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    • 61. 发明授权
    • Diagnostic device and method of treatment
    • 诊断装置及治疗方法
    • US3852432A
    • 1974-12-03
    • US28202472
    • 1972-08-21
    • DEPARTMENT OF HEALTH EDUCATION
    • HENKIN R
    • A61B5/00G01N33/00A61K27/00
    • A61B5/4017A61B5/00A61B5/4011A61B5/411G01N33/0001
    • A diagnostic device and method of utilizing the device to diagnose abnormal taste acuity in humans is presented. The device comprises a compact kit having a plurality of bottles with solutions therein useful to test patients according to a forced choice-three stimulus drop technique, two drops being water and the third an unknown stimulus, to determine taste detection and recognition acuity, a forced scale of subjective response to different concentrations of taste stimuli and to screen for genetic defects. Each bottle is numbered and arranged in a sequential array, labeled from normal to abnormal taste acuity through each of the four taste characteristics. The inside cover of the lid has a detailed key to the array containing the concentration and sequence for utilizing each container. The key and the array is visible, during testing, only to the person administering the test. A newly diagnosed disease, idiopathic hypogeusia is also described together with its symptoms and a method of treating the disease by administration of a therapeutic amount of zinc ion orally.
    • 提出了利用该装置诊断人体异常味觉的诊断装置和方法。 该装置包括具有多个瓶子的紧凑套件,其中可以使用根据强迫选择三刺激滴技术测试患者的溶液,两滴是水,第三种是未知刺激,以确定味觉检测和识别敏锐度,强迫 对不同浓度的味觉刺激的主观反应的规模和筛选遗传缺陷。 每个瓶子被编号并排列成顺序阵列,通过四种味道特征中的每一种标记为从正常到异常味觉。 盖的内盖具有包含利用每个容器的浓度和顺序的阵列的详细键。 键和数组在测试过程中只有管理测试者可见。 还通过口服施用治疗量的锌离子来描述新诊断的疾病,特发性hypogeusia及其症状和治疗疾病的方法。
    • 64. 发明专利
    • 生体情報生成方法、生体情報生成プログラム及び生体情報生成装置
    • 生物信息生成方法,生物信息生成程序和生物信息生成装置
    • JP2015123144A
    • 2015-07-06
    • JP2013268117
    • 2013-12-25
    • 軍場 大樹
    • 軍場 大樹
    • A61B10/00A61B5/16
    • A61B5/4011A61B5/7264A61B5/7275A61B5/742A61B5/7475
    • 【課題】 匂いに対するヒトの応答を利用して、簡易に生体状態に係る情報を取得することが可能な、生体情報生成方法、生体情報生成プログラム及び生体情報生成装置の提供。 【解決手段】 嗅覚刺激物を用いて被験者の生体状態を診断するための図形情報を生成する方法であって、芳香分子が極性の高低及び帯電状態に応じて分類された状況下、嗅覚刺激物を構成し得る各芳香成分をN種類の分類に分類するステップと、各分類毎の芳香成分とその作用とを対応付けるステップと、N種類の嗅覚刺激物の夫々について、被験者に与える嗅覚刺激に対する不快度数の判定付けを行うステップと、N種類の嗅覚刺激物における主成分に係る分類と当該分類に対応付けられた作用との相関係数を割り当てるステップと、各分類の夫々に対して、被験者の生体状態を図示するための図形情報を生成するステップと、を含む、生体情報生成方法。 【選択図】 図1
    • 要解决的问题:提供一种生物信息生成方法,生物信息生成程序和生物信息生成装置,其能够使用人体对气味的响应容易地获取与生物状态有关的信息。解决方案:一种生物信息生成方法, 是使用嗅觉刺激来生成用于诊断对象的生物状态的图形信息的方法,包括:在芳香族分子根据本发明的分类的情况下将能构成嗅觉刺激的各芳香成分分类为N种的步骤 极性的电平和充电状态; 将每个类别的芳香组分与其作用相关联的步骤; 确定N种嗅觉刺激对受试者的嗅觉刺激的不适程度的步骤; 在N种嗅觉刺激中分配与主要成分有关的种类之间的相关系数与与该种类有关的效果的步骤; 以及用于生成用于说明每个类别的对象的生物学状态的图形信息的步骤。
    • 69. 发明申请
    • SYSTEM FOR EVALUATING AN INFANT'S PERCEPTION OF AROMA
    • 评估婴儿对芳香感知的系统
    • WO2009077906A2
    • 2009-06-25
    • PCT/IB2008/055078
    • 2008-12-03
    • KIMBERLY-CLARK WORLDWIDE, INC.COHEN, Jason, C.
