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61. 发明申请

US20040229203A1 Compositions and methods for the preservation of living tissues 审中-公开
公开(公告)号：US20040229203A1
公开(公告)日：2004-11-18
申请号：US10832722
申请日：2004-04-27
申请人： BIOSTORE NEW ZEALAND LTD.
发明人： Philippa M. Wiggins , Alexander B. Ferguson , James D. Watson
IPC分类号： A01N001/00 , A01N001/02
CPC分类号： C12N1/04 , A01N1/02 , A01N1/0221
摘要： The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of dihydrogen phosphate, bicarbonate, nitrate, bisulfate and iodide. In one embodiment, preferred for the preservation of platelets, the solutions comprise betaine, sodium chloride and sodium citrate. For the preservation of many living biological materials, the inventive solutions preferably contain a calcium salt selected from the group consisting of calcium sulfate and calcium chloride.

62. 发明申请

US20040224878A1 Fertilization of aged oocytes 审中-公开
标题翻译：老化卵母细胞受精
公开(公告)号：US20040224878A1
公开(公告)日：2004-11-11
申请号：US10276399
申请日：2002-11-15
发明人： Suna Cukurcam , Christa Hegele-Hartung , Thomas Blume , Peter Esperling
IPC分类号： A61K038/18 , A01N001/02
CPC分类号： C12N5/0609 , A61K31/00 , A61K31/575 , C12N2501/11 , C12N2501/392 , C12N2501/70 , C12N2517/10
摘要： The present invention relates to the use of FF-MAS and/or MAS analogues for the fertilization of aged ootcyts.
摘要翻译：本发明涉及FF-MAS和/或MAS类似物用于老化卵母细胞受精的用途。

63. 发明申请

US20040224299A1 Method and apparatus for transferring heat to or from an organ or tissue container 有权
标题翻译：用于将热量传递到器官或组织容器的方法和装置
公开(公告)号：US20040224299A1
公开(公告)日：2004-11-11
申请号：US10815853
申请日：2004-04-02
申请人： ORGAN RECOVERY SYSTEMS
发明人： Jeffrey C. Garland , Douglas Schein , David Walter Wright
IPC分类号： A01N001/02
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247 , Y10S435/809
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces of the cassette.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该装置和方法包括具有传热表面的盒和运输器，所述传热表面布置成在所述运送器中的冷却源和盒的传热表面之间传递热量。

64. 发明申请

US20040223957A1 Compositions, methods and apparatuses for preserving platelets 失效
公开(公告)号：US20040223957A1
公开(公告)日：2004-11-11
申请号：US10865292
申请日：2004-06-09
发明人： David O. Lucas , Vladamir Serebrennikov
IPC分类号： A61K045/00 , A01N001/02
CPC分类号： B01J3/04 , A01N1/021 , A01N1/0226 , A01N1/0231 , A01N1/0252 , A01N1/0257 , A01N1/0289 , B01J3/03
摘要： A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a concentration relative to the plasma such that the medium is in a sufficiently fluent state at about 37null C. to allow platelets to move within the medium and is in a sufficiently gelatinous state at about 5null C. to substantially prevent platelets from moving freely within the medium; and platelets.

65. 发明申请

US20040219507A1 Apparatus for and methods of preparing sperm 审中-公开
标题翻译：精子的制备方法和制备方法
公开(公告)号：US20040219507A1
公开(公告)日：2004-11-04
申请号：US10481536
申请日：2004-06-03
发明人： Farhang Abed
IPC分类号： A01N001/02
CPC分类号： A61B17/43
摘要： A device (12) for separating motile sperm from a sperm-containing sample of semen comprises a tubular conduit (14) with a constrictor (20) therein. The constrictor is dimensioned to establish capillary flow of fluid therethrough. The sample is deposited in the larger cross-section upstream end (16) of the device, together with a fluid medium which entrains the semen through the constriction. The motile sperm, having passed through the constriction, swim against the flow and collect in a harvesting zone at the distal end of the conduit, from where they can be aspirated. Non-motile sperm are flushed from the device.

