专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US4843089A Antimycotic agent 失效
标题翻译：抗真菌剂
公开(公告)号：US4843089A
公开(公告)日：1989-06-27
申请号：US55818
申请日：1987-05-29
申请人： Graham Holmwood , Wolfgang Kramer , Karl H. Buchel , Manfred Plempel
发明人： Graham Holmwood , Wolfgang Kramer , Karl H. Buchel , Manfred Plempel
IPC分类号： A61K31/41 , A61K31/415 , A61P31/00 , A61P31/04 , C07D233/60 , C07D233/61 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A method of combating mycoses which comprises administering to a patient an antimycotically effective amount of a hydroxyethyl-azole of the formula ##STR1## in which R.sup.1 represents alkyl or the grouping Ar--Y--,Ar represents optionally substituted aryl,Y represents a direct bond or the groupings --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --, --CH.dbd.CH-- or --C.dbd.C--,X represents a nitrogen atom or the CH group,Z represents oxygen or the NOR.sup.2 group andR.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl, or an acid addition salt thereof.
摘要翻译：一种防治真菌病的方法，其包括向患者施用抗真菌有效量的式“IMAGE”的羟乙基唑，其中R 1表示烷基或Ar-Y-，Ar表示任选取代的芳基，Y表示直接键或-CH 2 - ， - CH 2 -CH 2 - ， - OCH 2 - ， - CH 2 - ， - CH = CH-或-C = C-，X表示氮原子或CH基团，Z表示氧或NOR2基团和R 2表示氢，烷基，烯基，炔基，任选取代的芳烷基或任选取代的环烷基烷基，或其酸加成盐。

62. 发明授权

US4451281A Fungicidal and plant growth-regulating 1-azolyl-2-oximinobutane and use 失效
标题翻译：杀菌和植物生长调节1-吖唑-2-基亚氨基丁烷并使用
公开(公告)号：US4451281A
公开(公告)日：1984-05-29
申请号：US490688
申请日：1983-05-02
申请人： Hans-Ludwig Elbe , Wolfgang Kramer , Karl H. Buchel , Klaus Lurssen , Paul Reinecke , Hans Scheinpflug
发明人： Hans-Ludwig Elbe , Wolfgang Kramer , Karl H. Buchel , Klaus Lurssen , Paul Reinecke , Hans Scheinpflug
IPC分类号： A01N43/50 , A01N43/64 , A01N43/647 , A01N43/653 , A61K31/41 , A61P31/04 , C07C45/63 , C07C49/16 , C07D233/60 , C07D233/61 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07C323/00 , C07C45/63 , C07C49/16 , C07D233/56 , C07D249/08
摘要： 1-Azolyl-2-oximinobutane derivatives of the formula ##STR1## in which A is nitrogen or CH,R.sup.1 is hydrogen, alkyl, halogenoalkyl, alkenyl, alkinyl, or optionally substituted benzyl, phenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl, andR.sup.2 is optionally substituted phenyl, phenoxy, phenylthio, phenylsulphinyl or phenylsulphonyl,or physiologically acceptable addition products thereof with acids or metal salts, which possess fungicidal and plant growth-regulating activities.
摘要翻译：其中A为氮或CH，R 1为氢，烷基，卤代烷基，烯基，炔基或任选取代的苄基，苯基，环烷基，环烷基烷基或环烯基，而R2为1-芳基-2-肟基丁烷衍生物任选取代的苯基，苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基，或其与酸或金属盐的生理上可接受的加成产物，其具有杀真菌剂和植物生长调节活性。

