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61. 发明专利

DK2395002T3 Farmaceutisk sammensætning indeholdende en heterocyclisk modulator af ATP-bindende kassettetransportører 未知
公开(公告)号：DK2395002T3
公开(公告)日：2014-09-08
申请号：DK10192912
申请日：2006-11-08
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC分类号： C07D405/12 , A61K31/443 , A61P11/00

62. 发明专利

HRP20140103T1 IZOKINOLINSKI MODULATORI TRANSPORTERA ATP-VEŽUÄ†E KAZETE 未知
公开(公告)号：HRP20140103T1
公开(公告)日：2014-05-09
申请号：HRP20140103
申请日：2014-02-05
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER D J
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14

63. 发明专利

AU2008256717B2 Modulators of cystic fibrosis transmembrane conductance regulator 未知
公开(公告)号：AU2008256717B2
公开(公告)日：2013-11-21
申请号：AU2008256717
申请日：2008-05-23
申请人： VERTEX PHARMA
发明人： BINCH HAYLEY , HADIDA RUAH SARA , ZHOU JINGLAN , GROOTENHUIS PETER
IPC分类号： C07D495/04 , A61K31/407 , A61P11/00
摘要： The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

64. 发明专利

AU2013231151A1 Isoquinoline modulators of ATP-Binding Cassette transporters 未知
公开(公告)号：AU2013231151A1
公开(公告)日：2013-10-10
申请号：AU2013231151
申请日：2013-09-23
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. I R3' y, -N O (R1 )n (I)

65. 发明专利

AU2007351454B2 Azaindole derivatives as CFTR modulators 未知
公开(公告)号：AU2007351454B2
公开(公告)日：2013-07-18
申请号：AU2007351454
申请日：2007-11-02
申请人： VERTEX PHARMA
发明人： MILLER MARK , HADIDA RUAH SARA , ZHOU JINGLAN , BEAR BRIAN
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P25/00
摘要： The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

66. 发明专利

NZ581259A Modulators of cystic fibrosis transmembrane conductance regulator 未知
公开(公告)号：NZ581259A
公开(公告)日：2012-07-27
申请号：NZ58125908
申请日：2008-05-09
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , GROOTENHUIS PETER D
IPC分类号： C07D401/04 , A61K31/444 , A61P11/00 , A61P37/00 , C07D405/14
摘要： Disclosed herein are pyridyl-carboxamide compounds of formula I, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as modulators of Cystic Fibrosis Transmembrane Conductance Regulators (CFTR) and are therefore useful in the treatment of cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, protein C deficiency, Type 1 hereditary angioedema, lipid processing deficiencies, familial hypercholesterolemia, Type 1 chylomicronemia, abetalipoproteinemia, lysosomal storage diseases, I-cell disease/pseudo-Hurler, mucopolysaccharidoses, Sandhof/Tay-Sachs, Crigler-Najjar type II, polyendocrinopathy/hyperinsulemia, Diabetes mellitus, Laron dwarfism, myeloperoxidase deficiency, primary hypoparathyroidism, melanoma, glycanosis CDG type 1, congenital hyperthyroidism, osteogenesis imperfecta, hereditary hypofibrinogenemia, ACT deficiency, Diabetes insipidus (DI), neurophyseal DI, neprogenic DI, Charcot-Marie Tooth syndrome, Perlizaeus-Merzbacher disease, neurodegenerative diseases Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, progressive supranuclear plasy, Pick's disease, several polyglutamine neurological disorders, Huntington, spinocerebullar ataxia type I, spinal and bulbar muscular atrophy, dentatorubal pallidoluysian, and myotonic dystrophy, as well as spongiform encephalopathies, hereditary Creutzfeldt-Jakob disease (due to prion protein processing defect), Fabry disease, Straussler-Scheinker syndrome, COPD, dry-eye disease, or Sjogren's disease.

67. 发明专利

AT533749T 未知
公开(公告)号：AT533749T
公开(公告)日：2011-12-15
申请号：AT06770825
申请日：2006-05-22
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , SINGH ASHVANI , GROOTENHUIS PETER , VAN GOOR FREDRICK , CLEVELAND THOMAS , HAZLEWOOD ANNA
IPC分类号： C07D239/42
摘要： 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

68. 发明专利

NZ566208A 2-Thiazolamide derivatives as modulators of cystic fibrosis transmembrane conductance regulators 未知
公开(公告)号：NZ566208A
公开(公告)日：2010-09-30
申请号：NZ56620806
申请日：2006-08-11
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , VAN GOOR FREDRICK F , MILLER MARK T , MCCARTNEY JASON , ARUMUGAM VIJAYALAKSMI , ZHOU JINGLAN
IPC分类号： C07D417/14 , A61K31/427 , A61P25/16
摘要： Disclosed is a compound of formula I or II, or a pharmaceutically acceptable salt thereof, wherein A is a 3-7 membered monocyclic cycloalkyl ring, RAA and RBB together are a substituted pyrrolidinyl ring, the Rx groups may be separate or may together form a ring, and wherein the other substituents are as defined in the specification. Also disclosed is the use of the compound for increasing the number of functional CFTR in a membrane of a cell, and for treating conditions implicated by CFTR in a patient. Also disclosed is a method of producing the compound.

69. 发明专利

HK1139666A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 未知
公开(公告)号：HK1139666A1
公开(公告)日：2010-09-24
申请号：HK10105677
申请日：2010-06-09
申请人： VERTEX PHARMA
发明人： BINCH HAYLEY , GROOTENHUIS PETER , HADIDA RUAH SARA , ZHOU JINGLAN
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101

70. 发明专利

CA2728985A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS FOR TREATING CYSTIC FIBROSIS 未知
公开(公告)号：CA2728985A1
公开(公告)日：2009-01-08
申请号：CA2728985
申请日：2008-06-27
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , MILLER MARK , GROOTENHUIS PETER , BEAR BRIAN , MCCARTNEY JASON
IPC分类号： A61K31/167 , A61P1/00 , A61P11/00
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

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