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61. 发明申请

US20090221531A1 NOVEL PHYTIC CITRATE COMPOUNDS AND PROCESS FOR PREPARING THE SAME 有权
标题翻译：新型植物化学化合物及其制备方法
公开(公告)号：US20090221531A1
公开(公告)日：2009-09-03
申请号：US12394885
申请日：2009-02-27
申请人： Carl A. Coppolino , Abulkalam M. Shamsuddin
发明人： Carl A. Coppolino , Abulkalam M. Shamsuddin
IPC分类号： A61K31/6615 , A61P25/28
CPC分类号： C07F9/093 , C07F9/096 , C07F9/117
摘要： The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+, K+, Mg2+, or Ca2+ salt of said chemical compound. The chemical compound is a chelator which chelates sodium, potassium or lithium, magnesium, calcium, copper, iron, lead, zinc, aluminum, mercury, cadmium, or chromium. It is also be used as an artery plaque dissolver and/or to treat age-related degenerative disorders, such as Alzheimer's disease. The present invention also provides a method for producing the phytic citrate compound and/or its salt.
摘要翻译：本发明提供具有以下化学式的化合物或其盐：其中所述R是H或柠檬酸盐，并且其中至少一个R是柠檬酸盐。化合物的盐是所述化合物的Na +，K +，Mg2 +或Ca2 +盐。该化合物是螯合剂，它螯合钠，钾或锂，镁，钙，铜，铁，铅，锌，铝，汞，镉或铬。它还可用作动脉斑块溶解器和/或治疗年龄相关的退行性疾病，例如阿尔茨海默病。本发明还提供了一种生产植酸柠檬酸化合物和/或其盐的方法。

62. 发明申请

US20050119233A1 Acyl phosphonate inhibitors of beta-lactamases 失效
标题翻译： β-内酰胺酶的酰基膦酸酯抑制剂
公开(公告)号：US20050119233A1
公开(公告)日：2005-06-02
申请号：US10628649
申请日：2003-07-28
申请人： Jeffrey Besterman , Jubrail Rahil , Rex Pratt
发明人： Jeffrey Besterman , Jubrail Rahil , Rex Pratt
IPC分类号： C07F9/09 , C07F9/40 , C07F9/6571 , C07F9/6574 , A61K31/66 , C07F9/02
CPC分类号： C07F9/65744 , C07F9/096 , C07F9/098 , C07F9/4093 , C07F9/657181 , C07F9/65742
摘要： The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not possess a β-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as β-lactamase inhibitors and as antibiotics.
摘要翻译：本发明提供了新型β-内酰胺酶抑制剂，其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关，并且不具有β-内酰胺药效团。这些新的抑制剂是完全合成的，可以方便地访问各种结构相关的类似物。这些新抑制剂的某些实施方案也结合细菌DD-肽酶，因此潜在地作为β-内酰胺酶抑制剂和抗生素起作用。

63. 发明授权

US06608046B1 &bgr;-lactamase and DD-peptidase inhibitors 失效
标题翻译： β-内酰胺酶和DD-肽酶抑制剂
公开(公告)号：US06608046B1
公开(公告)日：2003-08-19
申请号：US09582255
申请日：2000-09-01
申请人： Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
发明人： Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
IPC分类号： A61K31661
CPC分类号： C07F9/4093 , C07F9/096 , C07F9/098 , C07F9/657181 , C07F9/65742 , C07F9/65744
摘要： The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
摘要翻译：本发明提供新颖的β-内酰胺酶抑制剂，其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关，并且不具有β-内酰胺药效团。这些新的抑制剂是完全合成的，可以方便地访问各种结构相关的类似物。这些新抑制剂的某些实施方案也结合细菌DD-肽酶，因此潜在地作为β-内酰胺酶抑制剂和抗生素起作用。

