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61. 发明申请

WO2005048916A3 TETRAHYDROSPIRO-BETA-CARBOLINE-1,3 '-PYRROLIDINE DERIVATIVES AND THEIR USE IN GHSR-RELATED DISORDERS 审中-公开
标题翻译：四氢呋喃 - 吡咯烷-1,3'-吡咯烷衍生物及其在GHS相关疾病中的用途
公开(公告)号：WO2005048916A3
公开(公告)日：2007-12-13
申请号：PCT/SE2004001688
申请日：2004-11-18
申请人： BIOVITRUM AB , BRANDT PETER , BREMBERG ULF , CROSSLEY ROGER , GRAFFNER NORDBERG MALIN , JENMALM JENSEN ANNIKA , RINGBERG ERIK , WARD TERRY
发明人： BRANDT PETER , BREMBERG ULF , CROSSLEY ROGER , GRAFFNER NORDBERG MALIN , JENMALM JENSEN ANNIKA , RINGBERG ERIK , WARD TERRY
IPC分类号： C07D471/14 , A61K20060101 , A61K31/407 , A61K31/438 , A61K31/4747 , A61P3/04 , A61P3/10 , A61P5/08 , A61P9/04 , A61P9/10 , A61P35/00 , C07D209/00 , C07D221/00 , C07D317/00 , C07D471/00 , C07D471/18 , C07D471/20 , C07D471/22 , C07D491/00 , C07D491/14 , C07D491/20 , C07D491/22
CPC分类号： C07D471/20 , C07D491/20
摘要： The present invention relates to compounds of Formula (I): Formula (I) wherein R 3 -R 8 , X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.
摘要翻译：本发明涉及式（I）的化合物：式（I）其中R 3，R 3，X和Y如本文所述，制备方法化合物，包含该化合物的药物组合物，以及该化合物和组合物在预防或治疗GHSR受体相关病症中的用途。这种障碍的例子是肥胖症和相关疾病，例如II型糖尿病，血脂异常和代谢综合征Prader-Willi综合征，心血管疾病如动脉粥样硬化性血管疾病，心绞痛，心肌梗死和中风，肢端肥大症和癌症，特别是乳腺，肺，前列腺，甲状腺和内分泌腺癌。

62. 发明申请

WO2006062481A1 NEW BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS . 审中-公开
标题翻译：新的苯唑嘌呤衍生物及其在治疗肥胖，II型糖尿病和CNS病症中的用途。
公开(公告)号：WO2006062481A1
公开(公告)日：2006-06-15
申请号：PCT/SE2005/001885
申请日：2005-12-09
申请人： BIOVITRUM AB , DYKES, Graeme
发明人： DYKES, Graeme
IPC分类号： C07D405/04 , A61K31/496 , A61K31/5513 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/36 , A61P3/04 , C07D405/06 , C07D405/12
CPC分类号： C07D307/79 , C07D405/12
摘要： The present invention relates to compounds of the general Formula (I), wherein R 1 , R 2 and R 3 are as defined in the description; to pharmaceutical compositions comprising these compounds; and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1，R 2和R 3是如说明书中所定义的 ; 涉及包含这些化合物的药物组合物; 以及该化合物用于预防和治疗与肥胖症，II型糖尿病和/或CNS疾病有关的医学病症的用途。

63. 发明申请

WO2006001770A1 METHOD FOR IDENTIFYING MODULATORS OF CYTOKINE CLASS I RECEPTOR 审中-公开
标题翻译：鉴定细胞因子I类受体调节剂的方法
公开(公告)号：WO2006001770A1
公开(公告)日：2006-01-05
申请号：PCT/SE2005/001001
申请日：2005-06-23
申请人： BIOVITRUM AB , CHMIELEWSKA, Joanna , GRÄSLUND, Susanne , TJERNBERG, Agneta
发明人： CHMIELEWSKA, Joanna , GRÄSLUND, Susanne , TJERNBERG, Agneta
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , C07K14/72
摘要： The present invention relates to methods for the identification of modulators of cytokine class I receptors, in particular the growth hormone receptor, said method comprising identifying a molecule binding to a site at the receptor different from the binding site of the natural ligand of the said receptor; and using the said molecule in a competitive binding assay for identifying modulators of the said cytokine class I receptor.
摘要翻译：本发明涉及用于鉴定细胞因子I类受体，特别是生长激素受体的调节剂的方法，所述方法包括鉴定与不同于所述受体的天然配体结合位点的受体位点结合的分子 ; 并在竞争性结合测定中使用所述分子鉴定所述细胞因子I类受体的调节剂。