66. 发明申请

US20040202993A1 Apparatus and method for organ preservation and transportation 审中-公开
标题翻译：器官保存和运输的装置和方法
公开(公告)号：US20040202993A1
公开(公告)日：2004-10-14
申请号：US10410954
申请日：2003-04-10
发明人： Ramon E. Poo , Camillo Ricordi
IPC分类号： A01N001/00 , A01N001/02
CPC分类号： A01N1/0263 , A01N1/02
摘要： A method for storing organs, cells, and tissues, includes the steps of providing a gas impermeable container; providing a preservation solution containing dissolved oxygen; placing the preservation solution into the container with the organ, cell or tissue; and hermetically closing said container. A system for storing organs, cells, and tissue includes a gas impermeable organ container for the organs, cells and tissue. A hermetically sealable solution container is provided for storing a preservation solution. The preservation solution contains dissolved oxygen. A dispensing structure is provided for placing the solution into the organ container. The preservation solution can include an oxygen-carrier solution and UW solution. The oxygen-carrier solution can be perfluorocarbon.
摘要翻译：用于储存器官，细胞和组织的方法包括提供不透气容器的步骤; 提供含有溶解氧的保存溶液; 将保存液置于器皿，细胞或组织的容器中; 并密封所述容器。用于储存器官，细胞和组织的系统包括用于器官，细胞和组织的不透气器官容器。提供一种用于储存保存溶液的气密密封的溶液容器。保存液含有溶解氧。提供了用于将溶液置于器官容器中的分配结构。保存溶液可以包括氧载体溶液和UW溶液。氧载体溶液可以是全氟化碳。

67. 发明申请

US20040171139A1 Fabricated biofilm storage device 审中-公开
标题翻译：制造生物膜储存装置
公开(公告)号：US20040171139A1
公开(公告)日：2004-09-02
申请号：US10668600
申请日：2003-09-24
发明人： Angela M. Belcher , Seung-Wuk Lee , Brent L. Iverson , Soo-Kwan Lee
IPC分类号： A01N001/02 , C12M001/34
CPC分类号： A01N1/0231 , A01N1/02 , C12M23/20 , C12M45/22
摘要： The present invention includes a method and composition of storing and preserving biofilms for input and output of high-density information. One form of the present invention is a fabricated biofilm storage device with a biologic material applied to a substrate to form, e.g., a dry thin film stable at room temperature for extended periods of time. Another form of the present invention is a method of fabricating a biofilm storage device in which a biologic material is applied to a substrate under conditions that promote alignment of the biologic material on the substrate. The composition, method, and kit of the present invention have universal application in biologics, magnetics, optics and microelectronics.
摘要翻译：本发明包括存储和保存用于输入和输出高密度信息的生物膜的方法和组合物。本发明的一种形式是制造的生物膜存储装置，其具有施加到基底的生物材料以形成例如在室温下长时间稳定的干薄膜。本发明的另一形式是制造生物膜存储装置的方法，其中在促进生物材料在基底上的对准的条件下将生物材料施加到基底上。本发明的组合物，方法和试剂盒在生物制剂，磁性材料，光学和微电子学方面具有普遍的应用。