    • COHEN, Jason, C.
    • A61J17/00A61B10/00
    • A61B5/1107A61B5/4011A61B5/682A61B5/6887A61B2503/04
    • Disclosed is a system, method, and device for detecting non-nutritive sucking events produced by an infant; patterns comprising such events (i.e., rhythmic sucking patterns, or RSPs); and relating said events and/or RSPs to an infant?s response to a olfactory sensory input. The frequency and/or amplitude and/or other characteristics of non-nutritive sucking can change in response to such inputs. Accordingly, changes to RSPs offer detectable and measurable indicia of an infant?s perception of these inputs. Furthermore, such information may be used to support and/or substantiate marketing communications to consumers; to guide selection and/or management of research-and-development projects; to help choose product designs that elicit RSPs identified as correlating with the well being of an infant; and other such uses.
    • 公开了用于检测由婴儿产生的非营养吸吮事件的系统,方法和设备; 包括这种事件的模式(即,节奏吸吮模式或RSP); 并将所述事件和/或RSP与婴儿对嗅觉感觉输入的反应相关联。 非营养吸吮的频率和/或振幅和/或其他特性可以响应于这种输入而改变。 因此,对RSPs的改变提供了可检测和可测量的婴儿对这些输入的看法。 此外,此类信息可用于支持和/或证实向消费者的营销传播; 指导研究和开发项目的选择和/或管理; 帮助选择能够引导被确定为与婴儿健康相关的RSPs的产品设计; 和其他此类用途。
    • 70. 发明申请
    • OLFACTORY IDENTIFICATION TESTS FOR COGNITIVE DISEASES AND DISORDERS
    • 恶性疾病和疾病的OLFACTORY鉴定试验
    • WO2006135368A1
    • 2006-12-21
    • PCT/US2005/020764
    • 2005-06-10
    • THE TRUSTREES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKDEVANAND, Davangere, P.TABERT, Matthias, H.LIU, XinhuaDOTY, Richard, L.
    • DEVANAND, Davangere, P.TABERT, Matthias, H.LIU, XinhuaDOTY, Richard, L.
    • A61B5/00A61B5/08
    • A61B5/4011A61B5/4017
    • The present invention provides smell tests (odor identification tests) that are shorter that UPSIT, yet has a statistical sensitivity and specificity equivalent to or better than UPSIT. The odor identification tests of the invention are based on a core set of sip odorants, where the six odorants can be selected from the following group of odorants: menthol, clove, leather, strawberry, lilac, pineapple, smoke, soap, natural gas and lemon. The present invention provides odor identification tests that can: (1) discriminate between subjects who are normal and who have a neuropsychiatric condition, cognitive disease or disorder, and/or (2) predict which subjects with mild cognitive disorders will develop various neuropsychiatric conditions or cognitive diseases and disorders. In one embodiment, the test and methods of the invention can provide an early prediction or diagnosis of Alzheimer's disease that is important for patients (including patients who have mild cognitive disorders, such as MCI) and clinicians to make plans for the future and to institute early treatment.
    • 本发明提供比UPSIT更短的气味测试(气味鉴定测试),但具有与UPSIT相当或优于UPSIT的统计灵敏度和特异性。 本发明的气味鉴定试验基于一组核心气味剂,其中六种气味剂可以选自以下一组气味剂:薄荷醇,丁香,皮革,草莓,丁香,菠萝,烟,肥皂,天然气和 柠檬。 本发明提供了气味鉴别测试,其可以:(1)区分正常和具有神经精神状况,认知疾病或病症的受试者和/或(2)预测具有轻度认知障碍的受试者将发展各种神经精神病症或 认知障碍和疾病。 在一个实施方案中,本发明的测试和方法可以提供对患者(包括具有轻度认知障碍的患者,例如MCI)和临床医师对未来进行计划和重建的阿尔茨海默氏病的早期预测或诊断 早期治疗。