermined distance. A sample containing portion (13) is formed between the front end of the stopper member (12) and the front end of the outer tube (11). A ventilation passage (14) is formed around the stopper member (12) within the outer tube (11). A suction device (21) is connected to the base end side of the outer tube (11). The suction device (21) is communicated and connected with the sample containing portion (13) via the ventilation passage (14).
摘要翻译：穿刺针（2）具有形成为叶片形状的前端的开口边缘的外管（11）和设置在外管（11）内的前端的止挡构件（12）在与外管（11）的前端隔开预定距离的位置处。在止动件（12）的前端和外管（11）的前端之间形成有样品容纳部分（13）。在外管（11）内的止动件（12）周围形成通风通道（14）。抽吸装置（21）连接到外管（11）的基端侧。抽吸装置（21）经由通风通道（14）与样品容纳部分（13）连通并连接。

72. 发明公开

EP1944034A1 ADSORBENT FOR ADVANCED GLYCATION ENDPRODUCTS 审中-公开
标题翻译： ADSORBENSFÜRAGE（ADVANCED GLYCATION ENDPRODUCTS）
公开(公告)号：EP1944034A1
公开(公告)日：2008-07-16
申请号：EP06811369.5
申请日：2006-09-29
申请人： Kurume University
发明人： INOUE, Hiroyoshic/o School of Medicine , YAMAGISHI, Shoichi , TAKEUCHI, Masayoshi
IPC分类号： A61K31/787 , A61M1/36 , A61P3/10 , A61P7/08 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , B01J20/26 , C08F212/14 , C08F220/32 , C08F222/20 , C08F226/06
CPC分类号： B01J20/26 , A61K31/787 , B01J20/261 , B01J20/264 , B01J20/267 , B01J41/14 , C08F220/32 , C08F222/1006 , C08F226/06 , C08L2203/00 , C08F212/14
摘要： The object of the present invention is to provide an adsorbent having an excellent AGEs adsorption ability. The present invention provides an adsorbent for advanced glycation end products consists of a copolymer resin having hydrophilic methacrylate, wherein the constituent unit of said copolymer resin consists of a particular methacrylate compounds and vinyl compounds. Preferably, the copolymer resin having hydrophilic methacrylate has one or more basic ion-exchange groups.
摘要翻译：本发明的目的是提供具有优异的AGEs吸附能力的吸附剂。本发明提供一种用于晚期糖基化终产物的吸附剂，由具有亲水性甲基丙烯酸酯的共聚物树脂组成，其中所述共聚物树脂的构成单元由特定的甲基丙烯酸酯化合物和乙烯基化合物组成优选地，具有亲水性甲基丙烯酸酯的共聚物树脂具有一个或多个碱性离子交换基团。

73. 发明公开

EP1908826A1 PROSTATE CANCER RELATED PROTEIN DERIVED PEPTIDE WHICH IS A PEPTIDE VACCINE CANDIDATE FOR PROSTATE CANCER PATIENTS WITH HLA-A3 SUPERTYPE ALLELES 审中-公开
标题翻译：来自蛋白质在患有前列腺癌疫苗衍生肽连接的候选人，HLA-A3-SUPER-TYPEALLELMOLEKÜL-阳性前列腺癌症患者
公开(公告)号：EP1908826A1
公开(公告)日：2008-04-09
申请号：EP06767196.6
申请日：2006-06-22
申请人： Kurume University
发明人： ITOH, Kyogo , HARADA, Mamoru , NOGUCHI, Masanori
IPC分类号： C12N15/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N5/06 , C12N15/09
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/705
摘要： According to the present invention, a peptide, which is a prostate-related protein derived peptide, capable of binding to an HLA-A3 supertype allele and recognized by the cellular and/or humoral immune system is provided. The peptides of the present invention make feasible the peptide-based anti-cancer vaccine therapy for prostate cancer patients with HLA-A3 supertype allele and useful for the treatment of prostate cancer patients with alleles other than HLA-A2 and - A24 to which cancer vaccine peptide candidates had been identified.
摘要翻译：。根据本发明，肽，所有这些是前列腺相关蛋白衍生肽，能够结合HLA-A3超型等位基因和认可由蜂窝和/或体液免疫系统。本发明的肽使可行的基于肽的抗癌症疫苗治疗的前列腺癌患者的HLA-A3超型等位基因的和有用的用于治疗前列腺癌患者具有比HLA-A2其它等位基因和 - A24到哪个癌症疫苗肽候选人已经确定。

