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61. 发明申请

US20030022158A1 Peptides from the TT virus sequence and monospecific antibodies binding to the TT virus 审中-公开
标题翻译：来自TT病毒序列的肽和与TT病毒结合的单特异性抗体
公开(公告)号：US20030022158A1
公开(公告)日：2003-01-30
申请号：US09992896
申请日：2001-11-05
发明人： Matti Sallberg
IPC分类号： C12Q001/70 , C07H021/04 , A61K039/395 , A61K039/12 , C07K002/00 , C07K004/00 , C07K005/00 , C07K007/00 , C07K014/00 , C07K016/00 , C07K017/00 , A61K038/00 , C12N005/06 , C12N005/16 , C07K001/00 , G01N033/53 , G01N033/537 , G01N033/543
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2750/00022
摘要： The present invention relates to peptides derived from the genomic sequence of the TT virus and antibodies generated therefrom, which can be used in diagnostics and medicaments for the diagnosis, treatment, and prevention of TT virus infection. Several synthetic peptides generated according to the methods described herein were found to be reactive to antibodies present in serum from patients suffering from TT virus infection. A peptide having the sequence of SEQ ID NO: 1 was introduced into mammals and was found to induce the production of antibodies specific for said peptide.
摘要翻译：本发明涉及衍生自TT病毒的基因组序列的肽和由其产生的抗体，其可用于诊断和药物用于TT病毒感染的诊断，治疗和预防。发现根据本文描述的方法产生的几种合成肽对存在于患有TT病毒感染的患者的血清中的抗体具有反应性。将具有SEQ ID NO：1的序列的肽引入哺乳动物中，并发现其诱导产生对所述肽特异性的抗体。

62. 发明授权

US5846705A Nucleotide sequence of two circular SSDNA associated with banana bunchy top virus and method for detection of banana bunchy top virus 失效
标题翻译：与香蕉束顶病毒相关的两个环状SSDNA的核苷酸序列和用于检测香蕉束顶病毒的方法
公开(公告)号：US5846705A
公开(公告)日：1998-12-08
申请号：US418071
申请日：1995-04-06
申请人： Rey-Yuh Wu , Li-Ru You , Tai-Seng Soong
发明人： Rey-Yuh Wu , Li-Ru You , Tai-Seng Soong
IPC分类号： C07K14/01 , C12Q1/70 , C07K14/00 , C12P19/34 , C12Q1/68
CPC分类号： C07K14/005 , C12N2750/00022
摘要： Nucleotide sequences of two circular single-stranded DNAs associated with Banana Bunchy Top Virus and the proteins encoded by the open reading frames in the nucleotide sequences are provided. A method for detecting Banana Bunchy Top Virus using the PCR technique based on the nucleotide sequences is also provided.
摘要翻译：提供了与香蕉芽顶病毒相关联的两个环状单链DNA的核苷酸序列和由核苷酸序列中的开放阅读框编码的蛋白质。还提供了使用基于核苷酸序列的PCR技术来检测香蕉薄荷顶部病毒的方法。

63. 发明授权

US5756708A DNA sequences of banana bunchy top virus 失效
标题翻译：香蕉束顶病毒的DNA序列
公开(公告)号：US5756708A
公开(公告)日：1998-05-26
申请号：US202186
申请日：1994-02-24
申请人： Mirko Karan , Thomas Michael Burns , James Langham Dale , Robert Maxwell Harding
发明人： Mirko Karan , Thomas Michael Burns , James Langham Dale , Robert Maxwell Harding
IPC分类号： C07K14/01 , C12N15/11 , C12N15/34
CPC分类号： C07K14/005 , C12N2750/00021 , C12N2750/00022
摘要： The invention provides DNA molecules consisting essentially of a nucleotide sequence or part thereof which are asosciated with the genome of banana bunchy top virus (BBTV) as illustrated in FIGS. 1 through 8 (SEQ ID NOS: 49-54, 27-37, 55-60, 38-48, and 9-23, respectively) of the specification attached herewith.
摘要翻译：本发明提供了基本上由与如图1和2所示的香蕉束顶病毒（BBTV）的基因组一致的核苷酸序列或其部分组成的DNA分子。 1至8（分别为SEQ ID NO：49-54,27-37,55-60,38-48和9-23）。

