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61. 发明授权

US10488329B2 Calibration apparatus, calibration curve creation method, and independent component analysis method 有权
公开(公告)号：US10488329B2
公开(公告)日：2019-11-26
申请号：US15708610
申请日：2017-09-19
申请人： Seiko Epson Corporation
发明人： Tsukasa Eguchi , Hideto Ishiguro , Hikaru Kurasawa
IPC分类号： G01N21/27 , G01N21/359
CPC分类号： G01N21/274 , G01N21/359 , G01N2201/12746
摘要： A calibration data acquisition unit uses an equation X=YW in which an optical spectrum matrix X is the same as a product between a component natural spectrum matrix Y and a component amount matrix X, performs independent component analysis in which column vectors of the component amount matrix W are treated as independent components so as to determine the component natural spectrum matrix Y, and employs row vectors of a general inverse matrix Y† of the component natural spectrum matrix Y as component calibration spectra corresponding to a plurality of components. A calibration curve is created by using a target component calibration spectrum corresponding to a target component.

62. 发明申请

US20180327826A1 Systems and Methods for Calibration Using Dye Signal Amplification 审中-公开
公开(公告)号：US20180327826A1
公开(公告)日：2018-11-15
申请号：US15979129
申请日：2018-05-14
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Stephen J. Gunstream
IPC分类号： C12Q1/6851 , G01N21/64 , G06F19/22 , G01N21/27
CPC分类号： C12Q1/6851 , G01N21/274 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2021/6441 , G01N2201/12 , G01N2201/12746 , G06F19/22 , C12Q2545/113 , C12Q2545/101
摘要： The present teachings relate to a method of generating calibration information during a real-time polymerase chain reaction (RT-PCR) or other amplification reaction. A sample well plate or other support can contain one or more dyes or other reference materials that are subjected to the same RT-PCR thermal cycles or other conditions used to conduct amplification or other reactions on a biological sample. A set of maxima values and a set of minimum values, and/or other calibration information useful for adjusting emission data for sample dyes can be recorded, for example, for 10 cycles, 20 cycles, or each cycle of a complete RT-PCR run. Such testing of dye response under realistic operating conditions can enable more accurate characterization of plate, dye, filter, or instrument response and therefore more accurate calibration corrections and other and/or adjustments.

63. 发明申请

US20180156721A1 PORTABLE CORTISOL SENSING PLATFORM BASED ON COMPACT UV LIGHT SOURCES 审中-公开
公开(公告)号：US20180156721A1
公开(公告)日：2018-06-07
申请号：US15668760
申请日：2017-08-04
申请人： Nezih Pala , Raju Sinha , Phani Kiran Vabbina
发明人： Nezih Pala , Raju Sinha , Phani Kiran Vabbina
IPC分类号： G01N21/33 , G01N33/487 , G01N21/03
CPC分类号： G01N21/33 , A61B5/0002 , A61B5/14546 , A61B5/1455 , A61B5/6898 , G01N21/03 , G01N33/487 , G01N2201/12746
摘要： Systems and methods for detecting a biological analyte are provided. The biological analyte can be, for example, cortisol. Detection can be achieved without external labels/mediators. Microfluidic systems can be incorporated into the optical sensor for enhanced point-of-care applications. The sensor can be used in a variety of low-power electronics for wearable applications.

64. 发明授权

US09952234B2 Calibration method for photometry 有权
公开(公告)号：US09952234B2
公开(公告)日：2018-04-24
申请号：US14966804
申请日：2015-12-11
申请人： Roche Diagnostics Operations, Inc.
发明人： Martin Horstmann , Fridl Lang
IPC分类号： G01N33/96 , G01N21/75 , G01N35/00 , G01J1/02 , G01N21/27 , G01N33/487
CPC分类号： G01N33/96 , G01J1/0295 , G01N21/274 , G01N21/75 , G01N33/487 , G01N35/00693 , G01N2201/12746 , G01N2496/00
摘要： A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

