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61. 发明授权

US08417335B2 Synchronized ventricular pacing to promote atrial sensing 失效
公开(公告)号：US08417335B2
公开(公告)日：2013-04-09
申请号：US12539167
申请日：2009-08-11
申请人： Jaeho Kim , Joseph Bocek , Anthony Harrington
发明人： Jaeho Kim , Joseph Bocek , Anthony Harrington
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/3682
摘要： Methods and systems are described that involve synchronized ventricular pacing that promotes sensing of atrial events. The atrioventricular pacing delay is modified based on characteristics of previously sensed atrial events. The modified AV delay is implemented relative to a first atrial event. A second AV delay is implemented relative to a second atrial event if the second atrial event is sensed during the modified AV delay. A ventricular pacing pulse is delivered following the second AV delay.

62. 发明授权

US08409618B2 Odor-reducing quinone compounds 有权
标题翻译：气味降低醌化合物
公开(公告)号：US08409618B2
公开(公告)日：2013-04-02
申请号：US10955316
申请日：2004-09-30
申请人： John Gavin MacDonald , Stephanie M. Martin , Jaeho Kim
发明人： John Gavin MacDonald , Stephanie M. Martin , Jaeho Kim
IPC分类号： A61K9/14
CPC分类号： D06M13/005 , A23L27/32 , A23L27/77 , A23V2002/00 , A61K31/197 , A61K31/375 , A61K31/57 , A61K31/65 , A61L9/01 , A61L9/014 , A61L15/46 , A61L2300/216 , A61L2300/442 , A61L2300/624 , D21H17/06 , D21H21/14 , D21H21/28 , Y10T442/2525 , A23V2200/25
摘要： An odor control composition that comprises an odor-reducing quinone compound and optionally high surface area particles is provided. In one embodiment, the odor-reducing quinone compound is an anthraquinone having the following structure: wherein the numbers 1 through 8 refer to optional substitution positions for functional groups. For example, positions 5 through 8 of the anthraquinone may be unsubstituted with functional groups. Examples of such quinone compounds may include those obtained from a dye selected from the group consisting of Acid Blue 25, Acid Green 41, Acid Blue 45, Mordant Violet 5, Acid Blue 129, Acid Green 25, D&C Green No. 5, Acid Green 27, and combinations thereof.
摘要翻译：提供了包含气味降低醌化合物和任选的高表面积颗粒的气味控制组合物。在一个实施方案中，气味降低醌化合物是具有以下结构的蒽醌：其中数字1至8表示官能团的任选取代位置。例如，蒽醌的5至8位可以被官能团取代。这样的醌化合物的实例可以包括从由酸性蓝25，酸性绿41，酸性蓝45，媒染紫5，酸性蓝129，酸性绿25，D＆C绿5，酸性绿 27及其组合。

63. 发明申请

US20130052121A1 CARBON FILM LAMINATE 有权
标题翻译：碳膜层压板
公开(公告)号：US20130052121A1
公开(公告)日：2013-02-28
申请号：US13580468
申请日：2011-02-25
申请人： Masataka Hasegawa , Masatou Ishihara , Yoshinori Koga , Jaeho Kim , Kazuo Tsugawa , Sumio Iijima
发明人： Masataka Hasegawa , Masatou Ishihara , Yoshinori Koga , Jaeho Kim , Kazuo Tsugawa , Sumio Iijima
IPC分类号： B32B15/20 , B32B33/00 , C01B31/00 , B32B15/04 , B32B9/04 , B82Y30/00
CPC分类号： C23C16/0281 , B82Y30/00 , B82Y40/00 , C01B32/05 , C01B32/186 , C01B32/50 , C23C16/26 , C30B29/02 , C30B29/04 , C30B29/20 , Y10T428/30 , Y10T428/31678
摘要： An object of the present invention is to solve a problem such as a small crystal size, which is the issue of a conventional method for formation of a film of graphene by a thermal CVD technique using a copper foil as a substrate, and thus providing a carbon film laminate in which graphene having a larger crystal size is formed. The carbon film laminate is configured to include a sapphire (0001) single crystal having a surface composed of terrace surfaces which are flat at the atomic level, and atomic-layer steps, a copper (111) single crystal thin film formed by epitaxial growth on the substrate and graphene deposited on the copper (111) single crystal thin film, and thus enabling formation of graphene having a large crystal size.
摘要翻译：本发明的目的是解决诸如小晶体尺寸的问题，这是通过使用铜箔作为基板的热CVD技术形成石墨烯的薄膜的常规方法的问题，因此提供形成具有较大晶体尺寸的石墨烯的碳膜层压体。碳膜层压体被构造为包括具有由原子层平坦的台面表面构成的表面的蓝宝石（0001）单晶，以及原子层台阶，通过外延生长形成的铜（111）单晶薄膜衬底和石墨烯沉积在铜（111）单晶薄膜上，从而形成具有大晶体尺寸的石墨烯。

