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    • 69. 发明申请
    • Method for Ionically Cross-Linking Polysaccharide Material for Thin Film Applications and Products Produced Therefrom
    • 用于薄膜应用的多糖材料的离子交联方法及其生产的产品
    • US20070128247A1
    • 2007-06-07
    • US11565055
    • 2006-11-30
    • Yasushi Kato
    • Yasushi Kato
    • A61L15/00
    • A61L27/34A61L27/507A61L31/10C08L5/06
    • A method for producing ionically cross-linked polysaccharide material (e.g. pectin) that includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the polysaccharide-based coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca2+), or possibly strontium (Sr2+), magnesium (Mg2+), barium (Ba2+), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.
    • 用于生产离子交联的多糖材料(例如果胶)的方法,其包括将该材料溶解在包括溶解液体的第一液体溶液中。 将第一液体溶液施加到工件上以在工件上形成多糖基涂层。 将涂层干燥以除去大部分溶解液。 在干燥之后,将涂层暴露于第二液体溶液,其包括促进多糖类涂层的离子交联的化合物。 在优选的实施方案中,溶解液体包含水和可能的极性溶剂。 离子交联化合物优选包含二价阳离子如钙(Ca 2+),或可能的锶(Sr 2+),镁(Mg 2+) +),钡(Ba 2+)或其它多价离子。 这种方法形成用于各种应用的均匀的离子交联膜和/或涂层,包括诸如可植入血管移植物,支架移植物和/或支架的医疗装置。