专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO1996016663A1 THIONOPHOSPHATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：硫代磷酸酯衍生物，其制备方法及含有它们的药物组合物
公开(公告)号：WO1996016663A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015199
申请日：1995-11-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , TIROSH, Oren , KATZHENDLER, Joshua , GINSBURG, Isaac , BARENHOLZ, Yehezkel , KOHEN, Ron
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61K31/66
CPC分类号： C07F9/2458 , A61K8/55 , A61K2800/522 , A61Q17/00
摘要： The invention relates to a compound of formula (I) in which X1 and X2 each independently represents an oxygen or nitrogen atom; p, m and n are each independently an integer of at least 2; R, R1 and R2 each independently represents a hydrogen atom; a halogen atom; an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group R3O in which R3 is hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl or optionally substituted aryl or heteroaryl; a group R4O(O)C in which R4 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group -SR5 in which R5 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group -NR6R7 in which R6 and R7 each independently represents a hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl; or an optionally substituted phosphate ester group. The invention also relates to processes for the preparation of compounds of the formula and to pharmaceutical compositions containing the same.
摘要翻译：本发明涉及式（I）化合物，其中X 1和X 2各自独立地表示氧或氮原子; p，m和n各自独立地为至少2的整数; R，R 1和R 2各自独立地表示氢原子; 卤素原子; 任选取代的直链或支链烷基，烯基或炔基; R3为氢原子的基团R3O，任意取代的直链或支链烷基，链烯基或炔基; 任选取代的酰基或任选取代的芳基或杂芳基; R 4为氢原子的基团R 4 O（O）C或任选取代的直链或支链烷基，链烯基或炔基; R5为氢原子的基团-SR5或任意取代的直链或支链烷基，链烯基或炔基; R 6和R 7各自独立地表示氢原子的基团-NR 6 R 7，任选取代的直链或支链烷基，烯基或炔基; 任选取代的酰基; 或任选取代的磷酸酯基团。本发明还涉及制备式的化合物的方法和含有该化合物的药物组合物。

62. 发明申请

WO1996015225A1 IN VITRO MICROORGANS 审中-公开
标题翻译：在体外微生物
公开(公告)号：WO1996015225A1
公开(公告)日：1996-05-23
申请号：PCT/US1994014822
申请日：1994-12-21
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MITRANI, Eduardo
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C12N05/00
CPC分类号： A61K8/02 , A61K2800/86 , A61Q7/02 , A61Q19/00 , C12N5/0062
摘要： An in vitro microorgan culture, method for forming the same and uses thereof are provided. The cells in the culture, for example hair follicles, are capable of proliferation and/or homeostasis over an extended period of time while maintaining their natural affinity for neighboring cells. The microorgan cultures are characterized by a surface area to volume ratio of at least 1.5mm .
摘要翻译：提供体外微生物培养，其形成方法及其用途。培养物中的细胞，例如毛囊，能够在延长的时间内能够增殖和/或体内平衡，同时保持对相邻细胞的天然亲和力。微生物培养物的特征在于表面积与体积比至少为1.5mm -1。