74. 发明公开

EP1767198A1 REGULATOR OF PHYSIOLOGICAL FUNCTION OF GHRELIN AND USE THEREOF 审中-公开
标题翻译：雷神德生物化学学报
公开(公告)号：EP1767198A1
公开(公告)日：2007-03-28
申请号：EP05734737.9
申请日：2005-04-19
申请人： KURUME UNIVERSITY , SUNTORY LIMITED
发明人： KOJIMA, Masayasu , Nishi, Yoshihiro , KANGAWA, Kenji , ABE, Keiichi Suntory Lim.,World Head Quaters , IZUMI, Reiko Suntory Lim.,Research Center , NAKAMURA, Junichi Suntory Lim.,World Head Quaters
IPC分类号： A61K31/19 , A61K31/20 , A61K31/22 , A61K31/23 , A61P1/04 , A61P1/14 , A61P3/00 , A61P3/02 , A61P3/04 , A61P5/08 , A61P9/00 , A61P17/02 , A61P19/02 , A61P19/10 , A23L1/30
CPC分类号： A61K31/19 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/22 , A61K31/23 , A23V2200/326 , A23V2200/306 , A23V2250/186
摘要： A regulator for regulating physiological functions, such as activity of increasing an intracellular calcium ion concentration, activity of promoting growth hormone secretion, activity of promoting eating, regulatory activity relating to fat accumulation, activity of ameliorating heart function and activity of stimulating gastric acid secretion, of ghrelin, which regulator comprises a fatty acid of carbon number 2-35 or its derivative, and use thereof.
摘要翻译：用于调节生理功能的调节剂，例如增加细胞内钙离子浓度的活性，促进生长激素分泌的活性，促进饮食的活性，与脂肪蓄积有关的调节活性，改善心脏功能的活性和刺激胃酸分泌的活性，的生长素释放肽，其调节剂包含碳数为2-35的脂肪酸或其衍生物及其用途。

75. 发明公开

EP4290287A1 ADAPTER 审中-实审
公开(公告)号：EP4290287A1
公开(公告)日：2023-12-13
申请号：EP22749408.5
申请日：2022-01-07
申请人： JMS Co., Ltd. , KURUME UNIVERSITY , MDI Co., Ltd.
发明人： YUKI Takehiko , MUTSUKADO Masaya , KANDA Ken , TOYOTA Koichiro , KINOSHITA Masahiro , IWATA Osuke , MOCHIZUKI Manabu , IMAMURA Yasuo
IPC分类号： G02B6/42 , A61B90/30 , A61J15/00 , A61M25/095 , A61M39/10 , F21S2/00 , F21V8/00 , G02B6/032 , G02B6/32 , G02B23/26
摘要： A connector (50) includes a tubular member (52) and a base tube (58). A light-guiding tube (60) is drawn out from the base tube (58) toward the opposite side to the tubular member (52). An adapter (1) includes: a first connecting portion (10) that can be connected to and disconnected from a light source device (70); a second connecting portion (20) that can be connected to and disconnected from the connector (50); and a light-guiding member (30) that guides light emitted from the light source device (70) to a proximal end surface (61) of the tube (60).

76. 发明授权

EP2754693B1 EMBEDDING RESIN COMPOSITION FOR ELECTRON MICROSCOPE, AND METHOD FOR OBSERVING SAMPLE ON ELECTRON MICROSCOPE USING SAID COMPOSITION 有权
公开(公告)号：EP2754693B1
公开(公告)日：2018-11-14
申请号：EP12830712.1
申请日：2012-09-04
申请人： Kurume University
发明人： OHTA, Keisuke , KIRYU, Toshiyuki
IPC分类号： C08L63/00 , G01N1/28 , G01N23/225
CPC分类号： H01J37/26 , C08L63/00 , C09D163/00 , G01N1/36 , G01N23/00 , G01N23/225
摘要： The present invention provides an embedding resin composition for electron microscopy having satisfactory performance as an embedding medium, including embedding performance and sectioning quality, and exhibiting excellent antistatic performance; and a method for observing a sample with an electron microscope using the composition. The embedding resin composition for electron microscopy of the present invention having antistatic performance comprises an ionic liquid and an embedding medium comprising an epoxy-based resin, a methacrylate resin or an unsaturated polyester resin. Preferably, the ionic liquid comprising a quaternary ammonium compound based on the formula (I): and an anion selected from the group consisting of BF 4 - , PF 6 - , (CF 3 SO 2 ) 2 N - , a halide ion, a conjugate base of carboxylic acid, a conjugate base of sulfonic acid and a conjugate base of an inorganic acid.

