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61. 发明专利

ES526731A0 未知
公开(公告)号：ES526731A0
公开(公告)日：1985-04-16
申请号：ES526731
申请日：1983-10-25
申请人： IKEDA MOHANDO CO , OTSUKA PHARMA CO LTD
IPC分类号： C07D277/62 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61P1/04 , A61P43/00 , C07C205/26 , C07D209/48 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/30 , C07D239/47 , C07D249/14 , C07D263/54 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D277/60 , A61K31/425
摘要： This invention relates to new heterocyclic compounds having the general formula shown below, and medically allowable salts, hydrates and solvates thereof: … … These heterocylclic compounds are effective as antagonists against histamine H2 receptors. They also show gastric mucus secretion-accelerating activities and are useful as agents for protecting and reinforcing the gastric mucosal surface. The heterocyclic compounds are therefore extremely useful as agents for peptic ulcer.

62. 发明专利

GB2027028B PREPARING O-(2,6-DICHLOROANILINO)PHENYLACETIC ACID 未知
公开(公告)号：GB2027028B
公开(公告)日：1982-11-17
申请号：GB7927553
申请日：1979-08-07
申请人： IKEDA MOHANDO CO
IPC分类号： C07B61/00 , B01J23/00 , B01J27/00 , C07C67/00 , C07C227/00 , C07C227/02 , C07C229/42 , C07C231/00 , C07C231/12 , C07C237/20 , C07D295/185 , C07C99/00 , C07C102/00 , C07C103/75
摘要： Disclosed is a process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid (Diclofenac) or its pharmacologically acceptable acid addition salt, which comprises hydrolyzing an N,N-disubstituted-o-(2,6-dichloroanilino)phenylacetamide derivative with an alkali. Also a novel intermediate for use in the preparation of Diclofenac, that is, an N,N-disubstituted-o-halogenophenylacetamide in which the halogen is iodine or bromine, is disclosed.

63. 发明专利

NO144667C 未知
公开(公告)号：NO144667C
公开(公告)日：1981-10-14
申请号：NO761097
申请日：1976-03-30
申请人： IKEDA MOHANDO CO
发明人： NOHARA FUJIO
IPC分类号： A61K31/19 , A61K31/195 , A61K31/196 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/20 , C07C229/42 , C07C241/00 , C07C257/08 , C07C101/447

64. 发明专利

AU504223B2 PREPARATION OF 0-(2,6-DICHLOROANILINO)PHENYLACETIC ACID (DICLOFENAC) 未知
公开(公告)号：AU504223B2
公开(公告)日：1979-10-04
申请号：AU1237076
申请日：1976-03-25
申请人： IKEDA MOHANDO CO
发明人： NOHARA F
IPC分类号： A61K31/19 , A61K31/195 , A61K31/196 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/20 , C07C229/42 , C07C241/00 , C07C257/08 , C07C101/447 , C07C103/84 , C07C119/20

65. 发明专利

CH610877A5 Process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid and of the addition salts of this acid 未知
公开(公告)号：CH610877A5
公开(公告)日：1979-05-15
申请号：CH379076
申请日：1976-03-26
申请人： IKEDA MOHANDO CO
发明人： NOHARA FUJIO
IPC分类号： A61K31/19 , A61K31/195 , A61K31/196 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/20 , C07C229/42 , C07C241/00 , C07C257/08 , C07C101/447
摘要： Substituted phenyl N-(2,6-dichlorophenyl)benzymidate, obtained by condensation of a salt of 2,6-dichlorophenol with the imidoyl chloride, is converted by the Chapman rearrangement to the compound of formula in which Q is a radical chosen from the cyano and alkoxycarbonyl groups and Z is a substituted or unsubstituted phenyl group. By hydrolysis of the compound (III), o-(2,6-dichloroanilino)phenylacetic acid is obtained. This compound is useful as an analgesic and non-steroidal anti-inflammatory agent.