63. 发明申请

WO1995034294A1 CONTROLLED RELEASE ORAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：控制释放口服药物输送系统
公开(公告)号：WO1995034294A1
公开(公告)日：1995-12-21
申请号：PCT/US1995007519
申请日：1995-06-13
申请人： HAMILTON, BROOK, SMITH & REYNOLDS, P.C. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , RUBINSTEIN, Abraham , RADAI, Raphael , FRIEDMAN, Michael , TIROSH, Boaz , BALUOM, Muhammad , NASSAR, Taher
发明人： HAMILTON, BROOK, SMITH & REYNOLDS, P.C. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K09/20
CPC分类号： A61K9/2013 , A61K9/2027
摘要： The present invention relates to a controlled release drug delivery system comprising a drug which is susceptible to enzymatic degradation by enzymes present in the intestinal tract; and a polymeric matrix which undergoes erosion in the gastrointestinal tract comprising a hydrogel-forming polymer selected from the group consisting of (a) polymers which are themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inhibiting degradation of said drug by intestinal enzymes; and (b) polymers which are not themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inhibiting degradation of said drug by intestinal enzymes; wherein when the matrix comprises a polymer belonging to group (b) the delivery system further comprises an agent which enhances absorption of said drug across the intestinal mucosal tissues and/or an agent which inhibits degradation of said drug by intestinal enzymes and when the matrix comprises a polymer belonging to group (a) the delivery system optionally further comprises an agent which enhances absorption of said drug across the intestinal mucosal tissues and/or an agent which inhibits degradation of said drug by intestinal enzymes.
摘要翻译：本发明涉及一种控释药物递送系统，其包含易于通过存在于肠道中的酶进行酶降解的药物; 以及在胃肠道中遭受侵蚀的聚合物基质，其包含选自以下的水凝胶形成性聚合物：（a）本身能够增强所述药物穿过肠粘膜组织的吸收并且通过以下方式抑制所述药物的降解的聚合物：肠酶; 和（b）本身不能增强所述药物穿过肠粘膜组织的吸收并且通过肠酶抑制所述药物降解的聚合物; 其中当所述基质包含属于组（b）的聚合物时，所述递送系统还包含增强所述药物穿过肠粘膜组织的吸收的试剂和/或通过肠酶抑制所述药物降解的药剂，并且当所述基质包含属于（a）组的聚合物任选地还包含增强所述药物穿过肠粘膜组织的吸收的试剂和/或通过肠酶抑制所述药物降解的试剂。

64. 发明申请

WO1995030439A2 PREVENTION OF TUMOR METASTASIS 审中-公开
标题翻译：预防肿瘤分化
公开(公告)号：WO1995030439A2
公开(公告)日：1995-11-16
申请号：PCT/US1995005819
申请日：1995-05-09
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT, MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD. , MCINNIS, Patricia, G. , NAOR, David , ZAHALKA, Muayad , OKON, Elimelech
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT, MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD. , MCINNIS, Patricia, G.
IPC分类号： A61K39/395
CPC分类号： C12N9/2408 , A61K38/00 , C07K16/2803 , C07K16/2842 , C07K16/2884
摘要： Tumor metastasis is inhibited by the use of active agents which block infiltration of tumor cells into secondary target organs. These agents include a number of antibodies and various fragments and derivatives thereof as well as hyaluronidase, hyaluronic acid and analogs thereof.
摘要翻译：通过使用阻断肿瘤细胞浸润到次要靶器官中的活性剂来抑制肿瘤转移。这些试剂包括许多抗体及其各种片段和衍生物，以及透明质酸酶，透明质酸及其类似物。

65. 发明申请

WO1995029666A1 SUSTAINED-RELEASE PHARMACEUTICAL SYSTEM FOR THE DELIVERY OF ANTIOXIDANTS 审中-公开
标题翻译：用于递送抗氧化剂的持续释放药物系统
公开(公告)号：WO1995029666A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005504
申请日：1995-05-03
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , FRIEDMAN, Michael , KOHEN, Ron
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61K09/22
CPC分类号： A61K31/375 , A61K9/2031 , A61K9/2054 , A61K9/2063 , A61K9/7007 , A61K31/015 , A61K31/355 , A61K33/04 , A61K2300/00
摘要： The invention relates to a sustained-release pharmaceutical delivery system for the administration of an antioxidant drug to a patient in need of such drug, wherein said delivery system comprises said drug in combination with a polymeric matrix, said matrix comprising a polymer which does not interact with said drug or a mixture of such polymers. The pharmaceutical delivery system of the invention is useful for the treatment of pathological conditions involving pathologically increased formation of active oxygen species.
摘要翻译：本发明涉及用于向需要这种药物的患者施用抗氧化药物的持续释放药物递送系统，其中所述递送系统包括与聚合物基质组合的所述药物，所述基质包含不相互作用的聚合物与所述药物或这些聚合物的混合物。本发明的药物递送系统可用于治疗涉及病理增加的活性氧形成的病理状况。

