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61. 发明申请

US20040096971A1 Thymic epithelial progenitor cells and uses thereof 审中-公开
标题翻译：胸腺上皮祖细胞及其用途
公开(公告)号：US20040096971A1
公开(公告)日：2004-05-20
申请号：US10451420
申请日：2003-12-16
发明人： Catherine Clare Blackburn , Craig Scott Nowell
IPC分类号： C12N005/08 , C12N015/85
CPC分类号： A01K67/0275 , A01K2217/05 , A61K35/12 , C12N5/0636 , C12N5/065 , C12N2502/1185 , C12N2503/00 , C12N2510/04 , C12N2517/02
摘要： A method for improving the viability of a population of isolated thymic epithelial progenitor cells (TEPCs) comprises contacting the cells, or one or more ancestors thereof, with at least one viability promoting agent A TEPC line is provided and used for restoring or anhancing thymic function and for generation of T cells from haematopoietic stem cells.
摘要翻译：一种用于改善分离的胸腺上皮祖细胞（TEPC）群体的存活力的方法包括将细胞或其一个或多个祖先与至少一种生存力促进剂接触。提供TEPC系，并用于恢复或增强胸腺功能以及来自造血干细胞的T细胞的产生。

62. 发明申请

US20040096967A1 Suspension method for producing embryoid bodies, compositions and methods related thereto 审中-公开
标题翻译：用于生产类胚体的悬浮方法，与其相关的组合物和方法
公开(公告)号：US20040096967A1
公开(公告)日：2004-05-20
申请号：US10698840
申请日：2003-10-31
申请人： Pfizer Inc
发明人： Timothy D. Gryseels , John E. Hambor , Steven J. Hawrylik , Marsh L. Roach
IPC分类号： C12N005/06 , C12N005/08
CPC分类号： C12N5/0645 , C12N5/0603 , C12N2500/32 , C12N2500/35 , C12N2501/125 , C12N2501/23 , C12N2501/235 , C12N2506/02
摘要： Suspension methods and compositions for effecting large-scale in vitro differentiation of mammalian embryonic stem cells are provided, as well as methods comprising the subject large-scale in vitro differentiation methods.
摘要翻译：提供了用于实现哺乳动物胚胎干细胞的大规模体外分化的悬浮方法和组合物，以及包含受试者大规模体外分化方法的方法。

63. 发明申请

US20040091936A1 Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank 审中-公开
标题翻译：用于产生具有与移植受体相匹配的HLA抗原的用于移植的细胞的干细胞库，以及制备和使用这种干细胞库的方法
公开(公告)号：US20040091936A1
公开(公告)日：2004-05-13
申请号：US10445195
申请日：2003-05-27
发明人： Michael West
IPC分类号： G01N033/53 , C12N005/08
CPC分类号： C12N5/0606 , A01K2217/05 , A01K2267/0393 , A61K35/12 , C12N15/85 , C12N2510/00 , C12N2517/10
摘要： Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous MHC allele cell lines are provided. These cells are produced preferably from parthenogenic, IVF, or same-species or cross-species nuclear transfer embryos or by de-differentiation of somatic cells by cytoplasm transfer. Methods for using these stem cell banks for producing stem and differentiated cells for therapy, especially acute therapies, and for screening for drugs for disease treatment are also provided.
摘要翻译：提供了可选地可以是转基因的例如由纯合MHC等位基因细胞系组成的干细胞组，优选人的方法。这些细胞优选地由单性生殖，IVF或相同种类或跨物种核转移胚胎或通过细胞质转移去体细胞细胞分化产生。还提供了使用这些干细胞库来产生干细胞和分化细胞用于治疗，特别是急性治疗以及筛选用于疾病治疗的药物的方法。

64. 发明申请

US20040091464A1 Isolated stromal cells for use in the treatment of diseases of the central nervous system 审中-公开
标题翻译：分离的基质细胞用于治疗中枢神经系统疾病
公开(公告)号：US20040091464A1
公开(公告)日：2004-05-13
申请号：US10608997
申请日：2003-06-27
申请人： Philadelphia Health & Education Corporation
发明人： Darwin J. Prockop , David G. Stokes , S. Ausim Azizi
IPC分类号： A61K048/00 , C12N005/08
CPC分类号： A61K35/28 , A61K38/00 , A61K38/177 , A61K38/2264 , A61K38/44 , A61K38/4846 , A61K48/00 , C07K14/4702 , C07K14/61 , C07K14/745 , C07K14/78 , C07K16/2845 , C12N5/0622 , C12N5/0663 , C12N2501/135 , C12N2502/08 , C12N2502/1311 , C12N2506/1353 , C12N2799/027 , C12Y114/16002 , C12Y304/21022 , A61K2300/00
摘要： Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and administering the isolated stromal cells to the central nervous system of the human patient, wherein the presence of the isolated stromal cells in the brain effects treatment of the disease, disorder or condition. Stromal cells which are isolated may be cultured in vitro, they may be genetically engineered to produce therapeutic compounds, and/or they may be pre-differentiated prior to administration into the central nervous system.
摘要翻译：公开了治疗患有中枢神经系统疾病，病症或状况的人类患者的方法。所述方法包括从人供体获得骨髓样品，从骨髓样品中分离基质细胞，以及将分离的基质细胞施用于人类患者的中枢神经系统，其中分离的基质细胞在脑中的存在作用治疗疾病，病症或病症。分离的基质细胞可以在体外培养，它们可以被遗传工程化以产生治疗化合物，和/或它们可以在给予中枢神经系统之前被预先分化。