63. 发明授权

US4215131A Antimicrobial agents 失效
标题翻译：抗微生物剂
公开(公告)号：US4215131A
公开(公告)日：1980-07-29
申请号：US21295
申请日：1979-03-16
申请人： Wolfgang Kramer , Karl H. Buchel , Manfred Plempel , Ingo Haller
发明人： Wolfgang Kramer , Karl H. Buchel , Manfred Plempel , Ingo Haller
IPC分类号： C07D249/08 , A61K31/41 , A61P31/04 , A61P31/10 , C07D233/60 , C07D521/00 , A01N9/00 , A01N9/22
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Pharmaceutical compositions free from pathogenic microorganisms which could be harmful to warm-blooded animals, are provided containing, as an active ingredient, an antimicrobially effective amount of at least one compound of the formula ##STR1## in which R represents hydrogen, --CO--R.sup.1 or --SO.sub.2 --R.sup.2, whereinR.sup.1 represents optionally substituted alkyl, alkenyl or alkinyl, optionally substituted phenyl, optionally substituted phenoxyalkyl, phenylalkyl, cycloalkyl, alkylamino, dialkylamino or optionally substituted phenylamino,R.sup.2 represents alkyl or optionally substituted phenyl,A represents a keto group or a --CH(OH)-- grouping,X represents hydrogen or an --OR grouping, whereinR is as defined above,X.sup.1 represents alkyl or optionally substituted phenyl,Y represents --CH-- or a nitrogen atom,Z represents halogen, alkyl, halogenoalkyl, cycloalkyl, alkoxy, alkythio, alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, amino, cyano or nitro andn represents 0 or an integer from 1 to 5, or a salt thereof, in admixture with a sterile pharmaceutical carrier, such as a solid or liquefied gaseous diluent, or with a liquid diluent other than a solvent of molecular weight less than 200 (preferably 300) except in the presence of a surface-active agent.The compositions of the invention are useful as antimycotic agents.Also included in the invention is the provision of the compositions of the invention in unit dosage form as well as the provision of methods of treatment wherein the compositions of the invention are administered to warm-blooded animals.
摘要翻译：提供了不含可能对温血动物有害的致病微生物的药物组合物，其含有抗微生物有效量的至少一种下式化合物（Ⅰ），其中R表示氢， - CO-R1或-SO2-R2，其中R1表示任选取代的烷基，烯基或炔基，任选取代的苯基，任选取代的苯氧基烷基，苯基烷基，环烷基，烷基氨基，二烷基氨基或任选取代的苯基氨基，R 2表示烷基或任选取代的苯基，A表示酮基或-CH（OH） - 基，X表示氢或-OR基团，其中R如上定义，X 1表示烷基或任选取代的苯基，Y表示-CH-或氮原子，Z表示卤素烷基，卤代烷基，环烷基，烷氧基，链烯基，烷氧基羰基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基，氨基，氰基或硝基，n代表0或1至5的整数，或其盐与无菌药物载体（例如固体或液化气体稀释剂）混合，或与分子量小于 200（优选300），除了在表面活性剂的存在下。本发明的组合物可用作抗真菌剂。本发明还包括以单位剂量形式提供本发明的组合物以及提供治疗方法，其中将本发明的组合物施用于温血动物。

64. 发明授权

US4904682A Treating mycoses with triazolylalkanols 失效
标题翻译：用三唑基烷醇处理真菌病
公开(公告)号：US4904682A
公开(公告)日：1990-02-27
申请号：US260082
申请日：1988-10-19
申请人： Wolfgang Kramer , Graham Holmwood , Karl H. Buchel , Manfred Plempel
发明人： Wolfgang Kramer , Graham Holmwood , Karl H. Buchel , Manfred Plempel
IPC分类号： A61K31/41 , A61P31/04 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A method of combating mycoses in a patient in need thereof which comprises administering to such patient an antimycotically effective amount of a triazolylalkanol of the formula ##STR1## in which Ar stands for optionally substituted aryl andX stands for one of the groups --CH.sub.2 --; --O--CH.sub.2 --; --S--CH.sub.2 --; --CH.sub.2 --CH.sub.2 --; --CH.dbd.CH-- or --C.tbd.C--,or a physiologically tolerable acid addition salt thereof.
摘要翻译：一种在有需要的患者中对抗真菌病的方法，其包括向所述患者施用抗真菌有效量的下式的三唑基烷醇：其中Ar表示任选取代的芳基，X表示基团-CH 2 - 之一; -O-CH 2 - ; -S-CH 2 - ; -CH 2 -CH 2 - ; -CH = CH-或-CB 3 C，或其生理上可耐受的酸加成盐。

