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71. 发明申请

WO2008147473A1 THERMOSET EPOXY POLYMERS FROM RENEWABLE RESOURCES 审中-公开
标题翻译：可再生资源的热固性环氧聚合物
公开(公告)号：WO2008147473A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/000410
申请日：2008-01-11
申请人： NEW JERSEY INSTITUTE OF TECHNOLOGY , EAST, Anthony , JAFFE, Michael , ZHANG, Yi , CATALANI, Luiz
发明人： EAST, Anthony , JAFFE, Michael , ZHANG, Yi , CATALANI, Luiz
IPC分类号： C08G83/00
CPC分类号： C07D493/04 , C08G59/26 , C08G59/32 , C08G59/502 , C08G59/504 , C08G2650/50
摘要： Novel thermoset epoxy polymers using the bisglycidyl ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, are disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. The anhydrosugars are derived from renewable sources and the bisglycidyl ethers are not xenoestrogenic and the thermoset curing agents are likewise derived form renewable resources.
摘要翻译：公开了使用脱水糖的双缩水甘油醚的新型热固性环氧聚合物，例如异山梨醇，异烟肼和异氰酸酯。双缩水甘油醚在制备热固性环氧醚时可用作双酚A的替代物。脱水葡萄糖源自可再生来源，双缩水甘油醚不是异源雌激素，热固性固化剂同样衍生自可再生资源。

72. 发明申请

WO2008130549A1 HEART FAILURE DETECTION USING RESPIRATION DISTRESS MANIFESTATIONS 审中-公开
标题翻译：心脏失效检测使用呼吸分支清除
公开(公告)号：WO2008130549A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004858
申请日：2008-04-15
申请人： CARDIAC PACEMAKERS, INC. , DALAL, Yousufali , HATLESTAD, John D. , ZHANG, Yi , LEWICKE, Aaron , STAHMANN, Jeffrey E.
发明人： DALAL, Yousufali , HATLESTAD, John D. , ZHANG, Yi , LEWICKE, Aaron , STAHMANN, Jeffrey E.
IPC分类号： A61B5/08 , A61B5/113 , A61N1/362
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生和评估关于其的信息来诊断一种或多种呼吸窘迫表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿态传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

73. 发明申请

WO2008085961A1 HIGHER PERFORMANCE DVD WRITING CURRENT CIRCUIT 审中-公开
标题翻译：高性能DVD写入电路
公开(公告)号：WO2008085961A1
公开(公告)日：2008-07-17
申请号：PCT/US2008/000241
申请日：2008-01-07
申请人： SILICON CORE TECHNOLOGY, INC. , LI, Eric , ZHANG, Yi
发明人： LI, Eric , ZHANG, Yi
IPC分类号： G02B26/00
CPC分类号： G11B7/00456 , G11B7/126
摘要： A writing current circuit (42) supplies a controlled electrical current to a laser diode (34) for recording data swiftly onto a DVD (16). A plurality of current sources (62) in the writing current circuit (42) supply electrical current to the laser diode (34). Each current source (62) respectively receives a single output signal from a current control register (52) included in the writing current circuit (42) which activates or deactivates the current source (62) for supplying a particular quantity of electrical current to the laser diode (34). In each current source (62), electrical current flows to the laser diode (34) through a MOSFET output transistor (142) connected in series with the laser diode (34). Each current source's MOSFET output transistor (142) has a gate insulating layer which is thinner than the gate insulating layer conventionally used for a MOSFET output transistor (142) that is energized by the electrical potential ths it applied to the writing current circuit (42).
摘要翻译：写入电流电路（42）将受控的电流提供给激光二极管（34），用于将数据迅速地记录到DVD（16）上。写入电流电路（42）中的多个电流源（62）向激光二极管（34）提供电流。每个电流源（62）分别从包括在写入电流电路（42）中的电流控制寄存器（52）接收单个输出信号，其激活或去激活用于向激光器提供特定数量的电流的电流源（62）二极管（34）。在每个电流源（62）中，电流通过与激光二极管（34）串联连接的MOSFET输出晶体管（142）流到激光二极管（34）。每个电流源的MOSFET输出晶体管（142）具有栅极绝缘层，其比通常用于MOSFET输出晶体管（142）的栅极绝缘层薄，该栅极绝缘层被施加到写入电流电路（42）的电位激励，。

