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71. 发明申请

WO1991010431A1 FAT EMULSION 审中-公开
标题翻译： FAT乳液
公开(公告)号：WO1991010431A1
公开(公告)日：1991-07-25
申请号：PCT/JP1991000006
申请日：1991-01-09
申请人： NIPPON SHINYAKU CO., LTD.
发明人： NIPPON SHINYAKU CO., LTD. , SEKI, Junzo , USHIMARU, Kouichi , SUGIYAMA, Makoto
IPC分类号： A61K31/40
CPC分类号： A61K9/1075 , A61K31/40
摘要： A fat emulsion mainly comprising 0.001 to 10 % (w/v) of a mitomycin C derivative of general formula (I), 0.5 to 30 % (w/v) of a simple lipid, a phospholipid in an amount of 0.05 to 2 times by weight as large as the simple lipid, and an appropriate amount of water: (I) wherein X represents -(CH2)n-O- or -(CH2)n-NHCOO-; n represents an integer of 0 to 4; and R represents a linear or branched, open-chain or cyclic, saturated or unsaturated hydrocarbon group containing 3 to 25 carbon atomes. This emulsion causes efficient migration of a prodrug of mitomycin C with a carcinostatic action in the form of an injection into the tissues, helps to maintain its blood level, and allows safe administration of an effective dose.

72. 发明申请

WO1991001733A1 REMEDY 审中-公开
标题翻译：补救
公开(公告)号：WO1991001733A1
公开(公告)日：1991-02-21
申请号：PCT/JP1990001007
申请日：1990-08-07
申请人： NIPPON SHINYAKU CO., LTD. , UEDA, Fusao , HARA, Katsumi , YAMAMOTO, Osamu , KIMURA, Kiyoshi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K31/53
CPC分类号： C07D251/18
摘要： Remedies based on a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof, wherein R , R and R may be the same or different from one another and each represents hydrogen, alkyl, halogen, alkoxy, or alkoxycarbonyl. They are used for curing wound, fulminant hepatitis and inflammatory intestinal diseases.
摘要翻译：基于由通式（I）表示的化合物或其药理学上可接受的酸加成盐的方法，其中R 1，R 2和R 3可以相同或不同，各自表示氢，烷基，卤素，烷氧基或烷氧基羰基。它们用于治疗伤口，暴发性肝炎和炎性肠道疾病。

73. 发明申请

WO1988007867A1 NOOTROPIC 审中-公开
标题翻译：促智
公开(公告)号：WO1988007867A1
公开(公告)日：1988-10-20
申请号：PCT/JP1988000347
申请日：1988-04-07
申请人： NIPPON SHINYAKU CO., LTD. , KIMURA, Kiyoshi , UKAI, Yojiro , OGASAWARA, Takashi , NAKAGAWA, Yutaka
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K37/02
CPC分类号： C07K5/0821 , A61K31/54 , A61K38/06
摘要： A novel nootropic to be applicable to senile dementia is disclosed. Known nootropics such as TRH (thyrotropin releasing hormone) have the defect that they are too rapidly decomposed in the body and cannot be administered orally. The present nootropic contains as the major component a compound having chemical structural formula (I), wherein R represents a lower alkyl. Remarkable effects are observed with animals with less toxicity, so that the nootropic can be expected to be useful as a medicine. This drug has an extreme significance in the coming aged society.

74. 发明申请

WO1988004668A1 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：单克隆抗体
公开(公告)号：WO1988004668A1
公开(公告)日：1988-06-30
申请号：PCT/JP1987000919
申请日：1987-11-26
申请人： NIPPON SHINYAKU CO., LTD. , KAKUNAGA, Takeo
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07K15/04
CPC分类号： C07K16/18 , A61K38/00 , C07K16/30
摘要： Monoclonal antibodies capable of specifically recognizing fodrin and having a subclass of G2 (G2a, G2b). The antibodies can detect fodrin of various origins in addition to animal species and from denatured to native origins. Some of the obtained monoclonal antibodies can detect a third subunit which cannot be detected with polyclonal antibodies. The antibodies can find wide applications to cancer, differentiation of cells, myotonic dystrophy, etc. Particularly with cancer generation, a monoclonal antibody (15A1) capable of specifically recognizing a fodrin beta subunit enables diagnosis of the extent of malignance of cancer and differentiation. Identification and determination of fodrin which is a cell-backing protein and which participate in an information transfer system are important for clarifying the mechanism of various diseases, and hence the monoclonal antibodies are quite important from the medical and physiological points of view.

