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61. 发明授权

US09450118B2 Detector apparatus 有权
标题翻译：检测仪
公开(公告)号：US09450118B2
公开(公告)日：2016-09-20
申请号：US14238849
申请日：2012-08-15
申请人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
发明人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
IPC分类号： H01J40/16 , H01L31/024 , H01J40/02 , H01J43/02 , H01J43/28
CPC分类号： H01L31/024 , H01J40/02 , H01J40/16 , H01J43/02 , H01J43/28
摘要： A detector apparatus that is embodied to receive light and to generate electrical signals has a housing and a detector arranged in the housing. The detector includes a light sensor that is embodied to receive light and to release electrons. The light sensor is at a lower electrical potential level than the housing; and that the detector is in thermally conductive contact with the housing via an electrically insulating intermediate arrangement, the thermal conduction direction inside the housing being opposite to the light propagation direction of the light to be detected.
摘要翻译：体现为接收光并产生电信号的检测器装置具有设置在壳体中的壳体和检测器。检测器包括被实现为接收光并释放电子的光传感器。光传感器处于比壳体更低的电位电平; 并且检测器经由电绝缘的中间布置与壳体导热接触，壳体内部的热传导方向与待检测光的光传播方向相反。

62. 发明授权

US09372334B2 Microscope and method for fluorescence imaging microscopy 有权
标题翻译：显微镜和荧光成像显微镜的方法
公开(公告)号：US09372334B2
公开(公告)日：2016-06-21
申请号：US13495538
申请日：2012-06-13
申请人： Volker Seyfried
发明人： Volker Seyfried
IPC分类号： G01N21/64 , H04N7/18 , G02B21/36 , G02B21/16
CPC分类号： G02B21/365 , G01N21/6408 , G01N21/6458 , G02B21/16
摘要： A microscope for fluorescence imaging microscopy, in particular for wide-field fluorescence microscopy, including a pulsed light source (1) and an imaging detector (11), is characterized in that means for gating are provided, and in that the gating causes the light source (1) and the detector (11) to be synchronized in order to suppress reflected/scattered light such that suitable fluorescence components are used for evaluation and unsuitable components are rejected. Furthermore, a method is used to perform fluorescence imaging microscopy using the microscope according to the present invention.
摘要翻译：用于荧光成像显微镜的显微镜，特别是用于宽场荧光显微术，包括脉冲光源（1）和成像检测器（11）的特征在于，提供用于门控的装置，并且门控引起光源（1）和检测器（11）进行同步，以抑制反射/散射光，使得适当的荧光成分用于评价，并且拒绝不合适的成分。此外，使用根据本发明的显微镜进行荧光成像显微镜的方法。

63. 发明授权

US08913317B2 Method and device for illuminating a sample in a laser microscope 有权
标题翻译：用于在激光显微镜中照射样品的方法和装置
公开(公告)号：US08913317B2
公开(公告)日：2014-12-16
申请号：US12674343
申请日：2008-08-11
申请人： Volker Seyfried , Hilmar Gugel , Carsten L. Thomsen
发明人： Volker Seyfried , Hilmar Gugel , Carsten L. Thomsen
IPC分类号： G02B21/08 , H01S3/131 , H01S4/00 , G02B21/00
CPC分类号： G02B21/0032
摘要： The invention relates to a method and a device for illuminating or irradiating an object, a sample (8), or the like, for the purpose of imaging or analysis, particularly for use in a laser microscope (1), preferably in a confocal microscope having a laser light source (2) emitting the illuminating light, the laser light being coupled directly or by means of a glass fiber into an illumination light path (4), characterized in that the laser light source (2) is switched on rapidly upon a trigger signal directly prior to the actual need, for example, directly prior to imaging.
摘要翻译：本发明涉及一种用于照射或照射物体的方法和装置，用于成像或分析的样品（8）等，特别是用于激光显微镜（1）中，优选在共聚焦显微镜具有发射所述照明光的激光源（2），所述激光直接或通过玻璃纤维耦合到照明光路（4）中，其特征在于，所述激光源（2）被快速地接通直接在实际需要之前的触发信号，例如直接在成像之前。

64. 发明申请

US20140306098A1 DETECTOR APPARATUS 有权
标题翻译：检测仪器
公开(公告)号：US20140306098A1
公开(公告)日：2014-10-16
申请号：US14238849
申请日：2012-08-15
申请人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
发明人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
IPC分类号： H01L31/024 , H01J40/02
CPC分类号： H01L31/024 , H01J40/02 , H01J40/16 , H01J43/02 , H01J43/28
摘要： A detector apparatus that is embodied to receive light and to generate electrical signals has a housing and a detector arranged in the housing. The detector includes a light sensor that is embodied to receive light and to release electrons. The light sensor is at a lower electrical potential level than the housing; and that the detector is in thermally conductive contact with the housing via an electrically insulating intermediate arrangement, the thermal conduction direction inside the housing being opposite to the light propagation direction of the light to be detected.
摘要翻译：体现为接收光并产生电信号的检测器装置具有设置在壳体中的壳体和检测器。检测器包括被实现为接收光并释放电子的光传感器。光传感器处于比壳体更低的电位电平; 并且检测器经由电绝缘的中间布置与壳体导热接触，壳体内部的热传导方向与待检测光的光传播方向相反。