74. 发明申请

WO2008054580A3 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR HEALTH MANAGEMENT 审中-公开
公开(公告)号：WO2008054580A3
公开(公告)日：2008-05-08
申请号：PCT/US2007/020425
申请日：2007-09-20
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , HATLESTAD, John, D. , CARLSON, Gerrard, M. , DALAL, Yousufali , BROCKWAY, Marina, V. , LEE, Kent , KUENZLER, Richard, O. , HARO, Carlos , SIEJKO, Krzysztof, Z. , PATANGAY, Abhilash
发明人： ZHANG, Yi , HATLESTAD, John, D. , CARLSON, Gerrard, M. , DALAL, Yousufali , BROCKWAY, Marina, V. , LEE, Kent , KUENZLER, Richard, O. , HARO, Carlos , SIEJKO, Krzysztof, Z. , PATANGAY, Abhilash
IPC分类号： A61B5/02
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. Baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. Prediction processing may be performed by the at-least one implantable device or by an external device in communication therewith. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

75. 发明申请

WO2007136971A3 PROCESS FOR THE HYDROLYSIS OF CELLULOSE MEDIATED BY TERNARY COMPLEXES OF CELLULOSE, CLOSTRIDIUM THERMOCELLUM CELLS, AND CELLULASE EXPRESSED BY THESE CELLS 审中-公开
标题翻译：由细胞周期性复合物介导的纤维素水解的方法，这些细胞表达的细胞因子和细胞因子
公开(公告)号：WO2007136971A3
公开(公告)日：2008-04-10
申请号：PCT/US2007067954
申请日：2007-05-01
申请人： DARTMOUTH COLLEGE , LYND LEE R , ZHANG YI-HENG PERCIVAL , LU YANPIN
发明人： LYND LEE R , ZHANG YI-HENG PERCIVAL , LU YANPIN
IPC分类号： C12P19/14
CPC分类号： C12P19/14
摘要： Methods of utilizing reduced cellulase loads to hydrolyze cellulosic substrates are disclosed. The methods include determining an amount of purified cellulase necessary to substantially hydrolyze a quantity of cellulosic substrate in a period of time; reducing the amount of purified cellulase by a factor of between 2 and 5 to determine a reduced cellulase load; and introducing to the cellulosic substrate either (1 ) a microorganism expressing cell-bound cellulase in a concentration equal to the reduced cellulase load or (2) a fermentation agent that has been engineered to express cell-bound cellulase in a concentration equal to the reduced cellulase load under suitable conditions and for said period of time sufficient to allow substantial hydrolysis of the cellulosic substrate.
摘要翻译：公开了利用降低的纤维素酶负载来水解纤维素基质的方法。所述方法包括确定在一段时间内基本上水解一定量的纤维素基质所需的纯化纤维素酶的量; 将纯化的纤维素酶的量减少2至5倍以确定纤维素酶负荷降低; 并且向纤维素底物引入（1）表达细胞结合的纤维素酶的微生物，其浓度等于降低的纤维素酶负荷，或者（2）发酵剂已经被工程化以表达细胞结合的纤维素酶，其浓度等于还原的纤维素酶负载在合适的条件下并持续足以允许纤维素底物显着水解的所述时间段。

76. 发明申请

WO2007136971A2 ENZYME-MICROBE SYNERGY 审中-公开
标题翻译：食品微生物综合征（ENZYME-MICROBE SYNERGY）
公开(公告)号：WO2007136971A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/067954
申请日：2007-05-01
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , LYND, Lee, R. , ZHANG, Yi-heng Percival , LU, Yanpin
发明人： LYND, Lee, R. , ZHANG, Yi-heng Percival , LU, Yanpin
IPC分类号： C12P19/14
CPC分类号： C12P19/14
摘要： Methods of utilizing reduced cellulase loads to hydrolyze cellulosic substrates are disclosed. The methods include determining an amount of purified cellulase necessary to substantially hydrolyze a quantity of cellulosic substrate in a period of time; reducing the amount of purified cellulase by a factor of between 2 and 5 to determine a reduced cellulase load; and introducing to the cellulosic substrate either (1 ) a microorganism expressing cell-bound cellulase in a concentration equal to the reduced cellulase load or (2) a fermentation agent that has been engineered to express cell-bound cellulase in a concentration equal to the reduced cellulase load under suitable conditions and for said period of time sufficient to allow substantial hydrolysis of the cellulosic substrate.
摘要翻译：公开了利用降低的纤维素酶负载来水解纤维素基质的方法。所述方法包括确定在一段时间内基本上水解一定量的纤维素基质所需的纯化纤维素酶的量; 将纯化的纤维素酶的量减少2至5倍以确定纤维素酶负荷降低; 并且向纤维素底物引入（1）表达细胞结合的纤维素酶的微生物，其浓度等于降低的纤维素酶负荷，或者（2）发酵剂已经被工程化以表达细胞结合的纤维素酶，其浓度等于还原的纤维素酶负载在合适的条件下并持续足以允许纤维素底物显着水解的所述时间段。