64. 发明申请

WO2005068646A1 METHODS FOR THE PROTEIN PRODUCTION AND PURIFICATION OF SOLUBLE RECOMBINANT POLYPEPTIDES 审中-公开
标题翻译：蛋白质生产和纯化可溶性重组多肽的方法
公开(公告)号：WO2005068646A1
公开(公告)日：2005-07-28
申请号：PCT/SE2005/000047
申请日：2005-01-18
申请人： BIOVITRUM AB , ABRAHMSÉN, Lars , NILSSON, Joakim , OPPERMAN, Udo , SVENSSON, Stefan
发明人： ABRAHMSÉN, Lars , NILSSON, Joakim , OPPERMAN, Udo , SVENSSON, Stefan
IPC分类号： C12P21/02
CPC分类号： C12N9/0006 , C12P21/02 , C12Y101/01146
摘要： The present invention relates to process for the production of a soluble polypeptide , such as 11β-hydroxysteroid dehydrogenase type 1, having at least one ligand binding site, the process comprising (i) providing a host cell comprising a nucleic acid sequence encoding the soluble polypeptide; (ii) culturing the host cell under conditions whereby the polypeptide is produced, wherein the cell culture medium comprises a non-proteinaceous ligand capable of binding to a ligand binding site of the polypeptide; and (iii) recovering said polypeptide.
摘要翻译：本发明涉及生产具有至少一个配体结合位点的可溶性多肽例如11β-羟类固醇脱氢酶1的方法，该方法包括（i）提供宿主细胞，其包含编码可溶性多肽的核酸序列 ; （ii）在产生多肽的条件下培养宿主细胞，其中所述细胞培养基包含能够结合所述多肽的配体结合位点的非蛋白质配体; 和（iii）回收所述多肽。

65. 发明申请

WO2004093781A3 PODOPHYLLOTOXIN DERIVATIVES AS IGF-1R INHIBITORS 审中-公开
标题翻译： PODOPHYLLOTOXIN衍生物作为IGF-1R抑制剂
公开(公告)号：WO2004093781A3
公开(公告)日：2005-02-17
申请号：PCT/SE2004000590
申请日：2004-04-15
申请人： BIOVITRUM AB , AXELSON MAGNUS , LARSSON OLLE
发明人： AXELSON MAGNUS , LARSSON OLLE
IPC分类号： A61K20060101 , A61K31/121 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/4355 , A61P5/06 , A61P9/10 , A61P17/06 , A61P35/00 , C07C49/213 , C07D317/48 , C07D491/153 , C07D493/04 , C07D493/14
CPC分类号： C07D305/14 , A61K31/165 , A61K31/215 , A61K31/353 , A61K31/382 , A61K31/44 , A61K31/444 , A61K31/47 , A61K31/695 , A61K41/00 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The invention refers to new compounds, e.g. podophyllotoxin derivatives, as well as to the use thereof and of known compounds as specific inhibitors of the insulin-like growth factor-1 receptor (IGF-1R). Said compounds can be used for treatment of IGF-1/IGF-1R dependent diseases, such as cancer, psoriasis, arteriosclerosis, certain endocrine and metabolic disorders etc.
摘要翻译：本发明涉及新化合物，例如，鬼臼毒素衍生物，以及其使用和已知化合物作为胰岛素样生长因子-1受体（IGF-1R）的特异性抑制剂。所述化合物可用于治疗IGF-1 / IGF-1R依赖性疾病，例如癌症，牛皮癣，动脉硬化，某些内分泌和代谢障碍等。

66. 发明申请

WO2004050904A1 PROTHROMBIN PURIFICATION 审中-公开
标题翻译：丙泊酚净化
公开(公告)号：WO2004050904A1
公开(公告)日：2004-06-17
申请号：PCT/SE2003/001549
申请日：2003-10-06
申请人： BIOVITRUM AB , WINGE, Stefan , AIZAWA, Peter
发明人： WINGE, Stefan , AIZAWA, Peter
IPC分类号： C12Q1/56
CPC分类号： C12N9/6429 , C12N9/6432 , C12Y304/21005 , C12Y304/21006
摘要： One aspect of the invention relates to a process for the preparation of a purified solution of prothrombin and factor X from a fraction of blood plasma obtainable by cryoprecipitation, which process comprises subjecting such a fraction to prepurification steps and to the following steps: (a) metal chelate gel chromatography and (b) affinity gel chromatography. Another aspect of the invention relates to a solution of prothrombin and factor X, wherein the prothrombin has the ability of being activated to thrombin in the substantial absence of other enzymes or cofactors. A further aspect of the invention relates to the use of a solution of prothrombin and factor X for the preparation of a thrombin solution.
摘要翻译：本发明的一个方面涉及一种通过冷沉淀制备可从血浆中分离出的凝血酶原和因子X的纯化溶液的方法，该方法包括使这种级分经过预纯化步骤和以下步骤：（a）金属螯合凝胶层析和（b）亲和凝胶层析。本发明的另一方面涉及凝血酶原和因子X的溶液，其中所述凝血酶原在基本上不存在其它酶或辅因子的情况下具有被激活至凝血酶的能力。本发明的另一方面涉及凝血酶原和因子X的溶液用于制备凝血酶溶液的用途。

