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71. 发明申请

US20140193519A1 INDIBULIN THERAPY 审中-公开
标题翻译： INDIBULIN治疗
公开(公告)号：US20140193519A1
公开(公告)日：2014-07-10
申请号：US13958160
申请日：2013-08-02
申请人： ZIOPHARM ONCOLOGY, INC.
发明人： Barbara P. Wallner , Brian Eric Schwartz , Philip B. Komarnitsky , Gerald Bacher , Bernhard Kutscher , Gerhard Raab
IPC分类号： A61K31/4439 , A61K31/475 , A61K31/337 , A61K31/138 , A61K31/282 , A61K33/24 , A61K31/517 , A61K31/7068 , A61K31/53 , A61K31/566 , A61K38/08 , A61K31/569 , A61K31/513 , A61K31/7048
CPC分类号： A61K31/4439 , A61K31/138 , A61K31/282 , A61K31/337 , A61K31/404 , A61K31/437 , A61K31/47 , A61K31/4709 , A61K31/475 , A61K31/496 , A61K31/513 , A61K31/517 , A61K31/53 , A61K31/565 , A61K31/566 , A61K31/569 , A61K31/573 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.
摘要翻译：本发明提供联合治疗，其中一种或多种其它治疗剂与靛蓝或其药学上可接受的盐一起给药，并且该组合是协同的。本发明的另一方面涉及用靛蓝作为单一药剂治疗癌症。本发明的另一方面涉及用于给药靛蓝的口服剂型的给药方案。

72. 发明授权

US08334398B2 Compounds and methods for the treatment of cancer 有权
标题翻译：化合物和治疗癌症的方法
公开(公告)号：US08334398B2
公开(公告)日：2012-12-18
申请号：US13150516
申请日：2011-06-01
申请人： Paul Gutsch , Brian Renzelmann
发明人： Paul Gutsch , Brian Renzelmann
IPC分类号： C07C229/26
CPC分类号： A61K45/06 , A61K31/285 , C07F9/72
摘要： The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
摘要翻译：本发明提供有机砷。许多这些化合物对许多人类肿瘤细胞系（包括固体和血液来源）以及来自患有白血病的患者的恶性血细胞具有有效的体外细胞毒活性。

73. 发明申请

US20120295861A1 Combination Therapy With Organic Arsenicals 审中-公开
标题翻译：有机砷联合疗法
公开(公告)号：US20120295861A1
公开(公告)日：2012-11-22
申请号：US13559036
申请日：2012-07-26
申请人： Barbara P. WALLNER , Philip B. KOMARNITSKY
发明人： Barbara P. WALLNER , Philip B. KOMARNITSKY
IPC分类号： A61K31/285 , A61K31/573 , A61K31/4745 , A61K31/704 , A61K31/44 , A61P35/00 , A61P35/02 , A61K31/69 , A61K31/513
CPC分类号： A61K31/285 , A61K31/282 , A61K31/44 , A61K31/4745 , A61K31/4965 , A61K31/513 , A61K31/573 , A61K31/69 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-I or a pharmaceutically acceptable salt thereof. The invention also relates to methods for the treatment of cancer, comprising administering SGLU-I in combination with another therapeutic agent. Another aspect of the invention relates to a kit comprising SGLU-I and another therapeutic agent.
摘要翻译：本发明提供了一种联合治疗，其中一种或多种其它治疗剂与有机砷进行给药，优选为SGLU-1或其药学上可接受的盐。本发明还涉及治疗癌症的方法，其包括与另一种治疗剂组合施用SGLU-1。本发明的另一方面涉及包含SGLU-1和另一种治疗剂的试剂盒。

74. 发明申请

US20120022229A1 COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER 有权
标题翻译：化合物和治疗癌症的方法
公开(公告)号：US20120022229A1
公开(公告)日：2012-01-26
申请号：US13150516
申请日：2011-06-01
申请人： Paul Gutsch , Brian Renzelmann
发明人： Paul Gutsch , Brian Renzelmann
IPC分类号： C07K1/107
CPC分类号： A61K45/06 , A61K31/285 , C07F9/72
摘要： The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
摘要翻译：本发明提供有机砷。许多这些化合物对许多人类肿瘤细胞系（包括固体和血液来源）以及来自患有白血病的患者的恶性血细胞具有有效的体外细胞毒活性。

75. 发明申请

US20140378704A1 SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 有权
标题翻译：磺酰胺酰胺盐的合成及其制备及其类似物
公开(公告)号：US20140378704A1
公开(公告)日：2014-12-25
申请号：US14167169
申请日：2014-01-29
申请人： Frank W. WALIGORA , John C. AMEDIO, JR.
发明人： Frank W. WALIGORA , John C. AMEDIO, JR.
IPC分类号： C07F9/22
CPC分类号： C07F9/222 , A61K31/66 , A61K31/664 , A61K31/675 , C07F9/1406 , C07F9/20 , C07F9/22 , C07F9/2429 , C07F9/2458
摘要： Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.
摘要翻译：本文公开了制备式（E）化合物的制剂和方法：其中X和Y独立地表示离去基团; 而A +是铵阳离子。

