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61. 发明申请

WO2007130780A2 BENZIMIDAZOLE MODULATORS OF VR1 审中-公开
标题翻译： VR1的苯并咪唑调节剂
公开(公告)号：WO2007130780A2
公开(公告)日：2007-11-15
申请号：PCT/US2007066748
申请日：2007-04-17
申请人： JANSSEN PHARMACEUTICA NV , CALVO RAUL L , PLAYER MARK R , DAX SCOTT L , PARSONS WILLIAM H , BRANDT MICHAEL , PATEL SHARMILA , LIU JIAN , CHEUNG WING S , JETTER MICHELE C , LEE YU-KAI , YOUNGMAN MARK A , PAN WENXI , WELLS KENNETH M , BEAUCHAMP DEREK A
发明人： CALVO RAUL L , PLAYER MARK R , DAX SCOTT L , PARSONS WILLIAM H , BRANDT MICHAEL , PATEL SHARMILA , LIU JIAN , CHEUNG WING S , JETTER MICHELE C , LEE YU-KAI , YOUNGMAN MARK A , PAN WENXI , WELLS KENNETH M , BEAUCHAMP DEREK A
IPC分类号： C07D235/08 , A61K31/4184 , A61K31/4706 , A61P29/00 , C07D401/06 , C07D403/06
CPC分类号： C07D401/06 , C07D235/08 , C07D403/06
摘要： The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.
摘要翻译：本发明涉及式（I）的化合物：含有这些化合物的药物组合物和使用它们的治疗方法。

62. 发明申请

WO2006036883A3 IMIDAZO{4,5-B}PYRAZINONE INHIBITORS OF PROTEIN KINASES 审中-公开
标题翻译：咪达唑（4,5-B）蛋白激酶的吡嗪酮抑制剂
公开(公告)号：WO2006036883A3
公开(公告)日：2006-06-22
申请号：PCT/US2005034395
申请日：2005-09-23
申请人： JANSSEN PHARMACEUTICA NV , LIU JIAN , PATCH RAYMOND J , PLAYER MARK R
发明人： LIU JIAN , PATCH RAYMOND J , PLAYER MARK R
IPC分类号： A01N43/58 , A01N43/60 , A61K31/495 , A61K31/50 , C07D471/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00
CPC分类号： C07D487/04
摘要： The invention is directed to compounds of Formula (I): Wherein Q, Y, A are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein kinases, especially Aurora-1, Aurora-2 and Aurora-3 kinases.
摘要翻译：本发明涉及式（I）的化合物：其中Q，Y，A在说明书中列出，以及其抑制蛋白激酶，特别是Aurora-1，Aurora的溶剂合物，水合物，互变异构体或其药学上可接受的盐 -2和Aurora-3激酶。

63. 发明申请

WO9922005B1 HEPARAN SULFATE D-GLUCOSAMINYL 3-O-SULFOTRANSFERASES, AN USES THEREFOR 审中-公开
标题翻译：硫酸乙酰肝素D-葡糖胺3-O-磺酸酯转运酶，用途
公开(公告)号：WO9922005B1
公开(公告)日：1999-11-11
申请号：PCT/US9822597
申请日：1998-10-23
申请人： MASSACHUSETTS INST TECHNOLOGY , ROSENBERG ROBERT D , SHWORAK NICHOLAS W , LIU JIAN , FRITZE LINDA M S , SCHWARTZ JOHN J , ZHANG LIJUAN
发明人： ROSENBERG ROBERT D , SHWORAK NICHOLAS W , LIU JIAN , FRITZE LINDA M S , SCHWARTZ JOHN J , ZHANG LIJUAN
IPC分类号： C12N9/10 , C12N15/54 , A01K67/027 , C07K16/40 , G01N33/68
CPC分类号： C12N9/13 , A01K2217/05 , C07K2319/20
摘要： Disclosed are novel isolated nucleic acids and substancially pure protein preparations for naturally occurring and synthetic or chimeric heparan sulfate D-glucosaminyl 3-O-sulfo-transferases (3-OSTs). Also disclosed are uses for these genes and proteins, including uses for the modification and sequencing of glycosaminoglycans.
摘要翻译：公开了用于天然存在的和合成的或嵌合的硫酸乙酰肝素D-葡糖胺基3-O-磺基转移酶（3-OST）的新型分离的核酸和基本纯的蛋白质制剂。还公开了这些基因和蛋白质的用途，包括用于糖胺聚糖的修饰和测序。