67. 发明申请

WO2004000830A1 NOVEL COMPOUNDS, THEIR USE AND PREPARATION 审中-公开
标题翻译：新化合物，其使用和制备
公开(公告)号：WO2004000830A1
公开(公告)日：2003-12-31
申请号：PCT/SE2003/001044
申请日：2003-06-18
申请人： BIOVITRUM AB , NILSSON, Björn , RINGBERG, Erik , JÖNSSON, Mattias , SJÖBERG, Birger
发明人： NILSSON, Björn , RINGBERG, Erik , JÖNSSON, Mattias , SJÖBERG, Birger
IPC分类号： C07D401/14
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to compounds of the general Formula (I). The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related disorder. The invention also relates to such use as well as to pharmaceutical compositions comprising a compound of Formula (I).
摘要翻译：本发明涉及通式（I）的化合物。化合物可以通过本身常规方法制备，并且可以用于治疗患有5-羟色胺相关病症的人或动物受试者。本发明还涉及这样的用途以及包含式（I）化合物的药物组合物。

68. 发明申请

WO2003064467A1 A COMPLEX OF A HUMAN FOXC2 PROTEIN AND A FOXC2-INTERACTING PROTEIN 审中-公开
标题翻译：人FOXC2蛋白和FOXC2相互作用蛋白的复合物
公开(公告)号：WO2003064467A1
公开(公告)日：2003-08-07
申请号：PCT/SE2003/000139
申请日：2003-01-28
申请人： BIOVITRUM AB , CLIMENT-JOHANSSON, Isabel , ENERBÄCK, Sven
发明人： CLIMENT-JOHANSSON, Isabel , ENERBÄCK, Sven
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to complexes of the FOXC2 protein with other proteins, in particular complexes of FOXC2 with proteins designated p621, NOLP, HSC71, FTP3, CLH1, and Kinase A Anchor Protein 84/149 (AKAP). The protein complexes can be used in methods of identifying agents useful for the treatment of medical conditions that can be treated by modulated FOXC2 activity, such as obesity, hypertriglyceridemia, diet-induced insulin resistance, and/or type 2 diabetes.
摘要翻译：本发明涉及FOXC2蛋白与其他蛋白质的复合物，特别是FOXC2与称为p621，NOLP，HSC71，FTP3，CLH1和激酶A锚定蛋白84/149（AKAP）的蛋白质的复合物。蛋白质复合物可用于鉴定可用于治疗可通过调节的FOXC2活性如肥胖，高甘油三酯血症，饮食诱导的胰岛素抵抗和/或2型糖尿病治疗的医学病症的药剂的方法。

69. 发明申请

WO2003039547A1 USE OF SULFONAMIDE DERIVATIVES IN THE TREATMENT OF OBESITY OR FOR THE REDUCTION OF FOOD INTAKE 审中-公开
标题翻译：磺酰胺衍生物在治疗肥胖或减少食物摄入方面的应用
公开(公告)号：WO2003039547A1
公开(公告)日：2003-05-15
申请号：PCT/SE2002/002019
申请日：2002-11-06
申请人： BIOVITRUM AB , CALDIROLA, Patrizia
发明人： CALDIROLA, Patrizia
IPC分类号： A61K31/496
CPC分类号： A61K31/18 , A61K31/496
摘要： The invention provides a method of treatment or prophylaxis of obesity or for the reduction of food intake, comprising administering to a patient in need of such treatment a therapeutically effective amount of a sulfonamide compound of formula (I). Wherein the substituents are described in the specification.
摘要翻译：本发明提供了一种治疗或预防肥胖症或减少食物摄入的方法，包括向需要这种治疗的患者施用治疗有效量的式I磺酰胺化合物。其中取代基在说明书中描述。

70. 发明申请

WO2003035061A1 USE OF INDOLE AND INDOLINE DERIVATIVES IN THE TREATMENT OF OBESITY OR FOR THE REDUCTION OF FOOD INTAKE 审中-公开
标题翻译：在治疗肥胖或减少食物摄入时使用吲哚和吲哚衍生物
公开(公告)号：WO2003035061A1
公开(公告)日：2003-05-01
申请号：PCT/SE2002/001929
申请日：2002-10-22
申请人： BIOVITRUM AB , CALDIROLA, Patrizia
发明人： CALDIROLA, Patrizia
IPC分类号： A61K31/4045
CPC分类号： A61K31/4045 , C07D209/16
摘要： The invention provides the use of an indole or indoline derivative of Formula, II or III: wherein the substituents are as described in the specification; in the manufacture of a medicament for the treatment or prophylaxis of obesity or for the reduction of food intake. The invention also relates to the use of indole or indoline derivatives of Formula I, II or III for improving the bodily appearance of a mammal by causing loss of weight, as well as cosmetic compositions containing said compounds.
摘要翻译：本发明提供了式II或III的吲哚或二氢吲哚衍生物的用途：其中取代基如说明书所述; 在制备用于治疗或预防肥胖或减少食物摄取的药物中。本发明还涉及式I，II或III的吲哚或二氢吲哚衍生物用于通过引起重量损失来改善哺乳动物的身体外观以及含有所述化合物的化妆品组合物的用途。

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