65. 发明授权

US09809849B2 Methods and systems for pure dye instrument normalization 有权
公开(公告)号：US09809849B2
公开(公告)日：2017-11-07
申请号：US15016713
申请日：2016-02-05
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Jeffrey Marks
IPC分类号： G01N21/64 , C12Q1/68 , G01N21/27
CPC分类号： C12Q1/686 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/04 , G01N2201/068 , G01N2201/12746
摘要： The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

66. 发明申请

US20170097301A1 METHOD FOR OPTIMISATION OF DETECTION WAVELENGTHS FOR MULTI-GAS DETECTION 审中-公开
公开(公告)号：US20170097301A1
公开(公告)日：2017-04-06
申请号：US15279955
申请日：2016-09-29
申请人： Commissariat A L'Energie Atomique et aux Energies Alternatives
发明人： Anthony LEFEBVRE , Sebastien BECKER , Salim BOUTAMI
IPC分类号： G01N21/27 , G01N21/61 , G01N21/3504
CPC分类号： G01N21/274 , G01N21/31 , G01N21/3504 , G01N21/61 , G01N2021/3133 , G01N2021/3137 , G01N2201/12746
摘要： Method for optimising the values of n detection wavelengths of an optical gas sensor capable of carrying out detection of n different gases, comprising the implementation of the following steps: a) calculation of a value of a determinant of an absorptivity matrix ε whose coefficients represent the spectral absorptivity of each of the n gases at n detection wavelengths, step a) being repeated several times, each time modifying at least one of said n detection wavelengths and such that the values of said n detection wavelengths are comprised within a range of values for which the spectral absorptivity of at least one of the n gases is non-zero; b) determination of the values of said n detection wavelengths for which the value of the determinant of the absorptivity matrix ε corresponds to the maximum value amongst the set of previously calculated values.

67. 发明申请

US20160103075A1 WIRELESS REMOTE OPTICAL MONITORING SYSTEM 审中-公开
标题翻译：无线远程光学监控系统
公开(公告)号：US20160103075A1
公开(公告)日：2016-04-14
申请号：US14878445
申请日：2015-10-08
申请人： Detekt Biomedical LLC.
发明人： Damon Vincent Borich , Alejandro Silveyra , Andrea Grbavac , Karen Borich
IPC分类号： G01N21/78 , H04W84/18
CPC分类号： G01N21/78 , G01N21/276 , G01N21/8483 , G01N2201/0221 , G01N2201/12746 , H04W84/18
摘要： An optical analysis system is disclosed. The optical analysis system includes a wireless optical device. The wireless optical device includes a body with a port that receives a test strip. A sensor array may be positioned within the body that aligns with at least part of the test strip. The sensor array may include a plurality of individually addressable sensors and at least one illumination element associated with each sensor. The at least one illumination element may illuminate a discrete portion of the test strip that is aligned with the individually addressable sensor associated with the at least one illumination element. The sensors may independently assess reflected illumination signals from the discrete portions of the test strip aligned with the individually addressable sensors.
摘要翻译：公开了一种光学分析系统。光学分析系统包括无线光学装置。无线光学设备包括具有接收测试条的端口的主体。传感器阵列可以位于体内，与至少部分测试条对准。传感器阵列可以包括多个可独立寻址的传感器和与每个传感器相关联的至少一个照明元件。所述至少一个照明元件可以照亮与所述至少一个照明元件相关联的可单独寻址的传感器对准的测试条的离散部分。传感器可以独立地评估来自与单独可寻址传感器对准的测试条的离散部分的反射照明信号。

