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61. 发明公开

EP1546387A2 MICROARRAY SYNTHESIS AND ASSEMBLY OF GENE-LENGTH POLYNUCLEOTIDES 有权转让
标题翻译： HAVING多核苷酸的基因长度的MICRO阵列合成和组装
公开(公告)号：EP1546387A2
公开(公告)日：2005-06-29
申请号：EP03752373.5
申请日：2003-09-12
申请人： Combimatrix Corporation
发明人： OLEINIKOV, Andrew, V.
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1068 , B01J19/0046 , B01J2219/00378 , B01J2219/00385 , B01J2219/00432 , B01J2219/00454 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00626 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00713 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B50/14 , C40B80/00
摘要： The invention relates to a process for assembling a polynucleotide from a plurality of oligonucleotides comprising: (a) synthesizing or spotting a plurality of different oligonucleotides on a microarray device or bead device having a solid or porous surface, wherein the plurality of oligonucleotides are attached to the solid or porous surface, and wherein each oligonucleotide comprises a sequence region of from about 10 to about 50 bases that is the same or substantially the same as a sequence region of another oligonucleotide; (b) forming an oligonucleotide complementary to a first oligonucleotide by extending a first primer, wherein said primer is complementary to a portion of said first oligonucleotide; (c) is associating said complementary oligonucleotide from said first oligonucleotide and annealing said complementary oligonucleotide to another oligonucleotide comprising a sequence region that is the same or substantially the same as a sequence region of said first oligonucleotide; (d) repeating the primer extension cycles of step (c) to produce a full-length complementary polynucleotide; and (e) amplifying the assembled full length complementary polynucleotide to produce a full length polynucleotide in desired quantities.

62. 发明公开

EP1352243A2 PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS 审中-公开
标题翻译： PERFLUORSULFONYLHALOGENIDE及其近缘种作为修饰的聚合物载体
公开(公告)号：EP1352243A2
公开(公告)日：2003-10-15
申请号：EP02714736.2
申请日：2002-01-11
申请人： Amersham plc
发明人： HOLMES, Christopher , PAN, Yijun
IPC分类号： G01N33/543
CPC分类号： C40B50/14 , B01J19/0046 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3257 , B01J31/10 , B01J31/1658 , B01J31/2208 , B01J31/2409 , B01J2219/00283 , B01J2219/00454 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/0072 , B01J2219/00738 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2531/824 , C07B2200/11 , C07C309/10 , C07C309/24 , C07C309/82 , C07C309/84 , C07F7/0834 , C40B60/14 , C40B80/00 , C40B99/00
摘要： Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided.

63. 发明授权

EP0990047B1 METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACIDS BY MASS SPECTROMETRY 失效
标题翻译：方法和连接的核酸通过质量分析
公开(公告)号：EP0990047B1
公开(公告)日：2003-05-14
申请号：EP98936928.5
申请日：1998-07-22
申请人： Qiagen Genomics, Inc.
发明人： VAN NESS, Jeffrey , TABONE, John, C. , HOWBERT, Jeffry , MULLIGAN, John, T.
IPC分类号： C12Q1/68
CPC分类号： C40B70/00 , B01J2219/00581 , B01J2219/00608 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722 , C07B2200/11 , C07F9/598 , C07F9/65586 , C07F9/6561 , C40B40/04 , C40B50/16 , C40B80/00

