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71. 发明授权

EP2136788B1 CANCER CELL TARGETING USING NANOPARTICLES 有权
标题翻译：癌细胞靶向纳米
公开(公告)号：EP2136788B1
公开(公告)日：2011-10-26
申请号：EP08744752.0
申请日：2008-03-31
申请人： Bind Biosciences, Inc.
发明人： ZALE, Stephen, E. , ALI, Mir Mukkaram
IPC分类号： A61K9/14 , B82B1/00 , A61P35/00 , A61K9/51 , A61K31/337
CPC分类号： A61K9/1647 , A61K9/146 , A61K9/5153 , A61K9/5192 , A61K31/136 , A61K31/197 , A61K31/337 , A61K31/704 , A61K47/34 , A61K47/542 , A61K47/60 , A61K47/6935 , A61K47/6937 , B82Y5/00 , C07C275/16 , C07C275/24 , C08G63/664 , C08G63/6852 , C08G63/6922 , Y10S977/904 , Y10S977/905 , Y10S977/906 , Y10S977/911 , Y10S977/915
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

72. 发明公开

EP2436376A1 Cancer cell targeting using nanoparticles 有权
标题翻译：癌细胞用纳米颗粒靶向
公开(公告)号：EP2436376A1
公开(公告)日：2012-04-04
申请号：EP11186037.5
申请日：2008-03-31
申请人： Bind Biosciences, Inc.
发明人： Zale, Stephen E. , Ali, Mir Mikkaram
IPC分类号： A61K9/14 , B82B1/00 , A61P35/00 , A61K9/51 , A61K31/337 , A61K9/48
CPC分类号： A61K9/1647 , A61K9/146 , A61K9/5153 , A61K9/5192 , A61K31/136 , A61K31/197 , A61K31/337 , A61K31/704 , A61K47/34 , A61K47/542 , A61K47/60 , A61K47/6935 , A61K47/6937 , B82Y5/00 , C07C275/16 , C07C275/24 , C08G63/664 , C08G63/6852 , C08G63/6922 , Y10S977/904 , Y10S977/905 , Y10S977/906 , Y10S977/911 , Y10S977/915
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

73. 发明公开

EP2309990A2 DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME 有权转让
标题翻译：药物负载的聚合物纳米颗粒及其制备和使用方法
公开(公告)号：EP2309990A2
公开(公告)日：2011-04-20
申请号：EP09794915.0
申请日：2009-06-16
申请人： Bind Biosciences, Inc.
发明人： TROIANO, Greg , FIGA, Michael , SABNIS, Abhimanyu
IPC分类号： A61K9/16 , A61K47/16 , A61K47/34 , A61K31/337
CPC分类号： A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.
摘要翻译：本公开总体涉及具有约0.2至约35重量百分比的治疗剂的纳米颗粒; 和约10至约99重量百分比的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）乙二醇。本发明的其他方面包括制造这种纳米颗粒的方法。

74. 发明公开

EP2309989A2 DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME 有权转让
公开(公告)号：EP2309989A2
公开(公告)日：2011-04-20
申请号：EP09794913.5
申请日：2009-06-16
申请人： Bind Biosciences, Inc.
发明人： ZALE, Stephen, E. , TROIANO, Greg , ALI, Mir Mukkaram , HRKACH, Jeff , WRIGHT, James
IPC分类号： A61K9/16 , A61K47/34 , A61K33/24 , A61K31/337
CPC分类号： A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.

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