68. 发明申请

US20160097785A1 CALIBRATION METHOD FOR PHOTOMETRY 有权
标题翻译：用于光度测定的校准方法
公开(公告)号：US20160097785A1
公开(公告)日：2016-04-07
申请号：US14966804
申请日：2015-12-11
申请人： Roche Diagnostics Operations, Inc.
发明人： Martin Horstmann , Fridl Lang
IPC分类号： G01N33/96 , G01N21/75 , G01J1/02 , G01N35/00
CPC分类号： G01N33/96 , G01J1/0295 , G01N21/274 , G01N21/75 , G01N33/487 , G01N35/00693 , G01N2201/12746 , G01N2496/00
摘要： A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.
摘要翻译：一种用于确定生物样品的物理性质的方法。该方法包括以下步骤：使用具有第一测光模块的自动分析仪获取试剂的第一批次的一组初步校准信号; 使用具有第二测光模块的校准分析仪获取所述第一批试剂的参考信号集; 通过从所述初步校准信号中减去所述参考信号组来确定一组模块特定组件; 使用第二测光模块获取第二批试剂的许多特定信号集合; 使用所述一组模块特定组件和所述特定的信号集来确定所述第一测光模块的批量校准; 使用第一测光模块和第二批试剂获取生物样品的测量信号; 以及使用测量信号和批次校准来确定生物样品的物理性质。

69. 发明申请

US20160040222A1 Systems And Methods For Baseline Correction Using Non-Linear Normalization 审中-公开
标题翻译：使用非线性规范化进行基线校正的系统和方法
公开(公告)号：US20160040222A1
公开(公告)日：2016-02-11
申请号：US14798709
申请日：2015-07-14
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Stephen J. Gunstream
IPC分类号： C12Q1/68 , G06F19/22 , G01N21/64
CPC分类号： C12Q1/6851 , G01N21/274 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2021/6441 , G01N2201/12 , G01N2201/12746 , G16B30/00 , C12Q2545/113 , C12Q2545/101
摘要： Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained.
摘要翻译：提供了系统和方法，用于校准在聚合酶链式反应（PCR），扩增反应，测定，过程或其他反应期间收集的排放数据或其他信息信号。可以在单个循环或运行期间或在多次反应运行期间实现多个可检测材料的校准。来自样品支架的每个孔，容器或其他支撑区域的读数不必采取。内插可用于确定未使用或未知的使用检测到的发射数据或其他检测到的信息信号的发射数据或其他信息信号的值。通过校准检测到的发射数据和内插数据，可以获得更准确的发射数据或信息信号读数。

70. 发明授权

US09016573B2 Sensor unit and measurement method 有权
标题翻译：传感器单元和测量方法
公开(公告)号：US09016573B2
公开(公告)日：2015-04-28
申请号：US13471917
申请日：2012-05-15
申请人： Achim Stangelmayer , Damian Andrzejewski
发明人： Achim Stangelmayer , Damian Andrzejewski
IPC分类号： G06K7/10 , G06T7/40
CPC分类号： G06T7/40 , G01N21/274 , G01N21/78 , G01N2021/7786 , G01N2201/1211 , G01N2201/1218 , G01N2201/12746
摘要： A sensor unit is disclosed which includes a sensor and an information module. The sensor exhibits an optical behavior dependent on at least one variable of a sample. Sensor related information can be emitted by the information module as optical radiation. In embodiments the sensor related information includes calibration data for the sensor. The sensor related information may additionally include identification data for the sensor. In embodiments the information module measures at least one ambient parameter, and emits the measurement value in an optical signal. The measurement value is taken into account when determining at least one variable of a sample by means of the sensor unit. In embodiments the information module may also transmit status information of the sensor unit. Furthermore a method for determining a variable of a sample with a sensor unit and a measurement system is disclosed.
摘要翻译：公开了一种传感器单元，其包括传感器和信息模块。传感器表现出取决于样品的至少一个变量的光学行为。传感器相关信息可由信息模块作为光辐射发射。在实施例中，传感器相关信息包括传感器的校准数据。传感器相关信息可另外包括传感器的识别数据。在实施例中，信息模块测量至少一个环境参数，并且在光信号中发射测量值。当通过传感器单元确定样品的至少一个变量时，考虑测量值。在实施例中，信息模块还可以传送传感器单元的状态信息。此外，公开了一种用传感器单元和测量系统确定样品的变量的方法。

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