77. 发明授权

EP2676664B1 POTENTIATOR OF ANTITUMOR ACTIVITY OF CHEMOTHERAPEUTIC AGENT 有权
标题翻译：化疗药物抗肿瘤活性的潜在价值
公开(公告)号：EP2676664B1
公开(公告)日：2017-06-21
申请号：EP12747713.1
申请日：2012-02-17
申请人： EA Pharma Co., Ltd. , KURUME UNIVERSITY
发明人： NISHITANI, Shinobu , YANO, Hirohisa
IPC分类号： A61K31/198 , A61K31/513 , A61P35/00
CPC分类号： A61K31/198 , A23L33/175 , A23V2002/00 , A61K31/4412 , A61K31/513 , A61K31/53 , A61K45/06 , A61K2300/00 , A23V2200/308

78. 发明公开

EP2851010A1 VASCULAR ANASTOMOSIS DEVICE AND VASCULAR ANASTOMOSIS METHOD 审中-公开
标题翻译： VORRICHTUNGFÜRVASKULÄREANASTOMOSE UND VERFAHRENFÜRVASKULÄREANASTOMOSE
公开(公告)号：EP2851010A1
公开(公告)日：2015-03-25
申请号：EP13743591.3
申请日：2013-01-23
申请人： Kurume University , Nhk Spring Co., Ltd.
发明人： WATANABE, Koichi
IPC分类号： A61B17/11 , A61B17/064 , A61B17/08 , A61B17/10
CPC分类号： A61B17/11 , A61B2017/1107 , A61B2017/1121 , A61B2017/1125 , A61B2017/1132
摘要： Provided is a vascular anastomosis device for favorably anastomosing two blood vessels with different diameters. T he vascular anastomosis device comprises two rings with pins 21 made of a flexible material and an openable ring holder 2 2, which is made of a pair of components and detachably hold s the rings with pins 21, the ring holder 22 has a means for deforming the rings with pins, the end portion of the large-diameter blood vessel is inserted through a ring 21 and the vascular wall is extended outward 90 degrees and impaled on the pins, the end portion of the small-diameter blood vessel is inserted through the other ring 21, an incision is made i n a longitudinal direction from the end surface of the small -diameter blood vessel, the two rings 21 are elliptically de formed into a same elliptical shape by the means for deformi ng the rings so that the minor axis agrees with the diameter of the small-diameter blood vessel, the small-diameter blood vessel is elliptically opened and the vascular wall is exte nded outward 90 degrees and impaled on the pins, and the two rings 21 are joined together by allowing the pins provided o n the ring in one component to stick into the ring in the oth er component.
摘要翻译：提供一种用于有利地吻合两个不同直径的血管的血管吻合装置。血管吻合装置包括具有由柔性材料制成的销21的两个环和由一对部件制成并且可拆卸地保持环的销的可打开的环保持器2 2，环保持器22具有用于使用针使环变形，大直径血管的端部穿过环21插入，血管壁向外延伸90度并刺入销，小直径血管的端部插入通过另一个环21，从小直径血管的端面沿长度方向形成切口，通过使环变形的装置将两个环21椭圆形地形成为相同的椭圆形状，使得短轴与小直径血管的直径一致，小直径血管椭圆形开口，血管壁向外偏出90度并刺入销，两个环21连接到通过允许在一个组件中的环上提供的销钉粘附到第二组件中的环中。

79. 发明公开

EP2754672A1 ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME 有权转让
标题翻译：抗体结合骨膜和方法的特定区域FOR PERIOSTINMESSUNG SO
公开(公告)号：EP2754672A1
公开(公告)日：2014-07-16
申请号：EP12829373.5
申请日：2012-09-06
申请人： Shino-Test Corporation , Saga University , Kurume University
发明人： IZUHARA, Kenji , OHTA, Shoichiro , ARIMA, Kazuhiko , SHIRAISHI, Hiroshi , SUZUKI, Shoichi , HOSHINO, Tomoaki , AZUMA, Yoshinori , ONO, Junya
IPC分类号： C07K16/28 , G01N33/53
CPC分类号： G01N33/6893 , C07K16/18 , C07K2317/14 , C07K2317/33 , G01N2333/47 , G01N2800/12
摘要： The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.

80. 发明授权

EP2295599B1 METHOD FOR DETECTION OF IDIOPATHIC INTERSTITIAL PNEUMONIA 有权
标题翻译：检测方法的间质性肺炎特发性
公开(公告)号：EP2295599B1
公开(公告)日：2013-07-31
申请号：EP09758451.0
申请日：2009-06-03
申请人： SAGA UNIVERSITY , Kurume University
发明人： IZUHARA, Kenji , OHTA, Shoichiro , SHIRAISHI, Hiroshi , AIZAWA, Hisamichi , HOSHINO, Tomoaki , OKAMOTO, Masaki
IPC分类号： C12Q1/68 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6884 , C07K16/28 , C12Q1/6883 , C12Q2600/136 , G01N2333/51 , G01N2500/00 , G01N2500/10 , G01N2800/12 , G01N2800/26

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