64. 发明申请

WO9922005A3 HEPARAN SULFATE D-GLUCOSAMINYL 3-O-SULFOTRANSFERASES, AN USES THEREFOR 审中-公开
公开(公告)号：WO9922005A3
公开(公告)日：1999-10-07
申请号：PCT/US9822597
申请日：1998-10-23
申请人： MASSACHUSETTS INST TECHNOLOGY , ROSENBERG ROBERT D , SHWORAK NICHOLAS W , LIU JIAN , FRITZE LINDA M S , SCHWARTZ JOHN J , ZHANG LIJUAN
发明人： ROSENBERG ROBERT D , SHWORAK NICHOLAS W , LIU JIAN , FRITZE LINDA M S , SCHWARTZ JOHN J , ZHANG LIJUAN
IPC分类号： C12N9/10 , C12N15/54 , A01K67/027 , C07K16/40 , G01N33/68
CPC分类号： C12N9/13 , A01K2217/05 , C07K2319/20
摘要： Disclosed are novel isolated nucleic acids and substancially pure protein preparations for naturally occurring and synthetic or chimeric heparan sulfate D-glucosaminyl 3-O-sulfo-transferases (3-OSTs). Also disclosed are uses for these genes and proteins, including uses for the modification and sequencing of glycosaminoglycans.

65. 发明申请

WO2016109217A3 BTK INHIBITORS 审中-公开
标题翻译： BTK抑制剂
公开(公告)号：WO2016109217A3
公开(公告)日：2016-08-25
申请号：PCT/US2015066220
申请日：2015-12-17
申请人： MERCK SHARP & DOHME , LIU JIAN , KOZLOWSKI JOSEPH A , BOGA SOBHANA BABU , GUIADEEN DEODIALSINGH , YU WENSHENG , CAI JIAQIANG , LIU SHILAN
发明人： LIU JIAN , KOZLOWSKI JOSEPH A , BOGA SOBHANA BABU , GUIADEEN DEODIALSINGH , YU WENSHENG , CAI JIAQIANG
IPC分类号： A61K31/5377 , A61K31/541 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
摘要翻译：本发明提供根据式（I）的布鲁顿氏酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐，或包含这些化合物的药物组合物及其在治疗中的用途。具体而言，本发明涉及式（I）的Btk抑制剂化合物在治疗Btk介导的病症中的用途。

66. 发明申请

WO2013130370A2 COMPOUNDS AS DGAT-1 INHIBITORS 审中-公开
标题翻译：化合物作为DGAT-1抑制剂
公开(公告)号：WO2013130370A2
公开(公告)日：2013-09-06
申请号：PCT/US2013027548
申请日：2013-02-25
申请人： MERCK SHARP & DOHME , DEVITA ROBERT J , YU YANG , LIU JIAN , HE SHUWEN , KRIKORIAN ARTO D , MILLER DANIEL J , WU ZHICAI , YANG GINGER XU-QIANG , HONG QUINGMEI , LAI ZHONG , ZORN NICOLAS , TING PAULINE C
发明人： DEVITA ROBERT J , YU YANG , LIU JIAN , HE SHUWEN , KRIKORIAN ARTO D , MILLER DANIEL J , WU ZHICAI , YANG GINGER XU-QIANG , HONG QUINGMEI , LAI ZHONG , ZORN NICOLAS , TING PAULINE C
IPC分类号： A61K31/513
CPC分类号： C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10 , C07D403/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds of formula I. The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译：本文描述了式I化合物。式I化合物起DGAT1抑制剂的作用，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的治疗剂。

