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71. 发明申请

WO1988010119A1 NOVEL THROMBOLYTIC PROTEINS 审中-公开
标题翻译：新型凝血酶蛋白
公开(公告)号：WO1988010119A1
公开(公告)日：1988-12-29
申请号：PCT/US1987001584
申请日：1987-07-03
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , LARSEN, Glenn, R. , AHERN, Tim, J.
IPC分类号： A61K37/47
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.
摘要翻译：公开了具有组织纤溶酶原型活性的溶血蛋白。蛋白质的特征在于在94个氨基酸的N末端和/或在Arg-275和/或一个或多个N-连接的糖基化位点处的修饰。公开了制备这些蛋白质的方法，其含有含有它们的治疗组合物。

72. 发明申请

WO1988000975A1 HIGH LEVEL INDUCIBLE EXPRESSION OF HETEROLOGOUS GENES 审中-公开
标题翻译：异位基因的高水平诱导表达
公开(公告)号：WO1988000975A1
公开(公告)日：1988-02-11
申请号：PCT/US1987001871
申请日：1987-07-31
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , KAUFMAN, Randal, J. , ISRAEL, David
IPC分类号： C12N15/00
CPC分类号： C12N15/67 , C07K14/755 , C12N15/85
摘要： A method for producing high level expression of a selected protein and stable cell lines useful therein. This method involves culturing a cell line containing amplified copies of a cDNA sequence encoding a steroid or other ligand receptor, and amplified copies of a vector comprising an expression control sequence (incuding a promoter) which is responsive to the complex of said ligand and its receptor in operative association with a selected exogenous protein, in the presence of the ligand.
摘要翻译：用于产生选择的蛋白质和其中有用的稳定细胞系的高水平表达的方法。该方法包括培养含有编码类固醇或其它配体受体的cDNA序列的扩增拷贝的细胞系，以及包含对所述配体及其受体的复合物有响应的表达调控序列（包括启动子）的载体的扩增拷贝在与配体的存在下与所选的外源蛋白质有效结合。

73. 发明申请

WO1987006954A1 PRODUCTION OF M-CSF 审中-公开
标题翻译：生产M-CSF
公开(公告)号：WO1987006954A1
公开(公告)日：1987-11-19
申请号：PCT/US1987000835
申请日：1987-04-13
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , CLARK, Steven, C. , WONG, Gordon, G.
IPC分类号： C12P21/00
CPC分类号： C07K14/53 , A61K38/00
摘要： Novel process for producing human M-CSF. The protein is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells.
摘要翻译：用于生产人M-CSF的新方法。该蛋白质可用于治疗以造血细胞缺陷为特征的疾病。

74. 发明申请

WO1987003911A1 DISPLACEMENT POLYNUCLEOTIDE METHOD AND REAGENT COMPLEX 审中-公开
标题翻译：位移多核苷酸方法和试剂复合物
公开(公告)号：WO1987003911A1
公开(公告)日：1987-07-02
申请号：PCT/US1986002788
申请日：1986-12-17
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , COLLINS, Mary , DOUGHERTY, Joseph, P. , FRITSCH, Edward, Francis , JACOBS, Kenneth, A.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6823 , C12Q1/6816 , C12Q2565/518 , C12Q2563/179 , C12Q2537/1373
摘要： Diagnostic assay methods for detecting the presence of a target nucleotide sequence (TNS) in a biological sample. A reagent complex for use in the first method is also provided which includes a labelled probe (LP) having a target binding region (TBR) and a second polynucleotide (SP) which binds to the probe in at least a portion of the target binding region. The complex is contacted with sample (G) and target displaces the second polynucleotide on the complex. Intact complex is then separated from probe/target hybrids, and the hybrids are detected. The second method involves capturing of the labeled strand after displacement from the probe which binds to the target.
摘要翻译：用于检测生物样品中靶核苷酸序列（TNS）的存在的诊断测定方法。还提供了用于第一种方法的试剂复合物，其包括具有靶结合区（TBR）的标记探针（LP）和在目标结合区域的至少一部分中与探针结合的第二多核苷酸（SP）。复合物与样品（G）接触，靶标置换复合物上的第二个多核苷酸。然后将完整复合物与探针/靶杂交体分离，并检测杂交体。第二种方法包括从与探针结合的探针置换后捕获标记的链。

75. 发明申请

WO1986006101A1 NOVEL PROCOAGULANT PROTEINS 审中-公开
标题翻译：新鲜流行蛋白
公开(公告)号：WO1986006101A1
公开(公告)日：1986-10-23
申请号：PCT/US1986000774
申请日：1986-04-11
申请人： GENETICS INSTITUTE, INC. , TOOLE, John, J., Jr.
发明人： GENETICS INSTITUTE, INC.
IPC分类号： C12P21/00
CPC分类号： C07K14/755 , A61K38/00 , Y10S435/948 , Y10S930/10 , Y10S930/30
摘要： Novel procoagulant proteins which comprise the amino acid sequence: A-X-B wherein region A represents the polypeptide sequence Ala-20 through Arg-759 substantially as shown in Table 1; region B represents the polypeptide sequence Ser-1709 through Tyr-2351 substantially as shown in Table 1; and region X represents a polypeptide sequence comprising up to 949 amino acids substantially duplicative of sequences of amino acids within the sequence Ser-760 through Arg-1708 of Table 1, wherein the amino terminus of X is covalently bonded through a peptide bond designated "-" to the carboxy terminus of A, and the carboxy terminus of X is likewise bonded to the amino terminus of B. Methods of making such proteins and their use in pharmaceutical preparations is also disclosed.
摘要翻译：包含氨基酸序列：A-X-B的新型促凝血蛋白，其中区域A基本上如表1所示，代表通过Arg-759的多肽序列Ala-20; 区域B基本上如表1所示，通过Tyr-2351表示多肽序列Ser-1709; 并且区域X表示包含多达949个氨基酸的多肽序列，其基本上与表1的Arg-170至Arg-1708序列中的氨基酸序列重复，其中X的氨基末端通过称为“ - “到A的羧基末端，X的羧基末端也与B的氨基末端键合。制备这些蛋白质的方法及其在药物制剂中的用途也被公开。