64. 发明申请

US20120215273A1 METHOD AND APPARATUS FOR CONCURRENT ATRIO-VENTRICULAR ANTI-TACHYCARDIA PACING 有权
标题翻译：相关性ATRIO-VENTRICULAR ANTI-TACHYCARDIA PACING的方法和装置
公开(公告)号：US20120215273A1
公开(公告)日：2012-08-23
申请号：US13457630
申请日：2012-04-27
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式，根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

65. 发明申请

US20120179057A1 BLENDING CARDIAC RHYTHM DETECTION PROCESSES 审中-公开
标题翻译：混合心脏RHYTHM检测过程
公开(公告)号：US20120179057A1
公开(公告)日：2012-07-12
申请号：US13428577
申请日：2012-03-23
申请人： Jaeho Kim , Joseph M. Bocek , Julie A. Thompson , Eric G. Lovett
发明人： Jaeho Kim , Joseph M. Bocek , Julie A. Thompson , Eric G. Lovett
IPC分类号： A61B5/0464
CPC分类号： A61N1/3962 , A61B5/04525 , A61B5/7264 , A61N1/3622 , A61N1/3925 , A61N1/395
摘要： Systems and methods are described for classifying a cardiac rhythm. A cardiac rhythm is classified using a classification process that includes a plurality of cardiac rhythm discriminators. Each rhythm discriminator provides an independent classification of the cardiac rhythm. The classification process is modified if the modification is likely to produce enhanced classification results. The rhythm is reclassified using the modified classification process.
摘要翻译：描述了用于分类心律的系统和方法。使用包括多个心律识别器的分类处理对心律进行分类。每个节律鉴别器提供心脏节律的独立分类。如果修改可能产生增强的分类结果，则修改分类过程。使用修改的分类过程重新分类节奏。

66. 发明授权

US08185195B2 Arrhythmia classification and therapy selection 失效
标题翻译：心律失常分类与治疗选择
公开(公告)号：US08185195B2
公开(公告)日：2012-05-22
申请号：US12708106
申请日：2010-02-18
申请人： Jaeho Kim , Joseph Bocek , Eric G. Lovett
发明人： Jaeho Kim , Joseph Bocek , Eric G. Lovett
IPC分类号： A61N1/36
CPC分类号： A61B5/7264 , A61B5/04525
摘要： Different types of cardiac arrhythmia are classified based on the morphology of the arrhythmic beats. Cardiac beats associated with an arrhythmic episode are compared to a plurality of representative beat morphologies, each representative beat morphology characterizing a type of arrhythmia of the heart. An arrhythmic episode may be classified as a particular type of arrhythmia if the morphology of the arrhythmic cardiac beats matches a representative beat morphology characterizing the particular type of arrhythmia. An appropriate therapy for the particular type of arrhythmia may be selected based on the arrhythmia classification. A particular type of arrhythmia may be associated with one or more therapies used to treat the arrhythmia. The therapy used to treat the arrhythmia may comprise a therapy identified as a previously successful therapy.
摘要翻译：基于心律失常节律的形态分类不同类型的心律失常。与心律失常发作相关的心脏搏动与多个代表性搏动形态进行比较，每个代表性搏动形态表征心脏心律失常的类型。如果心律失常心跳的形态与表征特定类型的心律失常的代表性搏动形态匹配，则心律失常发作可被分类为特定类型的心律失常。可以基于心律失常分类来选择针对特定类型的心律失常的适当疗法。特定类型的心律失常可能与用于治疗心律失常的一种或多种治疗相关联。用于治疗心律失常的治疗可以包括被确定为先前成功的治疗的治疗。

67. 发明授权

US08170669B2 Method and apparatus for concurrent atrio-ventricular anti-tachycardia pacing 有权
标题翻译：并发房室性心动过速起搏方法及装置
公开(公告)号：US08170669B2
公开(公告)日：2012-05-01
申请号：US12234840
申请日：2008-09-22
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式，根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