65. 发明授权

US08503076B2 Apparatus for the detection of light in a scanning microscope 有权
标题翻译：用于在扫描显微镜中检测光的装置
公开(公告)号：US08503076B2
公开(公告)日：2013-08-06
申请号：US12600646
申请日：2008-05-06
申请人： Holger Birk , Volker Seyfried
发明人： Holger Birk , Volker Seyfried
IPC分类号： G02B21/00
CPC分类号： G01J1/44 , G01J1/46 , G01J3/2803 , G02B21/0032 , G02B21/0096 , H01L31/107
摘要： A light detector for use in a line scanning microscope and a microscope comprising such a light detector are described. The light detector comprises a line array of avalanche semiconductor detectors; and an electronic trigger circuit that is adapted to operate the avalanche semiconductor detectors in at least one of a Geiger mode with internal charge amplification and in a linear mode. The trigger circuit further comprises a parallel counter that is designed to read out in parallel light pulses detected by the avalanche semiconductor detectors. The parallel counter is adapted to accumulate the light pulses detected by the avalanche semiconductor detectors over a preset counting time.
摘要翻译：描述在线扫描显微镜中使用的光检测器和包括这种光检测器的显微镜。光检测器包括雪崩半导体检测器的线阵列; 以及电子触发电路，其适于以具有内部电荷放大和线性模式的Geiger模式中的至少一个来操作雪崩半导体检测器。触发电路还包括并行计数器，其被设计为平行地读出由雪崩半导体检测器检测到的光脉冲。并行计数器适于在预设的计数时间内积累由雪崩半导体检测器检测的光脉冲。

66. 发明申请

US20120130670A1 System and Method for Computer-Controlled Execution of at Least One Test in a Scanning Microscope 有权
标题翻译：在扫描显微镜中进行最少一次测试的计算机控制执行系统和方法
公开(公告)号：US20120130670A1
公开(公告)日：2012-05-24
申请号：US13302025
申请日：2011-11-22
申请人： Holger Birk , Volker Seyfried , Roland Moschel , Derek Webster , Harald Brueggemann , Mario Belzer
发明人： Holger Birk , Volker Seyfried , Roland Moschel , Derek Webster , Harald Brueggemann , Mario Belzer
IPC分类号： G06F19/00
CPC分类号： G02B21/008 , G02B21/365
摘要： The invention relates to a method and a system for central computer controlled execution of at least one test run in a scanning microscope, particularly a confocal microscope, wherein at least one first software module of an application software is tested. The invention achieves the aim by a network made of individual scanning microscope clients and a central server. The clients can be contacted via a network interface and are administered in a central directory in the server. The application software for the individual components of a scanning microscope is made of individual software modules, each associated with a potential test. In order to be able to perform the various tests, the scanning microscope clients have been equipped on the hardware side with additional sensors and components that allow various operating parameters to be determined.
摘要翻译：本发明涉及一种用于中央计算机控制执行扫描显微镜，特别是共焦显微镜中的至少一个测试运行的方法和系统，其中测试应用软件的至少一个第一软件模块。本发明通过由单独的扫描显微镜客户端和中央服务器构成的网络实现了目的。可以通过网络接口联系客户端，并在服务器的中央目录中进行管理。扫描显微镜的各个组件的应用软件由单独的软件模块组成，每个软件模块都与潜在测试相关联。为了能够进行各种测试，扫描显微镜客户端已经在硬件方面配备了额外的传感器和组件，可以确定各种操作参数。

67. 发明授权

US07873241B2 Method for superimposing optical information in a scanning microscope 有权
标题翻译：在扫描显微镜中叠加光学信息的方法
公开(公告)号：US07873241B2
公开(公告)日：2011-01-18
申请号：US11236143
申请日：2005-09-27
申请人： Rafael Storz , Volker Seyfried
发明人： Rafael Storz , Volker Seyfried
IPC分类号： G06K9/32 , G09G5/00 , H04N1/04 , H04N5/44 , H04N9/74 , H04N3/223 , G01B11/26 , G01B11/14 , G01C17/00
CPC分类号： G02B21/002 , G02B21/365
摘要： A method for superimposing optical information in a scanning microscope includes determining a transformation matrix, and superimposing first optical information of a CCD image and second optical information of at least one piece of second image information using the transformation matrix.
摘要翻译：一种用于在扫描显微镜中叠加光学信息的方法包括：使用变换矩阵确定变换矩阵，并叠加CCD图像的第一光学信息和至少一条第二图像信息的第二光学信息。