65. 发明申请

US20040087784A1 Neuronal serine-threonine protein kinase 失效
标题翻译：神经丝氨酸 - 苏氨酸蛋白激酶
公开(公告)号：US20040087784A1
公开(公告)日：2004-05-06
申请号：US10276645
申请日：2003-06-04
发明人： Armin Schneider , Bettina Klaussner , Achim Fischer , Dieter Newrzella , Bernhard Gotz , Moritz Rossner , Gisela Eisenhardt , Rohini Kuner , Annette Trutzel , Birgitta Kammandel , Stephanie Jomana Naim , Markus Schwaninger
IPC分类号： C07H021/04 , C12N009/12 , C12N005/08
CPC分类号： A61K51/0491 , A01K2217/05 , A61K38/00 , C12N9/1205
摘要： The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of apoplexy.
摘要翻译：本发明涉及参与局部缺血后遗症发展的基因及其编码蛋白质。新蛋白质是丝氨酸苏氨酸蛋白激酶，为预防和治疗中风提供了一种新的治疗方法。

66. 发明申请

US20040087017A1 Method for isolation of cells from a solution 审中-公开
标题翻译：从溶液中分离细胞的方法
公开(公告)号：US20040087017A1
公开(公告)日：2004-05-06
申请号：US10600134
申请日：2003-06-20
发明人： Neil H. Bander , Leonard Michael Glode , Chang In Suh
IPC分类号： C12N005/08
CPC分类号： G01N33/56966 , G01N33/57434
摘要： The present invention relates to methods for the isolation of prostatic cancer tumor cells from a biological fluid, using a magnetic activated cell sorter (MACS).
摘要翻译：本发明涉及使用磁激活细胞分选仪（MACS）从生物流体分离前列腺癌肿瘤细胞的方法。

67. 发明申请

US20040082062A1 Method and medium for in vitro culture of human embryos 审中-公开
标题翻译：人类胚胎体外培养的方法和培养基
公开(公告)号：US20040082062A1
公开(公告)日：2004-04-29
申请号：US10631395
申请日：2003-07-31
发明人： Sarah Robertson , Matts F. Wikland , Cecilia Sjoblom
IPC分类号： C12N005/08 , C12N005/02
CPC分类号： C12N15/873 , C12N5/0604 , C12N2501/22
摘要： Disclosed is a medium for the propagation of early stage embryos to blastocyst stage. The medium contains an effective amount of human GM-CSF to increase the percentage of pre-blastocyst embryos which develop to transfer ready blastocysts. Also disclosed is a method of growing early stage human embryos to transfer ready blastocysts. The method includes the step of incubating the embryos in vitro in a culture medium containing an effective amount of human GM-CSF for a time and under conditions to increase the proportion of transfer ready blastocysts. An IVF program that includes the method of growing early stage human embryos to transfer ready blastocysts is also disclosed.
摘要翻译：公开了一种用于将早期胚胎扩展至胚泡期的培养基。该培养基含有有效量的人GM-CSF以增加胚泡胚胎发生转移准备囊胚的百分比。还公开了一种生长早期人类胚胎以转移准备好的囊胚的方法。该方法包括在含有有效量的人GM-CSF的培养基中体外孵育胚胎一段时间和在增加转移准备囊胚比例的条件下的步骤。还公开了一种IVF方案，其中包括增加早期人类胚胎转移准备的囊胚的方法。