64. 发明授权

US06217941B1 Isocyanates modified for being provided with surfactant property, composition containing same, resulting coating 有权
标题翻译：改性以提供表面活性剂的异氰酸酯，含有它的组合物，得到的涂层
公开(公告)号：US06217941B1
公开(公告)日：2001-04-17
申请号：US09380111
申请日：1999-11-12
申请人： Jean-Marie Bernard , Thierry Jeannette , Minow Nabavi
发明人： Jean-Marie Bernard , Thierry Jeannette , Minow Nabavi
IPC分类号： B05D302
CPC分类号： C07F9/3891 , C07F9/096 , C07F9/4065 , C08G18/706 , C08G18/8083
摘要： The invention concerns a compound of formula (I) in which m is to 0 or 1 Iso is the (poly)isocyanate radical (after elimination of an isocyanate function); R10 is selected among: a negative charge; a hydrocarbon-based radical (i.e. a residue containing hydrogen and carbon atoms) having a carbon as it binding point [i.e. the atom carrying the open bond ]; R11 is selected among: a negative charge. The invention is applicable to organic synthesis.
摘要翻译：本发明涉及式（I）化合物，其中m为0或1，Iso为（多）异氰酸酯基团（消除异氰酸酯官能团之后）; R10选自：负电荷; 具有碳作为结合点的烃基自由基（即，含有氢和碳原子的残基）[即携带开放债券的原子]; R11选自：负电荷。本发明适用于有机合成。

65. 发明授权

US5698563A Bis-�hydrazones! 失效
标题翻译：双 - [腙]
公开(公告)号：US5698563A
公开(公告)日：1997-12-16
申请号：US372672
申请日：1995-01-13
申请人： Dilip R. Wagle , Michael E. Lankin , David H. Shih
发明人： Dilip R. Wagle , Michael E. Lankin , David H. Shih
IPC分类号： C07C251/76 , C07C251/86 , C07C281/18 , C07D213/53 , C07D213/77 , C07D233/52 , C07D233/88 , C07D239/18 , C07D249/04 , C07D249/08 , C07D333/22 , C07D401/14 , C07D405/14 , C07D409/14 , C07F9/09 , A61K31/415 , A61K31/505
CPC分类号： C07D213/53 , C07C251/76 , C07C251/86 , C07C281/18 , C07D213/77 , C07D233/52 , C07D239/18 , C07D249/04 , C07D333/22 , C07D401/14 , C07D405/14 , C07D409/14 , C07F9/096
摘要： The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises bis(guanylhydrazone) of the formula ##STR1## capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
摘要翻译：本发明涉及抑制非酶交联（蛋白质老化）的组合物和方法。因此，公开了一种组合物，其包含式（I）的双（脒腙），其能够通过与由此类靶蛋白形成的这种靶蛋白的早期糖基化产物的羰基部分反应来抑制靶蛋白的高级糖基化终产物的形成它们的初始糖基化。该方法包括使靶蛋白与组合物接触。预想到本发明的工业和治疗应用，因为可以处理食物腐败和动物蛋白质老化。

66. 发明授权

US4701285A Acyl phosphate salts and their use 失效
标题翻译：酰基磷酸盐及其用途
公开(公告)号：US4701285A
公开(公告)日：1987-10-20
申请号：US793722
申请日：1985-10-31
申请人： George M. Whitesides , Debbie C. Crans , Romas J. Kazlaukas
发明人： George M. Whitesides , Debbie C. Crans , Romas J. Kazlaukas
IPC分类号： C07F9/09 , C07C153/00
CPC分类号： C07F9/096
摘要： This invention consists of the production of a salt of acyl phosphate in an aqueous solution by a process which involves (1) acylation of phosphoric acid (H.sub.3 PO.sub.4) with an acid anhydride of the general formula RCOX, where R can be hydrogen or a lower alkyl or aryl group having from 1 to 10 carbon atoms, and X can be a leaving group of the general formula OR, OCOR, X or NR.sub.2, followed by (2a) extraction of acyl phosphate to water by treatment of the reaction mixture with an aqueous bicarbonate or hydroxide solution or other basic aqueous solution, if the reaction is carried out in non-aqueous solvent or (2b) in the case where water has been used as reaction solvent acidification with acid or acid form of a carbon exchange resin. After (3) extraction of residual carboxylic acid from the resulting acidic aqueous mixture using a solvent in which the acid is soluble but with which water does not mix, the remaining aqueous solution of acyl phosphate is (4) neutralized by addition of a base such as sodium or potassium hydroxide.
摘要翻译：本发明包括在水溶液中制备酰基磷酸盐的方法，该方法包括：（1）用通式RCOX的酸酐使磷酸（H 3 PO 4）酰化，其中R可以是氢或低级烷基或具有1至10个碳原子的芳基，X可以是通式OR，OCOR，X或NR2的离去基团，然后（2a）通过用水溶液处理反应混合物（2a）将酰基磷酸酯提取到水中碳酸氢盐或氢氧化物溶液或其他碱性水溶液，如果反应在非水溶剂中进行，或（2b）在使用水作为与酸或酸形式的碳交换树脂反应溶剂酸化的情况下。（3）使用其中酸是可溶性但不与水混合的溶剂从所得酸性含水混合物中提取残余羧酸后，残留的酰基磷酸酯水溶液（4）通过加入碱中和作为氢氧化钠或氢氧化钾。