68. 发明申请

US20100177375A1 BEAM COMBINER AND A LIGHT SOURCE WITH SUCH A BEAM COMBINER 有权
标题翻译：光束组合器和具有这种光束组合的光源
公开(公告)号：US20100177375A1
公开(公告)日：2010-07-15
申请号：US12663616
申请日：2008-05-06
申请人： Volker Seyfried
发明人： Volker Seyfried
IPC分类号： G02B27/10 , G02F1/33
CPC分类号： G02B27/14 , G02B21/0032 , G02B21/06 , G02B27/1006 , G02B27/141
摘要： A beam combiner for combining at least two light beams (1, 2) into one combined light beam (3), in particular in the beam path of an optical arrangement, preferably of a microscope, is with respect to a flexible beam combination with structurally simple means characterized by an acousto-optical element (4) in which a mechanical wave or sound wave for deflecting or bending light beams can be generated, so that a first light beam (1) entering the acousto-optical element (4) and at least a second light beam (2) entering the acousto-optical element (4) exit the acousto-optical element (4) in a collinear manner as a combined light beam (3). Further, a light source with such a beam combiner is specified.
摘要翻译：用于将至少两个光束（1,2）组合成一个组合光束（3），特别是在光学装置的光束路径中，优选地由显微镜组合的光束组合器是相对于结构上的柔性光束组合特征在于其中可以产生用于偏转或弯曲光束的机械波或声波的声光元件（4）的简单装置，使得进入声光元件（4）的第一光束（1）进入声光元件（4）的至少一个第二光束（2）以共线方式离开声光元件（4）作为组合光束（3）。此外，具有这种光束组合器的光源被指定。

69. 发明申请

US20100134867A1 ACOUSTO-OPTICAL TUNABLE FILTER ELEMENT 审中-公开
标题翻译： ACOUSTO-OPTICAL TUNABLE过滤器元件
公开(公告)号：US20100134867A1
公开(公告)日：2010-06-03
申请号：US12622719
申请日：2009-11-20
申请人： Hilmar GUGEL , Volker Seyfried
发明人： Hilmar GUGEL , Volker Seyfried
IPC分类号： G02F1/11
CPC分类号： G02F1/116 , G02B3/0087 , G02B21/0032 , G02B21/0064 , G02B21/16 , G02B27/0927 , G02B27/42 , G02B27/46 , G02F1/00 , G02F1/01 , G02F1/03 , G02F1/11 , G02F1/29 , G02F1/33 , G02F1/353 , G02F2201/305 , G02F2202/32 , G02F2203/12 , G02F2203/18 , G02F2203/24
摘要： An acousto-optical filter element (114) is provided which has an acousto-optical crystal (118) having an acoustic signal transmitter (120) for generating acoustic signals in the acousto-optical crystal (118). The acousto-optical crystal (118) is designed to selectively spatially deflect light of a target wavelength from an input light beam (116) entering into the acousto-optical crystal (118), as a function of a high frequency applied to the acoustic signal transmitter (120), and to thereby produce a target light beam (126) having the target wavelength. In addition, the acousto-optical filter element (114) includes a spatial filter element (132) which is located in the target light beam (126) and is designed to selectively suppress the intensity of the target light beam (126) in a plane perpendicular to the propagation direction of the target light beam (126).
摘要翻译：提供一种声光滤波器元件（114），其具有声光晶体（118），该声光晶体具有用于在声光晶体（118）中产生声信号的声信号发射器（120）。声光晶体（118）被设计为根据进入声光晶体（118）的输入光束（116）选择性地空间偏转目标波长的光，作为施加到声信号的高频的函数发射器（120），从而产生具有目标波长的目标光束（126）。此外，声光滤波器元件（114）包括位于目标光束（126）中的空间滤光元件（132），并被设计成选择性地抑制平面中的目标光束（126）的强度垂直于目标光束（126）的传播方向。

70. 发明授权

US07586107B2 Photosensor-chip, laser-microscope comprising a photosensor-chip and method for reading a photosensor-chip 有权
标题翻译：光传感器芯片，包括光电传感器芯片的激光显微镜和用于读取光电传感器芯片的方法
公开(公告)号：US07586107B2
公开(公告)日：2009-09-08
申请号：US12041026
申请日：2008-03-03
申请人： Frank Schreiber , Volker Seyfried
发明人： Frank Schreiber , Volker Seyfried
IPC分类号： G01N21/64
CPC分类号： G02B21/008 , G01J3/2803 , G02B21/0064 , H04N5/3725
摘要： A photosensor chip includes a light-sensitive region with a plurality of detector elements and a light-insensitive region including a buffer memory. The light-insensitive region is at least double the light-sensitive region. A charge produced at different points in time in the detector elements is successively transferred into the buffer memory for being subsequently read out by a read-out register from the buffer memory. In one embodiment, the buffer memory includes a first and second buffer memory adjoining corresponding sides of the light-sensitive region. The first and second buffer memory can be used alternatively for buffer-storage and read-out.
摘要翻译：光传感器芯片包括具有多个检测器元件的光敏区域和包括缓冲存储器的不透光区域。光不敏感区域至少是光敏区域的两倍。在检测器元件中在不同时间点产生的电荷被连续传送到缓冲存储器中，以随后由缓冲存储器中的读出寄存器读出。在一个实施例中，缓冲存储器包括与光敏区域的相应侧邻接的第一和第二缓冲存储器。第一和第二缓冲存储器可以替代地用于缓冲存储和读出。

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