66. 发明申请

WO1995024503A1 SENSITIVE CANCER TEST 审中-公开
标题翻译：敏感性癌症检测
公开(公告)号：WO1995024503A1
公开(公告)日：1995-09-14
申请号：PCT/EP1995000823
申请日：1995-03-06
申请人： RAPAPORT, Erich , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD. , HOCHBERG, Abraham , ARIEL, Ilana
发明人： RAPAPORT, Erich , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6841 , C12Q1/6886 , C12Q2600/112
摘要： An extremely sensitive assay for the early detection of human cancer, of various types, is based on the use of a molecular marker, designated as Gene H19, which is used for in situ hybridization of a tissue sample and for indicating the absence or presence of a malignancy and its grading by a suitable marker. The probe can be derived from the H19 gene by subcloning at a suitable site in a plasmid, antisense RNA is produced by transcription with a polymerase and suitable fragments are labelled to produce, after hybridization, the desired signal. The label can be radioactive or fluorescent, or a color reagent can be used. Amongst malignancies assayed are a trophoblastic tumor, bladder carcinoma, ovarian teratoma, pediatric Wilms' Tumor, rhabdomyosarcoma, and testicular cancer. Also, a kit for carrying out such an assay is provided.
摘要翻译：用于各种类型的人类癌症的早期检测的非常敏感的测定是基于使用称为基因H19的分子标记，其用于组织样品的原位杂交，并指示不存在或不存在恶性肿瘤及其通过适当的标记分级。探针可以通过在质粒的合适位点亚克隆从H19基因衍生，反义RNA通过用聚合酶转录产生，合适的片段经过杂交后产生所需信号。标签可以是放射性的或荧光的，或者可以使用着色试剂。检测的恶性肿瘤之一是滋养细胞肿瘤，膀胱癌，卵巢畸胎瘤，儿科Wilms肿瘤，横纹肌肉瘤和睾丸癌。此外，提供了用于进行这种测定的试剂盒。

67. 发明申请

WO1995004473A1 REMOVAL OF CHOLESTEROL FROM EDIBLES 审中-公开
标题翻译：从食物中去除胆固醇
公开(公告)号：WO1995004473A1
公开(公告)日：1995-02-16
申请号：PCT/US1994008814
申请日：1994-08-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HEINE, Holliday, C. , GARTI, Nissim
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HEINE, Holliday, C.
IPC分类号： A23L01/015
CPC分类号： A23C7/043 , A23C15/145 , A23L5/273 , A23L15/00 , A23L29/238 , A23V2002/00 , A23V2200/3262 , A23V2300/02 , A23V2300/14
摘要： A process for the removal of a predetermined percentage of cholesterol from edibles which contain such cholesterol by hydrocolloid extractants according to the inventions, preferably galactomannoses, is disclosed. Also disclosed is the in vivo use of such extractants to provide control of cholesterol levels.
摘要翻译：公开了一种通过根据本发明的水解胶体提取物从包含这种胆固醇的食品中除去预定百分比的胆固醇的方法，优选为半乳糖甘露糖。还公开了这种提取剂的体内使用以提供对胆固醇水平的控制。