65. 发明授权

US4239766A Combating fungi with 1-(4-phenoxy)-3,3-dimethyl-2-(N-halogenoalkylmercapto-carbamoyloxy)-1-(1 ,2,4-triazol-1-yl)-butanes 失效
标题翻译：将1-（4-苯氧基）-3,3-二甲基-2-（N-卤代烷基巯基 - 氨基甲酰氧基）-1-（1,2,4-三唑-1-基） - 丁烷
公开(公告)号：US4239766A
公开(公告)日：1980-12-16
申请号：US46283
申请日：1979-06-07
申请人： Wolfgang Kramer , Karl H. Buchel , Engelbert Kuhle , Paul-Ernst Frohberger , Wilhelm Beandes
发明人： Wolfgang Kramer , Karl H. Buchel , Engelbert Kuhle , Paul-Ernst Frohberger , Wilhelm Beandes
IPC分类号： A01N47/24 , C07D233/60 , C07D249/08 , C07D521/00 , A01N47/12
CPC分类号： C07D231/12 , A01N47/24 , C07D233/56 , C07D249/08
摘要： A 1-(4-phenoxy)-3,3-dimethyl-2-(N-halogenoalkylmercapto-carbamoyloxy)-1-(1,2,4-triazol-1-yl)-butane of the formula ##STR1## in which R.sup.1 is alkyl or optionally substituted phenyl,R.sup.2 is halogenoalkyl,X is hydrogen or halogen,Y is hydrogen or halogen,Z each independently is alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, alkoxycarbonyl, optionally substituted phenyl, phenoxy or phenylalkyl, cyano or nitro, andn is 0, 1, 2, 3, 4 or 5,and physiologically acceptable acid addition salts and metal salt complexes thereof which possess fungicidal properties.
摘要翻译：具有式“IMAGE”的1-（4-苯氧基）-3,3-二甲基-2-（N-卤代烷基巯基 - 氨基甲酰氧基）-1-（1,2,4-三唑-1-基） - 丁烷，其中 R1是烷基或任选取代的苯基，R 2是卤代烷基，X是氢或卤素，Y是氢或卤素，Z各自独立地是烷基，环烷基，烷氧基，烷硫基，卤代烷基，烷氧基羰基，任选取代的苯基，苯氧基或苯基烷基，氰基或硝基，n为0,1,2,3,4或5，以及具有杀真菌性质的生理上可接受的酸加成盐和金属盐络合物。

66. 发明授权

US4233311A Antimicrobial agents and their use 失效
标题翻译：抗微生物剂及其用途
公开(公告)号：US4233311A
公开(公告)日：1980-11-11
申请号：US897900
申请日：1978-04-18
申请人： Wolfgang Kramer , Karl H. Buchel , Manfred Plempel , Ingo Haller
发明人： Wolfgang Kramer , Karl H. Buchel , Manfred Plempel , Ingo Haller
IPC分类号： A61K9/08 , A61K31/41 , A61K31/415 , A61P31/04 , C07C45/71 , C07C49/255 , C07D233/60 , C07D249/08 , C07D521/00 , A61K31/555
CPC分类号： C07D231/12 , C07C45/71 , C07C49/255 , C07D233/56 , C07D249/08
摘要： The invention involves the provision of compositions containing a 3,3-dialkyl- or 3-aryl-phenoxy-1-(1,2,4-triazol-1-yl)- and (imidazol-1-yl-alkan-2-ol) ethers which are particularly effective as antimicrobial especially antimycotic, agents. The invention also includes use of said compositions for providing antimicrobial, particularly antimycotic effect.
摘要翻译：本发明涉及提供含有3,3-二烷基 - 或3-芳基 - 苯氧基-1-（1,2,4-三唑-1-基） - 和（咪唑-1-基 - 烷-2-基 - 特别是抗微生物剂，特别是抗微生物剂。本发明还包括使用所述组合物提供抗微生物特别是抗真菌作用。

