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61. 发明申请

US20130079239A1 METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND INVOLVED IN PAIN AS WELL AS METHODS OF DIAGNOSING ALGESIA 审中-公开
标题翻译：方法和使用相关的化学物质参与疼痛参与诊断阿尔及利亚的方法
公开(公告)号：US20130079239A1
公开(公告)日：2013-03-28
申请号：US13583363
申请日：2011-03-17
申请人： Mathias Gebauer , Martin Michaelis , Danping Ding-Pfennigdorff , Anke M. Schulte , Daniel Ziemek , Christiane Metz-Weidmann
发明人： Mathias Gebauer , Martin Michaelis , Danping Ding-Pfennigdorff , Anke M. Schulte , Daniel Ziemek , Christiane Metz-Weidmann
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N2500/00 , G01N2800/2842
摘要： The present invention relates to a method of identifying a compound involved in pain, the use of Ifi205 nucleic acid or Ifi205 protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same.
摘要翻译：本发明涉及一种鉴定涉及疼痛的化合物的方法，使用Ifi205核酸或Ifi205蛋白鉴别涉及疼痛的化合物以及诊断涉及其的疼痛的方法。

62. 发明申请

US20130079238A1 METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND INVOLVED IN PAIN AS WELL AS METHODS OF DIAGNOSING ALGESIA 审中-公开
标题翻译：方法和使用相关的化学物质参与疼痛参与诊断阿尔及利亚的方法
公开(公告)号：US20130079238A1
公开(公告)日：2013-03-28
申请号：US13583351
申请日：2011-03-17
申请人： Mathias Gebauer , Martin Michaells , Danping Ding-Pfennigdorff , Anke M. Schulte , Daniel Ziemek , Christiane Metz-Weidmann
发明人： Mathias Gebauer , Martin Michaells , Danping Ding-Pfennigdorff , Anke M. Schulte , Daniel Ziemek , Christiane Metz-Weidmann
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N2500/00 , G01N2800/2842
摘要： The present invention relates to a method of identifying a compound involved in pain, the use of Irf8 nucleic acid or Irf8 protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same.
摘要翻译：本发明涉及鉴定涉及疼痛的化合物的方法，使用Irf8核酸或Irf8蛋白来鉴别涉及疼痛的化合物以及诊断涉及其的疼痛的方法。

63. 发明申请

US20130053265A1 METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND INVOLVED IN PAIN AS WELL AS METHODS OF DIAGNOSING ALGESIA 审中-公开
标题翻译：方法和使用相关的化学物质参与疼痛参与诊断阿尔及利亚的方法
公开(公告)号：US20130053265A1
公开(公告)日：2013-02-28
申请号：US13521545
申请日：2011-01-20
申请人： Mathias Gebauer , Martin Michaeils , Danping Ding-Pfennigdorff , Anke M. Schulte , Daniel Ziemek , Christiane Metz-Weidmann
发明人： Mathias Gebauer , Martin Michaeils , Danping Ding-Pfennigdorff , Anke M. Schulte , Daniel Ziemek , Christiane Metz-Weidmann
IPC分类号： C40B30/06 , C12Q1/02 , G01N33/566 , C12Q1/68 , C40B30/04
CPC分类号： G01N33/5008 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/2842
摘要： The present invention relates to a method of identifying a compound involved in pain, the use of Lrrfip1 nucleic acid or Lrrfip1 protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same.
摘要翻译：本发明涉及鉴定涉及疼痛的化合物的方法，使用Lrrfip1核酸或Lrrfip1蛋白来鉴别涉及疼痛的化合物以及诊断涉及其的疼痛的方法。

64. 发明申请

US20110165129A1 Ameliorating Nervous Systems Disorders 审中-公开
标题翻译：改善神经系统疾病
公开(公告)号：US20110165129A1
公开(公告)日：2011-07-07
申请号：US12991367
申请日：2009-05-05
申请人： Arnold Kriegstein , John L.R. Rubenstein , Scott C. Baraban , Arturo Alvarez-Buylla
发明人： Arnold Kriegstein , John L.R. Rubenstein , Scott C. Baraban , Arturo Alvarez-Buylla
IPC分类号： A61K35/12 , A61P25/00
CPC分类号： A61K35/30 , A61K9/0019 , A61K9/0085 , C12N5/0618 , C12N5/0622 , C12N2506/02 , G01N2800/28 , G01N2800/2835 , G01N2800/2842
摘要： The present disclosure provides methods for the treatment of a mammal having a neurological condition, disease, or injury. The methods involve increasing the number of functional GABAergic interneurons at or near the site of the neurological disease, injury, or condition.
摘要翻译：本公开提供了用于治疗具有神经病症，疾病或损伤的哺乳动物的方法。这些方法涉及增加神经系统疾病，损伤或病症部位处或附近的功能性GABA能中间神经元的数量。