64. 发明公开

EP1249499A1 Verfahren und Vorrichtung zur Bestimmung und Selektion von Molekül-Molekül-Wechselwirkungen 审中-公开
标题翻译：对于分子 - 分子相互作用的判定和选择的方法和装置
公开(公告)号：EP1249499A1
公开(公告)日：2002-10-16
申请号：EP01108919.0
申请日：2001-04-10
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Gillner, Arnold , Bremus-Köbberling, Elke , Barth, Stefan , Fischer, Rainer
IPC分类号： C12Q1/68 , B01J19/00 , G01N33/53
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C07B2200/11 , C12Q1/6837 , C40B40/06 , C40B80/00 , G01N33/6845 , C12Q2565/628 , C12Q2565/201 , C12Q2523/313
摘要： Die vorliegende Erfindung betrifft Biochips zur Dokumentation spezifischer Molekül-Molekül-Wechselwirkungen bzw. Zell-Moleküi-Wechseiwirkung, insbesondere von unbekannten, singulären Protein-Interaktionen und entsprechende Verfahren zur Selektion und Charakterisierung von Molekülen, insbesondere Polypeptiden und ihren komplementären Bindungsmolekülen.
摘要翻译：选择（M1）未知分子（I）通过固定在载体上的组合文库的分子，应用互补的单分子或细胞，以特定的固定化（I），从载体相互相互作用分子的选择性释放，且释放的分析分子。因此独立权利要求中包括了以下内容：（1）生物芯片（II）为新的进程，其包括载体用于固定的组合文库（或与此已经固定在其上）; （2）制备（M2）（II）; 和（3）的装置（III）的分子或细胞相互作用的自动测量及与低于100nm的空间分辨率协调分配。

65. 发明公开

EP1175427A2 LINKERS FOR SYNTHESIS OF OLIGOSACCHARIDES ON SOLID SUPPORTS 有权
标题翻译：左为合成低聚糖HARD媒体
公开(公告)号：EP1175427A2
公开(公告)日：2002-01-30
申请号：EP00917725.4
申请日：2000-03-03
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SEEBERGER, Peter, H. , ANDRADE, Rodrigo, P.
IPC分类号： C07H1/00 , C07H3/00 , C08B37/00 , C07B61/00
CPC分类号： C40B40/12 , C07B2200/11 , C07H1/00 , C07H3/06 , C07H15/18 , C40B50/18 , C40B80/00
摘要： In certain embodiments, the present invention relates to versatile linkers for tethering a molecule to a solid support, e.g. for tethering a monomer, oligomer or polymer to a solid support, which are stable to a wide range of reaction conditions, but can be cleaved under well-defined conditions, thereby liberating said molecule from the solid support. In preferred embodiments, the linkers of the present invention are used to tether to the solid support unprotected, partially-protected or fully-protected monosaccharides or oligosaccharides, or unprotected, partially-protected or fully-protected glycoconjugates. In other embodiments, the linkers of the present invention may be used to tether to solid supports building blocks useful in the assembly of libraries of other types of small molecules. In certain embodiments, the present invention relates to a molecule or plurality of molecules tethered to the solid support via a linker or linkers of the present invention. In certain embodiments, the present invention relates to processes for synthesizing molecules, e.g. monomers, oligomers or polymers, on a solid support, wherein a starting material in the synthesis of said molecule, intermediates in the synthesis of said molecule, and said molecule itself are tethered to the solid support during the process via one of the linkers of the present invention. In certain processes of the present invention, the molecule is liberated from the solid support by cleavage of the linker of the present invention.

66. 发明公开

EP1100759A1 TRANSITION METAL COMPLEXES AS LINKERS 有权
标题翻译：过渡金属配合物LEFT GROUP
公开(公告)号：EP1100759A1
公开(公告)日：2001-05-23
申请号：EP99936819.4
申请日：1999-07-29
申请人： AstraZeneca AB
发明人： COMELY, Alex Christian,Dept. of Chemistry , GIBSON, Sue Elizabeth,Dept. of Chemistry , HALES, Neil James , PEPLOW, Mark Andrew,Chemistry Dept. (ABB)
IPC分类号： C07B61/00 , C07F11/00
CPC分类号： C40B80/00 , C07B61/00 , C07B2200/11 , C07C41/26 , C07C45/673 , C07F11/005 , C40B40/04 , C40B50/16 , C40B50/18 , Y10T436/13 , C07C47/222 , C07C43/23
摘要： The invention relates to new traceless linkers which use transition metal complexes to link a π-orbital containing substrate for subsequent synthesis by, for example, combinatorial chemistry or multiple parallel synthesis (MPS) to a support.

