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61. 发明申请

WO2019217471A1 INTRAOCULAR IMPLANT WITH REMOVABLE OPTIC 审中-公开
公开(公告)号：WO2019217471A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031189
申请日：2019-05-07
申请人： ACUFOCUS, INC.
发明人： WEBB, R. Kyle
IPC分类号： A61F2/16 , A61L27/16
摘要： Intraocular implants and methods of forming intraocular implants are described herein. The intraocular implant can include a powered optic and a lens holder. The optic can be mechanically coupled to an inner periphery of the lens holder to form the intraocular implant. A portion of the lens holder can include a mask disposed about the optic to increase depth of focus in a human patient.

62. 发明申请

WO2017091520A1 TORIC SMALL APERTURE INTRAOCULAR LENS WITH EXTENDED DEPTH OF FOCUS 审中-公开
标题翻译：具有延伸焦深的TORIC小孔人工晶状体
公开(公告)号：WO2017091520A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063181
申请日：2016-11-21
申请人： ACUFOCUS, INC.
发明人： LINK, William, J. , WEBB, R., Kyle
IPC分类号： G02C7/04
CPC分类号： A61F2/1645 , A61F2002/1696
摘要： An intraocular lens is provided that includes a refractive element and a mask. The refractive element has a first power in a first meridian and a second power greater than the first power in a second meridian. A magnitude of the first and second powers and a location of the first and second meridians are configured to correct astigmatism in a human eye. The mask is configured to block a substantial portion of light from passing through an annular region thereof and to permit a substantial portion of light to pass through a central aperture thereof to enhance an astigmatism correction rotational misplacement range and depth of focus.
摘要翻译：提供了一种包括折射元件和掩模的人工晶状体。折射元件在第一经线中具有第一功率并且在第二子午线中具有比第一功率大的第二功率。第一和第二光焦度的大小以及第一和第二子午线的位置被配置为校正人眼中的散光。该掩模被配置为阻挡大部分光穿过其环形区域并且允许大部分光穿过其中心孔以增强散光校正旋转错位范围和聚焦深度。

63. 发明申请

WO2011069059A1 CORNEAL IMPLANT FOR REFRACTIVE CORRECTION 审中-公开
标题翻译：用于折射校正的CORNEAL植入物
公开(公告)号：WO2011069059A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058879
申请日：2010-12-03
申请人： ACUFOCUS, INC. , CHRISTIE, Bruce, A. , SILVESTRINI, Thomas
发明人： CHRISTIE, Bruce, A. , SILVESTRINI, Thomas
IPC分类号： A61F2/14
CPC分类号： A61F2/145 , A61F2/15 , A61F2250/0098
摘要： A corneal implant adapted for implantation between layers of a cornea to focus an image on a retina of an eye includes an inlay, an outer perimeter, and a clear central region capable of refracting light to compensate for a refractive error of an eye. The inlay also has an annular opaque region comprising a plurality of holes or otherwise being adapted to transport nutrients. The annular opaque region extends from the outer circumference of the inlay to the clear central portion. The opaque region extends over a minority of the surface area of the implant. The anterior and posterior surfaces of the inlay are configured to abut adjacent layers of the cornea.
摘要翻译：适于在角膜层之间植入以将图像聚焦在眼睛的视网膜上的角膜植入物包括镶嵌物，外周边和能够折射光以补偿眼睛的屈光不正的透明中心区域。嵌体还具有包括多个孔的环形不透明区域，或者其它适于运输营养物质的环形不透明区域。环形不透明区域从嵌体的外圆周延伸到透明中心部分。不透明区域在植入物的少数表面区域上延伸。嵌体的前表面和后表面构造成邻接角膜的相邻层。

64. 发明申请

WO2011020074A9 CORNEAL INLAY WITH NUTRIENT TRANSPORT STRUCTURES 审中-公开
公开(公告)号：WO2011020074A9
公开(公告)日：2011-02-17
申请号：PCT/US2010/045541
申请日：2010-08-13
申请人： ACUFOCUS, INC. , CHRISTIE, Bruce , PETERSON, Edward, W. , VAN DE POL, Corina
发明人： CHRISTIE, Bruce , PETERSON, Edward, W. , VAN DE POL, Corina
IPC分类号： A61F2/14
摘要： Corneal inlays and masks and methods of improving vision of a patient with corneal inlays and masks are provided. Masks with an aperture can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. For example, a mask can have an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion, such as a clear lens or aperture. This provides an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The mask may also include nutrient transport structures that provide nutrient flow through mask to prevent nutrient depletion. These nutrient transport structures can be configured to concentrate nutrient transmission near a center region of the mask to provide more nutrient flow near the center region.