65. 发明申请

US20110160434A1 FIBROMYALGIA TEST METHOD 审中-公开
标题翻译：纤维蛋白测试方法
公开(公告)号：US20110160434A1
公开(公告)日：2011-06-30
申请号：US12996649
申请日：2009-07-06
申请人： Kusuki Nishioka , Tomohiro Kato , Hiroki Fujisawa
发明人： Kusuki Nishioka , Tomohiro Kato , Hiroki Fujisawa
IPC分类号： C07K14/00 , H01J49/26 , A61B5/00
CPC分类号： G01N33/6851 , C07K14/472 , C07K14/75 , C07K14/765 , C07K14/775 , C07K14/8139 , G01N2800/2842
摘要： A method for diagnosing or testing for fibromyalgia with a specific peptide in the blood as an indicator, as well as a method for effectively evaluating or assessing a fibromyalgia drug with the peptide as an indicator. A method for diagnosing or testing for fibromyalgia or for evaluating or assessing a fibromyalgia drug, by subjecting a patient's serum to peptide analysis using as an indicator (biomarker) a peptide that demonstrates a specific expression amount in the blood of a fibromyalgia patient.
摘要翻译：用于以血液中的特定肽诊断或测试纤维肌痛的方法作为指标，以及用于作为指示剂有效评估或评估纤维肌痛药物的方法。用于诊断或测试纤维肌痛或用于评估或评估纤维肌痛药物的方法，通过使患者的血清进行肽分析，所述肽分析使用证明纤维肌痛患者血液中特定表达量的指示剂（生物标志物）。

66. 发明授权

US07825231B2 Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy 有权
标题翻译：酰胺化肽合成和体内递送的方法：内啡肽-2用于疼痛治疗
公开(公告)号：US07825231B2
公开(公告)日：2010-11-02
申请号：US11445837
申请日：2006-06-01
申请人： Darren P. Wolfe , Joseph C. Glorioso , David J. Fink
发明人： Darren P. Wolfe , Joseph C. Glorioso , David J. Fink
IPC分类号： C07H21/04 , A61K31/711 , C12N15/12 , C12N15/62
CPC分类号： C07K5/1016 , A61K48/005 , C07K7/22 , C07K14/67 , C07K14/695 , C07K14/70 , C07K2319/50 , C07K2319/60 , C12N15/86 , C12N2710/16643 , G01N33/6893 , G01N33/9486 , G01N2800/2842
摘要： The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.
摘要翻译：本发明提供了一种表达盒，其包含编码人前脑啡肽的氨基酸1-99的DNA序列，编码侧翼为二碱基切割位点的羧基酰胺化肽的前体的DNA序列和任选的编码标记蛋白的DNA序列（例如增强型绿色荧光蛋白（GFP））都在可操作的连锁和启动子的控制下。当羧基酰胺化肽的编码前体是阿片受体的激动剂时，本发明还提供了通过将包含这种表达盒的基因转移载体给予患者来治疗神经性疼痛的方法。本发明还提供了一种检测具有所需效果的肽的方法，包括将编码羧基酰胺化肽的一种或多种前体的DNA序列文库导入宿主细胞; 表达在文库中编码的羧基酰胺化肽以提供表达产物; 并从多肽表达产物筛选出所需的效果。

67. 发明申请

US20100272648A1 Methods of Identifying Improved NMDA Receptor Antagonists 审中-公开
标题翻译：识别改进的NMDA受体拮抗剂的方法
公开(公告)号：US20100272648A1
公开(公告)日：2010-10-28
申请号：US12772798
申请日：2010-05-03
申请人： Dennis C. Liotta , Raymond J. Dingledine , Stephen F. Traynelis
发明人： Dennis C. Liotta , Raymond J. Dingledine , Stephen F. Traynelis
IPC分类号： A61K49/00 , C12Q1/02
CPC分类号： G01N33/9406 , A61K49/0008 , G01N33/5058 , G01N33/5088 , G01N33/84 , G01N2800/2835 , G01N2800/2842 , G01N2800/2857 , G01N2800/2871
摘要： Processes are provided for the identification a compound that is useful to treat or prevent a disorder that lowers the pH in a region of affected tissue comprising assessing the difference in potency, or potency boost, of the compound at physiological pH versus disorder-induced pH in a cell that expresses a human NMDA receptor. The assessment of potency boost can include measuring an IC50 of a compound at physiological pH and at disorder-induced pH (the “potency boost”) until a 95% confidence interval for the potency boost does not change more than 15% with the addition of a new experiment, wherein the measurements are repeated at least 5 times. The processes can be used for the selection of safe NMDA receptor antagonists for the treatment or prevention of a human disorder that lowers the pH in a region affected tissue. Such disorders include, but are not limited to, neuropathic pain, ischemic, Parkinsons disease, epilepsy and traumatic brain injuries.
摘要翻译：提供了用于鉴定化合物的方法，该化合物可用于治疗或预防降低受影响组织的区域中的pH的病症，包括评估化合物在生理pH下与药物诱导的pH下的效力或效力升高的差异表达人NMDA受体的细胞。效力增强的评估可以包括测量化合物在生理pH和无序诱导的pH（“效力促进”）下的IC 50，直到效力增强的95％置信区间随着添加一个新的实验，其中测量重复至少5次。该方法可用于选择安全NMDA受体拮抗剂，用于治疗或预防降低受影响组织区域pH的人类病症。这些病症包括但不限于神经性疼痛，缺血性，帕金森病，癫痫和创伤性脑损伤。