67. 发明授权

US4183940A Antimycotic imidazolyl-9,10-dihydro-anthracene derivatives 失效
标题翻译：抗真菌咪唑基-9,10-二氢 - 蒽衍生物
公开(公告)号：US4183940A
公开(公告)日：1980-01-15
申请号：US840461
申请日：1977-10-07
申请人： Karl H. Buchel , Wolfgang Kramer , Manfred Plempel , Ingo Haller
发明人： Karl H. Buchel , Wolfgang Kramer , Manfred Plempel , Ingo Haller
IPC分类号： A61K31/415 , A61P31/04 , C07D233/56 , C07D233/58 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention provides new azolyl-9,10-dihydroanthracene derivatives of the formula ##STR1## in which A represents a CH group or a nitrogen atom,B represents a CO group or a group of the formula: ##STR2## X, Y and Z are identical or different and represent halogen, alkyl, halogenoalkyl, alkoxy, or alkylthio and n represents 0 or an integer of from 1 to 4,and their salts.Also included in the invention are methods for the preparation of said compounds, compositions containing said compounds and methods for their use. The compounds of the invention have antimycotic activity.
摘要翻译：本发明提供了式（I）的新的唑基-9,10-二氢蒽衍生物，其中A表示CH基团或氮原子，B表示CO基团或下式的基团：X， Y和Z相同或不同，表示卤素，烷基，卤代烷基，烷氧基或烷硫基，n表示0或1-4的整数，及其盐。本发明还包括制备所述化合物的方法，含有所述化合物的组合物及其使用方法。本发明的化合物具有抗真菌活性。

68. 发明授权

US4154842A Fungicidally and bactericidally active 1-azolyl-4-hydroxy-1-phenoxy-butane derivatives 失效
标题翻译：杀真菌和杀菌活性的1-噻唑基-4-羟基-1-苯氧基 - 丁烷衍生物
公开(公告)号：US4154842A
公开(公告)日：1979-05-15
申请号：US819534
申请日：1977-07-27
申请人： Wolfgang Kramer , Karl H. Buchel , Paul-Ernst Frohberger , Peter Kraus
发明人： Wolfgang Kramer , Karl H. Buchel , Paul-Ernst Frohberger , Peter Kraus
IPC分类号： A01N43/50 , A01N43/653 , C07C49/17 , C07D233/60 , C07D249/08 , C07D521/00 , A01N9/22 , A01N21/00
CPC分类号： C07D231/12 , A01N43/653 , C07D233/56 , C07D249/08
摘要： 1-Azolyl-4-hydroxy-1-phenoxy-butane derivatives of the formula ##STR1## in which R is hydrogen, --CO--R.sup.1 or --SO.sub.2 --R.sup.2,R.sup.1 is cycloalkyl, alkylamino, dialkylamino, alkenyl, alkynyl, or optionally substituted alkyl, phenyl, phenoxyalkyl, phenylalkyl or phenylamino,R.sup.2 is alkyl or optionally substituted phenyl,A is --CO--or CH(OH),X is H or --OR,X.sup.1 is alkyl or optionally substituted phenyl,Y is CH or N,Z is halogen, alkyl, halogenoalkyl, cycloalkyl, alkoxy, alkylthio, alkoxycarbonyl, amino, cyano, nitro, or optionally substituted phenyl, phenoxy or phenylalkyl, andN is 0, 1, 2, 3, 4 or 5,Or a salt thereof, which possess fungicidal and bactericidal properties.
摘要翻译：其中R是氢，-CO-R 1或-SO 2 -R 2，R 1是环烷基，烷基氨基，二烷基氨基，烯基，炔基或任选地被一个或多个取代基取代的具有式（I）的1-苯并恶唑-4-羟基-1-苯氧基 - 丁烷衍生物取代的烷基，苯基，苯氧基烷基，苯基烷基或苯基氨基，R2是烷基或任选取代的苯基，A是-CO-或CH（OH），X是H或-OR，X 1是烷基或任选取代的苯基，Y是CH或N ，Z是卤素，烷基，卤代烷基，环烷基，烷氧基，烷硫基，烷氧基羰基，氨基，氰基，硝基或任选取代的苯基，苯氧基或苯基烷基，和N IS 0,1,2,3,4或5，或盐因此，具有防伪和杀菌特性。