68. 发明申请

US20120065696A1 Method and System for Characterizing Supraventricular Rhythm during Cardiac Pacing 有权
标题翻译：心脏起搏过程中表现室性节律的方法与系统
公开(公告)号：US20120065696A1
公开(公告)日：2012-03-15
申请号：US13159686
申请日：2011-06-14
申请人： Joseph Bocek , Jaeho Kim , Anthony S. Harrington , Lorenzo A. DiCarlo , Harley G. White , Phillip D. Foshee , David L. Perschbacher
发明人： Joseph Bocek , Jaeho Kim , Anthony S. Harrington , Lorenzo A. DiCarlo , Harley G. White , Phillip D. Foshee , David L. Perschbacher
IPC分类号： A61N1/365
CPC分类号： A61N1/3622
摘要： A method and system for generating a characterization of one beat of a patient's supraventricular rhythm (SVR) involves performing such characterization while the heart is being paced. During SVR characterization, various pacing parameters are modified and the patient's supraventricular rhythm is characterized while the pacing parameters are modified. The SVR characterization process is effective in single and multiple chamber pacing modes.
摘要翻译：用于产生患者室上性节律（SVR）的一搏的表征的方法和系统涉及在心脏起搏时进行这种表征。在SVR表征期间，修改了各种起搏参数，并对患者的室上节律进行了表征，同时对起搏参数进行了修改。 SVR表征过程在单腔和多腔起搏模式中有效。

69. 发明申请

US20110288603A1 POST-SHOCK RECOVERY MONITORING FOR TACHYARRHYTHMIA DISCRIMINATION 有权
标题翻译：用于TACHYARRHYTHMIA分辨率的震后恢复监测
公开(公告)号：US20110288603A1
公开(公告)日：2011-11-24
申请号：US13195425
申请日：2011-08-01
申请人： Jaeho Kim , Joseph M. Bocek , Eric G. Lovett
发明人： Jaeho Kim , Joseph M. Bocek , Eric G. Lovett
IPC分类号： A61N1/39
CPC分类号： A61B5/0464 , A61N1/3925 , A61N1/3962
摘要： A cardiac rhythm management device is configured to discriminate between ventricular and supraventricular tachycardias (referred to as SVT/VT discrimination) by utilizing a morphology criterion in which the morphology of electrogram waveforms during ventricular beats are analyzed to determine if the beats are normally conducted. After the delivery of a cardioversion/defibrillation shock, however, the intraventricular conduction system is left in a modified state which alters the subsequently generated electrogram signal. Use of the morphology criterion for to SVT/VT discrimination is discontinued after delivery of such a shock and resumed after a predetermined minimum number of normally conducted ventricular beats has been detected.
摘要翻译：心律管理装置被配置为通过利用形态学标准来区分心室和室上性心动过速（称为SVT / VT鉴别），其中分析心室搏动时的电描记图波形的形态以确定节拍是否正常进行。然而，在输出心脏复律/除颤休克之后，心室内传导系统处于改变随后产生的电描记图信号的修改状态。在发生这种休克之后，停止使用SVT / VT鉴别的形态学标准，并且在检测到预定的最小数量的正常进行的心室搏动之后恢复。

70. 发明授权

US08041425B2 Atrial tachyarrhythmia detection using selected atrial intervals 失效
标题翻译：使用选择的心房间隔进行心房快速性心律失常检测
公开(公告)号：US08041425B2
公开(公告)日：2011-10-18
申请号：US12538294
申请日：2009-08-10
申请人： Jaeho Kim , Joseph Bocek , Anthony Harrington , Harley White
发明人： Jaeho Kim , Joseph Bocek , Anthony Harrington , Harley White
IPC分类号： A61B1/00
CPC分类号： A61N1/3702 , A61B5/0464 , A61N1/3622
摘要： Methods and systems are directed to detecting atrial tachyarrhythmia. A plurality of A-A intervals is detected. The detected A-A intervals are selected and used to detect atrial tachyarrhythmia. Selecting A-A intervals may be based on determining that A-A intervals are qualified. Qualified A-A intervals may be determined if a duration of the particular A-A interval falls outside a predetermined duration range, for example. Qualified A-A intervals may also be determined based on events occurring between consecutively sensed atrial events of the particular A-A interval, and whether the duration of the particular A-A interval falls within the predetermined duration range, for example.
摘要翻译：方法和系统旨在检测房性快速性心律失常。检测到多个A-A间隔。检测到的A-A间隔被选择并用于检测房性快速性心律失常。选择A-A间隔可以基于确定A-A间隔是合格的。例如，如果特定A-A间隔的持续时间落在预定的持续时间范围之外，则可以确定合格的A-A间隔。也可以基于特定A-A间隔的连续感测的心房事件之间发生的事件以及特定A-A间隔的持续时间是否落入预定持续时间范围内来确定合格的A-A间隔。

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