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61. 发明申请

US20130138145A1 TISSUE CLOSURE DEVICE WITH RESILIENT ARMS 有权
标题翻译：组织闭合装置与活力臂
公开(公告)号：US20130138145A1
公开(公告)日：2013-05-30
申请号：US13308240
申请日：2011-11-30
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00349 , A61B2017/00637 , A61B2017/00676 , A61B2017/22038 , A61B2017/2215 , A61B2017/2845 , A61B2090/036
摘要： A tissue closure device includes a main body, a sheath, and a biasing member. The main body has a plurality of resilient arms that each extend from a proximal end to a distal tip. The resilient arms are movable between an open configuration in which the distal tips are radially spaced apart from the longitudinal axis of the main body and from each other and a closed configuration in which the distal tips abut one another at or near the longitudinal axis. The sheath is longitudinally slideable on the main body to move the arms between the open and closed configurations. The biasing member causes the sheath to bias the arms toward the closed configuration.
摘要翻译：组织封闭装置包括主体，护套和偏置构件。主体具有多个弹性臂，每个弹性臂从近端延伸到远端。弹性臂可以在其中远侧末端与主体的纵向轴线径向间隔开并且彼此之间的打开构造可移动，并且闭合构型，其中远侧末端在纵向轴线处或附近彼此抵接。护套可以在主体上纵向滑动，以在打开和关闭构型之间移动臂。偏置构件使护套将臂朝向闭合构型偏置。

62. 发明申请

US20120285836A1 ELECTROCHEMICAL FORMATION OF FOIL-SHAPED STENT STRUTS 失效
标题翻译：电子形成的形状的STENT STRUTS
公开(公告)号：US20120285836A1
公开(公告)日：2012-11-15
申请号：US13107216
申请日：2011-05-13
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： C25F3/16
CPC分类号： C25F3/16 , A61F2/82 , C25F7/00 , C25F7/02
摘要： An apparatus and method for electrochemically treating the struts of an intravascular stent is disclosed. An intravascular stent is mounted in a chamber and is electrochemically treated in order to remove a portion of the stent struts in order to form an airfoil shape. The airfoil-shaped stent struts will reduce turbulent blood flow in the vasculature in which the stent is implanted thereby improving clinical outcome.
摘要翻译：公开了一种用于电化学处理血管内支架的支柱的装置和方法。将血管内支架安装在腔室中并进行电化学处理以便去除支架支架的一部分以形成翼型形状。翼型支架支架将减少植入支架植入的脉管系统中的湍流血流，从而改善临床结果。

63. 发明授权

US08246574B2 Support catheter 有权
标题翻译：支持导管
公开(公告)号：US08246574B2
公开(公告)日：2012-08-21
申请号：US11738368
申请日：2007-04-20
申请人： James M. Jacobs , Randolf von Oepen , Richard Newhauser , Travis Yribarren
发明人： James M. Jacobs , Randolf von Oepen , Richard Newhauser , Travis Yribarren
IPC分类号： A61M31/00 , A61M29/00 , A61M5/178 , A61M1/00 , A61B5/00 , A61F11/00
CPC分类号： A61M25/0045 , A61M25/0053
摘要： A support catheter that can be used to aid positioning of a guidewire and other medical devices. The support catheter includes a catheter body having a length, and a supporting structure formed or disposed in or on the catheter body. The catheter support structure, whether alone or in combination with the other portions of the support catheter, provides flexibility, stiffness, and torqueability to the support catheter.
摘要翻译：可用于辅助导丝和其他医疗装置的定位的支撑导管。支撑导管包括具有长度的导管主体和形成或设置在导管主体中或导管本体上的支撑结构。导管支撑结构，无论是单独还是与支撑导管的其他部分组合，都为支撑导管提供了灵活性，刚度和可逆性。

64. 发明申请

US20120165924A1 Method and Device for Treatment of Mitral Insufficiency 有权
标题翻译：治疗二尖瓣功能不全的方法和装置
公开(公告)号：US20120165924A1
公开(公告)日：2012-06-28
申请号：US13366540
申请日：2012-02-06
申请人： Jan Otto Solem , Per-Ola Kimblad , Randolf von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
发明人： Jan Otto Solem , Per-Ola Kimblad , Randolf von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/07 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2002/826 , A61F2002/828 , A61F2002/8483 , A61F2210/0004
摘要： A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.
摘要翻译：公开了一种用于治疗二尖瓣环扩张的装置，其中该装置包括两种状态。在这些状态中的第一个状态下，该装置可插入冠状窦并具有冠状窦的形状。当定位在冠状窦中时，假设曲率半径减小，装置可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。

65. 发明授权

US08076529B2 Expandable member formed of a fibrous matrix for intraluminal drug delivery 有权
标题翻译：由用于管腔内药物递送的纤维基质形成的可膨胀构件
公开(公告)号：US08076529B2
公开(公告)日：2011-12-13
申请号：US12238627
申请日：2008-09-26
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61F13/15 , A61F13/20 , A61M31/00 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。治疗剂可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