69. 发明授权

US4747869A Substituted azolyl-ketones and -alcohols 失效
标题翻译：取代的唑基酮和醇
公开(公告)号：US4747869A
公开(公告)日：1988-05-31
申请号：US724375
申请日：1985-04-18
申请人： Wolfgang Kramer , Karl H. Buchel , Klaus Ditgens , Hans-Ludwig Elbe , Gerhard Jager , Manfred Jautelat , Klaus Lurssen , Paul Reinecke
发明人： Wolfgang Kramer , Karl H. Buchel , Klaus Ditgens , Hans-Ludwig Elbe , Gerhard Jager , Manfred Jautelat , Klaus Lurssen , Paul Reinecke
IPC分类号： A01N43/50 , A01N43/653 , C07C17/269 , C07C43/225 , C07C45/51 , C07C45/59 , C07C49/16 , C07C49/185 , C07D233/60 , C07D249/08 , C07D317/26 , C07D521/00 , A61K31/41
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07C17/269 , C07C43/225 , C07C45/513 , C07C45/59 , C07C49/16 , C07C49/185 , C07D233/56 , C07D249/08 , C07D317/26
摘要： Substituted azoyl-ketones and -alcohols of the formula ##STR1## in which A is a nitrogen atom or the CH group,B is CO or CH(OH),R.sup.1 is alkyl, alkenyl, alkinyl, optionally substituted phenylalkyl, optionally substituted cycloalkyl or optionally substituted cycloalkylalkyl,R.sup.2 is optionally substituted cycloalkyl or the grouping --C(CH.sub.3).sub.2 R.sup.3, andR.sup.3 is alkyl having more than 2 carbon atoms, alkenyl, alkinyl or the --CH.dbd.O group or a derivative thereof,or addition products thereof with acids or metal salts, exhibit plant growth regulating and fungicidal properties, several intermediates therefor are new.
摘要翻译：取代的式（IMAGE）的芳基酮和醇，其中A是氮原子或CH基团，B是CO或CH（OH），R 1是烷基，烯基，炔基，任选取代的苯基烷基，任选取代的环烷基或任选取代的环烷基烷基，R 2是任选取代的环烷基或基团-C（CH 3）2 R 3，并且R 3是具有多于2个碳原子的烷基，烯基，炔基或-CH = O基团或其衍生物，或其加成产物与酸或金属盐，表现出植物生长调节和杀真菌性能，其中几个是新的。

70. 发明授权

US4147791A 1-Substituted-1,2,4-triazole fungicidal compositions and methods for combatting fungi that infect or attack plants 失效
标题翻译： 1-取代的-1,2,4-三唑杀真菌组合物和用于对抗感染或攻击植物的真菌的方法
公开(公告)号：US4147791A
公开(公告)日：1979-04-03
申请号：US550242
申请日：1975-02-14
申请人： Werner Meiser , Karl H. Buchel , Wolfgang Kramer , Ferdinand Grewe
发明人： Werner Meiser , Karl H. Buchel , Wolfgang Kramer , Ferdinand Grewe
IPC分类号： C07D249/08 , A01N9/22 , A01N21/00
CPC分类号： C07D249/08
摘要： 1-SUBSTITUTED-1,2,4-TRIAZOLES OF THE FORMULA ##STR1## in which X.sup.1 represents hydrogen or an alkyl radical,X.sup.2 represents hydrogen or an alkyl radical,R.sup.1 represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or optionally substituted aryl or aralkyl radical,R.sup.2 represents hydrogen or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or optionally substituted aryl or aralkyl radical,R.sup.3 represents hydrogen or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or optionally substituted aryl or aralkyl radical, andY represents a keto group or a functional keto derivative, which possess fungicidal properties.
摘要翻译：其中X 1表示氢或烷基，X 2表示氢或烷基，R 1表示烷基，烯基，炔基，环烷基，环烯基（C 1 -C 6）的1-取代的1,2,4-三唑或任选取代的芳基或芳烷基，R 2表示氢或烷基，烯基，炔基，环烷基，环烯基或任选取代的芳基或芳烷基，R 3表示氢或烷基，烯基，炔基，环烷基，环烯基或任选取代的芳基或芳烷基基团，Y表示具有杀真菌性质的酮基或官能酮衍生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式