76. 发明申请

WO1986003520A1 METHOD FOR THE PRODUCTION OF ERYTHROPOIETIN 审中-公开
标题翻译：生产抗坏血酸蛋白酶的方法
公开(公告)号：WO1986003520A1
公开(公告)日：1986-06-19
申请号：PCT/US1985002405
申请日：1985-12-03
申请人： GENETICS INSTITUTE, INC. , FRITSCH, Edward , HEWICK, Rodney, M. , JACOBS, Kenneth
发明人： GENETICS INSTITUTE, INC.
IPC分类号： C12P21/00
CPC分类号： C07K14/505 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2830/85 , C12N2840/44
摘要： Cloned genes for human erythropoietin (EPO) obtained from human fetal liver that provide surprisingly high levels of expression. Also described is the expression of said genes in vitro to produce active human EPO.
摘要翻译：从人胎肝获得的人促红细胞生成素（EPO）的克隆基因提供惊人的高水平表达。还描述了所述基因在体外的表达以产生活性人EPO。

77. 发明申请

WO1986001540A1 MODIFIED INSULIN PRECURSORS PRODUCTS AND PROCESSES 审中-公开
标题翻译：改性胰岛素前体产品和方法
公开(公告)号：WO1986001540A1
公开(公告)日：1986-03-13
申请号：PCT/US1985001673
申请日：1985-08-30
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , SCHENDEL, Paul , SEED, Brian
IPC分类号： C12P21/00
CPC分类号： C07K14/62
摘要： Products and processes for the generation in polypeptides of protease cleavage sites, thereby making said cleavage sites accessible for in vitro cleavage by highly specific proteases. More particularly, this concept has been employed in the production from a modified proinsulin of an insulin containing a B-chain having the proper carboxyl-terminus. A modified proinsulin with several amino acids deleted from its C-chain was cleaved at Thr30-Asp31 and at a site equivalent to the Arg65-Gly66 of the natural proinsulin C-chain (this site having been modified to a Met-Gly sequence) to yield active human insulin in vitro.
摘要翻译：用于在蛋白酶切割位点的多肽中产生的产物和方法，从而使所述切割位点可通过高度特异性蛋白酶体外切割获得。更具体地说，这一概念已被用于含有具有适当羧基末端的B链的胰岛素的修饰胰岛素原的生产中。在Thr30-Asp31处和与天然胰岛素原C链的Arg65-Gly66相当的位点（已被修饰为Met-Gly序列的该位点）被切割到具有从其C链缺失的几个氨基酸的修饰的胰岛素原被切割成在体外产生活性人胰岛素。

78. 发明申请

WO1998035043A1 HUMAN SDF-5 PROTEIN AND COMPOSITIONS 审中-公开
标题翻译：人类SDF-5蛋白质和组合物
公开(公告)号：WO1998035043A1
公开(公告)日：1998-08-13
申请号：PCT/US1997018369
申请日：1997-10-15
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , LaVALLIE, Edward, R. , RACIE, Lisa, A.
IPC分类号： C12N15/19
CPC分类号： C07K14/52 , A61K38/00
摘要： Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
摘要翻译：公开了纯化的人SDF-5蛋白质及其生产方法。还公开了编码人SDF-5蛋白的DNA分子。蛋白质可用于调节Wnt基因与其受体的结合。在优选的实施方案中，蛋白质可用于诱导软骨细胞和/或软骨组织的形成，生长，分化，增殖和/或维持，以及用于其它组织修复，例如胰腺组织修复。

79. 发明申请

WO1998022501A3 SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM 审中-公开
公开(公告)号：WO1998022501A3
公开(公告)日：1998-05-28
申请号：PCT/US1997021123
申请日：1997-11-19
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , JACOBS, Kenneth , MCCOY, John, M. , LAVALLIE, Edward, R. , RACIE, Lisa, A. , MERBERG, David , TREACY, Maurice , SPAULDING, Vikki , AGOSTINO, Michael, J.
IPC分类号： C12N15/12

80. 发明申请

WO1998012322A1 BONE MORPHOGENETIC PROTEIN-16 (BMP-16) COMPOSITIONS 审中-公开
标题翻译：骨形态蛋白16（BMP-16）组成
公开(公告)号：WO1998012322A1
公开(公告)日：1998-03-26
申请号：PCT/US1997011954
申请日：1997-07-09
申请人： GENETICS INSTITUTE, INC.
发明人： GENETICS INSTITUTE, INC. , CELESTE, Anthony, J. , MURRAY, Beth, L.
IPC分类号： C12N15/12
CPC分类号： C07K14/495 , A61K38/00 , C07K14/51 , C07K2319/00
摘要： Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
摘要翻译：公开了纯化的BMP-16蛋白质及其生产方法。还公开了编码BMP-16蛋白质的DNA分子。蛋白质可以用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮的组织的病症和缺陷，神经，肌肉，包括心肌和其他组织和伤口，以及诸如肝，肺，心脏，胰腺和肾组织的器官。蛋白质也可用于诱导未分化胚胎和干细胞的生长和/或分化。

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