67. 发明申请

WO2013016502A3 LONGEST PREFIX MATCH SCHEME 审中-公开
标题翻译：最早的PREFIX MATCH计划
公开(公告)号：WO2013016502A3
公开(公告)日：2013-07-11
申请号：PCT/US2012048273
申请日：2012-07-26
申请人： BROCADE COMM SYSTEMS INC , LIU JIAN , LEICHTY PHILIP LYNN , LIM HOW TUNG , TERRY JOHN MICHAEL , MADDURY MAHESH SRINIVASA , CHEUNG WING , KO KUNG LING
发明人： LIU JIAN , LEICHTY PHILIP LYNN , LIM HOW TUNG , TERRY JOHN MICHAEL , MADDURY MAHESH SRINIVASA , CHEUNG WING , KO KUNG LING
IPC分类号： G06F7/02
CPC分类号： G06F7/02 , H04L45/7457 , H04L45/748
摘要： A LPM search engine includes a plurality of exact match (EXM) engines and a moderately sized TCAM. Each EXM engine uses a prefix bitmap scheme that allows the EXM engine to cover multiple consecutive prefix lengths. Thus,instead of covering one prefix length L per EXM engine, the prefix bitmapscheme enables each EXM engine to cover entries having prefix lengths of L,L+1, L+2 and L+3, for example. As a result, fewer EXM engines are potentially underutilized, which effectively reduces quantization loss. Each EXM engine provides a search result with a determined fixed latency when using the prefix bitmap scheme. The results of multiple EXM engines and the moderately sizedTCAM are combined to provide a single search result, representative of the longest prefix match. In one embodiment, the LPM search engine supports 32-bitIPv4 (or 128-bit IPv6) search keys, each having associated 15-bit level 3 VPN identification values.
摘要翻译： LPM搜索引擎包括多个精确匹配（EXM）引擎和适度大小的TCAM。每个EXM引擎使用前缀位图方案，允许EXM引擎覆盖多个连续的前缀长度。因此，例如，前缀位图方案不是覆盖每个EXM引擎的一个前缀长度L，而是允许每个EXM引擎覆盖具有前缀长度L，L + 1，L + 2和L + 3的条目。因此，更少的EXM引擎可能未充分利用，从而有效减少量化损失。当使用前缀位图方案时，每个EXM引擎提供具有确定的固定延迟的搜索结果。将多个EXM引擎和中等大小的TCAM的结果组合起来以提供单个搜索结果，代表最长的前缀匹配。在一个实施例中，LPM搜索引擎支持32位IPv4（或128位IPv6）搜索关键字，每个搜索关键字具有关联的15位3级VPN标识值。

68. 发明申请

WO2012145597A3 RECOMBINANT VIRUS PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF MYOTILIN 审中-公开
标题翻译：重组病毒产品和抑制MYOTILIN表达的方法
公开(公告)号：WO2012145597A3
公开(公告)日：2012-12-27
申请号：PCT/US2012034408
申请日：2012-04-20
申请人： NATIONWIDE CHILDREN S HOSPITAL INC , HARPER SCOTT QUENTON , LIU JIAN
发明人： HARPER SCOTT QUENTON , LIU JIAN
IPC分类号： C12N7/01 , A61K31/7088 , A61K48/00
CPC分类号： C12N15/86 , C07K14/4707 , C12N15/113 , C12N2310/141 , C12N2330/51 , C12N2750/14143
摘要： The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
摘要翻译：本发明涉及用于抑制肌原蛋白基因表达的基于RNA干扰的方法。本发明的重组腺相关病毒递送编码击倒肌肉蛋白表达的微RNA的DNA。该方法可用于治疗肌营养不良症，如肢带型肌营养不良症1A型。

