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61. 发明专利

HK1215792A1 用於治療炎症後色素沉着過度的補骨脂酚組合物未知
公开(公告)号：HK1215792A1
公开(公告)日：2016-09-15
申请号：HK16103749
申请日：2016-04-01
申请人： UNIGEN INC
发明人： HONG MEI FENG , JIA QI , BROWNELL LIDIA ALFARO
IPC分类号： A61K20060101 , A61P20060101 , A61Q20060101

62. 发明专利

AU2008204909B2 Chromones as therapeutic agents 未知
公开(公告)号：AU2008204909B2
公开(公告)日：2013-05-30
申请号：AU2008204909
申请日：2008-01-09
申请人： UNIGEN INC
发明人： JIA QI , TSENG-CRANK JULIE , YIMAM MESFIN , ZHAO JI-FU
IPC分类号： A61K31/35
摘要： The present invention describes the identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial &bgr;-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPARα/RXRα liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included in the present invention are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.

63. 发明专利

ES2392164T3 7-Hidroxicromonas como antioxidantes potentes 未知
公开(公告)号：ES2392164T3
公开(公告)日：2012-12-05
申请号：ES03733934
申请日：2003-05-01
申请人： UNIGEN PHARMACEUTICALS INC , UNIGEN INC
发明人： JIA QI , FARROW THOMAS M
IPC分类号： A61K31/7048 , A61K31/353 , A61K36/185 , A61K36/282 , A61K36/296 , A61K36/38 , A61K36/48 , A61K36/489 , A61K36/704 , A61K36/886 , A61P3/10 , A61P9/10 , A61P25/28 , A61P27/12 , A61P35/00
摘要： 7-Hidroxicromona o mezcla de 7-hidroxicromonas cuya estructura es la siguiente:en la que:R1 es un grupo oxoalquilo u oxoalquenilo; yR2 y R3 se seleccionan independientemente el uno del otro entre el grupo que consiste en -H, -OH, alquilo,oxoalquilo, oxoalquenilo, hidroxialquilo, hidroxialquenilo, un éster seleccionado entre el grupo que consiste en galato,acetato, ésteres de cinamoílo y de hidroxicinamoílo, ésteres de trihidroxibenzoílo y ésteres de cafeoílo; un glucósidode carbono, de oxígeno, de nitrógeno o de azufre de uno solo o de una combinación de varios azúcaresseleccionados entre el grupo que consiste en aldopentosas, metilaldopentosa, aldohexosas, cetohexosa;en la que dicho grupo alquilo es una cadena lineal y/o ramificada que tiene entre 1 y 20 átomos de carbono con y/osin dobles enlaces en diferentes posiciones;para la utilización en un método de tratamiento de una enfermedad o afección mediada por las ERO seleccionadaentre el grupo que consiste en arterioesclerosis, cardiopatías coronarias, cataratas, demencia, enfermedad deAlzheimer, disfunción cognitiva, diabetes sacarina, cáncer y melanoma.

64. 发明专利

PL1748767T3 1-(3-metylo-2,4-dimetoksyfenylo)-3-(2',4'-dihydroksyfenylo)-propan jako silny inhibitor tyrozynazy 未知
公开(公告)号：PL1748767T3
公开(公告)日：2012-08-31
申请号：PL05762186
申请日：2005-05-27
申请人： UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/05 , A61K31/015 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00

65. 发明专利

AU2005249493B2 Diarylalkanes as potent inhibitors of binuclear enzymes 未知
公开(公告)号：AU2005249493B2
公开(公告)日：2011-09-08
申请号：AU2005249493
申请日：2005-05-27
申请人： UNIGEN INC
发明人： ZHAO JI-FU , JIA QI
IPC分类号： C07C43/23 , A61K31/015 , A61K31/05 , A61K31/704 , C07C39/15 , C07C39/367 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/68 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds - diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

66. 发明专利

HK1146712A1 FORMULATION OF A MIXTURE OF FREE-B-RING FLAVONOIDS AND FLAVANS AS A THERAPEUTIC AGENT 未知
公开(公告)号：HK1146712A1
公开(公告)日：2011-07-08
申请号：HK11100877
申请日：2011-01-27
申请人： UNIGEN INC
发明人： JIA QI
IPC分类号： A61K20060101 , A61K31/353 , A01N31/08 , A61K31/05 , A61K31/35 , A61K31/352 , A61K31/7048 , A61K36/00 , A61K36/18 , A61K36/47 , A61P20060101 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.; This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

67. 发明专利

AU2005295190A1 Flavonoid composition for treating oral diseases 未知
公开(公告)号：AU2005295190A1
公开(公告)日：2006-04-27
申请号：AU2005295190
申请日：2005-10-19
申请人： UNIGEN INC
发明人： JIA QI , ZHAO YUAN
IPC分类号： A61K31/35 , A61K8/00 , A61K8/97 , A61K9/00 , A61K9/14 , A61K9/68 , A61K47/00
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).

68. 发明专利

CA2826262C BAKUCHIOL COMPOSITIONS FOR TREATMENT OF POST INFLAMMATORY HYPERPIGMENTATION 未知
公开(公告)号：CA2826262C
公开(公告)日：2021-10-26
申请号：CA2826262
申请日：2012-02-02
申请人： UNIGEN INC
发明人： HONG MEI FENG , JIA QI , BROWNELL LIDIA ALFARO
IPC分类号： A61K31/05
摘要： Post inflammatory hyperpigmentation (PIH) is a unique skin pigmentation condition that can be derived from endogenous inflammatory skin disorders like acne and that involves increased melanin synthesis (melanogenesis) and deposition. Current therapeutic agents against acne are ineffective against PIH. The present disclosure provides using of bakuchiol compositions for alleviating, reducing or treating PIH derived from acne as well as for reducing melanogenesis, reducing melanocyte proliferation or preventing melanocyte apoptosis in a mammal.

69. 发明专利

HK1256611A1 天然防腐劑和抗菌劑，包括其組合物未知
公开(公告)号：HK1256611A1
公开(公告)日：2019-09-27
申请号：HK18115743
申请日：2018-12-07
申请人： UNIGEN INC
发明人： JIAO PING , JIA QI , HONG MEI FENG , KIM MISUN
IPC分类号： A23L20060101 , A61K20060101 , A61Q20060101

70. 发明专利

CA3128718A1 BAKUCHIOL COMPOSITIONS FOR TREATMENT OF POST INFLAMMATORY HYPERPIGMENTATION 未知
公开(公告)号：CA3128718A1
公开(公告)日：2012-08-09
申请号：CA3128718
申请日：2012-02-02
申请人： UNIGEN INC
发明人： HONG MEI FENG , JIA QI , BROWNELL LIDIA ALFARO
IPC分类号： A61K31/60 , A61K31/05 , A61P17/10 , A61P29/00
摘要： Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a patient in need thereof. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

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