64. 发明授权

US12134773B1 Mycovirus-induced gene silencing vector, construction method and application thereof 有权
公开(公告)号：US12134773B1
公开(公告)日：2024-11-05
申请号：US18529537
申请日：2023-12-05
申请人： Institute of Plant Protection(IPP), Chinese Academy of Agricultural Sciences(CAAS) , Beijing Zhongbao Green Agricultural Science and Technology Group Co., Ltd
发明人： Lihua Guo , Chang Chen , Lihang Zhang , Shuangchao Wang , Shaojian Ruan , Jun Xu , Yijun Zhao
IPC分类号： C12N15/09 , C12N9/10 , C12N9/16 , C12N15/10 , C12N15/113 , C12N15/80 , C12R1/77
CPC分类号： C12N15/80 , C12N9/1029 , C12N9/16 , C12N15/102 , C12N2750/00022 , C12N2750/00031 , C12N2750/00043 , C12R2001/77
摘要： A mycovirus-induced gene silencing vector and a construction method and an application thereof are provided. A nucleotide sequence of the mycovirus-induced gene silencing vector is shown in SEQ ID NO: 2, and construction method for the mycovirus-induced gene silencing vector includes: (1) connecting three single-stranded circular DNA molecules DNA-A, DNA-B and DNA-C of the mycovirus FgGMTV1/HB58 in series and introducing them into a same vector to construct a recombinant vector; and (2) carrying out a deletion mutation on a coding protein p26 of the DNA-C molecule in the recombinant vector to obtain the mycovirus-induced gene silencing vector.

65. 发明公开

US20240254512A1 ANELLOVECTORS AND METHODS OF USE 审中-公开
公开(公告)号：US20240254512A1
公开(公告)日：2024-08-01
申请号：US18559921
申请日：2022-05-11
申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.
发明人： Nathan Lawrence Yozwiak , Simeon Ungerleider Springer , Cesar A. Arze , Kristian Graugaard Andersen
IPC分类号： C12N15/86 , C07K14/005
CPC分类号： C12N15/86 , C07K14/005 , C12N2750/00022 , C12N2750/00043 , C12N2750/00051
摘要： This invention relates generally to anellovectors and compositions and uses thereof.

66. 发明申请

US20190211361A1 COMPOSITIONS COMPRISING CURONS AND USES THEREOF 审中-公开
公开(公告)号：US20190211361A1
公开(公告)日：2019-07-11
申请号：US16366571
申请日：2019-03-27
申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.
发明人： Avak Kahvejian , Erica Gabrielle Weinstein , Nicholas McCartney Plugis , Kevin James Lebo , Fernando Martin Diaz , Dhananjay Maniklal Nawandar
IPC分类号： C12N15/86 , C12N15/113 , C07K14/005
CPC分类号： C12N15/86 , C07K14/005 , C12N15/113 , C12N2310/141 , C12N2320/32 , C12N2750/00021 , C12N2750/00022 , C12N2750/00043
摘要： This invention relates generally to pharmaceutical compositions and preparations of curons and uses thereof.

67. 发明授权

US09730987B2 Vaccine formulations comprising saponin-containing adjuvants 有权
公开(公告)号：US09730987B2
公开(公告)日：2017-08-15
申请号：US14632863
申请日：2015-02-26
申请人： MERIAL INC.
发明人： Noel Joseph Francois Detraz , Guillaume Rigaut
IPC分类号： A61K39/00 , A61K47/26 , A61K9/00 , A61K9/107 , A61K45/06 , A61K47/06 , C12N7/00 , A61K39/39 , A61K39/02 , A61K39/12 , A61K39/135 , A61K39/125
CPC分类号： A61K39/00 , A61K9/0019 , A61K9/107 , A61K39/0241 , A61K39/12 , A61K39/125 , A61K39/135 , A61K39/39 , A61K45/06 , A61K47/06 , A61K47/26 , A61K2039/52 , A61K2039/525 , A61K2039/5252 , A61K2039/54 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , C12N7/00 , C12N2750/00022 , C12N2750/00034 , C12N2750/10034 , C12N2770/32022 , C12N2770/32134
摘要： The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.