65. 发明申请

WO2011020074A1 CORNEAL INLAY WITH NUTRIENT TRANSPORT STRUCTURES 审中-公开
标题翻译：带有营养运输结构的脊椎内衬
公开(公告)号：WO2011020074A1
公开(公告)日：2011-02-17
申请号：PCT/US2010045541
申请日：2010-08-13
申请人： ACUFOCUS INC , CHRISTIE BRUCE , PETERSON EDWARD W , VAN DE POL CORINA
发明人： CHRISTIE BRUCE , PETERSON EDWARD W , VAN DE POL CORINA
IPC分类号： A61F2/14
CPC分类号： A61F2/15 , A61F2/1451 , A61F2250/0024 , G02C7/046 , G02C7/165
摘要： Corneal inlays and masks and methods of improving vision of a patient with corneal inlays and masks are provided. Masks with an aperture can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. For example, a mask can have an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion, such as a clear lens or aperture. This provides an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The mask may also include nutrient transport structures that provide nutrient flow through mask to prevent nutrient depletion. These nutrient transport structures can be configured to concentrate nutrient transmission near a center region of the mask to provide more nutrient flow near the center region.
摘要翻译：提供角膜嵌体和面罩以及改善角膜嵌体和面罩患者视力的方法。具有孔径的面罩可以改善患者的视力，例如通过增加患者眼睛的焦点深度。例如，掩模可以具有围绕相对高的透射中心部分的相对较低的可见光透射的环形部分，例如透明透镜或光圈。这提供了具有小孔径的环形掩模，用于光通过到视网膜以增加聚焦深度。面罩还可以包括营养输送结构，其提供通过面罩的营养物流以防止营养物质耗尽。这些营养物质运输结构可以被配置为将营养物质传播集中在面罩的中心区域附近，以在中心区域附近提供更多的营养物流。

66. 发明申请

WO2006113377A3 CORNEAL MASK FORMED OF DEGRADATION RESISTANT POLYMER 审中-公开
公开(公告)号：WO2006113377A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/013944
申请日：2006-04-13
申请人： ACUFOCUS, INC. , SILVESTRINI, Thomas, A.
发明人： SILVESTRINI, Thomas, A.
IPC分类号： A61L27/16 , A61F9/007
摘要： Disclosed are masks (34) configured to be implanted in a cornea of a patient. In one embodiment, the body of the mask has a light transmitting portion (38) , a light blocking portion disposed about the light transmitting portion, and an outer periphery surrounding the light blocking portion (36) . The mask is adapted to reside between two intracorneal layers of a cornea. In a preferred embodiment, the mask is formed from a material comprising a highly fluorinated polymeric material and an opacification agent and is resistant to degradation upon exposure to ultraviolet light. In another embodiment, the mask is formed from a material which comprises a polyanionic compound. In some embodiments, the mask includes one or more wound healing modulator compounds to aid in proper healing following implantation.

67. 发明公开

EP3359987A1 METHODS OF MOLDING INTRAOCULAR LENSES 有权转让
公开(公告)号：EP3359987A1
公开(公告)日：2018-08-15
申请号：EP16854144.9
申请日：2016-10-03
申请人： AcuFocus, Inc.
发明人： WEBB, R., Kyle , TARANTINO, Nicholas , SIEMS, Daniel, David
IPC分类号： G02B3/00 , G02B27/00 , G02B1/04
CPC分类号： A61F2/15 , A61F2/16 , A61F2002/1696 , B29D11/00442 , B29D11/023
摘要： Intraocular implants and methods of making intraocular implants are disclosed. The intraocular implant can include a mask adapted to increase depth of focus. The method of manufacturing the implant can include filling an annular mask-forming trough with an opaque mask material and adding an optically transmissive optic material over the opaque mask material.

