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    • 63. 发明申请
    • STABILIZED PHARMACEUTICAL COMPOSITION
    • 稳定的药物组合物
    • US20110152342A1
    • 2011-06-23
    • US13058641
    • 2009-08-14
    • Hiroshi UchidaMamoru FukudaSeigo Aritomi
    • Hiroshi UchidaMamoru FukudaSeigo Aritomi
    • A61K31/40
    • A61K31/40A61K9/2018A61K9/2081A61K9/2866A61K9/5015
    • A pharmaceutical composition is provided which can easily be prepared and which can prevent decomposition of an aminoacetylpyrrolidine carbonitrile derivative, as an effective component, which derivative is in general instable in a pharmaceutical composition.More specifically, the pharmaceutical composition comprises an aminoacetyl pyrrolidine carbonitrile derivative represented by the following general formula (1): (in the formula (1), A represents CH2, CHF or CF2; and R1 represents a secondary amino group which may have a substituent), and the following components blended with the derivative: (1) a sugar alcohol; (2) calcium carbonate, sodium citrate or sodium sulfate; and (3) a neutral low melting point oily and/or fatty substance.
    • 提供了一种药物组合物,其可以容易地制备并且可以防止氨基乙酰基吡咯烷腈衍生物作为有效成分的分解,该衍生物通常在药物组合物中不稳定。 更具体地,药物组合物包含由以下通式(1)表示的氨基乙酰基吡咯烷腈衍生物:(在式(1)中,A表示CH 2,CHF或CF 2; R 1表示可具有取代基的仲氨基 ),并且以下组分与衍生物混合:(1)糖醇; (2)碳酸钙,柠檬酸钠或硫酸钠; 和(3)中性低熔点油性和/或脂肪物质。