67. 发明公开

EP1085941A2 KOMBINATORISCHES VERFAHREN ZUR HERSTELLUNG UND CHARAKTERISIERUNG VON KRISTALLINEN UND AMORPHEN MATERIALBIBLIOTHEKEN IM MIKROGRAMM-MASSSTAB 审中-公开
标题翻译：组合方法制备和结晶和无定形材质库表征IN微克尺度
公开(公告)号：EP1085941A2
公开(公告)日：2001-03-28
申请号：EP99924959.2
申请日：1999-05-12
申请人： Studiengesellschaft Kohle mbH
发明人： MAIER, Wilhelm-Friedrich , KLEIN, Jens , LEHMANN, Christian , SCHMIDT, Hans-Werner
IPC分类号： B01J19/00 , B01J3/04
CPC分类号： C40B80/00 , B01J3/04 , B01J19/0046 , B01J2219/00313 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00659 , B01J2219/00745 , B01J2219/00747 , B01J2219/00754 , B01L3/5085 , B01L2300/0893 , C40B30/08 , C40B40/18 , C40B50/08 , C40B60/14
摘要： The invention relates to a method for wet chemical production of a plurality of libraries of materials consisting of solids, whereby the solids are separated from reaction mixtures in microreaction chambers on a base plate serving at the same time as substrate for the library. Depending on the material chosen for the substrate of the library, solids can be subsequently investigated in a non-destructive manner, e.g. by means of reflecting or penetrating microarea x-ray scattering. Preferably, the reactor consists of a cylindrical pressurized container made of steel having a silicon monocrystal plate as library. A steel plate with tetrafluoroethylene coating is pressed on said Si-monocrystal plate by means of screws, the holes of which form the reaction chambers.

68. 发明公开

EP1002573A2 The combinatorial synthesis of novel materials 失效
标题翻译：新型材料的组合合成
公开(公告)号：EP1002573A2
公开(公告)日：2000-05-24
申请号：EP99203887.7
申请日：1995-10-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Symyx Technologies (US/US)
发明人： Schultz, Peter G. , Xiang, Xiaodong , Goldwasser, Isy
IPC分类号： B01J19/00 , C07B61/00 , B01J23/00 , C04B35/00 , C22C1/00
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic, organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties
摘要翻译：组合合成通过使用其上具有不同材料阵列的基材完成，所述基材通过将组分递送到基材上的预定义区域并同时使所述组分反应以形成至少两种材料来制备。可以使用这些方法制备的材料是共价网络固体，离子固体和分子固体。实例是无机，有机金属，金属间化合物，陶瓷，有机聚合物和复合材料。一旦准备好，这些材料可以筛选有用的属性。因此，本发明提供了具有有用性能的新型材料的平行合成和分析

69. 发明公开

EP1002572A2 The combinatorial synthesis of novel materials 无效
标题翻译：新材料组合Sythese
公开(公告)号：EP1002572A2
公开(公告)日：2000-05-24
申请号：EP99203886.9
申请日：1995-10-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Symyx Technologies (US/US)
发明人： Schultz, Peter G. , Xiang, Xiaodong , Goldwasser, Isy
IPC分类号： B01J19/00 , G01N21/00 , G01N22/00
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic, organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties

70. 发明公开

EP0789671A1 THE COMBINATORIAL SYNTHESIS OF NOVEL MATERIALS 无效
标题翻译：新材料联合SYTHESE
公开(公告)号：EP0789671A1
公开(公告)日：1997-08-20
申请号：EP95937472.0
申请日：1995-10-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SYMYX TECHNOLOGIES
发明人： SCHULTZ, Peter, G. , XIANG, Xiaodong , GOLDWASSER, Isy
IPC分类号： C01G1 , B01J19 , C01G51 , C04B35 , C23C14 , C23C16 , G01N27 , G01N35 , G01N37 , G01R33 , H01F1 , H01F10 , H01F41 , H01L43 , C07B61 , C40B30 , C40B40 , C40B60 , C40B70
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Giant magnetoresistive cobalt oxide compounds are produced by combinatorial synthesis. Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Other materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties such as magnetoresistance. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties.

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