68. 发明授权

US07795413B2 Nucleic acids encoding human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors 有权
标题翻译：编码人抗NGF中和抗体的核酸作为选择性NGF途径抑制剂
公开(公告)号：US07795413B2
公开(公告)日：2010-09-14
申请号：US11767326
申请日：2007-06-22
申请人： Kenneth D. Wild, Jr. , James J. S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
发明人： Kenneth D. Wild, Jr. , James J. S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
IPC分类号： C07H21/04 , C12N15/00 , C12N5/06 , A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
摘要翻译：本发明提供与人神经生长因子（NGF）相互作用或结合的抗体，从而中和NGF的功能。本发明还提供了所述抗体的药物组合物和中和NGF功能的方法，特别是通过施用药学上有效量的抗NGF抗体来治疗NGF相关疾病（例如慢性疼痛）。还提供了使用抗NGF抗体检测样品中NGF量的方法。

69. 发明授权

US07794949B2 Biomarkers of chronic pelvic pain syndrome 有权
标题翻译：慢性盆腔疼痛综合征的生物标志物
公开(公告)号：US07794949B2
公开(公告)日：2010-09-14
申请号：US11115747
申请日：2005-04-27
申请人： Anthony J. Schaeffer , Alisa E. Koch
发明人： Anthony J. Schaeffer , Alisa E. Koch
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2333/52 , G01N2800/2842 , G01N2800/36
摘要： The present invention provides biomarkers of chronic pelvic pain syndrome for use in diagnosis, drug screening, therapy monitoring, research and therapeutic applications. In particular, the present invention provides MCP-1 and MIP-1α as biomarkers of chronic pelvic pain syndrome.
摘要翻译：本发明提供用于诊断，药物筛选，治疗监测，研究和治疗应用的慢性盆腔疼痛综合征的生物标志物。特别地，本发明提供MCP-1和MIP-1α作为慢性盆腔疼痛综合征的生物标志物。

70. 发明申请

US20100004171A1 Therapeutic Methods for Neuropathic Pain 审中-公开
标题翻译：神经性疼痛治疗方法
公开(公告)号：US20100004171A1
公开(公告)日：2010-01-07
申请号：US12375634
申请日：2007-08-08
申请人： Nicolas G. Bazan , Jian-Guo Cui
发明人： Nicolas G. Bazan , Jian-Guo Cui
IPC分类号： A61K38/16 , A61K31/167 , C12Q1/02
CPC分类号： A61K38/1709 , G01N33/5058 , G01N2333/4722 , G01N2800/2842
摘要： The agrin protein was shown to be important in preventing the development of neuropathic pain, as well as in treating neuropathic pain. Both agrin protein and gene expression were shown to be down-regulated in mammals with neuropathic pain. Increasing either agrin gene expression or protein resulted in a decrease in the development of neuropathic pain. Agrin protein or the C-terminal agrin fragments can be administered in a number of ways, preferably by intrathecal injection. In addition, agrin can be increased by administering a compound shown to affect agrin gene expression or agrin protein concentration, e.g., SCP-I and SCP-M1 (also known as JMM). Agrin protein decrease was shown to be prevented by administering an NMDA receptor antagonist, e.g., MK801. Agrin and a C-terminal agrin fragment also induced phosphorylation of the NMDA receptor subunit NR1 at the serine residue site which led to suppression of neuropathic pain.
摘要翻译：显示出集聚蛋白蛋白对于预防神经性疼痛的发展以及治疗神经性疼痛是重要的。在具有神经性疼痛的哺乳动物中，集聚蛋白和基因表达都显示出下调。增加集聚蛋白基因表达或蛋白质导致神经性疼痛发展的减少。集聚蛋白或C末端集聚蛋白片段可以多种方式施用，优选通过鞘内注射。此外，通过施用显示影响集聚蛋白基因表达或集聚蛋白浓度的化合物，例如SCP-1和SCP-M1（也称为JMM），可以增加集聚蛋白。通过施用NMDA受体拮抗剂（例如MK801），可以防止集聚蛋白的降低。集聚蛋白和C末端集聚蛋白片段还诱导丝氨酸残基部位的NMDA受体亚基NR1的磷酸化，导致神经性疼痛的抑制。

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