68. 发明公开

EP3220859A1 FRACTURABLE MASK FOR TREATING PRESBYOPIA 有权转让
标题翻译：用于治疗编年史的可压缩面膜
公开(公告)号：EP3220859A1
公开(公告)日：2017-09-27
申请号：EP15860513.9
申请日：2015-11-17
申请人： Acufocus, Inc.
发明人： WEBB, R. Kyle , SIEMS, Daniel David
IPC分类号： A61F9/00
CPC分类号： A61F2/16 , A61F2/15 , A61F2002/1696 , A61F2240/001 , A61F2250/0018 , A61F2250/0071 , B29D11/023
摘要： A fracturable mask for treating presbyopia is disclosed. The fracturable mask can include an aperture for improving depth of focus. The fracturable mask can be embedded in an intraocular lens. The intraocular lens can include a lens body and the fracturable mask. The fracturable mask can be configured to fracture along a plurality of fracture pathways when the intraocular lens is manipulated. For example, fractures can be created in the mask during the process of injecting the intraocular lens through a cartridge tip into a patient's eye. The fractures can allow the resilient lens body to restore the fractured mask to its original, pre-injection optical performance specifications.
摘要翻译：公开了一种用于治疗老花眼的可折叠面膜。可破裂面罩可以包括用于改善焦点深度的孔。可分解的面罩可以嵌入人工晶状体中。人工晶状体可以包括镜片主体和可断裂面膜。当人工晶状体被操纵时，可断裂面罩可以被配置为沿着多个骨折路径断裂。例如，在通过药筒尖端将人工晶状体注入患者眼睛的过程中，可以在面罩中产生裂缝。这些裂缝可以使弹性镜片主体将破裂的面罩恢复到原来的预注射光学性能规格。

69. 发明公开

EP2969501A4 PROCESS FOR MANUFACTURING AN INTRAOCULAR LENS WITH AN EMBEDDED MASK 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER INTRAOKULARLINSE MIT EINER EINGEBETTETEN MASKE
公开(公告)号：EP2969501A4
公开(公告)日：2016-04-27
申请号：EP14775085
申请日：2014-02-27
申请人： ACUFOCUS INC
发明人： REBOUL ADAM C , BENZ PATRICK H , WEBB R KYLE
IPC分类号： B29D11/02 , A61F2/14
CPC分类号： B29D11/023 , A61F2/16 , A61F2002/1681 , A61F2230/0006 , B29C33/123 , B29D11/00442 , B29D11/0048 , B29K2627/16 , B29K2995/0093
摘要： Intraocular implants and methods of making intraocular implants are provided. The intraocular implant can include a mask adapted to increase depth of focus. The method of manufacturing the implant can include positioning the mask with an aperture on a protruding pin of a positioning mold portion. The protruding pin can be configured to center the mask in the intraocular lens.
摘要翻译：提供了眼内植入物和制造眼内植入物的方法。眼内植入物可以包括适于增加焦点深度的掩模。制造植入物的方法可以包括将具有孔的面罩定位在定位模具部分的突出销上。突出的销可以被配置为将面罩置于人工晶状体中。

70. 发明公开

EP2967839A1 IN SITU ADJUSTABLE OPTICAL MASK 有权
标题翻译：原位可调光学掩膜
公开(公告)号：EP2967839A1
公开(公告)日：2016-01-20
申请号：EP14780317.5
申请日：2014-03-04
申请人： Acufocus, Inc.
发明人： SILVESTRINI, Thomas, A.
IPC分类号： A61F2/14 , A61F9/04
CPC分类号： A61F2/1659 , A61F2/14 , A61F2/15 , A61F2002/1696 , G02F1/009 , G02F1/0126 , G02F1/0147 , G02F1/15 , G02F2202/022 , G02F2202/08 , G02F2202/14 , G02F2203/48 , G03C1/73 , G03C1/733
摘要： Implantable corneal and intraocular implants such as a mask are provided. The mask can improve the vision of a patient, such as by being configured to increase the depth of focus of an eye of a patient. The mask can include an aperture configured to transmit along an optical axis substantially all visible incident light. The mask can further include a transition portion that surrounds at least a portion of the aperture. This portion can be configured to switch from one level of opacity to another level of opacity through the use of a controllably variable absorbance feature such as a switchable photochromic chromophore within a polymer matrix.
摘要翻译：提供可植入的角膜和眼内植入物，例如面罩。面罩可以改善患者的视力，例如通过被配置为增加患者眼睛的焦点深度。面罩可以包括被配置为沿着光轴传输基本上全部可见入射光的光圈。面罩可以进一步包括围绕孔的至少一部分的过渡部分。这部分可以配置为通过使用可控可变吸光度特征（例如聚合物基质内的可切换光致变色发色团）从一个不透明等级切换到另一个不透明等级。

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