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61. 发明专利

CA2661027A1 APPARATUS AND METHOD FOR SEPARATING A COMPOSITE LIQUID INTO AT LEAST TWO COMPONENTS 未知
公开(公告)号：CA2661027A1
公开(公告)日：2008-03-13
申请号：CA2661027
申请日：2007-08-28
申请人： CARIDIANBCT INC
发明人： HOLMES BRIAN M , HOGBERG NICLAS , STANTON BRIDEN RAY , PERSSON LARS , STRANDBERG LARS , PIHLSTEDT PETER
IPC分类号： A61M1/36 , B04B5/04 , B04B13/00
摘要： Method and apparatus for separating a volume of composite liquid into at least a first component and a second component including centrifuging a sepa ration bag (1) containing a volume of composite liquid and a volume of gas s o as to sediment at least a first component and a second component separatio n bag (1); displacing a volume of hydraulic fluid against the separation bag to cause a transfer of at least one fraction of the content of the separati on bag (1) into at least one component bag (2, 3, 4, 5) connected to the sep aration bag (1); determining the volume of hydraulic fluid displaced and det ermining the volume of the composite liquid or the transferred components fr om the determined volume of displaced hydraulic fluid.

62. 发明专利

CA2677258A1 BLOOD PROCESSING APPARATUS WITH ROBUST OUTFLOW PROCESS CONTROL 未知
公开(公告)号：CA2677258A1
公开(公告)日：2008-02-21
申请号：CA2677258
申请日：2007-07-06
申请人： CARIDIANBCT INC
发明人： LINDNER JOHN R , KOLENBRANDER JEREMY , SWEAT WILLIAM
IPC分类号： G01N15/04 , G01N33/49
摘要： A density centrifuge blood processing system comprising a separation cham ber rotating about a central rotation axis, the separation chamber having an outflow passage, a light source in optical communication with the density c entrifuge blood processing system, the light source providing an incident li ght beam for illuminating an observation region and a viewing region on the outflow passage, a first detector for the separation chamber to detect light from the observation region, a second detector for the outflow passage, a c omputational apparatus distinguishing one or more phase boundaries in the ob servation region and distinguishing fluid composition in the viewing region as a function of light intensity received from the viewing region, and a con troller regulating speed of at least one pump or of said separation chamber in response to signals from the computational apparatus.

63. 发明专利

CA2657229A1 BLOOD PROCESSING APPARATUS WITH ROBUST AUTOMATED PROCESS CONTROL 未知
公开(公告)号：CA2657229A1
公开(公告)日：2008-02-21
申请号：CA2657229
申请日：2007-07-02
申请人： CARIDIANBCT INC
发明人： LINDNER JOHN R , DALVI ADITYA , FLETCHER CHRISTOPHER , SWEAT WILLIAM , KOLENBRANDER JEREMY
IPC分类号： G01N15/04 , G01N33/49
摘要： A centrifuge for separating blood having a camera observing fluid flow, a nd a controller controlling the flow. The location of an interface is detect ed by image processing steps, which may comprise the steps of "spoiling" the image, "diffusing" the image, "edge detection", "edge linking", "region-bas ed confirmation", and "interface calculation". "Spoiling" reduces the number of pixels to be examined preferentially on orthogonal axis oriented with re spect to the expected location of the interface or phase boundary. "Diffusin g" smoothes out small oscillations in the interface boundary, making the loc ation of the interface more distinct. "Edge detection" computes the rate of change in pixel intensity, or. "Edge linking" connects adjacent maxima. "Reg ion-based confirmation" creates a pseudo image of the regions that qualify a s distinct. "Final edge calculation" uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for t he interface position.

64. 发明专利

CA2672076A1 EXTRACORPOREAL BLOOD PROCESSING INFORMATION MANAGEMENT SYSTEM 未知
公开(公告)号：CA2672076A1
公开(公告)日：2001-09-07
申请号：CA2672076
申请日：2001-03-01
申请人： CARIDIANBCT INC
发明人： BUTZKE SCOTT , PEMBERTON KIM , LANGLEY ROBERT , URDAHL STEVEN G , FLETCHER CHRISTOPHER , FLETCHER-HAYNES PETER , CORBIN FRANK III , JUDY RICHARD , SWEAT WILLIAM
IPC分类号： A61M1/02 , A61M1/36 , A61M1/38 , G06F19/00
摘要： A blood component collection system with manipulation and optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