67. 发明授权

US4055714A Azo free radical initiators containing ultraviolet light stabilizing groups 失效
标题翻译：含有紫外光稳定基团的偶氮自由基引发剂
公开(公告)号：US4055714A
公开(公告)日：1977-10-25
申请号：US680545
申请日：1976-04-27
申请人： Chester S. Sheppard , Ronald E. MacLeay
发明人： Chester S. Sheppard , Ronald E. MacLeay
IPC分类号： C07C409/34 , C07F5/02 , C07F9/09 , C08F2/00 , C08F4/04 , C08F4/34 , C08F299/04 , C08F12/08
CPC分类号： C07F9/096 , C07F5/022 , C08F299/0457 , C08F4/04 , C08F4/34
摘要： Compounds which contain azo or peroxide linkages as well as the radical of an ultraviolet light stabilizing group are described. These compounds function as polymerization initiators which cause an ultraviolet light stabilization group to be chemically bound to the polymer.
摘要翻译：描述了含有偶氮或过氧化物键的化合物以及紫外光稳定基团的基团。这些化合物起着聚合引发剂的作用，其使紫外光稳定基团与聚合物化学键合。

68. 发明授权

US3248458A Organic phosphorus esters and anhydrides 失效
标题翻译：有机磷酯和酸酐
公开(公告)号：US3248458A
公开(公告)日：1966-04-26
申请号：US23259362
申请日：1962-10-23
申请人： BAYER AG
发明人： GUNTER OERTEL , HUGO MALZ , HANS HOLTSCHMIDT
IPC分类号： C07F9/06 , C07F9/08 , C07F9/09 , C07F9/141 , C07F9/16 , C07F9/165 , C07F9/201 , C07F9/22 , C07F9/24 , C07F9/30 , C07F9/32 , C07F9/38 , C07F9/44 , C07F9/46 , C07F9/48 , C07F9/59 , C07F9/6533
CPC分类号： C07F9/6533 , C07F9/06 , C07F9/08 , C07F9/096 , C07F9/141 , C07F9/1415 , C07F9/1417 , C07F9/16 , C07F9/1656 , C07F9/2015 , C07F9/22 , C07F9/2433 , C07F9/2441 , C07F9/2479 , C07F9/30 , C07F9/3294 , C07F9/38 , C07F9/4457 , C07F9/46 , C07F9/4883 , C07F9/591
摘要： The invention comprises organic phosphorus compounds of the general formula wherein R1 and R2, which may be the same or different represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylmercapto, C1-C4 alkylamino, di-C1-C4 alkylamine, cyano-substituted di-C1-C4-alkylamino, phenyl, C1-C4 alkylmercapto-substituted phenoxy, phenylamino, or morpholyl radicals or a further group or R2 and R2 together form an alkylene-dioxy group; R3 and R4, which may be the same or different, represent hydrogen atoms or C1-C4 alkyl, cyano-substituted C1-C4 alkyl, or phenyl radicals or the group represents a morpholyl or piperidyl radical; A represents the residue of carbonic, sulphurous, phenyldithiophosphonic, C1-C4 alkoxy-substituted phenyldithiophosphonic, phthalic, halogen-substituted phthalic, or maleic acid; and X represents an electron pair or a sulphur atom. These compounds may be produced by reacting an appropriate organic compound of trivalent phosphorus containing at least one phosphorus-nitrogen band with an appropriate organic or triorganic anhydride to give a compound in which X is an electron pair and, if desired, reacting said compound with elementary sulphur or a sulphur-yielding agent to give a compound in which X is a sulphur atom. The compounds of the invention exhibit pesticidal activity (see Division A5).ALSO:Pesticidal compositions contain an organophosphorus compound of the general formula wherein R1 and R2, which may be the same or different, represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylmercapto, C1-C4 alkylamino, di-C1-C4-alkylamino, cyano-substituted-di-C1-C4 alkylamino, phenyl, C1-C4 alkylmercapto-substituted phenoxy, phenylamino, or morpholyl radicals or a further group or R1 and R2 together form an alkylenedioxy group; R3 and R4, which may be the same or different, represent hydrogen atoms or C1-C4 alkyl, cyano-substituted C1-C4 alkyl, or phenyl radicals or the group represents a morpholyl or piperidyl radical; A represents the residue of carbonic, sulphurous, phenyldithiophosphoric, C1-C4 alkoxy-substituted phenyldithiophosphoric, phthalic, halogen substituted phthalic or maleic acid; and X represents an eletron pair or a sulphur atom, in admixture with a solid or liquid diluent or carrier.