75. 发明申请

WO2021153716A1 CONTROLLED RELEASE COMPOSITION 审中-公开
公开(公告)号：WO2021153716A1
公开(公告)日：2021-08-05
申请号：PCT/JP2021/003157
申请日：2021-01-29
申请人： NIPPON SHINYAKU CO., LTD.
发明人： FURUTA, Shoji , WAKAMORI, Hiroki , HATTORI, Naoto , ISHIDA, Chihiro
IPC分类号： A61K47/10 , A61K9/22 , A61K9/26 , A61K31/4965 , A61K47/32 , A61K47/36 , A61K47/38 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/12 , A61P11/00 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/14 , A61P43/00
摘要： It is an object of the present invention to provide a controlled release composition which can prevent a sudden rise in the blood concentration of an active ingredient and can maintain the blood concentration for a long time.

76. 发明申请

WO1997015546A1 CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：羧酸衍生物和药物组合物
公开(公告)号：WO1997015546A1
公开(公告)日：1997-05-01
申请号：PCT/JP1996003056
申请日：1996-10-21
申请人： NIPPON SHINYAKU CO., LTD. , AOKI, Tomiyoshi , KUWABARA, Kenji
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07C59/68
CPC分类号： C07C59/68 , C07C59/84
摘要： Carboxylic acid derivatives of general formula (1); pharmaceutically acceptable salts thereof; and solvates of these (wherein R , R , R and R are each independently hydrogen, alkyl, halogeno, hydroxy or alkoxy; R and R are each independently alkyl; R is hydrogen or alkyl; -X- is -O- or -S-; Y is hydrogen, alkyl, halogeno, hydroxy or alkoxy, and Z and Z are each hydrogen, or alternatively Y, Z and Z are joined together to represent -CH=; -A- is >CH-OH, >C=O, >CH-OR or >CH-OCOR wherein R is alkyl and R is alkyl or aryl; and T is alkylene optionally containing a multiple bond or the like). The above compounds are efficacious in preventing and treating arterial sclerosis, ischemic heart diseases, cerebral infarction, post-PTCA restenosis, and so on.
摘要翻译：通式（1）的羧酸衍生物; 其药学上可接受的盐; 和这些的溶剂合物（其中R 1，R 2，R 3和R 4各自独立地为氢，烷基，卤代，羟基或烷氧基; R 5和R 6各自独立地为烷基; R 7是氢或烷基; -X-是-O-或-S-; Y是氢，烷基，卤代，羟基或烷氧基，Z 1和Z 2分别是氢或或者Y，Z 1和Z 2连接在一起以表示-CH =; -A-是> CH-OH，> C = O，> CH-OR 8或> CH-OCOR 9 其中R 8为烷基，R 9为烷基或芳基; T为任选含有多重键的亚烷基等）。上述化合物在预防和治疗动脉硬化，缺血性心脏病，脑梗死，PTCA后再狭窄等方面是有效的。

77. 发明申请

WO1997011092A1 CYCLOSPORIN PHOSPHATE DERIVATIVES AND MEDICINAL COMPOSITION 审中-公开
标题翻译：环磷酰胺磷酸盐衍生物和药物组合物
公开(公告)号：WO1997011092A1
公开(公告)日：1997-03-27
申请号：PCT/JP1995001906
申请日：1995-09-21
申请人： NIPPON SHINYAKU CO., LTD. , KONNO, Kiyotaka , SETO, Takashi , YOSHIFUSA, Hiroto , EZURE, Yoji
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07K07/64
CPC分类号： C07K7/645 , A61K38/00
摘要： Novel cyclosporins having a high water-solubility, a high peroral absorbability and a reduced nephrotoxicity and a medicinal composition containing the same. The compounds include phosphates, salts thereof and solvates thereof of [phosphonothreonine ]cyclosporin A, [phosphono-4-hydroxynorvaline ]cyclosporin A, [phosphono-D-serine ]cyclosporin A, and [phosphonothreonine , phosphono-D-serine ]cyclosporin A.
摘要翻译：具有高水溶性，高口服吸收性和降低的肾毒性的新型环孢菌素和含有它们的药物组合物。这些化合物包括磷酸盐，其盐和[膦酰氨基苯二酚2]环孢菌素A，[膦酰基-4-羟基宁缬氨酸2]环孢菌素A，[膦酰-D-丝氨酸3]环孢菌素A和[膦酰基氨基] 2，膦酰-D-丝氨酸3]环孢菌素A.