68. 发明申请

WO1998009641A1 SEMIPEPTOID FARNESYL PROTEIN TRANSFERASE INHIBITORS AND ANALOGS THEREOF 审中-公开
标题翻译： SEMIPEPTOID FARNESYL蛋白转移酶抑制剂及其类似物
公开(公告)号：WO1998009641A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015157
申请日：1997-08-28
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , FRIEDMAN, Mark, M. , LEVITZKI, Alexander , GILON, Chaim , REUVENI, Hadas
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , FRIEDMAN, Mark, M.
IPC分类号： A61K38/06
CPC分类号： C07K5/1013 , A61K38/00
摘要： A farnesyl protein transferase (i.e., farnesyltransferase) inhibitors formed as peptoid and semipeptoid peptidomimetic compounds derived from a farnesyltransferase universal recognition tetrapeptide sequence CAAX (i.e., CAAX motif) and analogs thereof, and to the use of these compounds and analogs and ester derivatives thereof as chemotherapeutic agents in oncogenic or non-oncogenic Ras associated cancers and proliferative diseases.
摘要翻译：由法呢基转移酶通用识别四肽序列CAAX（即CAAX基序）及其类似物衍生的拟胆碱和半皮下模拟肽化合物形成的法呢基蛋白转移酶（即法呢基转移酶）抑制剂以及这些化合物及其类似物和酯衍生物作为致癌或非致癌性Ras相关癌症和增殖性疾病中的化学治疗剂。

69. 发明申请

WO1997045372A1 ULTRAPURIFICATION METHOD AND SAMPLER 审中-公开
标题翻译：超声方法和采样器
公开(公告)号：WO1997045372A1
公开(公告)日：1997-12-04
申请号：PCT/IL1997000172
申请日：1997-05-29
申请人： STATE OF ISRAEL, ATOMIC ENERGY COMMISSION SOREQ NUCLEAR RESEARCH CENTER , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , TEL-OR, Elisha , COHEN, Nava , ZAFRIR, Hovav , ILZYCER, Danielle
发明人： STATE OF ISRAEL, ATOMIC ENERGY COMMISSION SOREQ NUCLEAR RESEARCH CENTER , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C02F01/28
CPC分类号： C02F1/286 , C02F3/327 , C02F2101/006 , Y02W10/18
摘要： The remarkable metal binding properties of the dried biomass of the water fern Azolla are exploited to purify various contaminated liquids. One aspect of the invention relates to a method for the ultrapurification of an aqueous solution from a heavy metal ion comprising passing the solution through a dried biomass of the water fern Azolla. Further aspects relate to the reclamation of potable water from contaminated water and the purification of radioactively contaminated liquid waste. Also disclosed is a sampler for determining the presence of a heavy metal ion in an aqueous solution comprising a receptacle containing a dried biomass of the water fern Azolla.
摘要翻译：利用水蕨Azolla的干燥生物质的显着的金属结合性能来净化各种污染的液体。本发明的一个方面涉及一种用于从重金属离子超级净化水溶液的方法，包括使溶液通过水蕨Azolla的干燥生物质。其他方面涉及从受污染的水中回收饮用水和净化放射性污染的废液。还公开了一种用于测定水溶液中重金属离子的存在的取样器，该水溶液包含含有蕨类植物Azolla的干燥生物质的容器。

70. 发明申请

WO1997045012A1 TOPICAL PEDICULICIDAL COMPOSITIONS 审中-公开
标题翻译：局部药用组合物
公开(公告)号：WO1997045012A1
公开(公告)日：1997-12-04
申请号：PCT/GB1997001434
申请日：1997-05-27
申请人： BEN GURION UNIVERSITY OF THE NEGEV , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , GODWIN, Edgar, James , SINTOV, Amnon , WOLF, David , MUMCUOGLU, Kosta, Yani , MARKUS, Arie
发明人： BEN GURION UNIVERSITY OF THE NEGEV , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , GODWIN, Edgar, James
IPC分类号： A01N25/24
CPC分类号： A01N25/24 , A61K8/731 , A61K8/737 , A61K8/8182 , A61K2800/5426 , A61Q17/02
摘要： The invention provides a topical pediculicidal composition for the treatment of human and animal and other arthropod ectoparasites comprising an insecticidally effective amount of at least one active ingredient in combination with a bioadhesive cationic polymer, having affinity for the hair and providing retention of the active ingredient in the hair.
摘要翻译：本发明提供了一种用于治疗人和动物和其他节肢动物外寄生虫的局部杀菌组合物，其包含杀虫有效量的至少一种活性成分与生物粘附性阳离子聚合物的组合，对毛发具有亲和力并且提供活性成分的保留头发。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式