69. 发明授权

EP2825544B1 MODIFIED ISOCYANATE COMPOSITIONS AND METHODS OF PREPARING THE SAME 有权
公开(公告)号：EP2825544B1
公开(公告)日：2018-08-08
申请号：EP13712078.8
申请日：2013-03-13
申请人： BASF SE
发明人： KUMAR, Rajesh , LEBEDINSKI, Nikolay
IPC分类号： C07F9/141 , C07F9/32 , C08G18/76 , C08G18/80 , C08K5/00 , C08G18/38 , C08K5/521
CPC分类号： C08G18/3206 , C07F9/096 , C07F9/247 , C08G18/4825 , C08G18/776 , C08K5/005 , C08K5/521 , C09D175/04
摘要： Modified isocyanate compositions having improved properties are provided. The compositions may be formed from the reaction of a isocyanate component, which is a compound terminated with at least one isocyanate group, and an organic acid derivative having the formula (RO)n(M)(E)(EH)3-n, wherein M is nitrogen, phosphorus, arsenic, antimony, or bismuth, n is 1 or 2, each E is independently oxygen, sulfur, selenium, or tellurium, each R is independently hydrogen, an alkyl group, a cyclic aryl group, an acyclic aryl group, a halogen-substituted alkyl group, a halogen-substituted cyclic aryl group or a halogen-substituted acyclic aryl group and wherein the ratio of the weight of the isocyanate component to the combined weight of the organic acid derivative and the isocyanate component is from 0.7 to 0.95. The compositions can be utilized in a variety of applications and are adapted to prolonged storage and transportation. Methods of preparing such compositions are also provided.

70. 发明授权

EP2633038B1 A METHOD OF PRODUCTION OF 2,4-DIHYDROBUTYRIC ACID 有权
标题翻译：用于生产2,4-二羟基丁酸
公开(公告)号：EP2633038B1
公开(公告)日：2017-04-05
申请号：EP11805587.0
申请日：2011-10-27
申请人： Adisseo France S.A.S.
发明人： WALTHER, Thomas , CORDIER Hélène , TOPHAM, Christopher , ANDRE, Isabelle , REMAUD-SIMEON, Magali , HUET, Robert , FRANCOIS, Jean-Marie
IPC分类号： C12N9/12 , C12N9/04 , C12P7/16 , C07C59/245 , C07C59/10 , C12N9/02
CPC分类号： C12P7/42 , C07F9/096 , C12N9/0006 , C12N9/0008 , C12N9/1217 , C12N15/70 , C12P7/40 , C12P9/00 , C12Y101/01 , C12Y102/01011 , C12Y102/01018 , C12Y207/02004

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