65. 发明专利

AU6234198A Centrifuge and container system for treatment of blood and blood components 未知
公开(公告)号：AU6234198A
公开(公告)日：1998-09-08
申请号：AU6234198
申请日：1998-02-12
申请人： CARIDIANBCT INC
发明人： UNGER PETER , WESTBERG ERIC
IPC分类号： B04B5/04 , B04B5/00
摘要： A centrifuge is provided for the separation and/or treatment of cells in a substantially annular or partially annular separation bag connected by at least one tube to at least one secondary bag. The centrifuge comprises a rotor bowl connected at the upper end of a rotor shaft. The rotor shaft includes a hollow upper portion defining a central compartment for receiving the at least one secondary bag. The rotor bowl includes a separation compartment for receiving the separation bag and an expandable hydraulic chamber located within the separation compartment for selectively squeezing the separation bag within the separation compartment so as to transfer a separated component from the separation bag into a secondary bag in the central compartment. A hydraulic system is connected to the hydraulic chamber by a duct extending through the rotor shaft for pumping a hydraulic liquid to and from the hydraulic chamber.

66. 发明专利

CA2678893C METHODS TO CONTROL CELL MOVEMENT IN HOLLOW FIBER BIOREACTORS 未知
公开(公告)号：CA2678893C
公开(公告)日：2015-12-29
申请号：CA2678893
申请日：2008-03-05
申请人： CARIDIANBCT INC
发明人： ANTWILER GLEN DELBERT
IPC分类号： C12M1/12 , C12M3/06 , C12N5/071
摘要： A method for moving cells in a hollow fiber bioreactor (10), using fluid flow. The hollow fibers have an intracapillary space and an extracapillary space and the method comprises the steps of loading cells in the intracapillary space or extracapillary space; flowing fluid into one of the intracapillary space or extracapillary space containing the cells; and providing a fluid flow pressure in one of the intracapillary space or extracapillary space greater than the fluid flow pressure in the other of the intracapillary or extracapillary space.

67. 发明专利

AT537907T 未知
公开(公告)号：AT537907T
公开(公告)日：2012-01-15
申请号：AT01990890
申请日：2001-11-02
申请人： CARIDIANBCT INC
发明人： FELT THOMAS , HLAVINKA DENNIS
IPC分类号： B04B5/04 , A61M1/02 , A61M1/36 , A61M1/38 , B04B7/08 , B04B9/08
摘要： A method for separating a composite fluid into components in a centrifugal fluid separation system. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.

68. 发明专利

AT537906T 未知
公开(公告)号：AT537906T
公开(公告)日：2012-01-15
申请号：AT01270123
申请日：2001-11-02
申请人： CARIDIANBCT INC
发明人： HLAVINKA DENNIS , FELT THOMAS
IPC分类号： B04B5/04 , A61M1/02 , A61M1/36 , A61M1/38 , B04B7/08 , B04B9/08
摘要： A method for separating a composite fluid into components in a centrifugal fluid separation system. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.

69. 发明专利

AT528032T 未知
公开(公告)号：AT528032T
公开(公告)日：2011-10-15
申请号：AT03751900
申请日：2003-08-25
申请人： CARIDIANBCT INC
发明人： HOLMES BRIAN , HAGSTROEM JOHAN-PETER , LUNDBERG PER-OLOV , VAN WAEG GEERT , NORDGREN PETER
IPC分类号： A61M1/02 , A61M1/36 , B04B5/04 , B04B9/14 , B04B13/00

70. 发明专利

AT527004T 未知
公开(公告)号：AT527004T
公开(公告)日：2011-10-15
申请号：AT03706072
申请日：2003-02-03
申请人： CARIDIANBCT INC
发明人： CORBIN FRANK , URDAHL STEVEN
IPC分类号： A61M1/38 , A61J1/00 , A61M1/02 , A61M1/36 , A61M39/14 , B01D36/00 , B01D37/00
摘要： A method is disclosed for collecting and processing whole blood. Whole blood is collected at several remote donor sites and transported to a central blood-processing center, where information regarding demand for blood products is used to direct processing of whole blood into blood products. Whole blood is initially collected in collection bags unattached to satellite bags instead of commonly used multiple bag sets. When the determination is made at the blood processing center as to which blood products are to be made, the appropriate satellite bags and/or other system components are sterile docked to the blood-collection bag and the whole blood is processed. The use of blood-collection bags initially unattached to satellite bags eliminates waste and simplifies the transportation and processing of whole blood. Also disclosed are blood collection systems that remove leukocytes and collect whole blood into blood-collection bags unattached to satellite bags.

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