68. 发明申请

US20040076646A1 Haptenizing cancer cell components 审中-公开
标题翻译：破坏癌细胞成分
公开(公告)号：US20040076646A1
公开(公告)日：2004-04-22
申请号：US10197376
申请日：2002-07-17
发明人： Michael J. Caplan , H. Kim Bottomly
IPC分类号： A61K039/00 , C12N005/08
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/6012
摘要： The present invention provides techniques and reagents that induce an immune response against tumor cells. According to the invention, tumor cell components are contacted with a sensitizing agent, preferably so that one or more tumor cell components become haptenized with a sensitizing agent, and the resulting combination is administered to a patient suffering from a tumor, so that an anti-tumor immune response is mounted. In some embodiments of the invention, sensitizing agent/tumor cell component compositions are administered directly to a patient; in other embodiments they are administered by means of an antigen presenting cell such as a dendritic cell.
摘要翻译：本发明提供诱导针对肿瘤细胞的免疫应答的技术和试剂。根据本发明，肿瘤细胞成分与敏化剂接触，优选使得一种或多种肿瘤细胞成分与敏化剂半抗原化，并将所得组合施用于患有肿瘤的患者，肿瘤免疫反应被安装。在本发明的一些实施方案中，敏化剂/肿瘤细胞组分组合物直接施用于患者; 在其它实施方案中，它们通过抗原呈递细胞例如树突状细胞施用。

69. 发明申请

US20040072347A1 Generation of fully mature and stable dendritic cells from leukaphereses products for clinical applications 审中-公开
标题翻译：从白细胞产品中产生完全成熟和稳定的树突状细胞用于临床应用
公开(公告)号：US20040072347A1
公开(公告)日：2004-04-15
申请号：US10206003
申请日：2002-07-26
发明人： Gerold Schuler , Beatrice Thurner-Schuler , Thomas Berger
IPC分类号： C12N005/08 , C12M001/00
CPC分类号： C12N5/0639 , A61K2035/124 , C12M23/08 , C12M23/34 , C12M25/00 , C12N2501/02 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： The present invention provides a method for producing mature and stable dendritic cells or immature dendritic cells which comprises cultivating hematopoietic progenitor cells in a sterile cultivating apparatus, an apparatus suitable for said method and a method for preparing peripheral blood mononuclear cells, which are suitable for cultivation of dendritic cells.
摘要翻译：本发明提供了一种生产成熟稳定的树突状细胞或未成熟树突状细胞的方法，包括在无菌培养装置中培养造血祖细胞，适用于所述方法的装置和适于培养的外周血单核细胞的制备方法的树突状细胞。

70. 发明申请

US20040071674A1 Therapeutic treatment of digestive organs with engineered stem cells 审中-公开
标题翻译：用工程干细胞治疗消化器官
公开(公告)号：US20040071674A1
公开(公告)日：2004-04-15
申请号：US10392377
申请日：2003-03-19
发明人： Hiroshi Mashimo , Satish K. Singh
IPC分类号： A61K048/00 , C12N005/06 , C12N005/08
CPC分类号： A61K38/44 , C12Y114/13039
摘要： A method of directly implanting embryonic or adult somatic stem cells into a desired site in a mammal, e.g., into the adult digestive tract, for gene therapy and/or cell replacement is disclosed. Stem cells with their inherent pluripotency have been found to be capable of being implanted directly, e.g., in the digestive system where they become permanently engrafted. The advantage of cultured stem cells is that they can be expanded in vitro and engineered to produce cells that stably express a variety of gene products. Stem cells directly implanted in the gastrointestinal tract according to the method of the invention, have been shown to differentiate into specialized cells of the adult gut (such as nerves, muscles and epithelia). These cells remain at the site of injection and respect local tissue architecture while permanently expressing transfected genes, e.g., nitric oxide synthase, which catalyzes the production of nitric gas in vivo. This approach is particularly well suited for such a diffusible, unstable and transiently bioactive compound as nitric oxide. This technology is useful, e.g., in treating gastrointestinal disorders where key components of a normally functioning bowel are missing, and where local administration of the gene product is thought to be essential.
摘要翻译：公开了将胚胎或成体体细胞干细胞直接植入哺乳动物（例如成人消化道）中用于基因治疗和/或细胞置换的期望部位的方法。已经发现具有其固有多能性的干细胞能够被直接植入，例如在其被永久植入的消化系统中。培养的干细胞的优点是它们可以在体外扩增并被工程化以产生稳定表达多种基因产物的细胞。已经显示根据本发明的方法直接植入胃肠道的干细胞分化成成年肠道（如神经，肌肉和上皮细胞）的特殊细胞。这些细胞保留在注射部位并且尊重局部组织结构，同时永久表达转染的基因，例如催化体内硝酸生成的一氧化氮合酶。这种方法特别适用于像一氧化氮这样的可扩散，不稳定和瞬时生物活性化合物。该技术可用于例如在正常功能性肠道的关键成分缺失以及基因产物的局部给药被认为是必需的胃肠疾病中。

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