78. 发明申请

WO1996040634A1 PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION 审中-公开
标题翻译：吡咯衍生物和药物组合物
公开(公告)号：WO1996040634A1
公开(公告)日：1996-12-19
申请号：PCT/JP1996001526
申请日：1996-06-06
申请人： NIPPON SHINYAKU CO., LTD. , TSUDA, Masami , TANAKA Mitsushi , NAKAMURA, Ayatsugu
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D207/335
CPC分类号： C07D401/04 , C07D207/34 , C07D207/50 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D491/04
摘要： A medicinal composition which comprises as the active ingredient a pyrrole derivative represented by general formula (1), a pharmaceutically acceptable salt thereof, or a solvate of either of the same, wherein R represents hydrogen or alkoxycarbonylamino; R represents alkyl, optionally substituted aryl, an optionally substituted aromatic heterocycle, unsubstituted amino, monoalkyl-substituted amino, dialkyl-substituted amino or optionally substituted cyclic amino; R represents cyano or carbamoyl; R represents hydrogen or alkyl; E represents alkylene; q is 0 or 1; and A represents methyl, optionally substituted aryl or an optionally substituted aromatic heterocycle. The medicinal composition is efficacious in treating frequent urination or urinary incontinence.
摘要翻译：作为活性成分含有通式（1）表示的吡咯衍生物，其药学上可接受的盐或其中任意一种的溶剂化物的药物组合物，其中R 1表示氢或烷氧基羰基氨基; R 2表示烷基，任选取代的芳基，任选取代的芳族杂环，未取代的氨基，单烷基取代的氨基，二烷基取代的氨基或任选取代的环状氨基; R 3表示氰基或氨基甲酰基; R 4表示氢或烷基; E表示亚烷基; q为0或1; A表示甲基，任选取代的芳基或任选取代的芳族杂环。药物组合物可有效治疗尿频尿失禁或尿失禁。

79. 发明申请

WO1996028164A1 REMEDY FOR PANCREATITIS 审中-公开
标题翻译：补救措施
公开(公告)号：WO1996028164A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000581
申请日：1996-03-08
申请人： NIPPON SHINYAKU CO., LTD. , UEDA, Fusao
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K31/53
CPC分类号： A61K31/5355 , A61K31/53 , A61K31/5377
摘要： A remedy for pancreatitis which comprises as the active ingredient a compound represented by general formula (I) or its salt or a solvate of the same, wherein R and R are the same or different and each represents hydrogen or optionally substituted alkyl, aralkyl, arylalkenyl or aryl, or R and R together with N to which they are bonded may form 4- to 8-membered cyclic amino NR R optionally having N, O or S in addition to the above-mentioned N and substituent(s).
摘要翻译：胰腺炎的治疗方法，其包含作为活性成分的由通式（I）表示的化合物或其盐或其溶剂合物，其中R 1和R 2相同或不同，各自表示氢或任选地取代的烷基，芳烷基，芳基烯基或芳基，或R 1和R 2与它们所键合的N一起可以形成任选具有N，O的4-至8-元环氨基NR 1 R 2 或S除了上述的N和取代基之外。

80. 发明申请

WO1996018640A1 ANTISENSE NUCLEIC ACID HOMOLOG 审中-公开
标题翻译：抗原核酸同源异构体
公开(公告)号：WO1996018640A1
公开(公告)日：1996-06-20
申请号：PCT/JP1995002584
申请日：1995-12-15
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , ISHIYAMA, Kouichi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N2310/321 , C12N2310/322 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533
摘要： An antisense nucleic acid homolog having at least one nucleoside represented by general formula (1) in the same chain of a nucleic acid homolog having been modified or replaced at DNA, RNA or a phosphoric acid diester bond, wherein B represents adenin-9-yl, guanin-9-yl, hypoxanthin-9-yl, thymin-1-yl, uracil-1-yl or cytosin-1-yl; and X and Y are the same or different and each represents hydrogen, hydroxy, halogeno or lower alkoxy. Examples of the modified phosphoric acid diester bond of this antisense nucleic acid derivative include phosphorothioate, alkylphosphorothiate, N-alkylphosphoamidate, phosphorodithioate and alkylphosphonate bonds. Thus it is possible to provide an antisense molecular drug having a low toxicity and suppressing infection with herpesvirus, influenza virus, human immunodeficiency virus, etc., or the action of oncogenes.
摘要翻译：在具有在DNA，RNA或磷酸二酯键被修饰或替换的核酸同系物的同一链中具有至少一个由通式（1）表示的核苷酸的反义核酸同源物，其中B代表腺嘌呤-9-基胍胺-9-基，次黄嘌呤-9-基，甲氨基-1-基，尿嘧啶-1-基或细胞蛋白-1-基; X和Y相同或不同，各自表示氢，羟基，卤代或低级烷氧基。该反义核酸衍生物的改性磷酸二酯键的实例包括硫代磷酸酯，磷酸烷基酯，N-烷基磷酸酯，二硫代磷酸酯和烷基膦酸酯键。因此，可以提供具有低毒性并抑制疱疹病毒，流感病毒，人类免疫缺陷病毒等感染或癌基因作用的反义分子药物。

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