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    • 62. 发明申请
    • Novel dequalinium analogs
    • 新型脱喹啉类似物
    • US20030118529A1
    • 2003-06-26
    • US10328693
    • 2002-12-24
    • Research Foundation of the City University of New York
    • Susan A. RotenbergA. David Baker
    • A61K007/42C07D41/02
    • A61Q17/04A61K8/492A61Q17/00
    • A composition for protecting human skin from harmful effects of the sun, the composition comprising a topically effective amount of: (a) a first chemical compound that absorbs ultraviolet light sufficiently to reduce significantly the damage to human skin from harmful effects of ultraviolet light; and (b) a second chemical compound having the formula: (Q-L-Q)wnull2Xynullz or (Q-T)unullXnullv nullwherein: Q represents 4-E-2-R3-1-quinolinium; E represents NR1R2, COO R1, OR1, I, Br, Cl, F, or NO3 N represents a nitrogen atom; R1 and R2 independently represent hydrogen or lower alkyl; R3 represents E, hydrogen or lower alkyl; L represents a chain comprising n atoms, the atoms in the chain being t carbon atoms and 0 to approximately 0.5 t heteroatoms; the minimum value of n is 12; the maximum value of n is 22; T represents hydrogen or a chain comprising m atoms, the atoms in the chain being t carbon atoms and 0 to approximately 0.5 t heteroatoms; the minimum value of m is 6; the maximum value of m is 22; X represents an anion; w represents 1 or 3, y and z represent 1 or 2, with the proviso that 2wnullyz; and u and v represent 1, 2, or 3 with the proviso that unullv.
    • 一种用于保护人体皮肤免受太阳的有害影响的组合物,所述组合物包含局部有效量的:(a)第一化学化合物,其充分地吸收紫外线以显着减少紫外线的有害影响对人体皮肤的损害; 和(b)具有下式的第二化合物:(Q-L-Q)w + 2Xy-z或(Q-T)u + X-v其中:Q表示4-E-2-R3-1-喹啉; E表示NR 1 R 2,COO R 1,OR 1,I,Br,Cl,F或NO 3 N表示氮原子; R1和R2独立地表示氢或低级烷基; R3代表E,氢或低级烷基; L表示包含n个原子的链,链中的原子是t个碳原子和0到约0.5个的杂原子; n的最小值为12; n的最大值为22; T表示氢或包含m个原子的链,链中的原子是t个碳原子和0到约0.5个杂原子; m的最小值为6; m的最大值为22; X表示阴离子; w表示1或3,y和z表示1或2,条件是2w = yz; u和v表示1,2或3,条件是u = v。