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    • 76. 发明授权
    • High specific gravity intragastric device
    • 高比重胃内装置
    • US08758385B2
    • 2014-06-24
    • US12645466
    • 2009-12-22
    • John Hancock
    • John Hancock
    • A61M29/00
    • A61F5/0036A61F5/003
    • The teachings are directed to an intragastric device comprising a flexible and expandable bladder having a predetermined shape upon expansion for contacting the antrum of the stomach of a subject. The device is designed to avoid passage of any part of the device beyond the pylorus and lower esophageal sphincter while the bladder is expanded during use. In these embodiments, the bladder can contain a high specific gravity material when expanded; wherein, the high specific gravity material contributes to an in vivo specific gravity of the device that ranges from about 1.2 g/ml to about 2.1 g/ml and functions to direct the device to the pyloric antrum of the subject during use of the device. Moreover, these embodiments can include a filling material comprising a biocompatible fluid component and a hydrogel component to make the device substantially leakproof and contribute to the in vivo specific gravity of the device.
    • 该教导涉及一种胃内装置,其包括在膨胀时具有预定形状的柔性和可膨胀囊,用于接触受试者胃的胃窦。 该装置被设计成在使用过程中膀胱膨胀时避免设备的任何部分超过幽门和食管下括约肌。 在这些实施例中,当膨胀时,气囊可以包含高比重材料; 其中,所述高比重物质有助于所述装置的体内比重为约1.2g / ml至约2.1g / ml,并且用于在使用所述装置期间将所述装置引导至所述受试者的幽门窦。 此外,这些实施方案可以包括包含生物相容性流体组分和水凝胶组分的填充材料,以使得该装置基本上防漏并有助于该装置的体内比重。
    • 80. 发明授权
    • Compliant fill tube assembly, fill tube therefore and method of use
    • 因此,填充管总成,填充管和使用方法
    • US08066936B2
    • 2011-11-29
    • US12548413
    • 2009-08-26
    • Marshall A. KlingensmithMark A. RipepiRabindra K. BhattacharyyaJames T. Burg
    • Marshall A. KlingensmithMark A. RipepiRabindra K. BhattacharyyaJames T. Burg
    • B22D41/50B22C9/08
    • B22D41/56B22D17/20B22D18/04B22D35/04B22D45/00Y10T29/49826
    • A fill tube assembly is for a casting mold. The fill tube assembly includes a fill tube having a tubular member with a receiving end, a mold-engaging end and an intermediate portion. The mold-engaging end has a tapered flange radially extending therefrom, the remainder of the tubular member has a substantially, uniform cross-section. A clamping assembly is structured to maintain a substantially leakproof seal at the fill tube, casting mold interface while accommodating dimensional variations. The clamping assembly includes a gasket, a load ring, a clamping plate and a pre-load gap between the clamping plate and the casting mold and optionally includes a dimensional compensating ring. When tightened, the clamping plate biases the load ring against the flange thereby distributing a uniform load against the casting mold, compressing the gasket therebetween while narrowing the pre-load gap to accommodate dimensional variations. A method of use is also disclosed.
    • 填充管组件用于铸模。 填充管组件包括具有带有接收端的管状构件,模具接合端和中间部分的填充管。 模具接合端具有从其径向延伸的锥形凸缘,管状构件的其余部分具有基本上均匀的横截面。 夹紧组件被构造成在填充管中保持基本上防漏的密封,在容纳尺寸变化的同时铸造模具界面。 夹紧组件包括垫圈,负载环,夹紧板和夹紧板和铸模之间的预加载间隙,并且可选地包括尺寸补偿环。 当紧固时,夹紧板将负载环偏压在凸缘上,从而将均匀的载荷分配到铸模上,在其间压缩垫圈,同时缩小预加载间隙以适应尺寸变化。 还公开了一种使用方法。