66. 发明授权

US08075616B2 Apparatus for applying a compressive load on body tissue 有权
标题翻译：用于在身体组织上施加压缩载荷的装置
公开(公告)号：US08075616B2
公开(公告)日：2011-12-13
申请号：US10500188
申请日：2002-12-20
申请人： Jan Otto Solem , Per Ola Kimblad , Randolf von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
发明人： Jan Otto Solem , Per Ola Kimblad , Randolf von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/07 , A61F2/2481 , A61F2/26 , A61F2002/043 , A61F2002/072 , A61F2002/826 , A61F2002/828 , A61F2002/8483 , A61F2210/0004
摘要： A device for reshaping a cardiac valve (26), which is elongate and has such dimensions as to be insertable into a cardiac vessel (24). The device has two states, in a first state (K) of which the device has a shape that is adaptable to the shape of the vessel (24), and to the second state (k′) of which the device is transferable from said first state (K). Further, the device comprises a fixing means (22,23;22a,23a) for fixing the ends of the device within the vessel (24), when the device is first positioned therein, a shape-changing member (20;20a) for transferring the device to the second state (K′) by reshaping it, and a delay means (21;21a) for delaying said reshaping until the fixing of the ends of the device has been reinforced by keeping said device in said first state (K) until the delay means (21;21a) is resorbed.
摘要翻译：一种用于整形心脏瓣膜（26）的装置，其是细长的并且具有可插入心脏容器（24）的尺寸。该装置具有两种状态，其处于第一状态（K），其装置具有适应于容器（24）的形状的形状，以及第二状态（k'），其中装置可从所述第二状态第一个状态（K）。此外，该装置包括固定装置（22,23; 22a，23a），用于当装置首先定位在容器（24）内时将装置的端部固定，形状改变构件（20; 20a）通过重新形成将装置转移到第二状态（K'），以及用于延迟所述重新成形的延迟装置（21; 21a），直到通过将所述装置保持在所述第一状态（K ），直到延迟装置（21; 21a）被再吸收。

67. 发明申请

US20110270381A1 METHODS AND APPARATUS FOR STENTING COMPRISING ENHANCED EMBOLIC PROTECTION COUPLED WITH IMPROVED PROTECTIONS AGAINST RESTENOSIS AND THROMBUS FORMATION 有权
标题翻译：用于包括增强的保护性保护的改进方法和装置与改进的保护和血栓形成的保护
公开(公告)号：US20110270381A1
公开(公告)日：2011-11-03
申请号：US13089039
申请日：2011-04-18
申请人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

68. 发明授权

US07927305B2 Systems, methods, and devices for injecting media contrast 有权
标题翻译：用于注入媒体对比度的系统，方法和设备
公开(公告)号：US07927305B2
公开(公告)日：2011-04-19
申请号：US11738372
申请日：2007-04-20
申请人： Travis Yribarren , Richard Newhauser , Randolf von Oepen , James M. Jacobs
发明人： Travis Yribarren , Richard Newhauser , Randolf von Oepen , James M. Jacobs
IPC分类号： A61M37/00 , A61M5/00
CPC分类号： A61M25/10 , A61B2017/22038 , A61M5/007 , A61M5/14526 , A61M5/172 , A61M2025/0004 , A61M2025/0681 , A61M2025/1052
摘要： A system for delivering a contrast medium to a treatment site including a delivery device, and a portable power injector. The delivery device includes a guidewire lumen and a contrast injection lumen, the guidewire lumen and contrast injection lumen being at least partially coaxial. The portable power injector includes an injector body and is configured to contain a contrast medium. The injector body has a plunger disposed therein. The portable power injector also includes a pressure generator, the pressure generator being configured to apply a pressure to the plunger to drive the contrast medium from the injector body and through a distal end of the contrast injection lumen.
摘要翻译：一种用于将造影剂输送到包括输送装置和便携式动力注射器的治疗部位的系统。输送装置包括导丝管腔和造影剂注射内腔，导丝管腔和造影剂注射腔至少部分同轴。便携式动力注射器包括注射器主体并且构造成容纳造影剂。喷射器主体具有设置在其中的柱塞。便携式动力注射器还包括压力发生器，压力发生器被配置为向柱塞施加压力以从注射器主体和造影剂注射腔的远端驱动造影剂。

69. 发明授权

US07824434B2 Self foreshortening fastener 失效
标题翻译：自动缩短紧固件
公开(公告)号：US07824434B2
公开(公告)日：2010-11-02
申请号：US11146433
申请日：2005-06-06
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/04
CPC分类号： A61B17/866 , A61B2017/00004
摘要： Disclosed is a fastener that can be mounted to a bone of a patient and can foreshorten and swell of a desired period of time. The fastener can include a head portion and a body portion extending from the head portion. At least one of the head portion and the body portion has a first width that changes to a second width greater than the first width and collectively the head portion and the body portion have a first length that changes to a second length shorter than the first length upon the head portion and the body portion being exposed to a temperature below a glass transition temperature of a polymeric material forming the head portion and the body portion.
摘要翻译：公开了一种紧固件，其可以安装到患者的骨骼并且可以缩短和膨胀期望的时间段。紧固件可以包括头部和从头部延伸的主体部分。所述头部和所述主体部分中的至少一个具有变成大于所述第一宽度的第二宽度的第一宽度，并且所述头部部分和所述主体部分具有变成比所述第一长度短的第二长度的第一长度在头部和主体部分暴露于形成头部和主体部分的聚合物材料的玻璃化转变温度以下的温度。

70. 发明授权

US07811314B2 Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权
标题翻译：用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护
公开(公告)号：US07811314B2
公开(公告)日：2010-10-12
申请号：US11732244
申请日：2007-04-02
申请人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

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