76. 发明申请

US20130196000A1 COMBINATION THERAPY INCLUDING ISOPHOSPHORAMIDE MUSTARD, ANALOGS, OR SALTS THEREOF 审中-公开
标题翻译：组合治疗，包括异磷酰胺的保护，模拟或其它
公开(公告)号：US20130196000A1
公开(公告)日：2013-08-01
申请号：US13753975
申请日：2013-01-30
申请人： Ziopharm Oncology, Inc.
发明人： Lawrence EINHORN , Jonathan LEWIS , Hagop YOUSSOUFIAN
IPC分类号： A61K31/7048 , A61K31/555 , A61K31/664
CPC分类号： A61K31/7048 , A61K31/555 , A61K31/664 , A61K33/24 , A61K2300/00
摘要： In one aspect, a method for treating a subject having a hyperproliferative disorder is disclosed, including administering to the subject a composition including: IPM, an IPM analog, or a pharmaceutically acceptable salt thereof in the dosage from about 70 mg/m2/day to about 160 mg/m2/day; etoposide in the dosage up to about 100 mg/m2/day; and one or more of carboplatin, cisplatin, oxaliplatin, picoplatin, or a combination thereof in the dosage of from AUC 2 mg/mL/min to AUC 7 mg/mL/min; wherein the treatment does not result in a dose limiting toxicity.
摘要翻译：一方面，公开了一种治疗具有过度增殖性疾病的受试者的方法，包括向受试者施用组合物，其含量包括：IPM，IPM类似物或其药学上可接受的盐，剂量为约70mg / m 2 /天至约160 mg / m2 /天; 依托泊苷的剂量高达约100mg / m2 /天; 以及AUC 2mg / mL / min至AUC 7mg / mL / min的剂量中的一种或多种卡铂，顺铂，奥沙利铂，吡铂或其组合。其中所述治疗不会导致剂量限制性毒性。

77. 发明授权

US07968738B2 Compounds and methods for the treatment of cancer 有权
标题翻译：化合物和治疗癌症的方法
公开(公告)号：US07968738B2
公开(公告)日：2011-06-28
申请号：US11495172
申请日：2006-07-28
申请人： Paul Gutsch , Brian Renzelmann
发明人： Paul Gutsch , Brian Renzelmann
IPC分类号： C07C229/26
CPC分类号： A61K45/06 , A61K31/285 , C07F9/72
摘要： The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
摘要翻译：本发明提供有机砷。许多这些化合物对许多人类肿瘤细胞系（包括固体和血液来源）以及来自患有白血病的患者的恶性血细胞具有有效的体外细胞毒活性。

78. 发明授权

US07964583B2 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents 有权
标题翻译：异磷酰胺芥酸盐及其类似物作为抗肿瘤剂
公开(公告)号：US07964583B2
公开(公告)日：2011-06-21
申请号：US11709319
申请日：2007-02-20
申请人： Robert Peter Gale
发明人： Robert Peter Gale
IPC分类号： A61K31/675 , A61K31/66 , A61K31/415
CPC分类号： A61K31/66 , A61K31/14 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
摘要翻译：本公开涉及异磷酰胺芥酸和异磷酰胺芥菜类似物的盐和组合物。在一个实施方案中，盐可以由下式表示：其中A +表示选自质子化（共轭酸）或季形式的脂族胺和芳族胺的铵物质，包括碱性氨基酸，杂环胺，取代和未取代的吡啶，胍和胍脒 X和Y独立地表示离去基团。本文还公开了制备这些化合物和配制其药物组合物的方法。公开了给予受试者，特别是治疗过度增殖性疾病的方法。

79. 发明申请

US20080241274A1 Indibulin therapy 审中-公开
标题翻译：靛蓝疗法
公开(公告)号：US20080241274A1
公开(公告)日：2008-10-02
申请号：US11986844
申请日：2007-11-27
申请人： Barbara P. Wallner , Brian Eric Schwartz , Philip B. Komarnitsky , Gerald Bacher , Bernhard Kutscher , Gerhard Raab
发明人： Barbara P. Wallner , Brian Eric Schwartz , Philip B. Komarnitsky , Gerald Bacher , Bernhard Kutscher , Gerhard Raab
IPC分类号： A61K33/24 , A61K31/4439 , A61K31/517 , A61K31/7048 , A61P35/00 , A61K31/56 , A61K31/704 , A61K31/505
CPC分类号： A61K31/4439 , A61K31/138 , A61K31/282 , A61K31/337 , A61K31/404 , A61K31/437 , A61K31/47 , A61K31/4709 , A61K31/475 , A61K31/496 , A61K31/513 , A61K31/517 , A61K31/53 , A61K31/565 , A61K31/566 , A61K31/569 , A61K31/573 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.
摘要翻译：本发明提供联合治疗，其中一种或多种其它治疗剂与靛蓝或其药学上可接受的盐一起给药，并且该组合是协同的。本发明的另一方面涉及用靛蓝作为单一药剂治疗癌症。本发明的另一方面涉及用于给药靛蓝的口服剂型的给药方案。

80. 发明授权

EP2155682B1 SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 有权
标题翻译： ISOPHOSPHORAMIDLOST及其类似物的盐
公开(公告)号：EP2155682B1
公开(公告)日：2015-06-24
申请号：EP08727299.3
申请日：2008-04-04
申请人： ZIOPHARM ONCOLOGY, INC.
发明人： AMEDIO, John, C. , WALLNER, Barbara, P. , KOMARNITSKY, Philip, B.
IPC分类号： C07D213/74 , C07F9/24 , A61K31/13 , A61K31/133 , A61K31/198 , A61K31/4409 , A61K31/664 , C07C211/35 , C07C215/10 , C07C229/26 , C07C279/14 , A61P35/00 , C07F9/22 , A61K31/704 , A61K31/337
CPC分类号： C07F9/22 , A61K31/337 , A61K31/664 , A61K31/704 , C07D213/74 , C07F9/2458

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