68. 发明申请

US20040170950A1 Organ preservation apparatus and methods 审中-公开
标题翻译：器官保存仪器及方法
公开(公告)号：US20040170950A1
公开(公告)日：2004-09-02
申请号：US10756795
申请日：2004-01-13
发明人： Samuel D. Prien
IPC分类号： A01N001/02
CPC分类号： A01N1/0247 , A01N1/02
摘要： This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a recipient. A chilled oxygenated nutrient solution can be pumped through the vascular bed of the organ after excision of the organ from the donor and during transport. The device of the present invention uses flexible permeable tubing to oxygenate the perfusion fluid while the CO2 produced by the organ diffuses out of the perfusion fluid. One pressurized two-liter nullCnull cylinder can supply oxygen for up to 34 hours of perfusion time. The device can use a simple electric pump driven by a storage battery to circulate the perfusion fluid through the organ being transported. The vessel containing the organ to be transported can be held at a suitable temperature by a chiller.
摘要翻译：本发明是一种可运输的器官保存系统，其大大增加了器官可以维持生存以成功植入接受者的时间。冷冻氧合营养液可以在器官从供体切除后和运输过程中泵入器官的血管床。本发明的装置使用柔性可渗透管来对灌注流体进行氧化，同时由器官产生的CO 2从灌注液中扩散出来。一个加压的两升“C”气瓶可以供给氧气长达34小时的灌注时间。该装置可以使用由蓄电池驱动的简单电动泵来使灌注流体循环通过被运送的器官。容纳运输器官的容器可以通过冷却器保持在合适的温度。

69. 发明申请

US20040161735A1 Cryopreservation of oocytes and embryos and methods for producing animals involving the same 审中-公开
标题翻译：卵母细胞和胚胎的冷冻保存及涉及其的动物的生产方法
公开(公告)号：US20040161735A1
公开(公告)日：2004-08-19
申请号：US10777149
申请日：2004-02-13
申请人： THE UNIVERSITY OF QUEENSLAND , BRESAGEN LIMITED
发明人： Mark Brenton Nottle , Ranald Cameron , Luke Francis Sharkerley Beebe , Alan Weaver Blackshaw , Hiroshi Nagashima
IPC分类号： A01N001/02 , A01K067/027
CPC分类号： C12N15/873 , A01N1/02 , A01N1/0221
摘要： A method for the cryopreservation of oocytes or embryos, which comprises centrifugation of oocytes or embryos to polarize cytoplasmic lipid outside the oocyte or embryonic cells, subjecting the oocytes or embryos to low temperature conditions in the presence of a cryoprotectant which results in freezing of the oocytes or embryos prior to lipid depolarization, followed by low temperature storage of the frozen lipid polarized oocytes or embryos are described, as are oocytes and embryos produced according to such methods, and methods for producing live animals.
摘要翻译：一种用于卵母细胞或胚胎的低温保存的方法，其包括将卵母细胞或胚胎离心以使卵母细胞或胚胎细胞外的细胞质脂质极化，使卵母细胞或胚胎在存在导致卵母细胞冻结的冷冻保护剂的情况下进行低温条件或脂质去极化之前的胚胎，随后是冷冻的脂质极化卵母细胞或胚胎的低温储存，以及根据这些方法制备的卵母细胞和胚胎以及用于生产活的动物的方法。

70. 发明申请

US20040132002A1 Methods for preserving blood 审中-公开
标题翻译：保存血液的方法
公开(公告)号：US20040132002A1
公开(公告)日：2004-07-08
申请号：US10666519
申请日：2003-09-17
发明人： Jackson Streeter
IPC分类号： A01N001/02
CPC分类号： A61N5/0613 , A61N2005/007 , A61N2005/0652 , A61N2005/0659 , A61N2005/067
摘要： Methods for preserving donated blood and blood products are described, including embodiments which involve the application of a preservation effective amount of electromagnetic energy from a laser or other electromagnetic energy source, the energy having a wavelength in the visible to near-infrared wavelength range and delivering the effective amount of energy includes selecting a predetermined power density (mW/cm2) of energy to deliver to the blood. The methods can be used in combination with other blood preservation techniques including hypothermic storage and the use of preservative compositions.
摘要翻译：描述了用于保存捐献的血液和血液制品的方法，包括涉及从激光或其它电磁能源施加保存有效量的电磁能量的实施例，所述能量具有可见至近红外波长范围的波长并递送能量的有效量包括选择预定功率密度（mW / cm 2）的能量输送到血液。该方法可以与其他保血技术结合使用，包括低温储存和使用防腐剂组合物。

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