68. 发明授权

US09676828B2 Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity 有权
公开(公告)号：US09676828B2
公开(公告)日：2017-06-13
申请号：US13719835
申请日：2012-12-19
申请人： Deutsches Krebsforschungszentrum
发明人： Ethel-Michele De Villiers , Harald Zur Hausen
IPC分类号： C07K14/01 , C12N7/00 , C07K16/08 , G01N33/569 , C12Q1/70 , C12N15/113 , C12Q1/68 , C07K14/005
CPC分类号： C07K14/01 , C07K14/005 , C07K16/081 , C12N7/00 , C12N15/1131 , C12N2750/00021 , C12N2750/00022 , C12Q1/6883 , C12Q1/6886 , C12Q1/701 , G01N33/56983 , G01N2800/50
摘要： The present invention relates to rearranged molecules of (a) a specific TT virus sequence and (b) a nucleotide sequence encoding a polypeptide showing homology to mammalian proteins associated with cancer and autoimmune diseases that are capable of replicating autonomously for use in diagnosis, prevention and treatment of diseases like cancer and autoimmunity.

69. 发明授权

US09228242B2 Porcine torque teno virus vaccines and diagnosis 有权
标题翻译：猪扭矩o病毒疫苗及诊断
公开(公告)号：US09228242B2
公开(公告)日：2016-01-05
申请号：US12861378
申请日：2010-08-23
申请人： Xiang-Jin Meng , Yaowei Huang
发明人： Xiang-Jin Meng , Yaowei Huang
IPC分类号： C12N15/33 , A61K39/12 , C12N15/70 , C12N1/21 , C12N7/00 , C12Q1/70 , C07K14/005 , C07K16/08 , G01N33/569 , A61K39/00
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
摘要： The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
摘要翻译：本发明提供了含有编码猪扭转腱病毒（PTTV）基因型或亚型PTTV1a-VA，PTTV1b-VA，PTTV2b-VA和PTTV2c-VA的多核酸分子的四种纯化制剂。本发明还提供感染性DNA克隆，含有该感染性核酸基因组分子的生物功能质粒或病毒载体。本发明进一步提供活的，减毒的载体表达和纯化的重组衣壳亚单位或灭活的病毒疫苗以防止PTTV感染。本发明另外提供了包含PTTV特异性基因产物的亚单位疫苗，特别是用于保护免受PTTV感染的ORF1衣壳基因产物。此外，本发明提供了使用PTTV1，PTTV2和个体PTTV1基因型的特异性引物通过聚合酶链反应（PCR）诊断PTTV感染的方法。最后，本发明提供了通过免疫学方法诊断PTTV感染的方法，例如使用PTTV特异性抗原检测血清PTTV特异性抗体的酶联免疫吸附测定（ELISA）和蛋白质印迹。

70. 发明申请

US20130315944A1 INFECTIOUS GENOMIC DNA CLONE AND SEROLOGICAL PROFILE OF TORQUE TENO SUS VIRUS 1 AND 2 有权
标题翻译：感染性基因组DNA克隆和扭转型TENO SUS病毒1和2的序列
公开(公告)号：US20130315944A1
公开(公告)日：2013-11-28
申请号：US13840805
申请日：2013-03-15
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： Xiang-Jin MENG , Yaowei HUANG
IPC分类号： C07K14/005 , C12N7/00 , G01N33/569 , C12N15/86
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/00043 , C12Q1/701 , G01N2333/01 , G01N2469/20
摘要： The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of Torque teno sus virus (TTsuV). The present invention also provides methods for diagnosing TTsuV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies which indicate infections TTsuV1, TTsuV2, and individual TTsuV1 genotypes.
摘要翻译：本发明还提供感染性DNA克隆，含有Torque teno sus病毒（TTsuV）的感染性核酸基因组分子的生物功能质粒或病毒载体。本发明还提供了通过免疫学方法例如酶联免疫吸附测定（ELISA）和使用PTTV特异性抗原检测表明感染TTsuV1，TTsuV2和个体TTsuV1基因型的血清PTTV特异性抗体的蛋白质印迹来诊断TTsuV感染的方法。

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