69. 发明申请

WO2006082509A3 A SOLID PHENOLIC CORE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：一种固体酚醛树脂及其制备方法
公开(公告)号：WO2006082509A3
公开(公告)日：2007-02-08
申请号：PCT/IB2006000211
申请日：2006-02-03
申请人： WILSONART SHANGHAI CO LTD , GUO CHAOHUI , ZHONG XIAOHANG , LIU JIAN , LI JING
发明人： GUO CHAOHUI , ZHONG XIAOHANG , LIU JIAN , LI JING
IPC分类号： B32B29/00
CPC分类号： B32B29/00 , B32B27/42 , B32B29/005 , B32B2250/26 , B32B2250/40 , B32B2260/028 , B32B2260/046 , B32B2307/306 , B32B2307/554 , B32B2307/714 , B32B2479/00
摘要： This invention discloses a three-layer-sandwich solid phenolic core (SPC) comprising first outside layer, middle layer and second outside layer. The middle layer of the SPC is a thick solid plate formed by using several layers of paper material through heat-pressing process; the first and second outside layers of the SPC are thin solid plates formed by using several layers of paper material through heat-pressing process; the three-layer-sandwich SPC is formed by coating adhesive on the outside surfaces of the middle layer (or the inner surfaces of the first and second outside layers) and then by pressing the first and second outside layers onto the outside surfaces of the middle layer. This invention is advantageous in increasing yield, increasing production elasticity, decreasing SPC cost and increasing the quality of the SPC.
摘要翻译：本发明公开了一种包含第一外层，中间层和第二外层的三层夹心固体酚醛芯（SPC）。 SPC的中间层是通过热压工艺使用几层纸材料形成的厚实心板; SPC的第一和第二外层是通过热压工艺使用数层纸材形成的薄的固体板; 通过将粘合剂涂覆在中间层（或第一和第二外层的内表面）的外表面上，然后通过将第一和第二外层压在中间层的外表面上而形成三层夹心SPC 层。本发明有利于提高产量，增加生产弹性，降低SPC成本，提高SPC质量。

70. 发明申请

WO2006044063A2 TRANSEPITHELIAL DELIVERY OF PEPTIDES WITH INCRETIN HORMONE ACTIVITIES 审中-公开
标题翻译：通过增加激素活性来递送肽
公开(公告)号：WO2006044063A2
公开(公告)日：2006-04-27
申请号：PCT/US2005032636
申请日：2005-09-14
申请人： NITTO DENKO CORP , KITAURA CHIEKO , MINOMI KENJIRO , OKUBO KATSUYUKI , OKADA KEISAKU , KAGEHISA NATSUKO , KAMIYAMA MASASHI , HOU ZHENG , LIU JIAN , SONG YUCHENG , YU LEI
发明人： KITAURA CHIEKO , MINOMI KENJIRO , OKUBO KATSUYUKI , OKADA KEISAKU , KAGEHISA NATSUKO , KAMIYAMA MASASHI , HOU ZHENG , LIU JIAN , SONG YUCHENG , YU LEI
IPC分类号： A61K47/48
CPC分类号： C07K14/605 , A61K9/0014 , A61K38/00 , A61K47/62 , A61K47/645 , C07K14/57563
摘要： Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.
摘要翻译：公开了使用具有肠降血糖素激素活性的肽治疗糖尿病和相关疾病的组合物和方法。优选地，具有肠降血糖素激素活性的肽是GLP-1，毒蜥外泌肽或GLP-1或毒蜥外泌肽类似物。具有肠过氧化物激素活性的肽通过经上皮载体肽经上皮内给药。跨上皮肽含有足够的氨基，胍或脒基以刺激跨上皮递送。在一些实施方案中，将经上皮载体和具有肠降血糖素激素活性的肽嵌入膏药或贴剂的压敏粘合剂层中。

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