77. 发明申请

WO2007121018A2 PROBE DENSITY CONSIDERATIONS AND ELONGATION OF SELF-COMPLEMENTARY LOOPED PROBES WHERE PROBES ARE ATTACHED TO A SOLID PHASE 审中-公开
标题翻译：探索密集度考察和自我补充循环探测器的延伸，探头附着在固体相位
公开(公告)号：WO2007121018A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/064118
申请日：2007-03-16
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , ZHANG, Yi , BANARJEE, Sukanta , YANG, Jiacheng , CHAU, Chiu
发明人： SEUL, Michael , ZHANG, Yi , BANARJEE, Sukanta , YANG, Jiacheng , CHAU, Chiu
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： in a multiplexed assay method earned out in solution, wherein the solution contains nucleic acid targets and., wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
摘要翻译：在溶液中获得的多重测定方法中，其中溶液含有核酸靶标，其中使用几个不同类型的寡核苷酸探针，每种类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加通过一种或多种以下方法有效浓度可用于结合探针的靶标：（i）在珠粒表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

78. 发明申请

WO2007038634A3 ENHANCED LINEARITY DVD WRITING CURRENT CIRCUIT 审中-公开
公开(公告)号：WO2007038634A3
公开(公告)日：2007-04-05
申请号：PCT/US2006/037749
申请日：2006-09-26
申请人： SILICON CORE TECHNOLOGY, INC. , LI, Eric , ZHANG, Yi
发明人： LI, Eric , ZHANG, Yi
IPC分类号： G11B7/00
摘要： A writing current circuit (42) supplies a controlled electrical current to a laser diode (34) for recording data swiftly onto a DVD (16) . A plurality of current sources (62) in the writing current circuit (42) supply electrical current directly to the laser diode (34) . Each current source (62) respectively receives a single output signal from a current control register (52) included in the writing current circuit (42) which activates or deactivates the current source (62) for supplying a particular quantity of current to the laser diode (34) . In one aspect, a pair of current reference signals received by the current source (62) control electrical current supply to the diode (34) . Incorporated into these controlling reference signals is a simulation of electrical characteristics of the diode (34) . In another aspect, each current source (62) responds to a logical inverse of the output signal from the current control register (52) for controlling overshoot in voltage applied across the diode (34) .

79. 发明申请

WO2006130720A3 PURIFICATION, CHARACTERIZATION AND RECONSTITUTION OF A UBIQUITIN E3 LIGASE 审中-公开
公开(公告)号：WO2006130720A3
公开(公告)日：2006-12-07
申请号：PCT/US2006/021159
申请日：2006-06-01
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , ZHANG, Yi , CAO, Ru , WANG, Hengbin
发明人： ZHANG, Yi , CAO, Ru , WANG, Hengbin
IPC分类号： G01N33/48 , C12M1/34
摘要： The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further comprises HPH2 and/or HPC3. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that modulate the ubiquitin E3 ligase activity of the native or reconstituted complex, and methods of identifying candidate compounds for treating cancer. Kits for determining modulation of protein ubiquitination and/or for ubiquitinating a target substrate are further provided.

80. 发明申请

WO2006115961A2 OPTICAL STORAGE WITH DIRECT DIGITAL OPTICAL DETECTION 审中-公开
标题翻译：具有直接数字光学检测的光学存储
公开(公告)号：WO2006115961A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/014828
申请日：2006-04-19
申请人： CALL/RECALL, INC. , ZHANG, Yi , ESENER, Sadik, C.
发明人： ZHANG, Yi , ESENER, Sadik, C.
IPC分类号： G11B7/00
CPC分类号： G11B7/13 , G11B7/09 , G11B7/131
摘要： Optical data storage devices and techniques that use digital optical detection to obtain digital signals from light returned from optical storage media without analog processing and analog to digital conversion.
摘要翻译：光学数据存储设备和技术，使用数字光学检测从光存储介质返回的光获得数字信号，无需模拟处理和模数转换。

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