66. 发明专利

GB1532087A PREPARATION OF PHENYLACETIC ACIDS AND INTERMEDIATES 未知
公开(公告)号：GB1532087A
公开(公告)日：1978-11-15
申请号：GB1217576
申请日：1976-03-26
申请人： IKEDA MOHANDO CO
IPC分类号： A61K31/19 , A61K31/195 , A61K31/196 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/20 , C07C229/42 , C07C241/00 , C07C257/08 , C07C101/64 , C07C103/84

67. 发明专利

NL7801523A 未知
公开(公告)号：NL7801523A
公开(公告)日：1978-08-11
申请号：NL7801523
申请日：1978-02-09
申请人： IKEDA MOHANDO CO
IPC分类号： C07C229/42 , C07C67/00 , C07C227/00 , C07C227/22 , C07D209/40 , C07C101/04 , A61K31/195

68. 发明专利

DK157576A 未知
公开(公告)号：DK157576A
公开(公告)日：1976-10-01
申请号：DK157576
申请日：1976-03-31
申请人： IKEDA MOHANDO CO
发明人： NOHARA F
IPC分类号： A61K31/19 , A61K31/195 , A61K31/196 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/20 , C07C229/42 , C07C241/00 , C07C257/08 , C07C

69. 发明专利

GB1391584A N-SUBSTITUTED ANTHRANILIC ACIDS 未知
公开(公告)号：GB1391584A
公开(公告)日：1975-04-23
申请号：GB2245273
申请日：1973-05-10
申请人： IKEDA MOHANDO CO
IPC分类号： A61K31/195 , A61K31/196 , A61P25/04 , A61P29/00 , B01J23/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07C17/093 , C07C17/12 , C07C17/26 , C07C45/46 , C07C49/788 , C07C67/00 , C07C205/12 , C07C227/00 , C07C227/08 , C07C227/18 , C07C229/58 , C07C101/50
摘要： 1391584 N-naphthyl-anthranilic acids IKEDA MOHANDO CO Ltd 10 May 1973 [11 May 1972] 22452/73 Heading C2C Novel compounds of Formula I in which R 1 is a hydrogen atom, a methyl group or a halogen atom, and R 2 is a halogen atom or an alkyl group containing from 1 to 6 carbon atoms, with the proviso that when R 1 is a hydrogen atom and R 2 is a methyl group, the methyl group R 2 is attached to the 3- or 4- position of the naphthalene nucleus are prepared by reacting together the compounds II and III in which Z is an amino group when Y is a halogen atom and Z is a halogen atom when Y is an amino group, or with a salt of such a naphthylamine or substituted benzoic acid, the reaction being carried out at a temperature of from 80‹ to 230‹ C. and in the presence of a catalyst, whereby the desired acid or salt is obtained, the acid obtained being converted if desired to a salt thereof. Naphthyl intermediates of Formula II above where Z is halogen, are prepared either by halogenation with halogen of the alkyl or dialkyl naphthalene, or by reaction of a halogenation agent, e.g. CuCl 2 , or sodium borofluorate on the diazotized amine of Formula II wherein Y is -NH 2 , the amine being obtained by hydrolysis of the corresponding N-acetyl compound obtained by various means such as halogenation or acylation of a precursor. Pharmaceutical compositions in conventional forms for oral, rectal or topical administration comprise an above novel compound and a carrier or diluent.

70. 发明专利

DK171350B1 未知
公开(公告)号：DK171350B1
公开(公告)日：1996-09-16
申请号：DK448885
申请日：1985-10-02
申请人： IKEDA MOHANDO CO
发明人： NOHARA FUJIO , FUJINAWA TOMOAKI
IPC分类号： A61K31/44 , A61K31/445 , A61K31/505 , A61K31/53 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/12
摘要： Pyridyloxy derivatives represented by the general formula: (1) wherein the substituted group Z is either one of the following groups: +TR were prepared. These derivatives exert antagonism against Histamine H2-receptors and hence are efficacious for the treatments of digestive ulcers.

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